DE69735162T2 - L-carnosin enthaltende mittel zur behandlung von nierenversagen - Google Patents
L-carnosin enthaltende mittel zur behandlung von nierenversagen Download PDFInfo
- Publication number
- DE69735162T2 DE69735162T2 DE69735162T DE69735162T DE69735162T2 DE 69735162 T2 DE69735162 T2 DE 69735162T2 DE 69735162 T DE69735162 T DE 69735162T DE 69735162 T DE69735162 T DE 69735162T DE 69735162 T2 DE69735162 T2 DE 69735162T2
- Authority
- DE
- Germany
- Prior art keywords
- carnosine
- meq
- peritoneal dialysis
- solution
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000011282 treatment Methods 0.000 title claims description 7
- 210000003734 kidney Anatomy 0.000 title description 5
- 108010087806 Carnosine Proteins 0.000 claims description 54
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 claims description 54
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims description 54
- 239000000385 dialysis solution Substances 0.000 claims description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- 239000008121 dextrose Substances 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 239000002357 osmotic agent Substances 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 208000020832 chronic kidney disease Diseases 0.000 claims description 3
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 239000003925 fat Substances 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 25
- 229960002885 histidine Drugs 0.000 description 15
- 238000000502 dialysis Methods 0.000 description 11
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 11
- 210000003205 muscle Anatomy 0.000 description 9
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 8
- 229940044199 carnosine Drugs 0.000 description 8
- 241000700159 Rattus Species 0.000 description 7
- 208000001647 Renal Insufficiency Diseases 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 201000006370 kidney failure Diseases 0.000 description 7
- 238000001631 haemodialysis Methods 0.000 description 6
- 230000000322 hemodialysis Effects 0.000 description 6
- 208000010444 Acidosis Diseases 0.000 description 5
- 230000007950 acidosis Effects 0.000 description 5
- 208000026545 acidosis disease Diseases 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 230000003834 intracellular effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 3
- 210000004303 peritoneum Anatomy 0.000 description 3
- 210000002027 skeletal muscle Anatomy 0.000 description 3
- 208000009304 Acute Kidney Injury Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000037157 Azotemia Diseases 0.000 description 2
- 208000033626 Renal failure acute Diseases 0.000 description 2
- 201000011040 acute kidney failure Diseases 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004768 organ dysfunction Effects 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- 206010016803 Fluid overload Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010049565 Muscle fatigue Diseases 0.000 description 1
- 206010061481 Renal injury Diseases 0.000 description 1
- 206010063897 Renal ischaemia Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000000758 acidotic effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 208000012998 acute renal failure Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 201000001883 cholelithiasis Diseases 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 208000001130 gallstones Diseases 0.000 description 1
- 230000024924 glomerular filtration Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 231100000508 hormonal effect Toxicity 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 208000037806 kidney injury Diseases 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000013188 needle biopsy Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 239000003330 peritoneal dialysis fluid Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000003314 quadriceps muscle Anatomy 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/742,018 US6017942A (en) | 1996-10-31 | 1996-10-31 | Method and compositions for the treatment of renal failure |
| US742018 | 1996-10-31 | ||
| PCT/US1997/018722 WO1998018467A1 (en) | 1996-10-31 | 1997-10-21 | Compositions for the treatment of renal failure, comprising l-carnosine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69735162D1 DE69735162D1 (de) | 2006-04-13 |
| DE69735162T2 true DE69735162T2 (de) | 2006-08-17 |
Family
ID=24983173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69735162T Expired - Lifetime DE69735162T2 (de) | 1996-10-31 | 1997-10-21 | L-carnosin enthaltende mittel zur behandlung von nierenversagen |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6017942A (ja) |
| EP (1) | EP0869788B1 (ja) |
| JP (2) | JP4364307B2 (ja) |
| KR (1) | KR19990076920A (ja) |
| BR (1) | BR9706908A (ja) |
| CA (1) | CA2241458A1 (ja) |
| DE (1) | DE69735162T2 (ja) |
| WO (1) | WO1998018467A1 (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE405277T1 (de) * | 1999-04-26 | 2008-09-15 | Edwards Lifesciences Ag | Substitutions-infusionflüssigkeit und zitratanticoagulation |
| US7186420B2 (en) * | 1999-04-26 | 2007-03-06 | Edwards Lifesciences Corporation | Multi-part substitution infusion fluids and matching anticoagulants |
| US8105258B2 (en) | 1999-04-26 | 2012-01-31 | Baxter International Inc. | Citrate anticoagulation system for extracorporeal blood treatments |
| GB0017028D0 (en) * | 2000-07-11 | 2000-08-30 | Ks Biomedix Ltd | Peptides and their therapeutic use |
| US7033498B2 (en) * | 2000-11-28 | 2006-04-25 | Renal Solutions, Inc. | Cartridges useful in cleaning dialysis solutions |
| US6627164B1 (en) * | 2000-11-28 | 2003-09-30 | Renal Solutions, Inc. | Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same |
| US6878283B2 (en) * | 2001-11-28 | 2005-04-12 | Renal Solutions, Inc. | Filter cartridge assemblies and methods for filtering fluids |
| SE0400523D0 (sv) * | 2004-03-01 | 2004-03-01 | Gambro Lundia Ab | A medical solution, a method for producing said medical solution and use thereof |
| SE0402507D0 (sv) * | 2004-10-14 | 2004-10-14 | Gambro Lundia Ab | Medicinsk lösning, förfarande för framställning och användning därav |
| CN101217960B (zh) * | 2005-07-08 | 2010-12-15 | 东丽株式会社 | 用于改善尿毒症的治疗药和处置方法 |
| CA2698754A1 (en) * | 2007-09-11 | 2009-03-19 | Dorian Bevec | Use of a peptide as a therapeutic agent |
| US9895189B2 (en) | 2009-06-19 | 2018-02-20 | Angiodynamics, Inc. | Methods of sterilization and treating infection using irreversible electroporation |
| TW201338803A (zh) * | 2012-03-23 | 2013-10-01 | zheng-yi Lin | 用於治療寵物腎衰竭之醫藥組合物 |
| US9669010B2 (en) | 2012-12-06 | 2017-06-06 | Bio Health Solutions, Llc | Treatment for chronic kidney disease |
| EP2928461B1 (en) * | 2012-12-06 | 2019-08-21 | Bio Health Solutions, LLC | Treatment for chronic kidney disease |
| AU2015231764B2 (en) | 2014-03-17 | 2017-02-09 | Fresenius Medical Care Holdings, Inc. | Cartridges useful in cleaning dialysis solutions |
| CN108025125B (zh) | 2015-09-16 | 2021-05-07 | 弗雷塞尼斯医疗保健控股公司 | 在净化透析溶液中可用的药筒 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2936070A1 (de) * | 1979-09-06 | 1981-03-26 | Dr. Falk GmbH & Co Pharm. Präparate KG, 7800 Freiburg | Gallenwegespuelloesungen |
| US4446149A (en) * | 1981-12-14 | 1984-05-01 | Kineshiro Nagai | Medicine for treatment of cervical erosion |
| US5576287A (en) * | 1994-04-29 | 1996-11-19 | Wake Forest University | Method for treating acute renal disease and failure |
-
1996
- 1996-10-31 US US08/742,018 patent/US6017942A/en not_active Expired - Fee Related
-
1997
- 1997-10-09 US US08/953,797 patent/US5968966A/en not_active Expired - Lifetime
- 1997-10-21 WO PCT/US1997/018722 patent/WO1998018467A1/en active IP Right Grant
- 1997-10-21 DE DE69735162T patent/DE69735162T2/de not_active Expired - Lifetime
- 1997-10-21 BR BR9706908A patent/BR9706908A/pt not_active Application Discontinuation
- 1997-10-21 JP JP52053298A patent/JP4364307B2/ja not_active Expired - Fee Related
- 1997-10-21 KR KR1019980705048A patent/KR19990076920A/ko not_active Application Discontinuation
- 1997-10-21 CA CA002241458A patent/CA2241458A1/en not_active Abandoned
- 1997-10-21 EP EP97911001A patent/EP0869788B1/en not_active Expired - Lifetime
-
2008
- 2008-10-10 JP JP2008264492A patent/JP2009051850A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US6017942A (en) | 2000-01-25 |
| EP0869788B1 (en) | 2006-01-25 |
| JP4364307B2 (ja) | 2009-11-18 |
| US5968966A (en) | 1999-10-19 |
| DE69735162D1 (de) | 2006-04-13 |
| WO1998018467A1 (en) | 1998-05-07 |
| CA2241458A1 (en) | 1998-05-07 |
| BR9706908A (pt) | 1999-07-20 |
| KR19990076920A (ko) | 1999-10-25 |
| JP2000503326A (ja) | 2000-03-21 |
| JP2009051850A (ja) | 2009-03-12 |
| EP0869788A1 (en) | 1998-10-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69735162T2 (de) | L-carnosin enthaltende mittel zur behandlung von nierenversagen | |
| DE69029388T2 (de) | Histidin gepufferte peritonealdialyselösung | |
| DE69531426T2 (de) | Lösungen für die peritonealdialyse, die maltodextrine und aminosäuren enthalten | |
| DE69929550T2 (de) | Albumin enthaltende Lösung für die Peritonealdialyse | |
| DE69827126T2 (de) | Verwendung von hypothalamus-hemmfaktor zur behandlung von ischämischen herzstörungen | |
| DE69016014T2 (de) | Blutdrucksenkendes Präparat. | |
| DE69332959T2 (de) | Lösungen für die Peritonealdialyse und deren Verwendung zum Verringern von Schädigungen an mesothelialen Zellen | |
| DE69028712T2 (de) | Zusammensetzung zur behandlung entzündlicher darmerkrankungen | |
| DE2934718A1 (de) | Loesung fuer die intravenoese verabreichung | |
| DE69332106T3 (de) | Lösung für die Peritonealdialyse | |
| DE2658237C3 (de) | Verwendung von Cystein oder N-Acetylcystein | |
| Simpson | A hypothesis proposing increased blood viscosity as a cause of proteinuria and increased vascular permeability | |
| DE3821043C2 (ja) | ||
| DE4114908A1 (de) | Dialyseloesung zur dialysebehandlung, konzentrat und vorrichtung zur dialysebehandlung | |
| DE69109676T2 (de) | Verminderung von kardiovaskulären gefässverschlüssen mit ascorbat und hemmstoffen der bindung von lipoprotein (a). | |
| DE60108880T2 (de) | Kardiopflegische lösung | |
| Closs et al. | Methanol poisoning | |
| DE2820899C2 (ja) | ||
| DE2821737C2 (ja) | ||
| Haapanen et al. | Hemoperfusion in quinidine intoxication | |
| Horrobin et al. | PRE‐ECLAMPTIC TOXAEMIA: POSSIBLE RELEVANCE OF PROGESTERONE, SALT AND FRUSEMIDE | |
| DE1939008A1 (de) | Arzneimittelkombination zur Behandlung von Mangeldurchblutungen des Gehirns | |
| Ohmura et al. | Effects of halothane and sodium nitroprusside on renal function and autoregulation | |
| RU2289395C2 (ru) | Способ лечения тяжелой компрессионной травмы мягких тканей | |
| WO1990011759A1 (de) | 2-stufen-zubereitung mit cumarin oder dobesilat-calcium zur behandlung von osteoarthrose |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |