DE69706135D1 - Verfahren zur Herstellung Simvastatin von Lovastatin oder Mevinolinsäure - Google Patents
Verfahren zur Herstellung Simvastatin von Lovastatin oder MevinolinsäureInfo
- Publication number
- DE69706135D1 DE69706135D1 DE69706135T DE69706135T DE69706135D1 DE 69706135 D1 DE69706135 D1 DE 69706135D1 DE 69706135 T DE69706135 T DE 69706135T DE 69706135 T DE69706135 T DE 69706135T DE 69706135 D1 DE69706135 D1 DE 69706135D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- treating
- iii
- compound
- produce
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/816,573 US5763646A (en) | 1997-03-13 | 1997-03-13 | Process for manufacturing simvastatin from lovastatin or mevinolinic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69706135D1 true DE69706135D1 (de) | 2001-09-20 |
DE69706135T2 DE69706135T2 (de) | 2002-05-02 |
Family
ID=25221004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69706135T Expired - Fee Related DE69706135T2 (de) | 1997-03-13 | 1997-07-04 | Verfahren zur Herstellung Simvastatin von Lovastatin oder Mevinolinsäure |
Country Status (7)
Country | Link |
---|---|
US (1) | US5763646A (de) |
EP (1) | EP0864569B1 (de) |
AT (1) | ATE204271T1 (de) |
AU (1) | AU693401B1 (de) |
DE (1) | DE69706135T2 (de) |
ES (1) | ES2162165T3 (de) |
ZA (1) | ZA974023B (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0940395A1 (de) * | 1998-03-05 | 1999-09-08 | Synthon B.V. | Verfahren zur Erzeugung von Simvatarin in und/oder deren Derivate |
NO991045L (no) * | 1998-03-05 | 1999-09-06 | Synthon Bv | FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater |
US6432931B1 (en) | 1998-06-24 | 2002-08-13 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
JP2002518448A (ja) * | 1998-06-24 | 2002-06-25 | メルク エンド カムパニー インコーポレーテッド | 高血中コレステロールを治療する組成物および方法 |
US20030078211A1 (en) * | 1998-06-24 | 2003-04-24 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
SI20070A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
EP1055671B1 (de) * | 1998-12-10 | 2004-12-01 | Kaneka Corporation | Verfahren zur herstellung eines simvastatin precursors |
CO5140104A1 (es) * | 1999-02-16 | 2002-03-22 | Novartis Ag | Derivados de mevinolina y preparacion farmaceuticas que los contienen |
AU2127500A (en) | 1999-11-11 | 2001-06-06 | Biocon India Limited | Process for manufacturing simvastatin and the novel intermediates |
US6573385B1 (en) | 1999-11-11 | 2003-06-03 | Biocon India Limited | Process for manufacturing simvastatin and novel intermediates thereof |
IN192861B (de) * | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
US6472542B1 (en) * | 2001-11-29 | 2002-10-29 | Fermic S.A. De C.V. | Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin |
SI21187A (sl) | 2002-03-26 | 2003-10-31 | Krka, Tovarna Zdravil D.D., Novo Mesto | Postopek za pripravo 4-oksitetrahidropiran-2-onov |
US6603022B1 (en) | 2002-05-10 | 2003-08-05 | Biocon India Limited | Process for manufacturing Simvastatin and novel intermediates thereof |
US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
ES2561354T3 (es) * | 2003-10-31 | 2016-02-25 | Sunshine Heart Company Pty Ltd | Sistema de control de sincronización |
EP1699774A1 (de) * | 2004-01-02 | 2006-09-13 | Hetero Drugs Limited | Neues verfahren zur herstellung von simvastatin |
US20100216863A1 (en) * | 2004-01-30 | 2010-08-26 | Decode Genetics Ehf. | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment |
US8158362B2 (en) * | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
CA2571379C (en) * | 2004-09-08 | 2012-08-07 | Jubilant Organosys Limited | An improved process for lactonization in the preparation of statins |
CN1754870A (zh) * | 2004-09-30 | 2006-04-05 | 淮北市辉克药业有限公司 | 辛伐他汀的制备方法 |
WO2006072963A1 (en) * | 2005-01-10 | 2006-07-13 | Concord Biotech Limited | Process for preparing simvastatin from lovastatin amine salts in three steps |
WO2007020079A2 (en) * | 2005-08-17 | 2007-02-22 | Synthon B.V. | Orally disintegratable simvastatin tablets |
US20070129437A1 (en) * | 2005-12-06 | 2007-06-07 | Ferenc Korodi | Process for preparing simvastatin and intermediates thereof |
ES2343049B1 (es) | 2008-10-15 | 2011-06-10 | Neuron Biopharma, S.A. | Biosintesis de derivados de monacolina j. |
ES2614804T3 (es) | 2009-09-30 | 2017-06-02 | Codexis, Inc. | Acilación mejorada mediada por LovD aciltransferasa |
EP2486129B1 (de) | 2009-10-08 | 2016-04-13 | The Regents of The University of California | Lov-D-MUTANTEN MIT VERBESSERTEN EIGENSCHAFTEN IN BEZUG AUF SIMVASTATIN-SYNTHESE |
CN104744416A (zh) * | 2015-03-25 | 2015-07-01 | 河南师范大学 | 一种辛伐他汀的制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5612114B2 (de) * | 1974-06-07 | 1981-03-18 | ||
US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
US4293496A (en) * | 1980-02-04 | 1981-10-06 | Merck & Co., Inc. | 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones |
US4450171A (en) * | 1980-08-05 | 1984-05-22 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
EP0137445B1 (de) * | 1983-10-11 | 1990-01-03 | Merck & Co. Inc. | Verfahren zur C-Methylierung von 2-Methylbutyraten |
US4584389A (en) * | 1983-10-11 | 1986-04-22 | Merck & Co., Inc. | Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one |
US4582915A (en) * | 1983-10-11 | 1986-04-15 | Merck & Co., Inc. | Process for C-methylation of 2-methylbutyrates |
US4611081A (en) * | 1985-07-05 | 1986-09-09 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
US4820850A (en) * | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
US5177104A (en) * | 1990-04-03 | 1993-01-05 | E. R. Squibb & Sons, Inc. | 6-α-hydroxy derivatives of mevinic acids |
US5223415A (en) * | 1990-10-15 | 1993-06-29 | Merck & Co., Inc. | Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid) |
US5159104A (en) * | 1991-05-01 | 1992-10-27 | Merck & Co., Inc. | Process to simvastatin ester |
US5393893A (en) * | 1993-11-08 | 1995-02-28 | Apotex, Inc. | Process for producing simvastatin and analogs thereof |
-
1997
- 1997-03-13 US US08/816,573 patent/US5763646A/en not_active Expired - Lifetime
- 1997-05-09 ZA ZA9704023A patent/ZA974023B/xx unknown
- 1997-05-14 AU AU21408/97A patent/AU693401B1/en not_active Ceased
- 1997-07-04 ES ES97111277T patent/ES2162165T3/es not_active Expired - Lifetime
- 1997-07-04 DE DE69706135T patent/DE69706135T2/de not_active Expired - Fee Related
- 1997-07-04 EP EP97111277A patent/EP0864569B1/de not_active Revoked
- 1997-07-04 AT AT97111277T patent/ATE204271T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU693401B1 (en) | 1998-06-25 |
EP0864569B1 (de) | 2001-08-16 |
ES2162165T3 (es) | 2001-12-16 |
DE69706135T2 (de) | 2002-05-02 |
US5763646A (en) | 1998-06-09 |
EP0864569A1 (de) | 1998-09-16 |
ZA974023B (en) | 1997-12-10 |
ATE204271T1 (de) | 2001-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |