ES2162165T3 - Procedimiento para la fabricacion de simvastatina o acido mevinolinico. - Google Patents

Procedimiento para la fabricacion de simvastatina o acido mevinolinico.

Info

Publication number
ES2162165T3
ES2162165T3 ES97111277T ES97111277T ES2162165T3 ES 2162165 T3 ES2162165 T3 ES 2162165T3 ES 97111277 T ES97111277 T ES 97111277T ES 97111277 T ES97111277 T ES 97111277T ES 2162165 T3 ES2162165 T3 ES 2162165T3
Authority
ES
Spain
Prior art keywords
formula
treating
iii
simvastatin
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97111277T
Other languages
English (en)
Inventor
Yatendra Kumar
Rajesh Kumar Thaper
Satyananda Misra
S M Dileep Kumar
Jag Mohan Khanna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25221004&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2162165(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Application granted granted Critical
Publication of ES2162165T3 publication Critical patent/ES2162165T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCESO PARA PREPARAR SIMVASTATINA A PARTIR DE LOVASTATINA O ACIDO MEVINOLINICO EN SU FORMA DE SAL INCLUYE TRATAR CUALQUIERA DE LOS MATERIALES DE PARTIDA CON CICLOPROPILO O BUTILAMIDA, ABRIENDOSE DE ESE MODO EL ANILLO PIRANONA CUANDO EL MATERIAL DE PARTIDA ES LOVASTATINA, AÑADIR UN GRUPO METILO A LA CADENA LATERAL 2 - METILBUTIRATO, Y POSTERIORMENTE CERRAR EL ANILLO PIRANONA ABIERTO PARA PRODUCIR SIMVASTATINA. EL PROCESO SE REALIZA SIN PROTEGER Y DESPROTEGER LOS DOS GRUPOS HIDROXI DEL ANILLO PIRANONA ABIERTO. EN UNA REALIZACION PREFERIDA, SE TRATA EL MATERIAL DE PARTIDA CON CICLOPROPILAMINA, LO CUAL PRODUCE SIMVASTATINA VIA EL NUEVO INTERMEDIO CICLOPROPILAMIDA DE LOVASTATINA.
ES97111277T 1997-03-13 1997-07-04 Procedimiento para la fabricacion de simvastatina o acido mevinolinico. Expired - Lifetime ES2162165T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/816,573 US5763646A (en) 1997-03-13 1997-03-13 Process for manufacturing simvastatin from lovastatin or mevinolinic acid

Publications (1)

Publication Number Publication Date
ES2162165T3 true ES2162165T3 (es) 2001-12-16

Family

ID=25221004

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97111277T Expired - Lifetime ES2162165T3 (es) 1997-03-13 1997-07-04 Procedimiento para la fabricacion de simvastatina o acido mevinolinico.

Country Status (7)

Country Link
US (1) US5763646A (es)
EP (1) EP0864569B1 (es)
AT (1) ATE204271T1 (es)
AU (1) AU693401B1 (es)
DE (1) DE69706135T2 (es)
ES (1) ES2162165T3 (es)
ZA (1) ZA974023B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0940395A1 (en) * 1998-03-05 1999-09-08 Synthon B.V. Process for producing simvastatin and/or its derivatives
NO991045L (no) * 1998-03-05 1999-09-06 Synthon Bv FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
US6432931B1 (en) 1998-06-24 2002-08-13 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
JP2002518448A (ja) * 1998-06-24 2002-06-25 メルク エンド カムパニー インコーポレーテッド 高血中コレステロールを治療する組成物および方法
US20030078211A1 (en) * 1998-06-24 2003-04-24 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
SI20070A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nove soli inhibitorjev HMG-CoA reduktaze
EP1055671B1 (en) * 1998-12-10 2004-12-01 Kaneka Corporation A process for producing a simvastatin precursor
CO5140104A1 (es) * 1999-02-16 2002-03-22 Novartis Ag Derivados de mevinolina y preparacion farmaceuticas que los contienen
AU2127500A (en) 1999-11-11 2001-06-06 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
IN192861B (es) * 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
US6472542B1 (en) * 2001-11-29 2002-10-29 Fermic S.A. De C.V. Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin
SI21187A (sl) 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Postopek za pripravo 4-oksitetrahidropiran-2-onov
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
US20060019269A1 (en) * 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
ES2561354T3 (es) * 2003-10-31 2016-02-25 Sunshine Heart Company Pty Ltd Sistema de control de sincronización
EP1699774A1 (en) * 2004-01-02 2006-09-13 Hetero Drugs Limited A novel process for the preparation of simvastatin
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
CA2571379C (en) * 2004-09-08 2012-08-07 Jubilant Organosys Limited An improved process for lactonization in the preparation of statins
CN1754870A (zh) * 2004-09-30 2006-04-05 淮北市辉克药业有限公司 辛伐他汀的制备方法
WO2006072963A1 (en) * 2005-01-10 2006-07-13 Concord Biotech Limited Process for preparing simvastatin from lovastatin amine salts in three steps
WO2007020079A2 (en) * 2005-08-17 2007-02-22 Synthon B.V. Orally disintegratable simvastatin tablets
US20070129437A1 (en) * 2005-12-06 2007-06-07 Ferenc Korodi Process for preparing simvastatin and intermediates thereof
ES2343049B1 (es) 2008-10-15 2011-06-10 Neuron Biopharma, S.A. Biosintesis de derivados de monacolina j.
ES2614804T3 (es) 2009-09-30 2017-06-02 Codexis, Inc. Acilación mejorada mediada por LovD aciltransferasa
EP2486129B1 (en) 2009-10-08 2016-04-13 The Regents of The University of California LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS
CN104744416A (zh) * 2015-03-25 2015-07-01 河南师范大学 一种辛伐他汀的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (es) * 1974-06-07 1981-03-18
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4293496A (en) * 1980-02-04 1981-10-06 Merck & Co., Inc. 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0137445B1 (en) * 1983-10-11 1990-01-03 Merck & Co. Inc. Process for c-methylation of 2-methylbutyrates
US4584389A (en) * 1983-10-11 1986-04-22 Merck & Co., Inc. Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
US4582915A (en) * 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
US4611081A (en) * 1985-07-05 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5177104A (en) * 1990-04-03 1993-01-05 E. R. Squibb & Sons, Inc. 6-α-hydroxy derivatives of mevinic acids
US5223415A (en) * 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof

Also Published As

Publication number Publication date
AU693401B1 (en) 1998-06-25
EP0864569B1 (en) 2001-08-16
DE69706135D1 (de) 2001-09-20
DE69706135T2 (de) 2002-05-02
US5763646A (en) 1998-06-09
EP0864569A1 (en) 1998-09-16
ZA974023B (en) 1997-12-10
ATE204271T1 (de) 2001-09-15

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