DE69732120T2 - Trizyklische inhibitoren der farnesyl protein transferase - Google Patents
Trizyklische inhibitoren der farnesyl protein transferase Download PDFInfo
- Publication number
- DE69732120T2 DE69732120T2 DE69732120T DE69732120T DE69732120T2 DE 69732120 T2 DE69732120 T2 DE 69732120T2 DE 69732120 T DE69732120 T DE 69732120T DE 69732120 T DE69732120 T DE 69732120T DE 69732120 T2 DE69732120 T2 DE 69732120T2
- Authority
- DE
- Germany
- Prior art keywords
- group
- alkyl
- compound
- formula
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C[O+]*1c2ccccc2**1 Chemical compound C[O+]*1c2ccccc2**1 0.000 description 15
- WOJRHOFUTPGDDS-YTRMGSRMSA-N CBc1cc(CC[C@H](C(C2N3CCNCC3)C(Br)=C3)C=C3Cl)c2nc1 Chemical compound CBc1cc(CC[C@H](C(C2N3CCNCC3)C(Br)=C3)C=C3Cl)c2nc1 WOJRHOFUTPGDDS-YTRMGSRMSA-N 0.000 description 1
- OLGJTTLXLPBGCS-UHFFFAOYSA-N CCOC(N(CC1)CCC1C(c(c(C=Cc1c2)c3)ccc3Cl)c1ncc2I)=O Chemical compound CCOC(N(CC1)CCC1C(c(c(C=Cc1c2)c3)ccc3Cl)c1ncc2I)=O OLGJTTLXLPBGCS-UHFFFAOYSA-N 0.000 description 1
- SHGWHWLYMGIVPN-UHFFFAOYSA-N ClC1=NCCC1 Chemical compound ClC1=NCCC1 SHGWHWLYMGIVPN-UHFFFAOYSA-N 0.000 description 1
- BFYRXCWLDJORHM-UHFFFAOYSA-N ClC1=NCCN1 Chemical compound ClC1=NCCN1 BFYRXCWLDJORHM-UHFFFAOYSA-N 0.000 description 1
- ZAHJWUQREINTQV-UHFFFAOYSA-N O=C(C(C1CCc2c3)C=CC(Cl)=C1Br)c2ncc3Br Chemical compound O=C(C(C1CCc2c3)C=CC(Cl)=C1Br)c2ncc3Br ZAHJWUQREINTQV-UHFFFAOYSA-N 0.000 description 1
- YJBINVJTNZDOSD-UHFFFAOYSA-N OC(c(c(Br)c1)c(CC2)cc1Cl)c(nc1)c2cc1Br Chemical compound OC(c(c(Br)c1)c(CC2)cc1Cl)c(nc1)c2cc1Br YJBINVJTNZDOSD-UHFFFAOYSA-N 0.000 description 1
- DGDFJXQYNIQVSD-UHFFFAOYSA-N OC(c(cc1)c(CC2)c(Br)c1[ClH+])c(nc1)c2cc1Br Chemical compound OC(c(cc1)c(CC2)c(Br)c1[ClH+])c(nc1)c2cc1Br DGDFJXQYNIQVSD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
- Cereal-Derived Products (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71332396A | 1996-09-13 | 1996-09-13 | |
| US713323 | 1996-09-13 | ||
| PCT/US1997/015907 WO1998011093A1 (en) | 1996-09-13 | 1997-09-11 | Tricyclic inhibitors of farnesyl protein transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69732120D1 DE69732120D1 (de) | 2005-02-03 |
| DE69732120T2 true DE69732120T2 (de) | 2005-12-08 |
Family
ID=24865689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69732120T Expired - Fee Related DE69732120T2 (de) | 1996-09-13 | 1997-09-11 | Trizyklische inhibitoren der farnesyl protein transferase |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0929545B1 (enExample) |
| JP (1) | JP2001500510A (enExample) |
| KR (1) | KR20000036120A (enExample) |
| CN (1) | CN1104427C (enExample) |
| AT (1) | ATE286046T1 (enExample) |
| AU (1) | AU4337997A (enExample) |
| BR (1) | BR9712831A (enExample) |
| CA (1) | CA2266016C (enExample) |
| CZ (1) | CZ84399A3 (enExample) |
| DE (1) | DE69732120T2 (enExample) |
| ES (1) | ES2235252T3 (enExample) |
| HU (1) | HUP0000121A2 (enExample) |
| ID (1) | ID21699A (enExample) |
| IL (1) | IL128928A0 (enExample) |
| NO (1) | NO991234L (enExample) |
| NZ (1) | NZ334453A (enExample) |
| PL (1) | PL332242A1 (enExample) |
| SK (1) | SK33899A3 (enExample) |
| TR (1) | TR199901276T2 (enExample) |
| WO (1) | WO1998011093A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3962B (en) | 1993-12-21 | 1996-05-27 | Albright & Wilson | Funcional fluids |
| US5939416A (en) * | 1997-06-17 | 1999-08-17 | Schering Corporation | Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| CN1289336A (zh) | 1998-01-21 | 2001-03-28 | 千禧药品公司 | 趋化因子受体拮抗剂和其使用方法 |
| EP1047675A1 (en) | 1998-01-21 | 2000-11-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| US9579088B2 (en) | 2007-02-20 | 2017-02-28 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices for surgical visualization and device manipulation |
| US8679096B2 (en) | 2007-06-21 | 2014-03-25 | Board Of Regents Of The University Of Nebraska | Multifunctional operational component for robotic devices |
| TW200902007A (en) * | 2007-05-25 | 2009-01-16 | Astrazeneca Ab | Spirocyclopropyl piperidine derivatives |
| EP2170564A4 (en) | 2007-07-12 | 2015-10-07 | Univ Nebraska | ACTUATING PROCESSES AND SYSTEMS IN ROBOTIC EQUIPMENT |
| US20090076536A1 (en) | 2007-08-15 | 2009-03-19 | Board Of Regents Of The University Of Nebraska | Medical inflation, attachment, and delivery devices and related methods |
| US9060781B2 (en) | 2011-06-10 | 2015-06-23 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to surgical end effectors |
| US9089353B2 (en) | 2011-07-11 | 2015-07-28 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| JP6502848B2 (ja) | 2011-10-03 | 2019-04-17 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | モジュール式手術用ロボットシステム |
| US20140058205A1 (en) | 2012-01-10 | 2014-02-27 | Board Of Regents Of The University Of Nebraska | Methods, Systems, and Devices for Surgical Access and Insertion |
| EP4357083A3 (en) | 2012-05-01 | 2024-08-21 | Board of Regents of the University of Nebraska | Single site robotic device and related systems and methods |
| EP4234185A3 (en) | 2012-06-22 | 2023-09-20 | Board of Regents of the University of Nebraska | Local control robotic surgical devices |
| US9770305B2 (en) | 2012-08-08 | 2017-09-26 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| CA2880622C (en) | 2012-08-08 | 2021-01-12 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| CA2905948C (en) | 2013-03-14 | 2022-01-11 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers |
| CA2906672C (en) | 2013-03-14 | 2022-03-15 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to force control surgical systems |
| EP4628042A2 (en) | 2013-03-15 | 2025-10-08 | Virtual Incision Corporation | Robotic surgical devices and systems |
| CA2918531A1 (en) | 2013-07-17 | 2015-01-22 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| EP3868322B1 (en) | 2014-09-12 | 2024-11-20 | Board of Regents of the University of Nebraska | Quick-release effectors and related systems |
| CA2967593C (en) | 2014-11-11 | 2024-02-27 | Board Of Regents Of The University Of Nebraska | Robotic device with compact joint design and related systems and methods |
| CN114027986B (zh) | 2015-08-03 | 2024-06-14 | 内布拉斯加大学董事会 | 机器人手术装置系统及相关方法 |
| CN114098975A (zh) | 2016-05-18 | 2022-03-01 | 虚拟切割有限公司 | 机器人外科装置、系统及相关方法 |
| WO2018039606A1 (en) | 2016-08-25 | 2018-03-01 | Virtual Incision Corporation | Quick-release tool coupler and related systems and methods |
| CA3035064A1 (en) | 2016-08-30 | 2018-03-08 | Board Of Regents Of The University Of Nebraska | Robotic device with compact joint design and an additional degree of freedom and related systems and methods |
| CN115337111B (zh) | 2016-11-22 | 2025-04-25 | 内布拉斯加大学董事会 | 改进的粗定位装置及相关系统和方法 |
| JP7099728B2 (ja) | 2016-11-29 | 2022-07-12 | バーチャル インシジョン コーポレイション | ユーザの存在検出機能を備えたユーザコントローラ、関連システムおよび方法 |
| US10722319B2 (en) | 2016-12-14 | 2020-07-28 | Virtual Incision Corporation | Releasable attachment device for coupling to medical devices and related systems and methods |
| EP3687370B1 (en) | 2017-09-27 | 2024-11-20 | Virtual Incision Corporation | Robotic surgical devices with tracking camera technology and related systems |
| US11013564B2 (en) | 2018-01-05 | 2021-05-25 | Board Of Regents Of The University Of Nebraska | Single-arm robotic device with compact joint design and related systems and methods |
| EP3908171A4 (en) | 2019-01-07 | 2022-09-14 | Virtual Incision Corporation | Robotically assisted surgical system and related devices and methods |
| CA3186863A1 (en) | 2020-07-06 | 2022-01-13 | Virtual Incision Corporation | Surgical robot positioning system and related devices and methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| KR920014799A (ko) * | 1991-01-18 | 1992-08-25 | 나오가따 다이도 | 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제 |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| ATE210652T1 (de) * | 1993-10-15 | 2001-12-15 | Schering Corp | Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| ES2164717T3 (es) * | 1993-10-15 | 2002-03-01 | Schering Corp | Compuestos triciclicos de sulfonamida utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas. |
| US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| EP1380581A1 (en) * | 1995-12-22 | 2004-01-14 | Schering Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative diseases |
-
1997
- 1997-09-11 DE DE69732120T patent/DE69732120T2/de not_active Expired - Fee Related
- 1997-09-11 TR TR1999/01276T patent/TR199901276T2/xx unknown
- 1997-09-11 ES ES97941480T patent/ES2235252T3/es not_active Expired - Lifetime
- 1997-09-11 HU HU0000121A patent/HUP0000121A2/hu unknown
- 1997-09-11 PL PL97332242A patent/PL332242A1/xx unknown
- 1997-09-11 SK SK338-99A patent/SK33899A3/sk unknown
- 1997-09-11 IL IL12892897A patent/IL128928A0/xx unknown
- 1997-09-11 CN CN97199598A patent/CN1104427C/zh not_active Expired - Fee Related
- 1997-09-11 KR KR1019997002149A patent/KR20000036120A/ko not_active Withdrawn
- 1997-09-11 CA CA002266016A patent/CA2266016C/en not_active Expired - Fee Related
- 1997-09-11 AU AU43379/97A patent/AU4337997A/en not_active Abandoned
- 1997-09-11 EP EP97941480A patent/EP0929545B1/en not_active Expired - Lifetime
- 1997-09-11 JP JP10513765A patent/JP2001500510A/ja not_active Ceased
- 1997-09-11 BR BR9712831-7A patent/BR9712831A/pt unknown
- 1997-09-11 NZ NZ334453A patent/NZ334453A/xx unknown
- 1997-09-11 WO PCT/US1997/015907 patent/WO1998011093A1/en not_active Ceased
- 1997-09-11 AT AT97941480T patent/ATE286046T1/de not_active IP Right Cessation
- 1997-09-11 CZ CZ99843A patent/CZ84399A3/cs unknown
- 1997-11-09 ID IDW990086A patent/ID21699A/id unknown
-
1999
- 1999-03-12 NO NO991234A patent/NO991234L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998011093A1 (en) | 1998-03-19 |
| ATE286046T1 (de) | 2005-01-15 |
| NO991234L (no) | 1999-05-12 |
| EP0929545A1 (en) | 1999-07-21 |
| JP2001500510A (ja) | 2001-01-16 |
| PL332242A1 (en) | 1999-08-30 |
| HUP0000121A2 (hu) | 2001-04-28 |
| AU4337997A (en) | 1998-04-02 |
| BR9712831A (pt) | 1999-11-16 |
| CN1104427C (zh) | 2003-04-02 |
| CZ84399A3 (cs) | 1999-11-17 |
| NZ334453A (en) | 2000-08-25 |
| DE69732120D1 (de) | 2005-02-03 |
| EP0929545B1 (en) | 2004-12-29 |
| ID21699A (id) | 1999-07-15 |
| ES2235252T3 (es) | 2005-07-01 |
| CA2266016A1 (en) | 1998-03-19 |
| NO991234D0 (no) | 1999-03-12 |
| CA2266016C (en) | 2004-06-01 |
| SK33899A3 (en) | 2000-02-14 |
| KR20000036120A (ko) | 2000-06-26 |
| IL128928A0 (en) | 2000-02-17 |
| TR199901276T2 (xx) | 1999-09-21 |
| CN1237165A (zh) | 1999-12-01 |
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| HK1028238B (en) | Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |