NO991232L - Substituerte benzosykloheptapyridinderivater anvendelige for inhibering av farnesylproteintransferase - Google Patents
Substituerte benzosykloheptapyridinderivater anvendelige for inhibering av farnesylproteintransferaseInfo
- Publication number
- NO991232L NO991232L NO991232A NO991232A NO991232L NO 991232 L NO991232 L NO 991232L NO 991232 A NO991232 A NO 991232A NO 991232 A NO991232 A NO 991232A NO 991232 L NO991232 L NO 991232L
- Authority
- NO
- Norway
- Prior art keywords
- protein transferase
- inhibition
- farnesyl protein
- derivatives useful
- substituted
- Prior art date
Links
- 102000004357 Transferases Human genes 0.000 title abstract 2
- 108090000992 Transferases Proteins 0.000 title abstract 2
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 2
- XYNHQVIVVBWVAG-UHFFFAOYSA-N 4h-cyclohepta[f]quinoline Chemical class C1=CC=CC=C2C3=CC=CNC3=CC=C21 XYNHQVIVVBWVAG-UHFFFAOYSA-N 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Nye forbindelser med formel (1.0) er beskrevet. Forbindelser med formel (1.0) er representert ved forbindelsene med formel (1.4) (1.4) (1.5) hvori R1, R3 og R4 uavhengig av hver- andre er utvalgt fra halogen. W l 2 betegner en gruppe utvalgt fra S02R eller P(O)R13R14. Fremgangsmåter for inhibering av farnesylproteintrans- ferase og veksten av unormale celler, slik som tumorceller, er også be- skrevet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71292496A | 1996-09-13 | 1996-09-13 | |
| PCT/US1997/015906 WO1998011100A1 (en) | 1996-09-13 | 1997-09-11 | Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO991232D0 NO991232D0 (no) | 1999-03-12 |
| NO991232L true NO991232L (no) | 1999-05-12 |
Family
ID=24864087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO991232A NO991232L (no) | 1996-09-13 | 1999-03-12 | Substituerte benzosykloheptapyridinderivater anvendelige for inhibering av farnesylproteintransferase |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0927179B1 (no) |
| JP (1) | JP2001500509A (no) |
| KR (1) | KR20000036112A (no) |
| CN (1) | CN1109685C (no) |
| AT (1) | ATE247106T1 (no) |
| AU (1) | AU4337897A (no) |
| BR (1) | BR9712825A (no) |
| CA (1) | CA2264508C (no) |
| CZ (1) | CZ84499A3 (no) |
| DE (1) | DE69724130T2 (no) |
| ES (1) | ES2205255T3 (no) |
| HU (1) | HUP0000126A2 (no) |
| ID (1) | ID22002A (no) |
| IL (1) | IL128927A0 (no) |
| NO (1) | NO991232L (no) |
| NZ (1) | NZ334451A (no) |
| PL (1) | PL332319A1 (no) |
| SK (1) | SK33999A3 (no) |
| TR (1) | TR199901189T2 (no) |
| WO (1) | WO1998011100A1 (no) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| DE69429440T2 (de) * | 1993-10-15 | 2002-08-08 | Schering Corp., Kenilworth | Tricyclische sulfonamide-derivate zur inhibierung der g-protein funktion und fur die bekandlung von proliferativen erkrantungen |
-
1997
- 1997-09-11 AT AT97941479T patent/ATE247106T1/de not_active IP Right Cessation
- 1997-09-11 PL PL97332319A patent/PL332319A1/xx unknown
- 1997-09-11 CA CA002264508A patent/CA2264508C/en not_active Expired - Fee Related
- 1997-09-11 DE DE69724130T patent/DE69724130T2/de not_active Expired - Fee Related
- 1997-09-11 NZ NZ334451A patent/NZ334451A/xx unknown
- 1997-09-11 CZ CZ99844A patent/CZ84499A3/cs unknown
- 1997-09-11 AU AU43378/97A patent/AU4337897A/en not_active Abandoned
- 1997-09-11 HU HU0000126A patent/HUP0000126A2/hu unknown
- 1997-09-11 WO PCT/US1997/015906 patent/WO1998011100A1/en active IP Right Grant
- 1997-09-11 KR KR1019997002135A patent/KR20000036112A/ko not_active Application Discontinuation
- 1997-09-11 ES ES97941479T patent/ES2205255T3/es not_active Expired - Lifetime
- 1997-09-11 SK SK339-99A patent/SK33999A3/sk unknown
- 1997-09-11 CN CN97199603A patent/CN1109685C/zh not_active Expired - Fee Related
- 1997-09-11 BR BR9712825-2A patent/BR9712825A/pt unknown
- 1997-09-11 TR TR1999/01189T patent/TR199901189T2/xx unknown
- 1997-09-11 EP EP97941479A patent/EP0927179B1/en not_active Expired - Lifetime
- 1997-09-11 IL IL12892797A patent/IL128927A0/xx unknown
- 1997-09-11 JP JP10513764A patent/JP2001500509A/ja not_active Ceased
- 1997-09-11 ID IDW990088D patent/ID22002A/id unknown
-
1999
- 1999-03-12 NO NO991232A patent/NO991232L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ334451A (en) | 2000-08-25 |
| KR20000036112A (ko) | 2000-06-26 |
| CZ84499A3 (cs) | 1999-08-11 |
| NO991232D0 (no) | 1999-03-12 |
| DE69724130T2 (de) | 2004-06-03 |
| EP0927179B1 (en) | 2003-08-13 |
| TR199901189T2 (xx) | 1999-07-21 |
| CA2264508C (en) | 2003-02-18 |
| IL128927A0 (en) | 2000-02-17 |
| EP0927179A1 (en) | 1999-07-07 |
| WO1998011100A1 (en) | 1998-03-19 |
| HUP0000126A2 (hu) | 2001-04-28 |
| BR9712825A (pt) | 1999-11-23 |
| ATE247106T1 (de) | 2003-08-15 |
| CA2264508A1 (en) | 1998-03-19 |
| CN1109685C (zh) | 2003-05-28 |
| ID22002A (id) | 1999-08-19 |
| DE69724130D1 (de) | 2003-09-18 |
| ES2205255T3 (es) | 2004-05-01 |
| JP2001500509A (ja) | 2001-01-16 |
| CN1237171A (zh) | 1999-12-01 |
| PL332319A1 (en) | 1999-08-30 |
| AU4337897A (en) | 1998-04-02 |
| SK33999A3 (en) | 2000-06-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO991234L (no) | Trisykliske inhibitorer av farnesylproteintransferase | |
| NO991229L (no) | Substituerte benzosykloheptapyridinderivater for inhibering av farnesylproteintransferase | |
| NO991235L (no) | Forbindelser anvendelige for inhibering av farnesylproteintransferase | |
| NO991232L (no) | Substituerte benzosykloheptapyridinderivater anvendelige for inhibering av farnesylproteintransferase | |
| NO991231L (no) | Forbindelser for inhibering av farnesylproteintransferase | |
| TR200000114T2 (tr) | Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |