DE69736432T2 - Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide - Google Patents

Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide Download PDF

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Publication number
DE69736432T2
DE69736432T2 DE69736432T DE69736432T DE69736432T2 DE 69736432 T2 DE69736432 T2 DE 69736432T2 DE 69736432 T DE69736432 T DE 69736432T DE 69736432 T DE69736432 T DE 69736432T DE 69736432 T2 DE69736432 T2 DE 69736432T2
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bcl
cells
cell
polynucleotide
composition
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DE69736432D1 (de
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Mar Tormo
M. Ana Houston TARA
Gabriel Bellaire LOPEZ-BERESTEIN
J. Timothy Houston MCDONNEL
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The University of Texas System
The University of Texas at Austin
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Plant Pathology (AREA)
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  • Biochemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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DE69736432T 1996-10-04 1997-10-03 Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide Expired - Lifetime DE69736432T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/726,211 US6977244B2 (en) 1996-10-04 1996-10-04 Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US726211 1996-10-04
PCT/US1997/018348 WO1998014172A1 (en) 1996-10-04 1997-10-03 Inhibition of bcl-2 protein expression by liposomal antisense oligodeoxynucleotides

Publications (2)

Publication Number Publication Date
DE69736432D1 DE69736432D1 (de) 2006-09-14
DE69736432T2 true DE69736432T2 (de) 2007-03-01

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DE69736432T Expired - Lifetime DE69736432T2 (de) 1996-10-04 1997-10-03 Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide

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US (2) US6977244B2 (enExample)
EP (1) EP0939621B1 (enExample)
JP (2) JP4402746B2 (enExample)
AT (1) ATE334657T1 (enExample)
CA (2) CA2266584C (enExample)
DE (1) DE69736432T2 (enExample)
ES (1) ES2270454T3 (enExample)
WO (1) WO1998014172A1 (enExample)

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CA2677176C (en) 2013-01-08
JP2001502172A (ja) 2001-02-20
EP0939621B1 (en) 2006-08-02
JP4402746B2 (ja) 2010-01-20
DE69736432D1 (de) 2006-09-14
EP0939621A1 (en) 1999-09-08
ATE334657T1 (de) 2006-08-15
JP2008069161A (ja) 2008-03-27
CA2677176A1 (en) 1998-04-09
CA2266584C (en) 2009-12-08
US6977244B2 (en) 2005-12-20
EP0939621A4 (en) 2005-02-02
US20030012812A1 (en) 2003-01-16
ES2270454T3 (es) 2007-04-01
CA2266584A1 (en) 1998-04-09
US20030219474A1 (en) 2003-11-27
WO1998014172A1 (en) 1998-04-09

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