NO991234L - Trisykliske inhibitorer av farnesylproteintransferase - Google Patents

Trisykliske inhibitorer av farnesylproteintransferase

Info

Publication number
NO991234L
NO991234L NO991234A NO991234A NO991234L NO 991234 L NO991234 L NO 991234L NO 991234 A NO991234 A NO 991234A NO 991234 A NO991234 A NO 991234A NO 991234 L NO991234 L NO 991234L
Authority
NO
Norway
Prior art keywords
protein transferase
farnesyl protein
tricyclic inhibitors
formula
compounds
Prior art date
Application number
NO991234A
Other languages
English (en)
Norwegian (no)
Other versions
NO991234D0 (no
Inventor
Arthur G Taveras
Alan K Mallams
Adriano Afonso
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO991234D0 publication Critical patent/NO991234D0/no
Publication of NO991234L publication Critical patent/NO991234L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Cereal-Derived Products (AREA)
  • Enzymes And Modification Thereof (AREA)
NO991234A 1996-09-13 1999-03-12 Trisykliske inhibitorer av farnesylproteintransferase NO991234L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71332396A 1996-09-13 1996-09-13
PCT/US1997/015907 WO1998011093A1 (en) 1996-09-13 1997-09-11 Tricyclic inhibitors of farnesyl protein transferase

Publications (2)

Publication Number Publication Date
NO991234D0 NO991234D0 (no) 1999-03-12
NO991234L true NO991234L (no) 1999-05-12

Family

ID=24865689

Family Applications (1)

Application Number Title Priority Date Filing Date
NO991234A NO991234L (no) 1996-09-13 1999-03-12 Trisykliske inhibitorer av farnesylproteintransferase

Country Status (20)

Country Link
EP (1) EP0929545B1 (enExample)
JP (1) JP2001500510A (enExample)
KR (1) KR20000036120A (enExample)
CN (1) CN1104427C (enExample)
AT (1) ATE286046T1 (enExample)
AU (1) AU4337997A (enExample)
BR (1) BR9712831A (enExample)
CA (1) CA2266016C (enExample)
CZ (1) CZ84399A3 (enExample)
DE (1) DE69732120T2 (enExample)
ES (1) ES2235252T3 (enExample)
HU (1) HUP0000121A2 (enExample)
ID (1) ID21699A (enExample)
IL (1) IL128928A0 (enExample)
NO (1) NO991234L (enExample)
NZ (1) NZ334453A (enExample)
PL (1) PL332242A1 (enExample)
SK (1) SK33899A3 (enExample)
TR (1) TR199901276T2 (enExample)
WO (1) WO1998011093A1 (enExample)

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LT3962B (en) 1993-12-21 1996-05-27 Albright & Wilson Funcional fluids
US5939416A (en) * 1997-06-17 1999-08-17 Schering Corporation Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CN1289336A (zh) 1998-01-21 2001-03-28 千禧药品公司 趋化因子受体拮抗剂和其使用方法
EP1047675A1 (en) 1998-01-21 2000-11-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
US9579088B2 (en) 2007-02-20 2017-02-28 Board Of Regents Of The University Of Nebraska Methods, systems, and devices for surgical visualization and device manipulation
US8679096B2 (en) 2007-06-21 2014-03-25 Board Of Regents Of The University Of Nebraska Multifunctional operational component for robotic devices
TW200902007A (en) * 2007-05-25 2009-01-16 Astrazeneca Ab Spirocyclopropyl piperidine derivatives
EP2170564A4 (en) 2007-07-12 2015-10-07 Univ Nebraska ACTUATING PROCESSES AND SYSTEMS IN ROBOTIC EQUIPMENT
US20090076536A1 (en) 2007-08-15 2009-03-19 Board Of Regents Of The University Of Nebraska Medical inflation, attachment, and delivery devices and related methods
US9060781B2 (en) 2011-06-10 2015-06-23 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to surgical end effectors
US9089353B2 (en) 2011-07-11 2015-07-28 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems, and related methods
JP6502848B2 (ja) 2011-10-03 2019-04-17 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ モジュール式手術用ロボットシステム
US20140058205A1 (en) 2012-01-10 2014-02-27 Board Of Regents Of The University Of Nebraska Methods, Systems, and Devices for Surgical Access and Insertion
EP4357083A3 (en) 2012-05-01 2024-08-21 Board of Regents of the University of Nebraska Single site robotic device and related systems and methods
EP4234185A3 (en) 2012-06-22 2023-09-20 Board of Regents of the University of Nebraska Local control robotic surgical devices
US9770305B2 (en) 2012-08-08 2017-09-26 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems, and related methods
CA2880622C (en) 2012-08-08 2021-01-12 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems and related methods
CA2905948C (en) 2013-03-14 2022-01-11 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers
CA2906672C (en) 2013-03-14 2022-03-15 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to force control surgical systems
EP4628042A2 (en) 2013-03-15 2025-10-08 Virtual Incision Corporation Robotic surgical devices and systems
CA2918531A1 (en) 2013-07-17 2015-01-22 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems and related methods
EP3868322B1 (en) 2014-09-12 2024-11-20 Board of Regents of the University of Nebraska Quick-release effectors and related systems
CA2967593C (en) 2014-11-11 2024-02-27 Board Of Regents Of The University Of Nebraska Robotic device with compact joint design and related systems and methods
CN114027986B (zh) 2015-08-03 2024-06-14 内布拉斯加大学董事会 机器人手术装置系统及相关方法
CN114098975A (zh) 2016-05-18 2022-03-01 虚拟切割有限公司 机器人外科装置、系统及相关方法
WO2018039606A1 (en) 2016-08-25 2018-03-01 Virtual Incision Corporation Quick-release tool coupler and related systems and methods
CA3035064A1 (en) 2016-08-30 2018-03-08 Board Of Regents Of The University Of Nebraska Robotic device with compact joint design and an additional degree of freedom and related systems and methods
CN115337111B (zh) 2016-11-22 2025-04-25 内布拉斯加大学董事会 改进的粗定位装置及相关系统和方法
JP7099728B2 (ja) 2016-11-29 2022-07-12 バーチャル インシジョン コーポレイション ユーザの存在検出機能を備えたユーザコントローラ、関連システムおよび方法
US10722319B2 (en) 2016-12-14 2020-07-28 Virtual Incision Corporation Releasable attachment device for coupling to medical devices and related systems and methods
EP3687370B1 (en) 2017-09-27 2024-11-20 Virtual Incision Corporation Robotic surgical devices with tracking camera technology and related systems
US11013564B2 (en) 2018-01-05 2021-05-25 Board Of Regents Of The University Of Nebraska Single-arm robotic device with compact joint design and related systems and methods
EP3908171A4 (en) 2019-01-07 2022-09-14 Virtual Incision Corporation Robotically assisted surgical system and related devices and methods
CA3186863A1 (en) 2020-07-06 2022-01-13 Virtual Incision Corporation Surgical robot positioning system and related devices and methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
KR920014799A (ko) * 1991-01-18 1992-08-25 나오가따 다이도 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
ATE210652T1 (de) * 1993-10-15 2001-12-15 Schering Corp Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
ES2164717T3 (es) * 1993-10-15 2002-03-01 Schering Corp Compuestos triciclicos de sulfonamida utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
EP1380581A1 (en) * 1995-12-22 2004-01-14 Schering Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
WO1998011093A1 (en) 1998-03-19
ATE286046T1 (de) 2005-01-15
EP0929545A1 (en) 1999-07-21
JP2001500510A (ja) 2001-01-16
PL332242A1 (en) 1999-08-30
HUP0000121A2 (hu) 2001-04-28
AU4337997A (en) 1998-04-02
BR9712831A (pt) 1999-11-16
CN1104427C (zh) 2003-04-02
CZ84399A3 (cs) 1999-11-17
NZ334453A (en) 2000-08-25
DE69732120D1 (de) 2005-02-03
EP0929545B1 (en) 2004-12-29
ID21699A (id) 1999-07-15
ES2235252T3 (es) 2005-07-01
CA2266016A1 (en) 1998-03-19
NO991234D0 (no) 1999-03-12
CA2266016C (en) 2004-06-01
SK33899A3 (en) 2000-02-14
KR20000036120A (ko) 2000-06-26
IL128928A0 (en) 2000-02-17
DE69732120T2 (de) 2005-12-08
TR199901276T2 (xx) 1999-09-21
CN1237165A (zh) 1999-12-01

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