CN1104427C - 法呢基蛋白转移酶的三环抑制剂 - Google Patents

法呢基蛋白转移酶的三环抑制剂 Download PDF

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Publication number
CN1104427C
CN1104427C CN97199598A CN97199598A CN1104427C CN 1104427 C CN1104427 C CN 1104427C CN 97199598 A CN97199598 A CN 97199598A CN 97199598 A CN97199598 A CN 97199598A CN 1104427 C CN1104427 C CN 1104427C
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China
Prior art keywords
compound
formula
compounds
tumor cells
group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN97199598A
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English (en)
Chinese (zh)
Other versions
CN1237165A (zh
Inventor
A·G·塔韦拉斯
A·K·马拉姆斯
A·阿福索
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Cereal-Derived Products (AREA)
  • Enzymes And Modification Thereof (AREA)
CN97199598A 1996-09-13 1997-09-11 法呢基蛋白转移酶的三环抑制剂 Expired - Fee Related CN1104427C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71332396A 1996-09-13 1996-09-13
US08/713,323 1996-09-13
US08/713323 1996-09-13

Publications (2)

Publication Number Publication Date
CN1237165A CN1237165A (zh) 1999-12-01
CN1104427C true CN1104427C (zh) 2003-04-02

Family

ID=24865689

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97199598A Expired - Fee Related CN1104427C (zh) 1996-09-13 1997-09-11 法呢基蛋白转移酶的三环抑制剂

Country Status (20)

Country Link
EP (1) EP0929545B1 (enExample)
JP (1) JP2001500510A (enExample)
KR (1) KR20000036120A (enExample)
CN (1) CN1104427C (enExample)
AT (1) ATE286046T1 (enExample)
AU (1) AU4337997A (enExample)
BR (1) BR9712831A (enExample)
CA (1) CA2266016C (enExample)
CZ (1) CZ84399A3 (enExample)
DE (1) DE69732120T2 (enExample)
ES (1) ES2235252T3 (enExample)
HU (1) HUP0000121A2 (enExample)
ID (1) ID21699A (enExample)
IL (1) IL128928A0 (enExample)
NO (1) NO991234L (enExample)
NZ (1) NZ334453A (enExample)
PL (1) PL332242A1 (enExample)
SK (1) SK33899A3 (enExample)
TR (1) TR199901276T2 (enExample)
WO (1) WO1998011093A1 (enExample)

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LT3962B (en) 1993-12-21 1996-05-27 Albright & Wilson Funcional fluids
US5939416A (en) * 1997-06-17 1999-08-17 Schering Corporation Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CN1289336A (zh) 1998-01-21 2001-03-28 千禧药品公司 趋化因子受体拮抗剂和其使用方法
EP1047675A1 (en) 1998-01-21 2000-11-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
US9579088B2 (en) 2007-02-20 2017-02-28 Board Of Regents Of The University Of Nebraska Methods, systems, and devices for surgical visualization and device manipulation
US8679096B2 (en) 2007-06-21 2014-03-25 Board Of Regents Of The University Of Nebraska Multifunctional operational component for robotic devices
TW200902007A (en) * 2007-05-25 2009-01-16 Astrazeneca Ab Spirocyclopropyl piperidine derivatives
EP2170564A4 (en) 2007-07-12 2015-10-07 Univ Nebraska ACTUATING PROCESSES AND SYSTEMS IN ROBOTIC EQUIPMENT
US20090076536A1 (en) 2007-08-15 2009-03-19 Board Of Regents Of The University Of Nebraska Medical inflation, attachment, and delivery devices and related methods
US9060781B2 (en) 2011-06-10 2015-06-23 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to surgical end effectors
US9089353B2 (en) 2011-07-11 2015-07-28 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems, and related methods
JP6502848B2 (ja) 2011-10-03 2019-04-17 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ モジュール式手術用ロボットシステム
US20140058205A1 (en) 2012-01-10 2014-02-27 Board Of Regents Of The University Of Nebraska Methods, Systems, and Devices for Surgical Access and Insertion
EP4357083A3 (en) 2012-05-01 2024-08-21 Board of Regents of the University of Nebraska Single site robotic device and related systems and methods
EP4234185A3 (en) 2012-06-22 2023-09-20 Board of Regents of the University of Nebraska Local control robotic surgical devices
US9770305B2 (en) 2012-08-08 2017-09-26 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems, and related methods
CA2880622C (en) 2012-08-08 2021-01-12 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems and related methods
CA2905948C (en) 2013-03-14 2022-01-11 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers
CA2906672C (en) 2013-03-14 2022-03-15 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to force control surgical systems
EP4628042A2 (en) 2013-03-15 2025-10-08 Virtual Incision Corporation Robotic surgical devices and systems
CA2918531A1 (en) 2013-07-17 2015-01-22 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems and related methods
EP3868322B1 (en) 2014-09-12 2024-11-20 Board of Regents of the University of Nebraska Quick-release effectors and related systems
CA2967593C (en) 2014-11-11 2024-02-27 Board Of Regents Of The University Of Nebraska Robotic device with compact joint design and related systems and methods
CN114027986B (zh) 2015-08-03 2024-06-14 内布拉斯加大学董事会 机器人手术装置系统及相关方法
CN114098975A (zh) 2016-05-18 2022-03-01 虚拟切割有限公司 机器人外科装置、系统及相关方法
WO2018039606A1 (en) 2016-08-25 2018-03-01 Virtual Incision Corporation Quick-release tool coupler and related systems and methods
CA3035064A1 (en) 2016-08-30 2018-03-08 Board Of Regents Of The University Of Nebraska Robotic device with compact joint design and an additional degree of freedom and related systems and methods
CN115337111B (zh) 2016-11-22 2025-04-25 内布拉斯加大学董事会 改进的粗定位装置及相关系统和方法
JP7099728B2 (ja) 2016-11-29 2022-07-12 バーチャル インシジョン コーポレイション ユーザの存在検出機能を備えたユーザコントローラ、関連システムおよび方法
US10722319B2 (en) 2016-12-14 2020-07-28 Virtual Incision Corporation Releasable attachment device for coupling to medical devices and related systems and methods
EP3687370B1 (en) 2017-09-27 2024-11-20 Virtual Incision Corporation Robotic surgical devices with tracking camera technology and related systems
US11013564B2 (en) 2018-01-05 2021-05-25 Board Of Regents Of The University Of Nebraska Single-arm robotic device with compact joint design and related systems and methods
EP3908171A4 (en) 2019-01-07 2022-09-14 Virtual Incision Corporation Robotically assisted surgical system and related devices and methods
CA3186863A1 (en) 2020-07-06 2022-01-13 Virtual Incision Corporation Surgical robot positioning system and related devices and methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010516A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
WO1995010515A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

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US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
KR920014799A (ko) * 1991-01-18 1992-08-25 나오가따 다이도 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
ES2164717T3 (es) * 1993-10-15 2002-03-01 Schering Corp Compuestos triciclicos de sulfonamida utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
EP1380581A1 (en) * 1995-12-22 2004-01-14 Schering Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010516A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
WO1995010515A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.BIO.CHEM.VOL.270(5) 1995-01-01 W.ROBERT.BISHOP.ET.AL. *

Also Published As

Publication number Publication date
WO1998011093A1 (en) 1998-03-19
ATE286046T1 (de) 2005-01-15
NO991234L (no) 1999-05-12
EP0929545A1 (en) 1999-07-21
JP2001500510A (ja) 2001-01-16
PL332242A1 (en) 1999-08-30
HUP0000121A2 (hu) 2001-04-28
AU4337997A (en) 1998-04-02
BR9712831A (pt) 1999-11-16
CZ84399A3 (cs) 1999-11-17
NZ334453A (en) 2000-08-25
DE69732120D1 (de) 2005-02-03
EP0929545B1 (en) 2004-12-29
ID21699A (id) 1999-07-15
ES2235252T3 (es) 2005-07-01
CA2266016A1 (en) 1998-03-19
NO991234D0 (no) 1999-03-12
CA2266016C (en) 2004-06-01
SK33899A3 (en) 2000-02-14
KR20000036120A (ko) 2000-06-26
IL128928A0 (en) 2000-02-17
DE69732120T2 (de) 2005-12-08
TR199901276T2 (xx) 1999-09-21
CN1237165A (zh) 1999-12-01

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