DE69631970D1 - Archaeoliposome, koenzym q10 enthaltende archaeoliposome und koenzym q10 enthaltende liposome als adjuvans und wirkstoffabgabevehikel - Google Patents

Archaeoliposome, koenzym q10 enthaltende archaeoliposome und koenzym q10 enthaltende liposome als adjuvans und wirkstoffabgabevehikel

Info

Publication number
DE69631970D1
DE69631970D1 DE69631970T DE69631970T DE69631970D1 DE 69631970 D1 DE69631970 D1 DE 69631970D1 DE 69631970 T DE69631970 T DE 69631970T DE 69631970 T DE69631970 T DE 69631970T DE 69631970 D1 DE69631970 D1 DE 69631970D1
Authority
DE
Germany
Prior art keywords
koenzyme
archaeoliposome
adjuvans
active substance
delivery vehicle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69631970T
Other languages
English (en)
Other versions
DE69631970T2 (de
Inventor
Dennis Sprott
B Patel
Boby Makabi-Panzu
L Tolson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Publication of DE69631970D1 publication Critical patent/DE69631970D1/de
Application granted granted Critical
Publication of DE69631970T2 publication Critical patent/DE69631970T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69631970T 1995-12-15 1996-12-13 Archaeoliposome, Koenzym Q10 enthaltende Archaeoliposome und Koenzym Q10 enthaltende Liposome als Adjuvans und Wirkstoffabgabevehikel Expired - Fee Related DE69631970T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US872495P 1995-12-15 1995-12-15
US8724P 1995-12-15
PCT/CA1996/000835 WO1997022333A1 (en) 1995-12-15 1996-12-13 Archaeosomes, archaeosomes containing coenzyme q10, and other types of liposomes containing coenzyme q10 as adjuvants and as delivery vehicles

Publications (2)

Publication Number Publication Date
DE69631970D1 true DE69631970D1 (de) 2004-04-29
DE69631970T2 DE69631970T2 (de) 2005-04-14

Family

ID=21733297

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69631970T Expired - Fee Related DE69631970T2 (de) 1995-12-15 1996-12-13 Archaeoliposome, Koenzym Q10 enthaltende Archaeoliposome und Koenzym Q10 enthaltende Liposome als Adjuvans und Wirkstoffabgabevehikel

Country Status (6)

Country Link
US (2) US6132789A (de)
EP (1) EP0869773B1 (de)
JP (1) JP2000502087A (de)
CA (1) CA2241247C (de)
DE (1) DE69631970T2 (de)
WO (1) WO1997022333A1 (de)

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US7865567B1 (en) 1993-12-02 2011-01-04 Discovery Patent Holdings, Llc Virtual on-demand electronic book
US7861166B1 (en) 1993-12-02 2010-12-28 Discovery Patent Holding, Llc Resizing document pages to fit available hardware screens
ES2154560B1 (es) * 1998-09-16 2001-12-01 Lipotec Sa Composicion a base de derivados de cromanos y su uso para reducir quimicamente las reacciones oxidativas o inducidas por radicales libres.
US6200550B1 (en) * 1998-12-11 2001-03-13 Q-Pharma, Inc. Oral care compositions comprising coenzyme Q10
ES2320971T3 (es) * 1999-10-12 2009-06-01 National Research Council Of Canada Arqueosomas como adjuvantes y vehiculos para vacunas acelulares para inducir respuestas de linfocitos t cototoxicos.
WO2002009678A2 (en) 2000-07-31 2002-02-07 Ottawa Heart Institute Research Corporation Charged phospholipid compositions and methods for their use
US6897196B1 (en) * 2001-02-07 2005-05-24 The Regents Of The University Of California pH sensitive lipids based on ortho ester linkers, composition and method
AR036316A1 (es) * 2002-08-29 2004-08-25 Monte Verde S A Una composicion farmaceutica de liposomas de tamano pequeno y metodo de preparacion
JP2006508126A (ja) * 2002-11-06 2006-03-09 アザヤ セラピューティクス インコーポレイティッド 薬学的製剤のタンパク質安定化されたリポソーム製剤
CA2519927A1 (en) * 2003-04-02 2004-10-21 Pharmachem Laboratories, Inc. Novel probiotic compositions and methods of using the same
US8252322B2 (en) 2003-06-03 2012-08-28 Corn Products Development, Inc. Delivery system with increased bioavailability
US20050158329A1 (en) * 2004-01-21 2005-07-21 Ghosh Swapan K. Novel phytol derived immunoadjuvants and their use in vaccine formulations
FR2878846B1 (fr) * 2004-12-07 2007-02-23 Enscr Composes analogues de lipides membranaires d'archaebacteries et compositions liposomiales integrant de tel composes
US20100048595A1 (en) * 2005-03-23 2010-02-25 Washington University In St. Louis Use of archaea to modulate the nutrient harvesting functions of the gastrointestinal microbiota
WO2007112567A1 (en) * 2006-03-30 2007-10-11 National Research Council Of Canada Synthetic archaeal glycolipid adjuvants
TW200833709A (en) 2006-12-15 2008-08-16 Ca Nat Research Council Archaeal polar lipid aggregates for administration to animals
GB2463801B (en) * 2007-03-20 2011-07-13 Univ Plymouth Isoprenoid compounds, their isolation and use
WO2009004900A1 (ja) * 2007-06-29 2009-01-08 Josai University Corporation ユビキノン含有免疫アジュバント
JP5767812B2 (ja) * 2007-12-06 2015-08-19 バーグ リミテッド ライアビリティ カンパニー 生物学的利用率が向上した吸入可能な組成物
CN101368214B (zh) * 2008-09-24 2010-09-15 上海大学 用于古细菌多样性分析的针对16S rRNA基因的引物
MY163995A (en) 2010-03-12 2017-11-15 Berg Llc Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
EP2720680B1 (de) 2011-06-17 2020-02-12 Berg LLC Inhalbierbare pharmazeutische zusammensetzungen
MX347400B (es) * 2012-06-29 2017-04-18 Univ Nac Autónoma De México Vacuna de aplicacion nasal contra el desarrollo de la enfermedad aterosclerotica y el higado graso.
EP2968147A4 (de) * 2013-03-15 2017-02-22 The Penn State Research Foundation Säurestabile liposomale zusammensetzungen
WO2015166985A1 (ja) * 2014-04-30 2015-11-05 富士フイルム株式会社 リポソーム組成物及びその製造方法
EP3138555B1 (de) * 2014-04-30 2020-10-28 FUJIFILM Corporation Liposomzusammensetzung und herstellungsverfahren dafür
EP3166957B1 (de) 2014-07-11 2019-11-13 National Research Council of Canada Sulfatierte glycolipide als adjuvantien für impfstoffe
ES2773763T3 (es) * 2015-10-21 2020-07-14 Univ Heidelberg Formulación liposomal novedosa para la administración hepática oral de fármacos
EP3158992A1 (de) * 2015-10-21 2017-04-26 Universität Heidelberg Liposomen mit zellenpenetrierenden peptiden und tetraetherlipide zur oralen verabreichung von makromolekülen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS588010A (ja) * 1981-07-08 1983-01-18 Eisai Co Ltd ユビデカレノン含有リポソ−ム
JPS58201711A (ja) * 1982-05-19 1983-11-24 Eisai Co Ltd ユビデカレノン含有リポソ−ム被覆体
JPS6058915A (ja) * 1983-09-12 1985-04-05 Fujisawa Pharmaceut Co Ltd 薬物含有脂質小胞体製剤
FR2591105B1 (fr) * 1985-12-11 1989-03-24 Moet Hennessy Rech Composition pharmaceutique, notamment dermatologique, ou cosmetique, a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un retinoide ou un analogue structural dudit retinoide tel qu'un carotenoide.
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
JPH02295917A (ja) * 1989-05-10 1990-12-06 Terumo Corp 内包物の酸化を抑制したリポソームおよびその製法
CA2040847A1 (en) * 1990-04-21 1991-10-22 Eugene William Hammond Fat-based food products
JP3132039B2 (ja) * 1991-02-25 2001-02-05 大正製薬株式会社 ビタミンａ含有リポソーム水懸濁液
JPH04300838A (ja) * 1991-03-28 1992-10-23 Terumo Corp 人工赤血球および人工赤血球懸濁液
AU2776692A (en) * 1991-10-23 1993-05-21 National Research Council Of Canada Formation of stable liposomes from lipid extracts of archaeobacteria (archaea)
CA2139757C (en) * 1992-07-08 2009-04-14 Gunther Maierhofer Liposomes, method of preparing the same and use thereof in the preparation of drugs

Also Published As

Publication number Publication date
EP0869773A1 (de) 1998-10-14
WO1997022333A1 (en) 1997-06-26
EP0869773B1 (de) 2004-03-24
JP2000502087A (ja) 2000-02-22
US6132789A (en) 2000-10-17
CA2241247C (en) 2004-01-20
US6403117B1 (en) 2002-06-11
DE69631970T2 (de) 2005-04-14
CA2241247A1 (en) 1997-06-26

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication of lapse of patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee