MX9709744A - Enzima convertidora tnf-a. - Google Patents

Enzima convertidora tnf-a.

Info

Publication number
MX9709744A
MX9709744A MX9709744A MX9709744A MX9709744A MX 9709744 A MX9709744 A MX 9709744A MX 9709744 A MX9709744 A MX 9709744A MX 9709744 A MX9709744 A MX 9709744A MX 9709744 A MX9709744 A MX 9709744A
Authority
MX
Mexico
Prior art keywords
alpha
tnf
protease
converting enzyme
isolated
Prior art date
Application number
MX9709744A
Other languages
English (en)
Other versions
MXPA97009744A (es
Inventor
Roy A Black
Charles Rauch
Carl J March
Douglas P Cerretti
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/655,345 external-priority patent/US5830742A/en
Application filed by Immunex Corp filed Critical Immunex Corp
Publication of MX9709744A publication Critical patent/MX9709744A/es
Publication of MXPA97009744A publication Critical patent/MXPA97009744A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)

Abstract

Una metaloproteasa que convierte TNF-æ a partir de la forma de célula 26 kD a la forma de célula 17 kD, ha sido aislada y purificada y conocida la secuencia de cDNA. En particular, la proteasa tiene un peso molecular de aproximadamente 80 kD. La proteasa aislada y purificada es util para diseñar un inhibidor de la misma, y puede encontrar uso como un agente terapéutico. Los ensayos para detectar la actividad inhibidora de la proteasa de una molécula también son un aspecto de la invencion.
MXPA/A/1997/009744A 1995-06-08 1997-12-05 Enzima convertidora tnf-alfa MXPA97009744A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US48245895A 1995-06-08 1995-06-08
US428458 1995-06-08
US50461495A 1995-07-20 1995-07-20
US504614 1995-07-20
US08655345 1996-05-23
US08/655,345 US5830742A (en) 1995-06-08 1996-05-23 TNF-α converting enzyme

Publications (2)

Publication Number Publication Date
MX9709744A true MX9709744A (es) 1998-07-31
MXPA97009744A MXPA97009744A (es) 1998-11-09

Family

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Also Published As

Publication number Publication date
DE69633231T2 (de) 2005-08-04
DE69633231D1 (de) 2004-09-30
JP2002515020A (ja) 2002-05-21
EP0830130A4 (en) 2000-03-29
EP0830130B9 (en) 2004-12-29
CA2222650C (en) 2009-10-13
ES2227598T3 (es) 2005-04-01
EP0830130B1 (en) 2004-08-25
CA2222650A1 (en) 1996-12-27
AU712759C (en) 2001-08-09
NZ510390A (en) 2002-11-26
AU6378196A (en) 1997-01-09
AU712759B2 (en) 1999-11-18
NZ312285A (en) 2001-04-27
JP4326022B2 (ja) 2009-09-02
PT830130E (pt) 2004-11-30
WO1996041624A1 (en) 1996-12-27
IL122305A0 (en) 1998-04-05
NO975438L (no) 1998-02-06
NO323623B1 (no) 2007-06-18
ATE274346T1 (de) 2004-09-15
NO975438D0 (no) 1997-11-26
EP0830130A1 (en) 1998-03-25
DK0830130T3 (da) 2004-12-20

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees