DE69720458T2 - Programmierbares räumlich lichtmoduliertes Mikroskop und Mikroskopieverfahren - Google Patents
Programmierbares räumlich lichtmoduliertes Mikroskop und Mikroskopieverfahren Download PDFInfo
- Publication number
- DE69720458T2 DE69720458T2 DE69720458T DE69720458T DE69720458T2 DE 69720458 T2 DE69720458 T2 DE 69720458T2 DE 69720458 T DE69720458 T DE 69720458T DE 69720458 T DE69720458 T DE 69720458T DE 69720458 T2 DE69720458 T2 DE 69720458T2
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- DE
- Germany
- Prior art keywords
- image
- confocal
- optical imaging
- light
- confocal optical
- Prior art date
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- Expired - Lifetime
Links
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Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/008—Details of detection or image processing, including general computer control
- G02B21/0084—Details of detection or image processing, including general computer control time-scale detection, e.g. strobed, ultra-fast, heterodyne detection
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0036—Scanning details, e.g. scanning stages
- G02B21/004—Scanning details, e.g. scanning stages fixed arrays, e.g. switchable aperture arrays
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0036—Scanning details, e.g. scanning stages
- G02B21/0048—Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/008—Details of detection or image processing, including general computer control
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
- G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
- G02B26/0816—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements
- G02B26/0833—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements the reflecting element being a micromechanical device, e.g. a MEMS mirror, DMD
- G02B26/0841—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements the reflecting element being a micromechanical device, e.g. a MEMS mirror, DMD the reflecting element being moved or deformed by electrostatic means
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97118354A EP0911667B1 (en) | 1997-10-22 | 1997-10-22 | Programmable spatially light modulated microscope and microscopy method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69720458D1 DE69720458D1 (de) | 2003-05-08 |
| DE69720458T2 true DE69720458T2 (de) | 2004-02-26 |
Family
ID=8227511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69720458T Expired - Lifetime DE69720458T2 (de) | 1997-10-22 | 1997-10-22 | Programmierbares räumlich lichtmoduliertes Mikroskop und Mikroskopieverfahren |
Country Status (5)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005040471A1 (de) * | 2005-08-26 | 2007-03-15 | Leica Microsystems (Schweiz) Ag | Mikroskop |
| DE102006040636B3 (de) * | 2006-05-15 | 2007-12-20 | Leica Microsystems (Schweiz) Ag | Autofokus-System und Verfahren zum Autofokussieren |
| DE102018127281A1 (de) * | 2018-10-31 | 2020-04-30 | Carl Zeiss Microscopy Gmbh | Mikroskop und Verfahren zur Mikroskopie |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6388809B1 (en) | 1997-10-29 | 2002-05-14 | Digital Optical Imaging Corporation | Methods and apparatus for improved depth resolution use of out-of-focus information in microscopy |
| ATE220465T1 (de) | 1997-10-29 | 2002-07-15 | Calum E Macaulay | Gerät und verfahren zur mikroskopie unter verwendung räumlich modulierten lichtes |
| GB9901365D0 (en) * | 1999-01-22 | 1999-03-10 | Isis Innovations Ltd | Confocal microscopy apparatus and method |
| JP3544892B2 (ja) * | 1999-05-12 | 2004-07-21 | 株式会社東京精密 | 外観検査方法及び装置 |
| US6700606B1 (en) * | 1999-06-09 | 2004-03-02 | Activcard Ireland Limited | Micromirror optical imager |
| DE19932487A1 (de) * | 1999-07-09 | 2001-02-08 | Epigenomics Gmbh | Vorrichtung und Verfahren zur photolithographischen Belichtung von biologischen Stoffen |
| DE19960583A1 (de) * | 1999-12-15 | 2001-07-05 | Evotec Biosystems Ag | Verfahren und Vorrichtung zur Mikroskopie |
| US6663560B2 (en) * | 1999-12-17 | 2003-12-16 | Digital Optical Imaging Corporation | Methods and apparatus for imaging using a light guide bundle and a spatial light modulator |
| US6530882B1 (en) * | 2000-06-30 | 2003-03-11 | Inner Vision Imaging, L.L.C. | Endoscope having microscopic and macroscopic magnification |
| JP4610713B2 (ja) * | 2000-10-13 | 2011-01-12 | オリンパス株式会社 | 内視鏡装置 |
| JP4932076B2 (ja) * | 2000-10-30 | 2012-05-16 | オリンパス株式会社 | 走査型レーザ顕微鏡 |
| JP4153675B2 (ja) * | 2001-04-10 | 2008-09-24 | 三菱重工業株式会社 | 材料寿命の評価システム、及び、その評価方法 |
| EP1397668A2 (en) * | 2001-06-06 | 2004-03-17 | Digital Optical Imaging Corporation | Light modulated microarray reader and methods relating thereto |
| WO2003025656A1 (fr) * | 2001-09-03 | 2003-03-27 | Kabushiki Kaisha Hayashi Soken | Procede et dispositif de balayage a commande numerique |
| US6885492B2 (en) * | 2001-11-08 | 2005-04-26 | Imaginative Optics, Inc. | Spatial light modulator apparatus |
| ATE360227T1 (de) * | 2002-02-04 | 2007-05-15 | Zeiss Carl Surgical Gmbh | Stereo-untersuchungssysteme und stereo- bilderzeugungsvorrichtung sowie verfahren zum betrieb einer solchen |
| US6996292B1 (en) * | 2002-04-18 | 2006-02-07 | Sandia Corporation | Staring 2-D hadamard transform spectral imager |
| US7193775B2 (en) | 2002-05-30 | 2007-03-20 | Dmetrix, Inc. | EPI-illumination system for an array microscope |
| WO2004017069A1 (ja) * | 2002-08-16 | 2004-02-26 | Kabushiki Kaisha Hayashi Soken | バイオチップ分析装置およびオンライン分析システム |
| US7164533B2 (en) | 2003-01-22 | 2007-01-16 | Cyvera Corporation | Hybrid random bead/chip based microarray |
| US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
| US7900836B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
| US7923260B2 (en) | 2002-08-20 | 2011-04-12 | Illumina, Inc. | Method of reading encoded particles |
| US7508608B2 (en) | 2004-11-17 | 2009-03-24 | Illumina, Inc. | Lithographically fabricated holographic optical identification element |
| US7901630B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Diffraction grating-based encoded microparticle assay stick |
| US7092160B2 (en) | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
| US20100255603A9 (en) | 2002-09-12 | 2010-10-07 | Putnam Martin A | Method and apparatus for aligning microbeads in order to interrogate the same |
| US7706584B2 (en) * | 2002-10-22 | 2010-04-27 | Baylor College of Medicine and William Marsh Rice University | Random access high-speed confocal microscope |
| FR2848682B1 (fr) | 2002-12-13 | 2005-02-18 | Commissariat Energie Atomique | Microscope optique a eclairage structure modifiable |
| US7339148B2 (en) * | 2002-12-16 | 2008-03-04 | Olympus America Inc. | Confocal microscope |
| US7002164B2 (en) * | 2003-01-08 | 2006-02-21 | Intel Corporation | Source multiplexing in lithography |
| JP4031716B2 (ja) * | 2003-02-06 | 2008-01-09 | 株式会社コーナン・メディカル | 眼科用撮影装置 |
| DE10327987A1 (de) * | 2003-06-21 | 2005-01-20 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Konfokales optisches System |
| US7881502B2 (en) * | 2003-06-30 | 2011-02-01 | Weyerhaeuser Nr Company | Method and system for three-dimensionally imaging an apical dome of a plant embryo |
| DE602004024464D1 (de) * | 2003-07-04 | 2010-01-14 | Vincent Lauer | Bildgebungsvorrichtung für konfokale Mikroskopie mit Bildsubstraktion |
| US8269174B2 (en) * | 2003-07-18 | 2012-09-18 | Chemimage Corporation | Method and apparatus for compact spectrometer for multipoint sampling of an object |
| US7433123B2 (en) | 2004-02-19 | 2008-10-07 | Illumina, Inc. | Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein |
| WO2006020363A2 (en) | 2004-07-21 | 2006-02-23 | Illumina, Inc. | Method and apparatus for drug product tracking using encoded optical identification elements |
| EP1622200A1 (en) | 2004-07-26 | 2006-02-01 | CSEM Centre Suisse d'Electronique et de Microtechnique SA | Solid-state photodetector pixel and photodetecting method |
| US20060066842A1 (en) * | 2004-09-30 | 2006-03-30 | Saunders Winston A | Wafer inspection with a customized reflective optical channel component |
| JP2006133499A (ja) * | 2004-11-05 | 2006-05-25 | Shimadzu Corp | 共焦点スキャナ及び共焦点顕微鏡 |
| EP2194485B1 (en) | 2004-11-16 | 2012-10-17 | Illumina, Inc. | Method and apparatus for reading coded microbeads |
| WO2006055735A2 (en) * | 2004-11-16 | 2006-05-26 | Illumina, Inc | Scanner having spatial light modulator |
| JP2006154290A (ja) * | 2004-11-29 | 2006-06-15 | Hamamatsu Univ School Of Medicine | 蛍光顕微鏡システム |
| JP2006235420A (ja) * | 2005-02-28 | 2006-09-07 | Yokogawa Electric Corp | 共焦点顕微鏡 |
| JP3755888B2 (ja) * | 2005-06-14 | 2006-03-15 | 株式会社林創研 | バイオチップオンライン分析システム |
| GB0514656D0 (en) | 2005-07-16 | 2005-08-24 | Cairn Res Ltd | Control of illumination in microscopy |
| EP1746410B1 (en) | 2005-07-21 | 2018-08-22 | CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement | Apparatus and method for fluorescence lifetime imaging |
| US7593156B2 (en) * | 2005-08-26 | 2009-09-22 | Leica Microsystems (Schweiz) Ag | Microscope with micro-mirrors for optional deflection and/or beam splitting |
| DE502005010557D1 (de) * | 2005-09-13 | 2010-12-30 | Univ Albert Ludwigs Freiburg | Mikroskopieverfahren mit räumlich modulierbarer Beleuchtung |
| JP4831072B2 (ja) * | 2005-10-13 | 2011-12-07 | 株式会社ニコン | 顕微鏡装置 |
| DE102005058185A1 (de) * | 2005-12-01 | 2007-06-14 | Friedrich-Schiller-Universität Jena | Verfahren und Anordnung zur Detektion von Fluoreszenz- oder Reflexionsspektren beliebig wählbarer Bereiche und Strukturen eines vom Fremdlicht überlagerten Objekts unter geringer Strahlenbelastung |
| JP2007171598A (ja) * | 2005-12-22 | 2007-07-05 | Olympus Corp | 共焦点顕微鏡 |
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| WO2007124437A2 (en) * | 2006-04-20 | 2007-11-01 | Washington University In St. Louis | Objective-coupled selective plane illumination microscopy |
| DE102006022592B4 (de) * | 2006-05-15 | 2008-02-07 | Leica Microsystems (Schweiz) Ag | Mikroskop mit Beleuchtungseinheit |
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| WO2010036972A1 (en) | 2008-09-25 | 2010-04-01 | The Trustees Of Columbia University In The City Of New York | Devices, apparatus and method for providing photostimulation and imaging of structures |
| KR101495096B1 (ko) * | 2008-10-31 | 2015-02-25 | 삼성전자주식회사 | 협대역 엑스레이 필터링 장치 및 방법 |
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| DE102009047198A1 (de) * | 2009-11-26 | 2011-06-01 | Universität Rostock | Mikroarraybasiertes Ortsfilter |
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| US8237835B1 (en) * | 2011-05-19 | 2012-08-07 | Aeon Imaging, LLC | Confocal imaging device using spatially modulated illumination with electronic rolling shutter detection |
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| CN102928970B (zh) * | 2012-10-19 | 2014-10-29 | 华中科技大学 | 一种大样本快速三维显微成像的方法和系统 |
| DE102013001238B4 (de) * | 2013-01-25 | 2020-06-10 | Carl Zeiss Microscopy Gmbh | Lichtmikroskop und Mikroskopieverfahren |
| CN103364345B (zh) * | 2013-06-25 | 2015-11-11 | 浙江大学 | 基于数字微镜元件的全反射显微镜环形扫描方法和装置 |
| US9535242B1 (en) * | 2014-06-26 | 2017-01-03 | Verily Life Sciences Llc | Parallel programmable array microscope |
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| DE102015210016A1 (de) * | 2015-06-01 | 2016-12-01 | Carl Zeiss Microscopy Gmbh | Verfahren zum Ermitteln einer ortsaufgelösten Höheninformation einer Probe mit einem Weitfeldmikroskop und Weitfeldmikroskop |
| CN105092603B (zh) * | 2015-09-07 | 2017-09-05 | 哈尔滨理工大学 | 碗型工件内壁的在线视觉检测装置和方法 |
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| JP2019514051A (ja) | 2016-03-24 | 2019-05-30 | マツクス−プランク−ゲゼルシヤフト ツール フエルデルング デル ヴイツセンシヤフテン エー フアウＭＡＸ−ＰＬＡＮＣＫ−ＧＥＳＥＬＬＳＣＨＡＦＴ ＺＵＲ ＦＯｅＲＤＥＲＵＮＧ ＤＥＲ ＷＩＳＳＥＮＳＣＨＡＦＴＥＮ Ｅ．Ｖ． | 垂直方向のカメラを含む時空間光変調結像システム、および物体を共焦点結像させるための方法 |
| WO2017162257A1 (en) | 2016-03-24 | 2017-09-28 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Spatio-temporally light modulated imaging system, method for confocal imaging an object and carrier wheel device |
| US10551604B2 (en) | 2016-05-27 | 2020-02-04 | Verily Life Sciences Llc | Spatial light modulator based hyperspectral confocal microscopes and methods of use |
| DE102016119727A1 (de) * | 2016-10-17 | 2018-04-19 | Carl Zeiss Microscopy Gmbh | Vorrichtung zur Strahlmanipulation für ein Scanning-Mikroskop und Mikroskop |
| KR101907782B1 (ko) | 2017-04-12 | 2018-10-12 | 한국과학기술원 | 광학 현미경 장치 및 시편의 영상 측정 방법 |
| JP2019066706A (ja) | 2017-10-02 | 2019-04-25 | ソニー株式会社 | 蛍光顕微鏡装置及び蛍光顕微鏡システム |
| US20210003834A1 (en) * | 2017-12-20 | 2021-01-07 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E. V. | Method and apparatus for optical confocal imaging, using a programmable array microscope |
| WO2019159933A1 (ja) * | 2018-02-19 | 2019-08-22 | 京セラ株式会社 | 電磁波検出装置および情報取得システム |
| JP7260966B2 (ja) * | 2018-02-19 | 2023-04-19 | 京セラ株式会社 | 電磁波検出装置 |
| WO2020031668A1 (ja) | 2018-08-09 | 2020-02-13 | ソニー株式会社 | 光学顕微鏡装置及び光学顕微鏡システム |
| DE102019110869A1 (de) * | 2018-12-21 | 2020-06-25 | Leica Microsystems Cms Gmbh | Mikroskop |
| JP7395511B2 (ja) * | 2019-01-16 | 2023-12-11 | 株式会社小糸製作所 | イメージング装置、その演算処理装置、車両用灯具、車両、センシング方法 |
| US20230049486A1 (en) * | 2020-01-13 | 2023-02-16 | Haag-Streit Ag | Ophthalmologic microscope with micro-mirror balancing |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0485803B1 (de) * | 1990-11-10 | 1996-05-01 | Grosskopf, Rudolf, Dr.-Ing. | Optische Abtastvorrichtung mit konfokalem Strahlengang, in der Lichtquellen- und Detektormatrix verwendet werden |
| US5532873A (en) * | 1993-09-08 | 1996-07-02 | Dixon; Arthur E. | Scanning beam laser microscope with wide range of magnification |
| US5587832A (en) * | 1993-10-20 | 1996-12-24 | Biophysica Technologies, Inc. | Spatially light modulated confocal microscope and method |
| GB9603788D0 (en) * | 1996-02-22 | 1996-04-24 | Isis Innovation | Confocal microscope |
| AU1975197A (en) * | 1996-02-28 | 1997-10-01 | Kenneth C. Johnson | Microlens scanner for microlithography and wide-field confocal microscopy |
| US6038067A (en) * | 1996-05-23 | 2000-03-14 | The Regents Of The University Of California | Scanning computed confocal imager |
-
1997
- 1997-10-22 DE DE69720458T patent/DE69720458T2/de not_active Expired - Lifetime
- 1997-10-22 AT AT97118354T patent/ATE236412T1/de not_active IP Right Cessation
- 1997-10-22 EP EP97118354A patent/EP0911667B1/en not_active Expired - Lifetime
-
1998
- 1998-10-21 US US09/176,240 patent/US6399935B1/en not_active Expired - Lifetime
- 1998-10-22 JP JP30100398A patent/JP4064550B2/ja not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005040471A1 (de) * | 2005-08-26 | 2007-03-15 | Leica Microsystems (Schweiz) Ag | Mikroskop |
| DE102005040471B4 (de) * | 2005-08-26 | 2007-06-21 | Leica Microsystems (Schweiz) Ag | Mikroskop |
| DE102006040636B3 (de) * | 2006-05-15 | 2007-12-20 | Leica Microsystems (Schweiz) Ag | Autofokus-System und Verfahren zum Autofokussieren |
| DE102018127281A1 (de) * | 2018-10-31 | 2020-04-30 | Carl Zeiss Microscopy Gmbh | Mikroskop und Verfahren zur Mikroskopie |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11194275A (ja) | 1999-07-21 |
| US6399935B1 (en) | 2002-06-04 |
| DE69720458D1 (de) | 2003-05-08 |
| JP4064550B2 (ja) | 2008-03-19 |
| ATE236412T1 (de) | 2003-04-15 |
| EP0911667A1 (en) | 1999-04-28 |
| EP0911667B1 (en) | 2003-04-02 |
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