NO991231L - Forbindelser for inhibering av farnesylproteintransferase - Google Patents

Forbindelser for inhibering av farnesylproteintransferase

Info

Publication number
NO991231L
NO991231L NO991231A NO991231A NO991231L NO 991231 L NO991231 L NO 991231L NO 991231 A NO991231 A NO 991231A NO 991231 A NO991231 A NO 991231A NO 991231 L NO991231 L NO 991231L
Authority
NO
Norway
Prior art keywords
compounds
protein transferase
inhibition
farnesyl protein
formula
Prior art date
Application number
NO991231A
Other languages
English (en)
Other versions
NO991231D0 (no
Inventor
F George Njoroge
Arthur G Taveras
Ronald J Doll
Tarik Lalwani
Carmen Alvarez
Stacy W Remiszewski
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO991231D0 publication Critical patent/NO991231D0/no
Publication of NO991231L publication Critical patent/NO991231L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Nye forbindelser med formel (1.0). er beskrevet. Forbindelser med formel (1.0) er representert ved forbindelsene med formel (1.4). hvori,3 oguavhengig av hver-andre er utvalgt fra halogen. Frem-gangsmåter for inhibering av farnesyl-proteintransferase og veksten av unormale celler, slik som tumorceller, er også beskrevet.
NO991231A 1996-09-13 1999-03-12 Forbindelser for inhibering av farnesylproteintransferase NO991231L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71022596A 1996-09-13 1996-09-13
US87745397A 1997-06-17 1997-06-17
PCT/US1997/024295 WO1998030558A2 (en) 1996-09-13 1997-09-11 Tricyclic compounds useful for inhibition of farnesyl protein transferase

Publications (2)

Publication Number Publication Date
NO991231D0 NO991231D0 (no) 1999-03-12
NO991231L true NO991231L (no) 1999-05-14

Family

ID=27108399

Family Applications (1)

Application Number Title Priority Date Filing Date
NO991231A NO991231L (no) 1996-09-13 1999-03-12 Forbindelser for inhibering av farnesylproteintransferase

Country Status (20)

Country Link
EP (1) EP0942906B1 (no)
JP (1) JP2002515052A (no)
KR (1) KR20000068550A (no)
CN (1) CN1248253A (no)
AT (1) ATE281450T1 (no)
AU (1) AU7243298A (no)
BR (1) BR9712035A (no)
CA (1) CA2264511C (no)
CZ (1) CZ84299A3 (no)
DE (1) DE69731481T2 (no)
ES (1) ES2232888T3 (no)
HU (1) HUP0000240A2 (no)
ID (1) ID22067A (no)
IL (1) IL128930A0 (no)
NO (1) NO991231L (no)
NZ (1) NZ334342A (no)
PL (1) PL332279A1 (no)
SK (1) SK33299A3 (no)
TR (1) TR199901273T2 (no)
WO (1) WO1998030558A2 (no)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
KR920014799A (ko) * 1991-01-18 1992-08-25 나오가따 다이도 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제
ES2164717T3 (es) * 1993-10-15 2002-03-01 Schering Corp Compuestos triciclicos de sulfonamida utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
DK0723538T3 (da) * 1993-10-15 2002-03-18 Schering Corp Tricykliske carbamatforbindelser, der er nyttige til inhibition af funktion af G-protein og til behandling af proliferative sygdomme
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
CA2240846C (en) * 1995-12-22 2002-07-16 Schering Corporation Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
IL128930A0 (en) 2000-02-17
AU7243298A (en) 1998-08-03
HUP0000240A2 (hu) 2001-04-28
NZ334342A (en) 2000-07-28
EP0942906B1 (en) 2004-11-03
TR199901273T2 (xx) 1999-09-21
ES2232888T3 (es) 2005-06-01
SK33299A3 (en) 2000-06-12
CA2264511A1 (en) 1998-07-16
BR9712035A (pt) 1999-08-24
KR20000068550A (ko) 2000-11-25
DE69731481D1 (de) 2004-12-09
WO1998030558A2 (en) 1998-07-16
DE69731481T2 (de) 2005-10-27
EP0942906A2 (en) 1999-09-22
CZ84299A3 (cs) 1999-09-15
NO991231D0 (no) 1999-03-12
CA2264511C (en) 2003-08-05
PL332279A1 (en) 1999-08-30
ID22067A (id) 1999-08-26
CN1248253A (zh) 2000-03-22
WO1998030558A3 (en) 1998-10-08
ATE281450T1 (de) 2004-11-15
JP2002515052A (ja) 2002-05-21

Similar Documents

Publication Publication Date Title
NO991234L (no) Trisykliske inhibitorer av farnesylproteintransferase
NO991229L (no) Substituerte benzosykloheptapyridinderivater for inhibering av farnesylproteintransferase
NO991235D0 (no) Forbindelser anvendelige for inhibering av farnesylproteintransferase
NO991231L (no) Forbindelser for inhibering av farnesylproteintransferase
NO991232L (no) Substituerte benzosykloheptapyridinderivater anvendelige for inhibering av farnesylproteintransferase
MY117925A (en) Compounds for the inhibition of farnesyl protein transferase.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application