ATE217611T1 - Verfahren zur herstellung von phosphodiesterase iv inhibitoren - Google Patents
Verfahren zur herstellung von phosphodiesterase iv inhibitorenInfo
- Publication number
- ATE217611T1 ATE217611T1 AT97942446T AT97942446T ATE217611T1 AT E217611 T1 ATE217611 T1 AT E217611T1 AT 97942446 T AT97942446 T AT 97942446T AT 97942446 T AT97942446 T AT 97942446T AT E217611 T1 ATE217611 T1 AT E217611T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- aryl
- alkenyl
- group
- phosphodiesterase
- Prior art date
Links
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 -N(R<3>)2 Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2625096P | 1996-09-17 | 1996-09-17 | |
| GBGB9625819.9A GB9625819D0 (en) | 1996-12-12 | 1996-12-12 | Method of preparing phosphodiesterase IV inhibitors |
| PCT/US1997/016171 WO1998012178A1 (en) | 1996-09-17 | 1997-09-12 | Method of preparing phosphodiesterase iv inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE217611T1 true ATE217611T1 (de) | 2002-06-15 |
Family
ID=26310609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97942446T ATE217611T1 (de) | 1996-09-17 | 1997-09-12 | Verfahren zur herstellung von phosphodiesterase iv inhibitoren |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0931066B1 (de) |
| JP (1) | JP2001501927A (de) |
| AT (1) | ATE217611T1 (de) |
| AU (1) | AU712869B2 (de) |
| CA (1) | CA2265826A1 (de) |
| DE (1) | DE69712631D1 (de) |
| WO (1) | WO1998012178A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2797478B1 (fr) | 1999-08-09 | 2001-10-12 | Cit Alcatel | Palier magnetique de centrage a commande en basculement de grande amplitude |
| DE102005043337A1 (de) * | 2005-09-12 | 2007-03-15 | Ludwig-Maximilians-Universität München | Nickel- oder Eisen-katalysierte Kohlenstoff-Kohlenstoff-Kupplungsreaktion von Arylenen, Alkenen und Alkinen |
| EP2022783A1 (de) | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | 1-Phenyl-2-Pyridinylalkyl-Alkoholderivate als Phosphodiesterasehemmer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW263495B (de) * | 1992-12-23 | 1995-11-21 | Celltech Ltd | |
| GB9304920D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| GB9326173D0 (en) * | 1993-12-22 | 1994-02-23 | Celltech Ltd | Chemical compounds and process |
| AR006550A1 (es) * | 1996-04-17 | 1999-09-08 | Merck & Co Inc | Metodo de preparacion de inhibidores de fosfodiesterasa iv |
-
1997
- 1997-09-12 AT AT97942446T patent/ATE217611T1/de not_active IP Right Cessation
- 1997-09-12 AU AU44142/97A patent/AU712869B2/en not_active Ceased
- 1997-09-12 EP EP97942446A patent/EP0931066B1/de not_active Expired - Lifetime
- 1997-09-12 CA CA002265826A patent/CA2265826A1/en not_active Abandoned
- 1997-09-12 JP JP10514763A patent/JP2001501927A/ja active Pending
- 1997-09-12 WO PCT/US1997/016171 patent/WO1998012178A1/en not_active Ceased
- 1997-09-12 DE DE69712631T patent/DE69712631D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0931066B1 (de) | 2002-05-15 |
| EP0931066A1 (de) | 1999-07-28 |
| AU712869B2 (en) | 1999-11-18 |
| CA2265826A1 (en) | 1998-03-26 |
| AU4414297A (en) | 1998-04-14 |
| WO1998012178A1 (en) | 1998-03-26 |
| JP2001501927A (ja) | 2001-02-13 |
| DE69712631D1 (de) | 2002-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |