DE69735496T2 - Nukleinsäure zur Verwendung in Gentherapie, welche Therapie intestinale Zell-Expression der Gene involviert - Google Patents
Nukleinsäure zur Verwendung in Gentherapie, welche Therapie intestinale Zell-Expression der Gene involviert Download PDFInfo
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- DE69735496T2 DE69735496T2 DE69735496T DE69735496T DE69735496T2 DE 69735496 T2 DE69735496 T2 DE 69735496T2 DE 69735496 T DE69735496 T DE 69735496T DE 69735496 T DE69735496 T DE 69735496T DE 69735496 T2 DE69735496 T2 DE 69735496T2
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Classifications
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US717084 | 1991-06-18 | ||
| US08/717,084 US6225290B1 (en) | 1996-09-19 | 1996-09-19 | Systemic gene therapy by intestinal cell transformation |
| PCT/US1997/016523 WO1998011779A1 (en) | 1996-09-19 | 1997-09-18 | Delivery of therapeutic gene products by intestinal cell expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69735496D1 DE69735496D1 (de) | 2006-05-11 |
| DE69735496T2 true DE69735496T2 (de) | 2006-09-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69735496T Expired - Fee Related DE69735496T2 (de) | 1996-09-19 | 1997-09-18 | Nukleinsäure zur Verwendung in Gentherapie, welche Therapie intestinale Zell-Expression der Gene involviert |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US6225290B1 (https=) |
| EP (1) | EP0939590B1 (https=) |
| JP (1) | JP2001502303A (https=) |
| AT (1) | ATE320186T1 (https=) |
| AU (1) | AU729457B2 (https=) |
| CA (1) | CA2264744A1 (https=) |
| DE (1) | DE69735496T2 (https=) |
| DK (1) | DK0939590T3 (https=) |
| ES (1) | ES2256896T3 (https=) |
| WO (1) | WO1998011779A1 (https=) |
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| US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
| US6225290B1 (en) * | 1996-09-19 | 2001-05-01 | The Regents Of The University Of California | Systemic gene therapy by intestinal cell transformation |
| US20030129750A1 (en) * | 1998-02-05 | 2003-07-10 | Yitzhack Schwartz | Homing of donor cells to a target zone in tissue using active therapeutics or substances |
| US7749215B1 (en) * | 1998-02-05 | 2010-07-06 | Biosense, Inc. | Intracardiac cell delivery and cell transplantation |
| US20030113303A1 (en) * | 1998-02-05 | 2003-06-19 | Yitzhack Schwartz | Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances |
| AU3072799A (en) | 1998-03-19 | 1999-10-11 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
| WO1999049029A1 (en) * | 1998-03-20 | 1999-09-30 | Benitec Australia Ltd | Control of gene expression |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| BR9909918A (pt) * | 1998-05-06 | 2000-12-26 | Upjohn Co | Método para a liberação de um hormÈnio de crescimento ou citocina de proteìna, peptìdeo ou polipeptìdeo fisiologicamente ativos a um vertebrado não-humano |
| JPH11335269A (ja) * | 1998-05-19 | 1999-12-07 | Hisamitsu Pharmaceut Co Inc | 遺伝子関連医薬の経口投与固形製剤 |
| EP1889914A1 (en) * | 1999-02-19 | 2008-02-20 | Engene, Inc. | Compositions for gene therapy of diabetes |
| US6503887B1 (en) * | 1999-02-19 | 2003-01-07 | Matthew During | Peroral gene therapy of diabetes and obesity |
| EP2357192A1 (en) | 1999-02-26 | 2011-08-17 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
| DK1159415T3 (da) * | 1999-03-04 | 2010-05-03 | Revivicor Inc | Genetisk modifikation af somatiske celler og anvendelse deraf |
| US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
| US6953658B2 (en) | 2000-03-09 | 2005-10-11 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating gastrointestinal cancer |
| DK1274464T3 (da) | 2000-03-13 | 2012-01-23 | Engene Inc | Sammensætninger og fremgangsmåder til regulering af proteinekspression i tarm |
| PT1309726E (pt) * | 2000-03-30 | 2010-03-08 | Whitehead Biomedical Inst | Mediadores de interferência por rna específicos de sequência de rna |
| EP2206720A1 (en) | 2000-04-12 | 2010-07-14 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| GB0010630D0 (en) * | 2000-05-04 | 2000-06-21 | Univ Wales Medicine | Sequence |
| CA2413160A1 (en) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
| WO2002000939A2 (en) | 2000-06-28 | 2002-01-03 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating colon cancer |
| US20040259247A1 (en) | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20020151068A1 (en) * | 2001-01-03 | 2002-10-17 | Board Of Regents, The University Of Texas System | Compositions and methods for the diagnosis and treatment of organophosphate toxicity |
| JP2005503116A (ja) | 2001-02-09 | 2005-02-03 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０ |
| AU2002338345A1 (en) * | 2001-04-04 | 2002-10-21 | Digital Gene Technologies, Inc. | Genes expressed in intestinal epithelium and peyer's patch m cells |
| CA2444632A1 (en) | 2001-04-13 | 2002-10-24 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| AU2002311777A1 (en) * | 2001-04-17 | 2002-10-28 | Genetix Pharmaceuticals, Inc. | Method of treating arthritis using lentiviral vectors in gene therapy |
| EP1404713A4 (en) * | 2001-05-24 | 2004-09-22 | Human Dna Technology Inc | NEW KERATINOCYTE GROWTH FACTOR 2 ANALOG IN HAIR FOLLICULES |
| AU2002365188A1 (en) * | 2001-11-07 | 2003-07-30 | Musc Foundation For Research Development | Nucleic acid delivery and expression |
| US20030135195A1 (en) * | 2002-01-16 | 2003-07-17 | Oscar Jimenez | Highly lubricious hydrophilic coating utilizing dendrimers |
| DE60336754D1 (de) | 2002-02-14 | 2011-05-26 | Univ R | Enzymbehandlung von nahrungsmitteln für zöliakie-sprue |
| WO2003104439A2 (en) * | 2002-03-12 | 2003-12-18 | Surface Logix, Inc. | Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound |
| US7374930B2 (en) * | 2002-05-21 | 2008-05-20 | Expression Genetics, Inc. | GLP-1 gene delivery for the treatment of type 2 diabetes |
| US7977098B2 (en) | 2002-05-31 | 2011-07-12 | Children's Hospital Medical Center | Antigenic binding patterns of norovirus to human histo-blood group antigens |
| DE60336063D1 (de) * | 2002-05-31 | 2011-03-31 | Childrens Hosp Medical Center | Verfahren, zusammensetzung und kit für die antigenbindung von norwalk-ähnlichen viren |
| US20040016013A1 (en) * | 2002-07-18 | 2004-01-22 | Gonzalo Hortelano | Transgenic animals produced using oral administration of a genetic agent coupled to a transporting agent |
| US20040014704A1 (en) * | 2002-07-18 | 2004-01-22 | Gonzalo Hortelano | Oral administration of therapeutic agent coupled to transporting agent induces tolerance |
| US20040014698A1 (en) * | 2002-07-18 | 2004-01-22 | Gonzalo Hortelano | Oral administration of therapeutic agent coupled to transporting agent |
| CA2503437A1 (en) * | 2002-10-24 | 2004-05-06 | Biogen Idec Ma Inc. | High expression locus vector based on ferritin heavy chain gene locus |
| US20050026859A1 (en) * | 2002-11-12 | 2005-02-03 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
| US20080026077A1 (en) * | 2002-11-12 | 2008-01-31 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
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| US5643579A (en) * | 1984-11-01 | 1997-07-01 | American Home Products Corporation | Oral vaccines |
| US5997859A (en) * | 1988-03-21 | 1999-12-07 | Chiron Corporation | Method for treating a metastatic carcinoma using a conditionally lethal gene |
| WO1990005787A1 (en) | 1988-11-23 | 1990-05-31 | The Regents Of The University Of California | Position-specific insertion vectors and method of using same |
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| US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| ATE157012T1 (de) | 1989-11-03 | 1997-09-15 | Univ Vanderbilt | Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen |
| JP3534749B2 (ja) | 1991-08-20 | 2004-06-07 | アメリカ合衆国 | アデノウイルスが介在する胃腸管への遺伝子の輸送 |
| AU3972893A (en) * | 1992-04-03 | 1993-11-08 | Baylor College Of Medicine | Gene therapy using the intestine |
| WO1994016057A1 (en) * | 1992-12-31 | 1994-07-21 | Dana-Farber Cancer Institute, Inc. | Enhancer sequence for modulating expression in epithelial cells |
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| US5681744A (en) * | 1995-03-17 | 1997-10-28 | Greenstein; Robert J. | Delivery and expression of heterologus genes using upstream enhancer regions of mammalian gene promoters |
| US5885971A (en) * | 1995-03-24 | 1999-03-23 | The Regents Of The University Of California | Gene therapy by secretory gland expression |
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| US6225290B1 (en) * | 1996-09-19 | 2001-05-01 | The Regents Of The University Of California | Systemic gene therapy by intestinal cell transformation |
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1996
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1997
- 1997-09-18 AT AT97942543T patent/ATE320186T1/de not_active IP Right Cessation
- 1997-09-18 US US09/254,988 patent/US6258789B1/en not_active Expired - Lifetime
- 1997-09-18 AU AU44221/97A patent/AU729457B2/en not_active Ceased
- 1997-09-18 ES ES97942543T patent/ES2256896T3/es not_active Expired - Lifetime
- 1997-09-18 WO PCT/US1997/016523 patent/WO1998011779A1/en not_active Ceased
- 1997-09-18 DK DK97942543T patent/DK0939590T3/da active
- 1997-09-18 DE DE69735496T patent/DE69735496T2/de not_active Expired - Fee Related
- 1997-09-18 EP EP97942543A patent/EP0939590B1/en not_active Expired - Lifetime
- 1997-09-18 JP JP10514853A patent/JP2001502303A/ja not_active Ceased
- 1997-09-18 CA CA002264744A patent/CA2264744A1/en not_active Abandoned
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2001
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2004
- 2004-08-03 US US10/911,082 patent/US20050026863A1/en not_active Abandoned
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| DK0939590T3 (da) | 2006-07-24 |
| US20050026863A1 (en) | 2005-02-03 |
| CA2264744A1 (en) | 1998-03-26 |
| EP0939590A1 (en) | 1999-09-08 |
| EP0939590B1 (en) | 2006-03-15 |
| ATE320186T1 (de) | 2006-04-15 |
| US6258789B1 (en) | 2001-07-10 |
| WO1998011779A1 (en) | 1998-03-26 |
| US6831070B2 (en) | 2004-12-14 |
| EP0939590A4 (en) | 2002-09-04 |
| ES2256896T3 (es) | 2006-07-16 |
| AU4422197A (en) | 1998-04-14 |
| US6225290B1 (en) | 2001-05-01 |
| US20020039574A1 (en) | 2002-04-04 |
| AU729457B2 (en) | 2001-02-01 |
| DE69735496D1 (de) | 2006-05-11 |
| JP2001502303A (ja) | 2001-02-20 |
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