DE69736432T2 - Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide - Google Patents
Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide Download PDFInfo
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- DE69736432T2 DE69736432T2 DE69736432T DE69736432T DE69736432T2 DE 69736432 T2 DE69736432 T2 DE 69736432T2 DE 69736432 T DE69736432 T DE 69736432T DE 69736432 T DE69736432 T DE 69736432T DE 69736432 T2 DE69736432 T2 DE 69736432T2
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- Medicinal Preparation (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US726211 | 1985-04-23 | ||
| US08/726,211 US6977244B2 (en) | 1996-10-04 | 1996-10-04 | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| PCT/US1997/018348 WO1998014172A1 (en) | 1996-10-04 | 1997-10-03 | Inhibition of bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
Publications (2)
| Publication Number | Publication Date |
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| DE69736432D1 DE69736432D1 (de) | 2006-09-14 |
| DE69736432T2 true DE69736432T2 (de) | 2007-03-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| DE69736432T Expired - Lifetime DE69736432T2 (de) | 1996-10-04 | 1997-10-03 | Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide |
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| Country | Link |
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| US (2) | US6977244B2 (enExample) |
| EP (1) | EP0939621B1 (enExample) |
| JP (2) | JP4402746B2 (enExample) |
| AT (1) | ATE334657T1 (enExample) |
| CA (2) | CA2266584C (enExample) |
| DE (1) | DE69736432T2 (enExample) |
| ES (1) | ES2270454T3 (enExample) |
| WO (1) | WO1998014172A1 (enExample) |
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| US5855911A (en) * | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
| US6977244B2 (en) | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| US7704962B1 (en) | 1997-10-03 | 2010-04-27 | Board Of Regents, The University Of Texas System | Small oligonucleotides with anti-tumor activity |
| US7285288B1 (en) | 1997-10-03 | 2007-10-23 | Board Of Regents, The University Of Texas System | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| US20030171315A1 (en) * | 2001-07-18 | 2003-09-11 | Brown Bob D. | Oligonucleotide probes and primers comprising universal bases for therapeutic purposes |
| US20040077082A1 (en) * | 2002-10-18 | 2004-04-22 | Koehn Richard K. | RNA-based inhibitory oligonucleotides |
| EP1640452A4 (en) | 2003-05-30 | 2009-12-23 | Nippon Shinyaku Co Ltd | OLIGOBICATENARY RNA INHIBITING BCL-2 EXPRESSION AND MEDICINAL COMPOSITION CONTAINING THE SAME |
| US8815599B2 (en) * | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| US20060229267A1 (en) * | 2004-06-01 | 2006-10-12 | Reza Sheikhnejad | Methods and compositions for the inhibition of gene expression |
| RU2007138027A (ru) | 2005-03-14 | 2009-04-20 | Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем (Us) | Биоактивные пептиды fus-1 и комплексы полипептидов с наночастицами |
| US8895717B2 (en) * | 2005-04-15 | 2014-11-25 | The Board Of Regents Of The University Of Texas System | Delivery of siRNA by neutral lipid compositions |
| JP5122474B2 (ja) * | 2005-12-01 | 2013-01-16 | プロネイ・セラピューティクス・インコーポレイテッド | 両性リポソーム製剤 |
| WO2007065017A2 (en) * | 2005-12-01 | 2007-06-07 | Pronai Therapeutics, Inc. | Oligonucleotide cationic liposomal delivery system |
| JP5623016B2 (ja) * | 2005-12-01 | 2014-11-12 | プロネイ・セラピューティクス・インコーポレイテッドＰｒｏｎａｉｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 癌治療法およびそれに用いる医薬組成物 |
| US7850382B2 (en) | 2007-01-18 | 2010-12-14 | Sanford, L.P. | Valve made from two materials and writing utensil with retractable tip incorporating same |
| US7488130B2 (en) | 2007-02-01 | 2009-02-10 | Sanford, L.P. | Seal assembly for retractable instrument |
| WO2008103431A2 (en) * | 2007-02-23 | 2008-08-28 | Pronai Therapeutics, Inc. | Dnai - liposomes |
| WO2008109432A2 (en) * | 2007-03-02 | 2008-09-12 | The Board Of Regents Of The University Of Texas System | Therapeutic targeting of interleukins using sirna in neutral liposomes |
| WO2009071681A2 (en) * | 2007-12-07 | 2009-06-11 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of bcl-2 |
| US8226312B2 (en) | 2008-03-28 | 2012-07-24 | Sanford, L.P. | Valve door having a force directing component and retractable instruments comprising same |
| CN102112110A (zh) * | 2008-06-06 | 2011-06-29 | 米尔纳医疗股份有限公司 | 用于RNAi试剂体内递送的新型组合物 |
| US20100068235A1 (en) * | 2008-09-16 | 2010-03-18 | Searete LLC, a limited liability corporation of Deleware | Individualizable dosage form |
| CN108165548B (zh) * | 2008-09-22 | 2022-10-14 | 菲奥医药公司 | 减小大小的自递送RNAi化合物 |
| US8221012B2 (en) | 2008-11-07 | 2012-07-17 | Sanford, L.P. | Retractable instruments comprising a one-piece valve door actuating assembly |
| US8393814B2 (en) | 2009-01-30 | 2013-03-12 | Sanford, L.P. | Retractable instrument having a two stage protraction/retraction sequence |
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| JP2013519869A (ja) | 2010-02-10 | 2013-05-30 | ノバルティス アーゲー | 筋肉成長のための方法および化合物 |
| US9080171B2 (en) | 2010-03-24 | 2015-07-14 | RXi Parmaceuticals Corporation | Reduced size self-delivering RNAi compounds |
| JP5857378B2 (ja) | 2010-04-23 | 2016-02-10 | アローヘッド リサーチ コーポレイション | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
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| WO2013163346A1 (en) | 2012-04-25 | 2013-10-31 | The Regents Of The University Of California | Synthetic promoter for modulating gene expression |
| CN109481455A (zh) | 2012-05-02 | 2019-03-19 | 箭头研究公司 | 治疗kras相关疾病的有机组合物 |
| KR20150087270A (ko) * | 2012-11-05 | 2015-07-29 | 프로나이 테라퓨틱스, 인코포레이티드 | Bcl2 발현 조절에 의한 암치료용 바이오마커 이용 방법 |
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-
1996
- 1996-10-04 US US08/726,211 patent/US6977244B2/en not_active Expired - Fee Related
-
1997
- 1997-10-03 AT AT97910067T patent/ATE334657T1/de not_active IP Right Cessation
- 1997-10-03 CA CA002266584A patent/CA2266584C/en not_active Expired - Fee Related
- 1997-10-03 DE DE69736432T patent/DE69736432T2/de not_active Expired - Lifetime
- 1997-10-03 WO PCT/US1997/018348 patent/WO1998014172A1/en not_active Ceased
- 1997-10-03 EP EP97910067A patent/EP0939621B1/en not_active Expired - Lifetime
- 1997-10-03 CA CA2677176A patent/CA2677176C/en not_active Expired - Fee Related
- 1997-10-03 ES ES97910067T patent/ES2270454T3/es not_active Expired - Lifetime
- 1997-10-03 JP JP51698598A patent/JP4402746B2/ja not_active Expired - Fee Related
-
2003
- 2003-03-12 US US10/387,961 patent/US20030219474A1/en not_active Abandoned
-
2007
- 2007-09-25 JP JP2007248267A patent/JP2008069161A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2677176A1 (en) | 1998-04-09 |
| ES2270454T3 (es) | 2007-04-01 |
| EP0939621A4 (en) | 2005-02-02 |
| ATE334657T1 (de) | 2006-08-15 |
| EP0939621A1 (en) | 1999-09-08 |
| CA2677176C (en) | 2013-01-08 |
| EP0939621B1 (en) | 2006-08-02 |
| US6977244B2 (en) | 2005-12-20 |
| CA2266584C (en) | 2009-12-08 |
| JP4402746B2 (ja) | 2010-01-20 |
| US20030012812A1 (en) | 2003-01-16 |
| DE69736432D1 (de) | 2006-09-14 |
| US20030219474A1 (en) | 2003-11-27 |
| CA2266584A1 (en) | 1998-04-09 |
| WO1998014172A1 (en) | 1998-04-09 |
| JP2001502172A (ja) | 2001-02-20 |
| JP2008069161A (ja) | 2008-03-27 |
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