TR199901276T2 - Farnezil protein transferaz inhibisyonu i�in yararl� bile�ikler. - Google Patents
Farnezil protein transferaz inhibisyonu i�in yararl� bile�ikler.Info
- Publication number
- TR199901276T2 TR199901276T2 TR1999/01276T TR9901276T TR199901276T2 TR 199901276 T2 TR199901276 T2 TR 199901276T2 TR 1999/01276 T TR1999/01276 T TR 1999/01276T TR 9901276 T TR9901276 T TR 9901276T TR 199901276 T2 TR199901276 T2 TR 199901276T2
- Authority
- TR
- Turkey
- Prior art keywords
- protein transferase
- inhibition
- farnesyl protein
- compounds useful
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 102000004357 Transferases Human genes 0.000 title abstract 2
- 108090000992 Transferases Proteins 0.000 title abstract 2
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
- Cereal-Derived Products (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71332396A | 1996-09-13 | 1996-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199901276T2 true TR199901276T2 (xx) | 1999-09-21 |
Family
ID=24865689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/01276T TR199901276T2 (xx) | 1996-09-13 | 1997-09-11 | Farnezil protein transferaz inhibisyonu i�in yararl� bile�ikler. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0929545B1 (enExample) |
| JP (1) | JP2001500510A (enExample) |
| KR (1) | KR20000036120A (enExample) |
| CN (1) | CN1104427C (enExample) |
| AT (1) | ATE286046T1 (enExample) |
| AU (1) | AU4337997A (enExample) |
| BR (1) | BR9712831A (enExample) |
| CA (1) | CA2266016C (enExample) |
| CZ (1) | CZ84399A3 (enExample) |
| DE (1) | DE69732120T2 (enExample) |
| ES (1) | ES2235252T3 (enExample) |
| HU (1) | HUP0000121A2 (enExample) |
| ID (1) | ID21699A (enExample) |
| IL (1) | IL128928A0 (enExample) |
| NO (1) | NO991234L (enExample) |
| NZ (1) | NZ334453A (enExample) |
| PL (1) | PL332242A1 (enExample) |
| SK (1) | SK33899A3 (enExample) |
| TR (1) | TR199901276T2 (enExample) |
| WO (1) | WO1998011093A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3962B (en) | 1993-12-21 | 1996-05-27 | Albright & Wilson | Funcional fluids |
| US5939416A (en) * | 1997-06-17 | 1999-08-17 | Schering Corporation | Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors |
| ATE309249T1 (de) | 1998-01-21 | 2005-11-15 | Millennium Pharm Inc | Chemokin rezeptor antagonisten und verwndung |
| WO1999037619A1 (en) | 1998-01-21 | 1999-07-29 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| US9579088B2 (en) | 2007-02-20 | 2017-02-28 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices for surgical visualization and device manipulation |
| US8679096B2 (en) | 2007-06-21 | 2014-03-25 | Board Of Regents Of The University Of Nebraska | Multifunctional operational component for robotic devices |
| TW200902007A (en) * | 2007-05-25 | 2009-01-16 | Astrazeneca Ab | Spirocyclopropyl piperidine derivatives |
| EP3078344B1 (en) | 2007-07-12 | 2020-02-26 | Board of Regents of the University of Nebraska | Actuation in robotic devices |
| JP2010536435A (ja) | 2007-08-15 | 2010-12-02 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | 医療用膨張、取り付けおよび送達装置、ならびに関連する方法 |
| EP2717796B1 (en) | 2011-06-10 | 2020-02-26 | Board of Regents of the University of Nebraska | In vivo vessel sealing end effector |
| EP2732344B1 (en) | 2011-07-11 | 2019-06-05 | Board of Regents of the University of Nebraska | Robotic surgical system |
| EP3730031A1 (en) | 2011-10-03 | 2020-10-28 | Board of Regents of the University of Nebraska | Robotic surgical devices and systems |
| WO2013106569A2 (en) | 2012-01-10 | 2013-07-18 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices for surgical access and insertion |
| EP2844181B1 (en) | 2012-05-01 | 2021-03-10 | Board of Regents of the University of Nebraska | Single site robotic device and related systems |
| US9010214B2 (en) | 2012-06-22 | 2015-04-21 | Board Of Regents Of The University Of Nebraska | Local control robotic surgical devices and related methods |
| US9770305B2 (en) | 2012-08-08 | 2017-09-26 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| CA2880622C (en) | 2012-08-08 | 2021-01-12 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| US9743987B2 (en) | 2013-03-14 | 2017-08-29 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers |
| CA2906672C (en) | 2013-03-14 | 2022-03-15 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to force control surgical systems |
| CA2906772C (en) | 2013-03-15 | 2021-09-21 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| CA2918531A1 (en) | 2013-07-17 | 2015-01-22 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| EP3191009B1 (en) | 2014-09-12 | 2021-03-31 | Board of Regents of the University of Nebraska | Quick-release end effectors and related systems |
| WO2016077478A1 (en) | 2014-11-11 | 2016-05-19 | Board Of Regents Of The University Of Nebraska | Robotic device with compact joint design and related systems and methods |
| CN108472030B (zh) | 2015-08-03 | 2021-06-18 | 内布拉斯加大学董事会 | 机器人手术装置系统及相关方法 |
| US10751136B2 (en) | 2016-05-18 | 2020-08-25 | Virtual Incision Corporation | Robotic surgical devices, systems and related methods |
| CN110248614B (zh) | 2016-08-25 | 2023-04-18 | 内布拉斯加大学董事会 | 快速释放工具耦接器以及相关系统和方法 |
| WO2018045036A1 (en) | 2016-08-30 | 2018-03-08 | Board Of Regents Of The University Of Nebraska | Robotic device with compact joint design and an additional degree of freedom and related systems and methods |
| WO2018098319A1 (en) | 2016-11-22 | 2018-05-31 | Board Of Regents Of The University Of Nebraska | Improved gross positioning device and related systems and methods |
| WO2018102430A1 (en) | 2016-11-29 | 2018-06-07 | Virtual Incision Corporation | User controller with user presence detection and related systems and methods |
| WO2018112199A1 (en) | 2016-12-14 | 2018-06-21 | Virtual Incision Corporation | Releasable attachment device for coupling to medical devices and related systems and methods |
| EP3687370B1 (en) | 2017-09-27 | 2024-11-20 | Virtual Incision Corporation | Robotic surgical devices with tracking camera technology and related systems |
| WO2019136360A1 (en) | 2018-01-05 | 2019-07-11 | Board Of Regents Of The University Of Nebraska | Single-arm robotic device with compact joint design and related systems and methods |
| CN114302665B (zh) | 2019-01-07 | 2025-12-19 | 虚拟切割有限公司 | 机器人辅助手术系统以及相关装置和方法 |
| JP2023532977A (ja) | 2020-07-06 | 2023-08-01 | バーチャル インシジョン コーポレイション | 外科用ロボット位置決めシステム並びに関連する装置及び方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| JPH0676403B2 (ja) * | 1991-01-18 | 1994-09-28 | エスエス製薬株式会社 | 新規なベンゾ［５，６ シクロヘプタ［１，２−ｂ ピリジン誘導体及びこれを含有する抗アレルギー剤 |
| SG48750A1 (en) * | 1993-10-15 | 1998-05-18 | Schering Corp | Tricyclic carbonate compounds useful for inhabition of g-protein function for treatment of proliferative diseases |
| EP0723539B1 (en) * | 1993-10-15 | 2001-12-12 | Schering Corporation | Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| CZ292791B6 (cs) * | 1995-12-22 | 2003-12-17 | Schering Corporation | Tricyklické amidy, které se používají pro inhibici G-proteinové funkce a k léčení proliferativních onemocnění |
-
1997
- 1997-09-11 BR BR9712831-7A patent/BR9712831A/pt unknown
- 1997-09-11 PL PL97332242A patent/PL332242A1/xx unknown
- 1997-09-11 NZ NZ334453A patent/NZ334453A/xx unknown
- 1997-09-11 DE DE69732120T patent/DE69732120T2/de not_active Expired - Fee Related
- 1997-09-11 TR TR1999/01276T patent/TR199901276T2/xx unknown
- 1997-09-11 HU HU0000121A patent/HUP0000121A2/hu unknown
- 1997-09-11 WO PCT/US1997/015907 patent/WO1998011093A1/en not_active Ceased
- 1997-09-11 SK SK338-99A patent/SK33899A3/sk unknown
- 1997-09-11 JP JP10513765A patent/JP2001500510A/ja not_active Ceased
- 1997-09-11 AT AT97941480T patent/ATE286046T1/de not_active IP Right Cessation
- 1997-09-11 CA CA002266016A patent/CA2266016C/en not_active Expired - Fee Related
- 1997-09-11 EP EP97941480A patent/EP0929545B1/en not_active Expired - Lifetime
- 1997-09-11 IL IL12892897A patent/IL128928A0/xx unknown
- 1997-09-11 ES ES97941480T patent/ES2235252T3/es not_active Expired - Lifetime
- 1997-09-11 AU AU43379/97A patent/AU4337997A/en not_active Abandoned
- 1997-09-11 KR KR1019997002149A patent/KR20000036120A/ko not_active Withdrawn
- 1997-09-11 CZ CZ99843A patent/CZ84399A3/cs unknown
- 1997-09-11 CN CN97199598A patent/CN1104427C/zh not_active Expired - Fee Related
- 1997-11-09 ID IDW990086A patent/ID21699A/id unknown
-
1999
- 1999-03-12 NO NO991234A patent/NO991234L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69732120D1 (de) | 2005-02-03 |
| NO991234D0 (no) | 1999-03-12 |
| IL128928A0 (en) | 2000-02-17 |
| BR9712831A (pt) | 1999-11-16 |
| KR20000036120A (ko) | 2000-06-26 |
| PL332242A1 (en) | 1999-08-30 |
| SK33899A3 (en) | 2000-02-14 |
| ID21699A (id) | 1999-07-15 |
| JP2001500510A (ja) | 2001-01-16 |
| ATE286046T1 (de) | 2005-01-15 |
| CA2266016A1 (en) | 1998-03-19 |
| HUP0000121A2 (hu) | 2001-04-28 |
| CA2266016C (en) | 2004-06-01 |
| CN1104427C (zh) | 2003-04-02 |
| DE69732120T2 (de) | 2005-12-08 |
| EP0929545A1 (en) | 1999-07-21 |
| NO991234L (no) | 1999-05-12 |
| ES2235252T3 (es) | 2005-07-01 |
| EP0929545B1 (en) | 2004-12-29 |
| NZ334453A (en) | 2000-08-25 |
| WO1998011093A1 (en) | 1998-03-19 |
| CN1237165A (zh) | 1999-12-01 |
| CZ84399A3 (cs) | 1999-11-17 |
| AU4337997A (en) | 1998-04-02 |
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| TR199901273T2 (xx) | Farnezil protein transferaz inhibisyonu i�in yararl� bile�ikler. | |
| TR200003580T2 (tr) | Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri | |
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