DE69715230D1 - Bis(acridinecarboxamide) und bis(phenazinecarboxamide) als antikrebsmittel - Google Patents

Bis(acridinecarboxamide) und bis(phenazinecarboxamide) als antikrebsmittel

Info

Publication number
DE69715230D1
DE69715230D1 DE69715230T DE69715230T DE69715230D1 DE 69715230 D1 DE69715230 D1 DE 69715230D1 DE 69715230 T DE69715230 T DE 69715230T DE 69715230 T DE69715230 T DE 69715230T DE 69715230 D1 DE69715230 D1 DE 69715230D1
Authority
DE
Germany
Prior art keywords
bis
carboxamides
pct
alkyl
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69715230T
Other languages
English (en)
Other versions
DE69715230T2 (de
Inventor
Alexander Denny
A Gamage
Ann Spicer
Charles Baguley
John Finlay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenova Ltd
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Ltd filed Critical Xenova Ltd
Application granted granted Critical
Publication of DE69715230D1 publication Critical patent/DE69715230D1/de
Publication of DE69715230T2 publication Critical patent/DE69715230T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polishing Bodies And Polishing Tools (AREA)
  • Multicomponent Fibers (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Liquid Crystal (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69715230T 1996-10-18 1997-10-17 Bis(acridinecarboxamide) und bis(phenazinecarboxamide) als antikrebsmittel Expired - Fee Related DE69715230T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9621795.5A GB9621795D0 (en) 1996-10-18 1996-10-18 Pharmaceutical compounds
GB9621795 1996-10-18
PCT/GB1997/002886 WO1998017650A1 (en) 1996-10-18 1997-10-17 Bis(acridinecarboxamide) and bis(phenazinecarboxamide) as antitumour agents

Publications (2)

Publication Number Publication Date
DE69715230D1 true DE69715230D1 (de) 2002-10-10
DE69715230T2 DE69715230T2 (de) 2009-09-17

Family

ID=10801674

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69715230T Expired - Fee Related DE69715230T2 (de) 1996-10-18 1997-10-17 Bis(acridinecarboxamide) und bis(phenazinecarboxamide) als antikrebsmittel

Country Status (30)

Country Link
US (1) US6114332A (de)
EP (1) EP0934278B1 (de)
JP (1) JP2001503399A (de)
KR (1) KR20000049252A (de)
CN (1) CN1116285C (de)
AT (1) ATE223381T1 (de)
AU (1) AU717724B2 (de)
BG (1) BG64555B1 (de)
BR (1) BR9711948A (de)
CA (1) CA2268411C (de)
CZ (1) CZ295302B6 (de)
DE (1) DE69715230T2 (de)
DK (1) DK0934278T3 (de)
ES (1) ES2183142T3 (de)
GB (2) GB9621795D0 (de)
HK (1) HK1018773A1 (de)
HU (1) HU221953B1 (de)
ID (1) ID22444A (de)
MY (1) MY122017A (de)
NO (1) NO313381B1 (de)
NZ (1) NZ335055A (de)
PL (1) PL193669B1 (de)
PT (1) PT934278E (de)
RO (1) RO120636B1 (de)
RU (1) RU2179972C2 (de)
SK (1) SK285121B6 (de)
TW (1) TW432060B (de)
UA (1) UA67729C2 (de)
WO (1) WO1998017650A1 (de)
ZA (2) ZA979328B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974878B2 (en) 2001-03-21 2005-12-13 Symyx Technologies, Inc. Catalyst ligands, catalytic metal complexes and processes using same
WO2001019786A1 (en) * 1999-09-10 2001-03-22 Symyx Technologies Catalyst ligands, catalytic metal complexes and processes using and methods of making same
WO2005063760A1 (en) * 2003-12-31 2005-07-14 Council Of Scientific & Industrial Research C-8 LINKED PYRROLO[2,1-c][1,4]BENZODIAZEPINE-ACRIDONE/ACRIDINE HYBRIDS
US9856225B2 (en) * 2013-12-24 2018-01-02 University Of Florida Research Foundation, Incorporated Substituted phenazines as antimicrobial agents
CN104961801B (zh) * 2015-07-13 2018-01-19 兰州大学 一种具有多靶点的抗菌多肽偶联物及其二聚物的合成和应用
CN106554321B (zh) * 2015-09-25 2019-05-28 陆源 一种吩嗪类物质、其制备方法及其应用
KR20230087154A (ko) * 2021-12-09 2023-06-16 한국해양과학기술원 신규 다이페나진 화합물 및 이의 암 또는 신경염증질환 예방 또는 치료 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201084A (en) * 1982-06-25 1985-10-11 New Zealand Dev Finance 4-carboxamidoacridine derivatives and pharmaceutical compositions containing such
EP0172744A2 (de) * 1984-08-16 1986-02-26 Development Finance Corporation Of New Zealand Phenazincarboxamid-Verbindungen
IT1293525B1 (it) * 1997-08-01 1999-03-01 Uni Degli Studi Camerino Bis-acridincarbossiammidi aventi attivita' antitumorale

Also Published As

Publication number Publication date
DE69715230T2 (de) 2009-09-17
PL193669B1 (pl) 2007-03-30
US6114332A (en) 2000-09-05
MY122017A (en) 2006-03-31
NO991833D0 (no) 1999-04-16
NO991833L (no) 1999-06-03
ZA979331B (en) 1998-05-21
KR20000049252A (ko) 2000-07-25
AU717724B2 (en) 2000-03-30
AU4713797A (en) 1998-05-15
WO1998017650A1 (en) 1998-04-30
BG103329A (en) 2000-11-30
RU2179972C2 (ru) 2002-02-27
HU221953B1 (hu) 2003-03-28
CA2268411A1 (en) 1998-04-30
HUP9902883A3 (en) 2001-01-29
CZ295302B6 (cs) 2005-07-13
GB2334032B (en) 2000-11-08
NZ335055A (en) 2000-09-29
DK0934278T3 (da) 2003-01-06
GB9908192D0 (en) 1999-06-02
ATE223381T1 (de) 2002-09-15
PT934278E (pt) 2003-01-31
BR9711948A (pt) 1999-08-24
NO313381B1 (no) 2002-09-23
PL332877A1 (en) 1999-10-25
SK285121B6 (sk) 2006-06-01
RO120636B1 (ro) 2006-05-30
SK50499A3 (en) 2000-05-16
EP0934278B1 (de) 2002-09-04
JP2001503399A (ja) 2001-03-13
CN1116285C (zh) 2003-07-30
CA2268411C (en) 2008-07-22
ZA979328B (en) 1998-07-06
BG64555B1 (bg) 2005-07-29
HK1018773A1 (en) 2000-01-07
GB9621795D0 (en) 1996-12-11
CZ127199A3 (cs) 1999-09-15
EP0934278A1 (de) 1999-08-11
TW432060B (en) 2001-05-01
GB2334032A (en) 1999-08-11
CN1240430A (zh) 2000-01-05
UA67729C2 (uk) 2004-07-15
ES2183142T3 (es) 2003-03-16
ID22444A (id) 1999-10-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee