DE69735643T2 - IL12 zur Gentherapie der Tumoren - Google Patents
IL12 zur Gentherapie der Tumoren Download PDFInfo
- Publication number
- DE69735643T2 DE69735643T2 DE69735643T DE69735643T DE69735643T2 DE 69735643 T2 DE69735643 T2 DE 69735643T2 DE 69735643 T DE69735643 T DE 69735643T DE 69735643 T DE69735643 T DE 69735643T DE 69735643 T2 DE69735643 T2 DE 69735643T2
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- DE
- Germany
- Prior art keywords
- construct
- tumor
- tumors
- cells
- subunit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US659206 | 1996-06-05 | ||
| US08/659,206 US5922685A (en) | 1996-06-05 | 1996-06-05 | IL-12 gene therapy of tumors |
| PCT/US1997/009591 WO1997046263A1 (en) | 1996-06-05 | 1997-06-04 | Il-12 gene therapy of tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69735643D1 DE69735643D1 (de) | 2006-05-18 |
| DE69735643T2 true DE69735643T2 (de) | 2006-12-14 |
Family
ID=24644498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69735643T Expired - Fee Related DE69735643T2 (de) | 1996-06-05 | 1997-06-04 | IL12 zur Gentherapie der Tumoren |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5922685A (Direct) |
| EP (1) | EP0963207B1 (Direct) |
| JP (1) | JP2000512980A (Direct) |
| DE (1) | DE69735643T2 (Direct) |
| ES (1) | ES2262180T3 (Direct) |
| WO (1) | WO1997046263A1 (Direct) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998041229A1 (en) * | 1997-03-19 | 1998-09-24 | F. Hoffmann-La Roche Ag | USE OF IL-12p40 AS IMMUNOSTIMULANT |
| DK1037927T3 (da) | 1997-12-08 | 2004-09-06 | Emd Lexigen Res Ct Corp | Heterodimere fusionsproteiner, der er nyttige til målrettet immunterapi og generel immunstimulering |
| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| WO1999052562A2 (en) * | 1998-04-15 | 1999-10-21 | Lexigen Pharmaceuticals Corp. | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor |
| US6423308B1 (en) * | 1998-09-15 | 2002-07-23 | Wyeth | Treatment of Kaposi's sarcoma with IL-12 |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| PL202058B1 (pl) * | 1999-08-09 | 2009-05-29 | Merck Patent Gmbh | Wielofunkcyjne białko fuzyjne cytokin i przeciwciała |
| US20030190305A1 (en) * | 1999-09-15 | 2003-10-09 | Wyeth And National Institutes Of Health | Treatment of Kaposi's sarcoma with IL-12 |
| US7074210B2 (en) * | 1999-10-11 | 2006-07-11 | Felton International, Inc. | Universal protector cap with auto-disable features for needle-free injectors |
| ES2237476T3 (es) | 1999-10-11 | 2005-08-01 | Felton International, Inc. | Protector universal contra infecciones para inyectores sin aguja. |
| DK1142590T3 (da) * | 1999-10-29 | 2009-01-26 | Anges Mg Inc | Genterapi til diabetisk iskæmisk sygdom |
| JP2003514552A (ja) | 1999-11-12 | 2003-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改善された性質を有するエリトロポエチンの形態 |
| US6770054B1 (en) | 1999-11-23 | 2004-08-03 | Felton International, Inc. | Injector assembly with driving means and locking means |
| US7887506B1 (en) | 1999-11-23 | 2011-02-15 | Pulse Needlefree Systems, Inc. | Safety mechanism to prevent accidental patient injection and methods of same |
| US7115712B1 (en) | 1999-12-02 | 2006-10-03 | Maxygen, Inc. | Cytokine polypeptides |
| DE60122286T2 (de) | 2000-02-11 | 2007-08-02 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
| US20020120228A1 (en) * | 2000-06-08 | 2002-08-29 | Yuh-Fun Maa | Powder compositions |
| US20040213798A1 (en) * | 2000-06-08 | 2004-10-28 | Powderject Vaccines, Inc. | Spray-dried alum compositions |
| ES2288967T3 (es) * | 2000-06-29 | 2008-02-01 | Merck Patent Gmbh | Reforzamiento de las respuestas inmunes mediadas por la proteina de fusion anticuerpo-citoquina por medio del tratamiento combinado por agentes que mejoran la incorporacion de inmunocitoquina. |
| US20020086036A1 (en) | 2000-12-05 | 2002-07-04 | Allergan Sales, Inc. | Methods for treating hyperhidrosis |
| US7255865B2 (en) * | 2000-12-05 | 2007-08-14 | Allergan, Inc. | Methods of administering botulinum toxin |
| BR0207854A (pt) * | 2001-03-07 | 2004-08-24 | Merck Patent Gmbh | Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido |
| WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| HUP0400284A3 (en) | 2001-05-03 | 2012-09-28 | Merck Patent Gmbh | Recombinant tumor specific antibody and use thereof |
| CA2349506C (en) * | 2001-06-14 | 2009-12-08 | Duke University | A method for selective expression of therapeutic genes by hyperthermia |
| PL206975B1 (pl) * | 2001-12-04 | 2010-10-29 | Merck Patent Gmbh | Immunocytokiny o modulowanej selektywności oraz ich zastosowanie |
| RU2366664C2 (ru) * | 2002-12-17 | 2009-09-10 | Мерк Патент Гмбх | Гуманизированное антитело (н14.18) на основании антитела 14.18 мыши, связывающееся с gd2, и его слияние с il-2 |
| EP1702069A2 (en) * | 2004-01-05 | 2006-09-20 | EMD Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
| AU2006332138B2 (en) | 2005-12-30 | 2012-03-22 | Merck Patent Gmbh | Interleukin-12p40 variants with improved stability |
| US7833754B2 (en) * | 2006-01-13 | 2010-11-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | IL-12 for expression in mammalian cell |
| MX2010003720A (es) * | 2007-10-08 | 2010-10-20 | Intrexon Corp | Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer. |
| KR101361416B1 (ko) | 2008-10-08 | 2014-02-21 | 인트렉손 코포레이션 | 다수의 면역조절자를 발현하는 조작된 세포 및 그 용도 |
| EP2424887B1 (en) * | 2009-04-30 | 2015-09-30 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Inducible interleukin-12 |
| US20110014228A1 (en) * | 2009-06-15 | 2011-01-20 | New York University | Il23 modified viral vector for recombinant vaccines and tumor treatment |
| SG11201809381XA (en) | 2016-05-18 | 2018-12-28 | Modernatx Inc | Polynucleotides encoding interleukin-12 (il12) and uses thereof |
| US11421011B2 (en) | 2017-05-18 | 2022-08-23 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5015580A (en) * | 1987-07-29 | 1991-05-14 | Agracetus | Particle-mediated transformation of soybean plants and lines |
| US5149655A (en) * | 1990-06-21 | 1992-09-22 | Agracetus, Inc. | Apparatus for genetic transformation |
| DE69534348T2 (de) * | 1994-01-21 | 2006-05-24 | Powderject Vaccines, Inc., Madison | Gasbetätigtes Element zum Austragen von Genmaterial |
| AU4908197A (en) * | 1996-10-18 | 1998-05-15 | Valentis, Inc. | Gene expression and delivery systems and uses |
-
1996
- 1996-06-05 US US08/659,206 patent/US5922685A/en not_active Expired - Fee Related
-
1997
- 1997-06-04 DE DE69735643T patent/DE69735643T2/de not_active Expired - Fee Related
- 1997-06-04 ES ES97927949T patent/ES2262180T3/es not_active Expired - Lifetime
- 1997-06-04 WO PCT/US1997/009591 patent/WO1997046263A1/en not_active Ceased
- 1997-06-04 JP JP10500803A patent/JP2000512980A/ja not_active Ceased
- 1997-06-04 EP EP97927949A patent/EP0963207B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5922685A (en) | 1999-07-13 |
| DE69735643D1 (de) | 2006-05-18 |
| WO1997046263A1 (en) | 1997-12-11 |
| HK1024622A1 (en) | 2000-10-20 |
| EP0963207A1 (en) | 1999-12-15 |
| EP0963207B1 (en) | 2006-04-05 |
| ES2262180T3 (es) | 2006-11-16 |
| JP2000512980A (ja) | 2000-10-03 |
| EP0963207A4 (en) | 2003-01-22 |
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