DE69631970T2 - Archaeoliposome, Koenzym Q10 enthaltende Archaeoliposome und Koenzym Q10 enthaltende Liposome als Adjuvans und Wirkstoffabgabevehikel - Google Patents

Archaeoliposome, Koenzym Q10 enthaltende Archaeoliposome und Koenzym Q10 enthaltende Liposome als Adjuvans und Wirkstoffabgabevehikel Download PDF

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Publication number
DE69631970T2
DE69631970T2 DE69631970T DE69631970T DE69631970T2 DE 69631970 T2 DE69631970 T2 DE 69631970T2 DE 69631970 T DE69631970 T DE 69631970T DE 69631970 T DE69631970 T DE 69631970T DE 69631970 T2 DE69631970 T2 DE 69631970T2
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DE
Germany
Prior art keywords
composition according
liposomes
archaeobacterium
archaeosomes
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69631970T
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German (de)
English (en)
Other versions
DE69631970D1 (de
Inventor
Dennis G. Sprott
B. Girishchandra PATEL
Boby Makabi-Panzu
L. Douglas TOLSON
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National Research Council Canada
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National Research Council Canada
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Filing date
Publication date
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Publication of DE69631970D1 publication Critical patent/DE69631970D1/de
Publication of DE69631970T2 publication Critical patent/DE69631970T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69631970T 1995-12-15 1996-12-13 Archaeoliposome, Koenzym Q10 enthaltende Archaeoliposome und Koenzym Q10 enthaltende Liposome als Adjuvans und Wirkstoffabgabevehikel Expired - Fee Related DE69631970T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US872495P 1995-12-15 1995-12-15
US8724P 1995-12-15
PCT/CA1996/000835 WO1997022333A1 (en) 1995-12-15 1996-12-13 Archaeosomes, archaeosomes containing coenzyme q10, and other types of liposomes containing coenzyme q10 as adjuvants and as delivery vehicles

Publications (2)

Publication Number Publication Date
DE69631970D1 DE69631970D1 (de) 2004-04-29
DE69631970T2 true DE69631970T2 (de) 2005-04-14

Family

ID=21733297

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69631970T Expired - Fee Related DE69631970T2 (de) 1995-12-15 1996-12-13 Archaeoliposome, Koenzym Q10 enthaltende Archaeoliposome und Koenzym Q10 enthaltende Liposome als Adjuvans und Wirkstoffabgabevehikel

Country Status (6)

Country Link
US (2) US6132789A (enExample)
EP (1) EP0869773B1 (enExample)
JP (1) JP2000502087A (enExample)
CA (1) CA2241247C (enExample)
DE (1) DE69631970T2 (enExample)
WO (1) WO1997022333A1 (enExample)

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US7865567B1 (en) 1993-12-02 2011-01-04 Discovery Patent Holdings, Llc Virtual on-demand electronic book
US7861166B1 (en) 1993-12-02 2010-12-28 Discovery Patent Holding, Llc Resizing document pages to fit available hardware screens
ES2154560B1 (es) * 1998-09-16 2001-12-01 Lipotec Sa Composicion a base de derivados de cromanos y su uso para reducir quimicamente las reacciones oxidativas o inducidas por radicales libres.
US6200550B1 (en) * 1998-12-11 2001-03-13 Q-Pharma, Inc. Oral care compositions comprising coenzyme Q10
DE60041413D1 (de) * 1999-10-12 2009-03-05 Ca Nat Research Council Archaeosome als adjuvantien und träger für azelluläre impstoffe zur induktion einer zytotoxischen t-lymphozyten (ctl) immunantwort
AU2001278336B2 (en) 2000-07-31 2007-01-18 Ottawa Heart Institute Research Corporation Charged phospholipid compositions and methods for their use
US6897196B1 (en) * 2001-02-07 2005-05-24 The Regents Of The University Of California pH sensitive lipids based on ortho ester linkers, composition and method
AR036316A1 (es) * 2002-08-29 2004-08-25 Monte Verde S A Una composicion farmaceutica de liposomas de tamano pequeno y metodo de preparacion
JP2006508126A (ja) * 2002-11-06 2006-03-09 アザヤ セラピューティクス インコーポレイティッド 薬学的製剤のタンパク質安定化されたリポソーム製剤
AU2004227998A1 (en) * 2003-04-02 2004-10-21 Pharmachem Laboratories, Inc. Novel probiotic compositions and methods of using the same
US8252322B2 (en) 2003-06-03 2012-08-28 Corn Products Development, Inc. Delivery system with increased bioavailability
US20050158329A1 (en) * 2004-01-21 2005-07-21 Ghosh Swapan K. Novel phytol derived immunoadjuvants and their use in vaccine formulations
FR2878846B1 (fr) * 2004-12-07 2007-02-23 Enscr Composes analogues de lipides membranaires d'archaebacteries et compositions liposomiales integrant de tel composes
US20100048595A1 (en) * 2005-03-23 2010-02-25 Washington University In St. Louis Use of archaea to modulate the nutrient harvesting functions of the gastrointestinal microbiota
CA2647060C (en) * 2006-03-30 2014-10-21 National Research Council Of Canada Synthetic archaeal glycolipid adjuvants
US20080220028A1 (en) 2006-12-15 2008-09-11 National Research Council Of Canada Archaeal polar lipid aggregates for administration to animals
GB2463801B (en) * 2007-03-20 2011-07-13 Univ Plymouth Isoprenoid compounds, their isolation and use
JPWO2009004900A1 (ja) * 2007-06-29 2010-08-26 学校法人 城西大学 ユビキノン含有免疫アジュバント
EP2227085A4 (en) * 2007-12-06 2013-10-09 Berg Pharma Llc INGREDIBLE COMPOSITIONS WITH INCREASED BIOLOGICAL AVAILABILITY
CN101368214B (zh) * 2008-09-24 2010-09-15 上海大学 用于古细菌多样性分析的针对16S rRNA基因的引物
BR112012022916B1 (pt) 2010-03-12 2021-11-09 Berg Llc Formulações intravenosas de coenzima q10 (coq10), bem como método de preparação e uso da mesma
US20140239525A1 (en) 2011-06-17 2014-08-28 Board Of Regents, University Of Texas System Inhalable pharmaceutical compositions
MX347400B (es) * 2012-06-29 2017-04-18 Univ Nac Autónoma De México Vacuna de aplicacion nasal contra el desarrollo de la enfermedad aterosclerotica y el higado graso.
EP2968147A4 (en) * 2013-03-15 2017-02-22 The Penn State Research Foundation Acid stable liposomal compositions
DK3138555T3 (da) 2014-04-30 2020-12-14 Fujifilm Corp Liposomsammensætning og fremgangsmåde til fremstilling heraf
WO2015166985A1 (ja) * 2014-04-30 2015-11-05 富士フイルム株式会社 リポソーム組成物及びその製造方法
WO2016004512A1 (en) * 2014-07-11 2016-01-14 National Research Council Of Canada Sulfated-glycolipids as adjuvants for vaccines
EP3364953B1 (en) * 2015-10-21 2019-12-11 Universität Heidelberg Novel liposomal formulation for the oral hepatic delivery of drugs
EP3158992A1 (en) * 2015-10-21 2017-04-26 Universität Heidelberg Liposomes containing cell penetrating peptides and tetraetherlipids for the oral delivery of macromolecules
FI3811949T3 (fi) 2018-06-20 2024-09-13 Fujifilm Corp Liposomikoostumukseen kapseloitua gemsitabiinia ja immuunitarkistuspistesalpaajaa käsittävä yhdistelmälääke
EP3628309A1 (en) 2018-09-28 2020-04-01 Universität Heidelberg Method of making oral dosage forms
EP3708151A1 (en) * 2019-03-15 2020-09-16 Technische Universität Wien Method for producing a composition comprising archaeal lipids from a sulfolobus cell culture

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JPS588010A (ja) * 1981-07-08 1983-01-18 Eisai Co Ltd ユビデカレノン含有リポソ−ム
JPS58201711A (ja) * 1982-05-19 1983-11-24 Eisai Co Ltd ユビデカレノン含有リポソ−ム被覆体
JPS6058915A (ja) * 1983-09-12 1985-04-05 Fujisawa Pharmaceut Co Ltd 薬物含有脂質小胞体製剤
FR2591105B1 (fr) * 1985-12-11 1989-03-24 Moet Hennessy Rech Composition pharmaceutique, notamment dermatologique, ou cosmetique, a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un retinoide ou un analogue structural dudit retinoide tel qu'un carotenoide.
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
JPH02295917A (ja) * 1989-05-10 1990-12-06 Terumo Corp 内包物の酸化を抑制したリポソームおよびその製法
DE69100869T2 (de) * 1990-04-21 1994-07-28 United Biscuits Ltd Produkte auf der Basis von Fett.
JP3132039B2 (ja) * 1991-02-25 2001-02-05 大正製薬株式会社 ビタミンａ含有リポソーム水懸濁液
JPH04300838A (ja) * 1991-03-28 1992-10-23 Terumo Corp 人工赤血球および人工赤血球懸濁液
AU2776692A (en) * 1991-10-23 1993-05-21 National Research Council Of Canada Formation of stable liposomes from lipid extracts of archaeobacteria (archaea)
JPH08509202A (ja) * 1992-07-08 1996-10-01 ディアノルム―ゲレーテ・ゲー・マイエルホファー・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング リポソーム、それを調製する方法及び薬調製におけるその用途

Also Published As

Publication number Publication date
EP0869773B1 (en) 2004-03-24
DE69631970D1 (de) 2004-04-29
CA2241247C (en) 2004-01-20
US6132789A (en) 2000-10-17
WO1997022333A1 (en) 1997-06-26
JP2000502087A (ja) 2000-02-22
CA2241247A1 (en) 1997-06-26
EP0869773A1 (en) 1998-10-14
US6403117B1 (en) 2002-06-11

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8370 Indication of lapse of patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee