DE69633231T2 - Tnf-alpha konvertierendes enzym - Google Patents

Tnf-alpha konvertierendes enzym Download PDF

Info

Publication number
DE69633231T2
DE69633231T2 DE69633231T DE69633231T DE69633231T2 DE 69633231 T2 DE69633231 T2 DE 69633231T2 DE 69633231 T DE69633231 T DE 69633231T DE 69633231 T DE69633231 T DE 69633231T DE 69633231 T2 DE69633231 T2 DE 69633231T2
Authority
DE
Germany
Prior art keywords
tace
polypeptide
isolated
purified
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69633231T
Other languages
German (de)
English (en)
Other versions
DE69633231D1 (de
Inventor
A. Roy BLACK
Charles Rauch
J. Carl MARCH
P. Douglas CERRETTI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunex Corp
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/655,345 external-priority patent/US5830742A/en
Application filed by Immunex Corp filed Critical Immunex Corp
Publication of DE69633231D1 publication Critical patent/DE69633231D1/de
Application granted granted Critical
Publication of DE69633231T2 publication Critical patent/DE69633231T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • AIDS & HIV (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
DE69633231T 1995-06-08 1996-06-03 Tnf-alpha konvertierendes enzym Expired - Fee Related DE69633231T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US48245895A 1995-06-08 1995-06-08
US33169P 1995-06-08
US50461495A 1995-07-20 1995-07-20
US504614 1995-07-20
US08/655,345 US5830742A (en) 1995-06-08 1996-05-23 TNF-α converting enzyme
US655345 1996-05-23
PCT/US1996/008407 WO1996041624A1 (en) 1995-06-08 1996-06-03 TNF-α CONVERTING ENZYME

Publications (2)

Publication Number Publication Date
DE69633231D1 DE69633231D1 (de) 2004-09-30
DE69633231T2 true DE69633231T2 (de) 2005-08-04

Family

ID=27413615

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69633231T Expired - Fee Related DE69633231T2 (de) 1995-06-08 1996-06-03 Tnf-alpha konvertierendes enzym

Country Status (13)

Country Link
EP (1) EP0830130B9 (ja)
JP (1) JP4326022B2 (ja)
AT (1) ATE274346T1 (ja)
AU (1) AU712759C (ja)
CA (1) CA2222650C (ja)
DE (1) DE69633231T2 (ja)
DK (1) DK0830130T3 (ja)
ES (1) ES2227598T3 (ja)
IL (1) IL122305A0 (ja)
NO (1) NO323623B1 (ja)
NZ (2) NZ312285A (ja)
PT (1) PT830130E (ja)
WO (1) WO1996041624A1 (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180403B1 (en) 1999-10-28 2001-01-30 Isis Pharmaceuticals Inc. Antisense inhibition of tumor necrosis factor alpha converting enzyme (TACE) expression
US6255064B1 (en) 1996-03-01 2001-07-03 The Procter & Gamble Company Disintegrin metalloprotease and its use
CA2249985A1 (en) * 1996-03-26 1997-10-02 Glaxo Group Limited Tumour necrosis factor alpha convertase
JP2000500660A (ja) * 1996-07-12 2000-01-25 シェーリング コーポレイション 哺乳動物ＴＮＦ―αコンベルターゼ
US5853977A (en) 1996-07-12 1998-12-29 Schering Corporation Mammalian TNF-α convertases
AU6241698A (en) 1997-01-21 1998-08-07 Human Genome Sciences, Inc. Tace-like and matrilysin-like polypeptides
HUP0100780A2 (hu) * 1997-02-25 2001-06-28 Case Western Reserve University Új dezintegrin metalloproteáz, mutánsai, fragmentumai és hasonlók alkalmazása
US6551857B2 (en) 1997-04-04 2003-04-22 Elm Technology Corporation Three dimensional structure integrated circuits
US6548633B1 (en) 1998-12-22 2003-04-15 Genset, S.A. Complementary DNA's encoding proteins with signal peptides
CN1342200A (zh) * 1998-02-04 2002-03-27 免疫检查公司 晶体TNF－α－转换酶及其应用
US6842704B2 (en) 1998-02-04 2005-01-11 Immunex Corporation Crystalline TNF-α-converting enzyme and uses thereof
US6632667B1 (en) 1999-10-28 2003-10-14 Isis Pharmaceuticals, Inc. Modulation of L-selectin shedding via inhibition of tumor necrosis factor-α converting enzyme (TACE)
EP1449538A1 (en) * 2003-02-21 2004-08-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition of TACE or amphiregulin for the modulation of EGF receptor signal transactivation
WO2005030798A2 (en) 2003-09-24 2005-04-07 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services TNFαCONVERTING ENZYME INHIBITORY AGENTS AND STIMULATORY AGENTS-
EP2061802A1 (en) * 2006-08-28 2009-05-27 Ares Trading S.A. Process for the purification of fc-fusion proteins
FI2061803T4 (fi) * 2006-08-28 2023-03-14 Process for the purification of fc-containing proteins
EP2670775A1 (en) 2011-02-01 2013-12-11 Cancer Research Technology Limited Anti-tace antibody molecules and their uses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0491878T3 (da) * 1989-08-16 1997-06-23 Chiron Corp Præparater til inhibering af proteinhormondannelse og anvendelser deraf
DE69033457T2 (de) * 1989-08-16 2000-09-14 Chiron Corp Prohormonspaltungsplatzblockierungsantikörper
DE59106996D1 (de) * 1990-06-22 1996-01-11 Jens Luedemann Dna-sequenz für eine serin-protease und damit zusammenhängende gegenstände.
AU8337291A (en) * 1990-08-06 1992-03-02 Cetus Corporation Methods for the identification of cytokine convertase inhibitors
CA2139127A1 (en) * 1992-06-25 1994-01-06 Chiron Corporation Compositions for the inhibition of protein hormone formation and uses thereof
WO1995024501A1 (en) * 1994-03-07 1995-09-14 Cetus Oncology Corporation Compositions for the inhibition of tnf formation and uses thereof
CA2249985A1 (en) * 1996-03-26 1997-10-02 Glaxo Group Limited Tumour necrosis factor alpha convertase

Also Published As

Publication number Publication date
DE69633231D1 (de) 2004-09-30
AU712759C (en) 2001-08-09
PT830130E (pt) 2004-11-30
DK0830130T3 (da) 2004-12-20
WO1996041624A1 (en) 1996-12-27
ATE274346T1 (de) 2004-09-15
NO975438D0 (no) 1997-11-26
AU6378196A (en) 1997-01-09
AU712759B2 (en) 1999-11-18
CA2222650A1 (en) 1996-12-27
EP0830130B9 (en) 2004-12-29
NZ510390A (en) 2002-11-26
EP0830130A1 (en) 1998-03-25
CA2222650C (en) 2009-10-13
IL122305A0 (en) 1998-04-05
NZ312285A (en) 2001-04-27
JP4326022B2 (ja) 2009-09-02
JP2002515020A (ja) 2002-05-21
NO323623B1 (no) 2007-06-18
ES2227598T3 (es) 2005-04-01
MX9709744A (es) 1998-07-31
EP0830130A4 (en) 2000-03-29
EP0830130B1 (en) 2004-08-25
NO975438L (no) 1998-02-06

Similar Documents

Publication Publication Date Title
DE69633231T2 (de) Tnf-alpha konvertierendes enzym
US7695948B2 (en) Antibodies that bind TNF-α converting enzyme
DE69534593T2 (de) Onkostatin- m rezeptor
DE69535719T2 (de) Fas-antigenbindender ligand
DE69737978T2 (de) Als 2f1 bezeichnetes rezeptorprotein
DE69334070T2 (de) Neue zytokine die cd30 binden
DE69533923T2 (de) Cytokinin-designiertes lerk-5
DE69836088T2 (de) Als lerk6 bezeichnetes cytokin
DE69334100T2 (de) Elk ligand, ein cytokin
DE69334111T2 (de) Cd27 ligand
DE69433552T2 (de) An den zelloberflächenrezeptor hek bindendes cytokin
DE69534235T2 (de) Cytokin lerk-7
DE60024808T2 (de) Familie von immunregulatoren mit der bezeichnung 'leukozyten-immunoglobulin-ähnliche rezeptoren' (lir)
US5830742A (en) TNF-α converting enzyme
DE69535316T2 (de) Als lerk6 bezeichnetes cytokin
DE69932247T2 (de) Menschliches il-1 epsilon dna und polypeptide
US20090017492A1 (en) SVPH1-26 DNA and polypeptides
DE69927515T2 (de) Zil 1a4 ein homolog des interleukin-1
DE69930370T2 (de) Testisspezifische, menschliche proteinase, svph1-8
AU752369B2 (en) TNF-alpha converting enzyme
MXPA97009744A (en) Enzima convertidora tnf-a
JPH07115988A (ja) 可溶性膜タンパクの製造方法及び可溶性膜タンパク

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOCKHORNI & KOLLEGEN, 80687 MUENCHEN

8339 Ceased/non-payment of the annual fee