DE69728572T2 - Mikroabbildungssystem - Google Patents
Mikroabbildungssystem Download PDFInfo
- Publication number
- DE69728572T2 DE69728572T2 DE69728572T DE69728572T DE69728572T2 DE 69728572 T2 DE69728572 T2 DE 69728572T2 DE 69728572 T DE69728572 T DE 69728572T DE 69728572 T DE69728572 T DE 69728572T DE 69728572 T2 DE69728572 T2 DE 69728572T2
- Authority
- DE
- Germany
- Prior art keywords
- detector
- sample
- lens
- optical
- scanning system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000003287 optical effect Effects 0.000 claims description 35
- 210000001747 pupil Anatomy 0.000 claims description 34
- 238000003384 imaging method Methods 0.000 claims description 21
- 239000011159 matrix material Substances 0.000 claims description 11
- 238000012545 processing Methods 0.000 claims description 11
- 230000000007 visual effect Effects 0.000 claims description 9
- 238000005286 illumination Methods 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 3
- 230000010287 polarization Effects 0.000 claims description 2
- 239000003990 capacitor Substances 0.000 claims 1
- 230000009977 dual effect Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 238000000386 microscopy Methods 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 5
- 239000004065 semiconductor Substances 0.000 description 5
- 230000004075 alteration Effects 0.000 description 4
- 230000001427 coherent effect Effects 0.000 description 4
- 230000010354 integration Effects 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 238000002594 fluoroscopy Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 206010010071 Coma Diseases 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000010365 information processing Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000007847 structural defect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000010865 video microscopy Methods 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/02—Objectives
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Microscoopes, Condenser (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/716,858 US5754291A (en) | 1996-09-19 | 1996-09-19 | Micro-imaging system |
| US716858 | 1996-09-19 | ||
| PCT/US1997/016224 WO1998012536A1 (en) | 1996-09-19 | 1997-09-12 | Micro-imaging system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69728572D1 DE69728572D1 (de) | 2004-05-13 |
| DE69728572T2 true DE69728572T2 (de) | 2005-03-03 |
Family
ID=24879741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69728572T Expired - Lifetime DE69728572T2 (de) | 1996-09-19 | 1997-09-12 | Mikroabbildungssystem |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5754291A (enExample) |
| EP (1) | EP1015869B1 (enExample) |
| JP (1) | JP2001500986A (enExample) |
| DE (1) | DE69728572T2 (enExample) |
| WO (1) | WO1998012536A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011087454A1 (de) * | 2011-11-30 | 2013-06-06 | Leica Microsystems (Schweiz) Ag | Optische Vorrichtung zum Einsatz in der Medizintechnik |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5940545A (en) * | 1996-07-18 | 1999-08-17 | International Business Machines Corporation | Noninvasive optical method for measuring internal switching and other dynamic parameters of CMOS circuits |
| US7498164B2 (en) * | 1998-05-16 | 2009-03-03 | Applied Biosystems, Llc | Instrument for monitoring nucleic acid sequence amplification reaction |
| ATE425448T1 (de) * | 1998-05-16 | 2009-03-15 | Applera Corp | Optisches gerät insbesondere zur überwachung von dns-polymerasekettenreaktionen |
| US6818437B1 (en) | 1998-05-16 | 2004-11-16 | Applera Corporation | Instrument for monitoring polymerase chain reaction of DNA |
| IL143412A0 (en) | 1998-11-25 | 2002-04-21 | Phormax Corp | Dual-head phosphor screen scanner |
| US6246046B1 (en) | 1999-01-21 | 2001-06-12 | University Of Pittsburgh | Method and apparatus for electronically controlled scanning of micro-area devices |
| US7057732B2 (en) * | 1999-01-25 | 2006-06-06 | Amnis Corporation | Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis |
| US6608682B2 (en) | 1999-01-25 | 2003-08-19 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells |
| US20060257884A1 (en) * | 2004-05-20 | 2006-11-16 | Amnis Corporation | Methods for preparing and analyzing cells having chromosomal abnormalities |
| US6671044B2 (en) | 1999-01-25 | 2003-12-30 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells in broad flat flow |
| US8005314B2 (en) * | 2005-12-09 | 2011-08-23 | Amnis Corporation | Extended depth of field imaging for high speed object analysis |
| US8131053B2 (en) * | 1999-01-25 | 2012-03-06 | Amnis Corporation | Detection of circulating tumor cells using imaging flow cytometry |
| US6707551B2 (en) * | 2000-01-24 | 2004-03-16 | Amnis Corporation | Multipass cavity for illumination and excitation of moving objects |
| US8406498B2 (en) * | 1999-01-25 | 2013-03-26 | Amnis Corporation | Blood and cell analysis using an imaging flow cytometer |
| US7450229B2 (en) * | 1999-01-25 | 2008-11-11 | Amnis Corporation | Methods for analyzing inter-cellular phenomena |
| US8885913B2 (en) | 1999-01-25 | 2014-11-11 | Amnis Corporation | Detection of circulating tumor cells using imaging flow cytometry |
| US6473176B2 (en) | 1999-01-25 | 2002-10-29 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells |
| US6975400B2 (en) * | 1999-01-25 | 2005-12-13 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells |
| US6249341B1 (en) * | 1999-01-25 | 2001-06-19 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells |
| EP1272822A4 (en) * | 2000-01-24 | 2008-03-12 | Amnis Corp | PARAMETERS FOR IMAGING AND ANALYZING SMALL MOBILE OBJECTS SUCH AS CELLS |
| US6862142B2 (en) * | 2000-03-10 | 2005-03-01 | Kla-Tencor Technologies Corporation | Multi-detector microscopic inspection system |
| US6711283B1 (en) | 2000-05-03 | 2004-03-23 | Aperio Technologies, Inc. | Fully automatic rapid microscope slide scanner |
| US7668362B2 (en) | 2000-05-03 | 2010-02-23 | Aperio Technologies, Inc. | System and method for assessing virtual slide image quality |
| US7738688B2 (en) | 2000-05-03 | 2010-06-15 | Aperio Technologies, Inc. | System and method for viewing virtual slides |
| US7518652B2 (en) | 2000-05-03 | 2009-04-14 | Aperio Technologies, Inc. | Method and apparatus for pre-focus in a linear array based slide scanner |
| US6690467B1 (en) * | 2000-05-05 | 2004-02-10 | Pe Corporation | Optical system and method for optically analyzing light from a sample |
| JP3818867B2 (ja) * | 2000-05-12 | 2006-09-06 | リオン株式会社 | 光散乱式粒子検出器 |
| DE10029680B4 (de) * | 2000-06-23 | 2016-06-16 | Leica Microsystems Cms Gmbh | Mikroskop-Aufbau |
| US6608680B2 (en) * | 2000-08-25 | 2003-08-19 | Amnis Corporation | TDI imaging system for kinetic studies |
| EP1328894A4 (en) | 2000-08-25 | 2005-11-09 | Amnis Corp | MEASURING THE SPEED OF SMALL MOBILE OBJECTS SUCH AS CELLS |
| US6934408B2 (en) * | 2000-08-25 | 2005-08-23 | Amnis Corporation | Method and apparatus for reading reporter labeled beads |
| US6875973B2 (en) * | 2000-08-25 | 2005-04-05 | Amnis Corporation | Auto focus for a flow imaging system |
| US6583865B2 (en) * | 2000-08-25 | 2003-06-24 | Amnis Corporation | Alternative detector configuration and mode of operation of a time delay integration particle analyzer |
| US6778263B2 (en) * | 2000-08-25 | 2004-08-17 | Amnis Corporation | Methods of calibrating an imaging system using calibration beads |
| AU2002213157A1 (en) | 2000-10-12 | 2002-04-22 | Amnis Corporation | System and method for high numeric aperture imaging systems |
| JP2002168787A (ja) * | 2000-12-04 | 2002-06-14 | Fuji Photo Film Co Ltd | 画像読み取り方法および装置 |
| WO2002100157A2 (en) * | 2001-02-21 | 2002-12-19 | Amnis Corporation | Method and apparatus for labeling and analyzing cellular components |
| EP1389956B1 (en) * | 2001-04-25 | 2012-10-31 | Amnis Corporation | Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging |
| US6716683B1 (en) * | 2001-06-22 | 2004-04-06 | Advanced Mircor Devices, Inc. | Optical analysis for SOI integrated circuits |
| US7190832B2 (en) | 2001-07-17 | 2007-03-13 | Amnis Corporation | Computational methods for the segmentation of images of objects from background in a flow imaging instrument |
| US7265833B2 (en) * | 2001-07-25 | 2007-09-04 | Applera Corporation | Electrophoretic system with multi-notch filter and laser excitation source |
| US7280207B2 (en) | 2001-07-25 | 2007-10-09 | Applera Corporation | Time-delay integration in a flow cytometry system |
| US6856390B2 (en) | 2001-07-25 | 2005-02-15 | Applera Corporation | Time-delay integration in electrophoretic detection systems |
| US6891363B2 (en) * | 2002-09-03 | 2005-05-10 | Credence Systems Corporation | Apparatus and method for detecting photon emissions from transistors |
| US6943572B2 (en) * | 2002-09-03 | 2005-09-13 | Credence Systems Corporation | Apparatus and method for detecting photon emissions from transistors |
| DE10246521B4 (de) * | 2002-10-05 | 2005-11-10 | Karl Storz Gmbh & Co. Kg | Endoskop |
| WO2004065544A2 (en) * | 2003-01-15 | 2004-08-05 | Amnis Corporation | Cell suspension rotating fluidic pump |
| US20050012057A1 (en) * | 2003-05-08 | 2005-01-20 | Alara, Inc. | Method and apparatus for radiation image erasure |
| US20040259270A1 (en) * | 2003-06-19 | 2004-12-23 | Wolf David E. | System, device and method for exciting a sensor and detecting analyte |
| DE102004012161B3 (de) * | 2004-03-12 | 2005-11-03 | Nanofilm Technologie Gmbh | Abbildendes Ellipsometer mit synchronisiertem Probenvorschub und ellipsometrisches Messverfahren |
| US8953866B2 (en) | 2004-03-16 | 2015-02-10 | Amnis Corporation | Method for imaging and differential analysis of cells |
| WO2005090945A1 (en) | 2004-03-16 | 2005-09-29 | Amnis Corporation | Method for imaging and differential analysis of cells |
| US8150136B2 (en) | 2004-03-16 | 2012-04-03 | Amnis Corporation | Image based quantitation of molecular translocation |
| US7463761B2 (en) | 2004-05-27 | 2008-12-09 | Aperio Technologies, Inc. | Systems and methods for creating and viewing three dimensional virtual slides |
| CA2574343C (en) * | 2004-07-23 | 2012-05-01 | Paul Donders | Method and apparatus for fluorescent confocal microscopy |
| US7768638B2 (en) * | 2005-03-18 | 2010-08-03 | Illumina, Inc. | Systems for and methods of facilitating focusing an optical scanner |
| US8164622B2 (en) | 2005-07-01 | 2012-04-24 | Aperio Technologies, Inc. | System and method for single optical axis multi-detector microscope slide scanner |
| US7483127B1 (en) * | 2005-08-08 | 2009-01-27 | Sru Biosystems, Inc. | Method and apparatus for generating an image of biomolecular sensor target area |
| JP4666619B2 (ja) * | 2005-09-29 | 2011-04-06 | 株式会社栃木ニコン | テラヘルツ波イメージング装置 |
| US7329860B2 (en) | 2005-11-23 | 2008-02-12 | Illumina, Inc. | Confocal imaging methods and apparatus |
| US7813013B2 (en) * | 2006-11-21 | 2010-10-12 | Illumina, Inc. | Hexagonal site line scanning method and system |
| US7791013B2 (en) * | 2006-11-21 | 2010-09-07 | Illumina, Inc. | Biological microarray line scanning method and system |
| US7692162B2 (en) * | 2006-12-21 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Imaging of two-dimensional arrays |
| GB0625775D0 (en) * | 2006-12-22 | 2007-02-07 | Isis Innovation | Focusing apparatus and method |
| US8179526B2 (en) * | 2007-01-25 | 2012-05-15 | Renishaw Plc | Spectroscopic apparatus with dispersive device for collecting sample data in synchronism with relative movement of a focus |
| GB0708582D0 (en) * | 2007-05-03 | 2007-06-13 | Renishaw Plc | Spectroscope apparatus and methods |
| EP2279268A4 (en) * | 2008-04-04 | 2011-12-07 | Life Technologies Corp | SCANNING SYSTEM AND METHOD OF IMAGING AND SEQUENCING |
| WO2010048584A2 (en) | 2008-10-24 | 2010-04-29 | Aperio Technologies, Inc. | Whole slide fluorescence scanner |
| US8570370B2 (en) * | 2009-08-31 | 2013-10-29 | Bio-Rad Laboratories, Inc. | Compact automated cell counter |
| US8451524B2 (en) * | 2009-09-29 | 2013-05-28 | Amnis Corporation | Modifying the output of a laser to achieve a flat top in the laser's Gaussian beam intensity profile |
| CN102741683B (zh) | 2009-12-18 | 2016-06-01 | Fp创新研究中心 | 在线大污染物分析器和方法 |
| US8817115B1 (en) | 2010-05-05 | 2014-08-26 | Amnis Corporation | Spatial alignment of image data from a multichannel detector using a reference image |
| US9029103B2 (en) | 2010-08-27 | 2015-05-12 | Illumina Cambridge Limited | Methods for sequencing polynucleotides |
| US8575071B2 (en) | 2010-11-03 | 2013-11-05 | Illumina, Inc. | Reducing adapter dimer formation |
| DE102011055294B4 (de) * | 2011-11-11 | 2013-11-07 | Leica Microsystems Cms Gmbh | Mikroskopische Einrichtung und Verfahren zur dreidimensionalen Lokalisierung von punktförmigen Objekten in einer Probe |
| WO2013117595A2 (en) | 2012-02-07 | 2013-08-15 | Illumina Cambridge Limited | Targeted enrichment and amplification of nucleic acids on a support |
| US10537889B2 (en) | 2013-12-31 | 2020-01-21 | Illumina, Inc. | Addressable flow cell using patterned electrodes |
| CN113049553B (zh) * | 2015-02-06 | 2024-08-20 | 生命技术公司 | 用于评价生物样本的系统和方法 |
| US10766242B2 (en) * | 2017-08-24 | 2020-09-08 | General Electric Company | System and methods for fabricating a component using a consolidating device |
| AU2019400090B2 (en) | 2018-12-14 | 2025-11-27 | Illumina Cambridge Limited | Decreasing phasing with unlabeled nucleotides during sequencing |
| WO2020126593A1 (en) | 2018-12-17 | 2020-06-25 | Illumina Cambridge Limited | Compositions for use in polyunucleotide sequencing |
| WO2020126595A1 (en) | 2018-12-17 | 2020-06-25 | Illumina Cambridge Limited | Primer oligonucleotide for sequencing |
| WO2020188368A1 (en) * | 2019-03-19 | 2020-09-24 | Omek Optics Ltd. | Unit magnification microscope |
| US12298240B2 (en) * | 2020-07-02 | 2025-05-13 | Konica Minolta, Inc. | Optical system for measuring optical characteristics and device for measuring optical characteristics |
| US12480157B2 (en) | 2021-09-30 | 2025-11-25 | Illumina, Inc. | Polynucleotide sequencing |
| US20250215491A1 (en) | 2023-12-28 | 2025-07-03 | Illumina, Inc. | Sequencing with single-stranded binding proteins |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1777262A (en) * | 1927-09-07 | 1930-09-30 | Hasselkus John William | Objective suitable for photographic purposes |
| JPS5896206A (ja) * | 1981-12-04 | 1983-06-08 | Oki Electric Ind Co Ltd | 表面荒さの評価装置 |
| JPS6189501A (ja) * | 1984-10-08 | 1986-05-07 | Hitachi Ltd | 境界面測定装置 |
| US4680635A (en) * | 1986-04-01 | 1987-07-14 | Intel Corporation | Emission microscope |
| US4755874A (en) * | 1987-08-31 | 1988-07-05 | Kla Instruments Corporation | Emission microscopy system |
| US5034613A (en) * | 1989-11-14 | 1991-07-23 | Cornell Research Foundation, Inc. | Two-photon laser microscopy |
| JPH03221912A (ja) * | 1990-01-29 | 1991-09-30 | Fuji Photo Film Co Ltd | 走査型顕微鏡における撮像方法 |
| CA2034162A1 (en) * | 1990-02-23 | 1991-08-24 | Akira Inoue | Method and apparatus for measuring the thickness of a coating |
| US5141609A (en) * | 1990-11-16 | 1992-08-25 | The Trustees Of The Leland Stanford Junior University | Method and device employing time-delayed integration for detecting sample components after separation |
| US5159412A (en) * | 1991-03-15 | 1992-10-27 | Therma-Wave, Inc. | Optical measurement device with enhanced sensitivity |
| JP3082346B2 (ja) * | 1991-09-12 | 2000-08-28 | 株式会社ニコン | 蛍光コンフォーカル顕微鏡 |
| EP0626578B1 (en) * | 1993-05-26 | 1998-07-29 | Hitachi Electronics Engineering Co., Ltd. | Apparatus for gel electrophoresis |
| IL107549A (en) * | 1993-11-09 | 1996-01-31 | Nova Measuring Instr Ltd | Device for measuring the thickness of thin films |
| JP3495797B2 (ja) * | 1994-11-29 | 2004-02-09 | 東レエンジニアリング株式会社 | 光学定数測定方法およびその装置 |
| JP3544019B2 (ja) * | 1994-12-02 | 2004-07-21 | 株式会社キーエンス | 光学顕微鏡及び光学顕微鏡の深度測定方法 |
| US5500770A (en) * | 1994-12-30 | 1996-03-19 | Amarel Precision Instruments | Macrolens system for emission microscopy |
-
1996
- 1996-09-19 US US08/716,858 patent/US5754291A/en not_active Expired - Lifetime
-
1997
- 1997-09-12 JP JP10514777A patent/JP2001500986A/ja active Pending
- 1997-09-12 EP EP97941059A patent/EP1015869B1/en not_active Expired - Lifetime
- 1997-09-12 WO PCT/US1997/016224 patent/WO1998012536A1/en not_active Ceased
- 1997-09-12 DE DE69728572T patent/DE69728572T2/de not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011087454A1 (de) * | 2011-11-30 | 2013-06-06 | Leica Microsystems (Schweiz) Ag | Optische Vorrichtung zum Einsatz in der Medizintechnik |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998012536A1 (en) | 1998-03-26 |
| EP1015869A4 (en) | 2000-07-05 |
| DE69728572D1 (de) | 2004-05-13 |
| EP1015869A1 (en) | 2000-07-05 |
| JP2001500986A (ja) | 2001-01-23 |
| US5754291A (en) | 1998-05-19 |
| EP1015869B1 (en) | 2004-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: GE HEALTHCARE )SV) CORP.(N.D.GES.D.STAATES DELAWAR |