CN1104427C - 法呢基蛋白转移酶的三环抑制剂 - Google Patents

法呢基蛋白转移酶的三环抑制剂 Download PDF

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Publication number
CN1104427C
CN1104427C CN97199598A CN97199598A CN1104427C CN 1104427 C CN1104427 C CN 1104427C CN 97199598 A CN97199598 A CN 97199598A CN 97199598 A CN97199598 A CN 97199598A CN 1104427 C CN1104427 C CN 1104427C
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China
Prior art keywords
compound
formula
compounds
tumor cells
group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN97199598A
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English (en)
Chinese (zh)
Other versions
CN1237165A (zh
Inventor
A·G·塔韦拉斯
A·K·马拉姆斯
A·阿福索
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Cereal-Derived Products (AREA)
  • Enzymes And Modification Thereof (AREA)
CN97199598A 1996-09-13 1997-09-11 法呢基蛋白转移酶的三环抑制剂 Expired - Fee Related CN1104427C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71332396A 1996-09-13 1996-09-13
US08/713,323 1996-09-13
US08/713323 1996-09-13

Publications (2)

Publication Number Publication Date
CN1237165A CN1237165A (zh) 1999-12-01
CN1104427C true CN1104427C (zh) 2003-04-02

Family

ID=24865689

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97199598A Expired - Fee Related CN1104427C (zh) 1996-09-13 1997-09-11 法呢基蛋白转移酶的三环抑制剂

Country Status (20)

Country Link
EP (1) EP0929545B1 (enExample)
JP (1) JP2001500510A (enExample)
KR (1) KR20000036120A (enExample)
CN (1) CN1104427C (enExample)
AT (1) ATE286046T1 (enExample)
AU (1) AU4337997A (enExample)
BR (1) BR9712831A (enExample)
CA (1) CA2266016C (enExample)
CZ (1) CZ84399A3 (enExample)
DE (1) DE69732120T2 (enExample)
ES (1) ES2235252T3 (enExample)
HU (1) HUP0000121A2 (enExample)
ID (1) ID21699A (enExample)
IL (1) IL128928A0 (enExample)
NO (1) NO991234L (enExample)
NZ (1) NZ334453A (enExample)
PL (1) PL332242A1 (enExample)
SK (1) SK33899A3 (enExample)
TR (1) TR199901276T2 (enExample)
WO (1) WO1998011093A1 (enExample)

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LT3962B (en) 1993-12-21 1996-05-27 Albright & Wilson Funcional fluids
US5939416A (en) * 1997-06-17 1999-08-17 Schering Corporation Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
ATE309249T1 (de) 1998-01-21 2005-11-15 Millennium Pharm Inc Chemokin rezeptor antagonisten und verwndung
WO1999037619A1 (en) 1998-01-21 1999-07-29 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
US9579088B2 (en) 2007-02-20 2017-02-28 Board Of Regents Of The University Of Nebraska Methods, systems, and devices for surgical visualization and device manipulation
US8679096B2 (en) 2007-06-21 2014-03-25 Board Of Regents Of The University Of Nebraska Multifunctional operational component for robotic devices
TW200902007A (en) * 2007-05-25 2009-01-16 Astrazeneca Ab Spirocyclopropyl piperidine derivatives
EP3078344B1 (en) 2007-07-12 2020-02-26 Board of Regents of the University of Nebraska Actuation in robotic devices
JP2010536435A (ja) 2007-08-15 2010-12-02 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ 医療用膨張、取り付けおよび送達装置、ならびに関連する方法
EP2717796B1 (en) 2011-06-10 2020-02-26 Board of Regents of the University of Nebraska In vivo vessel sealing end effector
EP2732344B1 (en) 2011-07-11 2019-06-05 Board of Regents of the University of Nebraska Robotic surgical system
EP3730031A1 (en) 2011-10-03 2020-10-28 Board of Regents of the University of Nebraska Robotic surgical devices and systems
WO2013106569A2 (en) 2012-01-10 2013-07-18 Board Of Regents Of The University Of Nebraska Methods, systems, and devices for surgical access and insertion
EP2844181B1 (en) 2012-05-01 2021-03-10 Board of Regents of the University of Nebraska Single site robotic device and related systems
US9010214B2 (en) 2012-06-22 2015-04-21 Board Of Regents Of The University Of Nebraska Local control robotic surgical devices and related methods
US9770305B2 (en) 2012-08-08 2017-09-26 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems, and related methods
CA2880622C (en) 2012-08-08 2021-01-12 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems and related methods
US9743987B2 (en) 2013-03-14 2017-08-29 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers
CA2906672C (en) 2013-03-14 2022-03-15 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to force control surgical systems
CA2906772C (en) 2013-03-15 2021-09-21 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems and related methods
CA2918531A1 (en) 2013-07-17 2015-01-22 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems and related methods
EP3191009B1 (en) 2014-09-12 2021-03-31 Board of Regents of the University of Nebraska Quick-release end effectors and related systems
WO2016077478A1 (en) 2014-11-11 2016-05-19 Board Of Regents Of The University Of Nebraska Robotic device with compact joint design and related systems and methods
CN108472030B (zh) 2015-08-03 2021-06-18 内布拉斯加大学董事会 机器人手术装置系统及相关方法
US10751136B2 (en) 2016-05-18 2020-08-25 Virtual Incision Corporation Robotic surgical devices, systems and related methods
CN110248614B (zh) 2016-08-25 2023-04-18 内布拉斯加大学董事会 快速释放工具耦接器以及相关系统和方法
WO2018045036A1 (en) 2016-08-30 2018-03-08 Board Of Regents Of The University Of Nebraska Robotic device with compact joint design and an additional degree of freedom and related systems and methods
WO2018098319A1 (en) 2016-11-22 2018-05-31 Board Of Regents Of The University Of Nebraska Improved gross positioning device and related systems and methods
WO2018102430A1 (en) 2016-11-29 2018-06-07 Virtual Incision Corporation User controller with user presence detection and related systems and methods
WO2018112199A1 (en) 2016-12-14 2018-06-21 Virtual Incision Corporation Releasable attachment device for coupling to medical devices and related systems and methods
EP3687370B1 (en) 2017-09-27 2024-11-20 Virtual Incision Corporation Robotic surgical devices with tracking camera technology and related systems
WO2019136360A1 (en) 2018-01-05 2019-07-11 Board Of Regents Of The University Of Nebraska Single-arm robotic device with compact joint design and related systems and methods
CN114302665B (zh) 2019-01-07 2025-12-19 虚拟切割有限公司 机器人辅助手术系统以及相关装置和方法
JP2023532977A (ja) 2020-07-06 2023-08-01 バーチャル インシジョン コーポレイション 外科用ロボット位置決めシステム並びに関連する装置及び方法

Citations (2)

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WO1995010515A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
WO1995010516A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

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US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
JPH0676403B2 (ja) * 1991-01-18 1994-09-28 エスエス製薬株式会社 新規なベンゾ［５，６ シクロヘプタ［１，２−ｂ ピリジン誘導体及びこれを含有する抗アレルギー剤
EP0723539B1 (en) * 1993-10-15 2001-12-12 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
CZ292791B6 (cs) * 1995-12-22 2003-12-17 Schering Corporation Tricyklické amidy, které se používají pro inhibici G-proteinové funkce a k léčení proliferativních onemocnění

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010515A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
WO1995010516A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.BIO.CHEM.VOL.270(5) 1995-01-01 W.ROBERT.BISHOP.ET.AL. *

Also Published As

Publication number Publication date
DE69732120D1 (de) 2005-02-03
NO991234D0 (no) 1999-03-12
IL128928A0 (en) 2000-02-17
TR199901276T2 (xx) 1999-09-21
BR9712831A (pt) 1999-11-16
KR20000036120A (ko) 2000-06-26
PL332242A1 (en) 1999-08-30
SK33899A3 (en) 2000-02-14
ID21699A (id) 1999-07-15
JP2001500510A (ja) 2001-01-16
ATE286046T1 (de) 2005-01-15
CA2266016A1 (en) 1998-03-19
HUP0000121A2 (hu) 2001-04-28
CA2266016C (en) 2004-06-01
DE69732120T2 (de) 2005-12-08
EP0929545A1 (en) 1999-07-21
NO991234L (no) 1999-05-12
ES2235252T3 (es) 2005-07-01
EP0929545B1 (en) 2004-12-29
NZ334453A (en) 2000-08-25
WO1998011093A1 (en) 1998-03-19
CN1237165A (zh) 1999-12-01
CZ84399A3 (cs) 1999-11-17
AU4337997A (en) 1998-04-02

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