DE69621645D1 - Zwischenverbindungen von fortgeschrittenen glykosylierung-endprodukten und post-amadorische inhibitor - Google Patents

Zwischenverbindungen von fortgeschrittenen glykosylierung-endprodukten und post-amadorische inhibitor

Info

Publication number
DE69621645D1
DE69621645D1 DE69621645T DE69621645T DE69621645D1 DE 69621645 D1 DE69621645 D1 DE 69621645D1 DE 69621645 T DE69621645 T DE 69621645T DE 69621645 T DE69621645 T DE 69621645T DE 69621645 D1 DE69621645 D1 DE 69621645D1
Authority
DE
Germany
Prior art keywords
amadoric
inhibitor
post
end products
advanced glycosylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69621645T
Other languages
English (en)
Other versions
DE69621645T2 (de
Inventor
G Hudson
Parvin Todd
Gabriel Khalifah
Ashley Booth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KANSAS MEDICAL CT KANSAS, University of
University of Kansas Medical Center
Original Assignee
KANSAS MEDICAL CT KANSAS, University of
University of Kansas Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KANSAS MEDICAL CT KANSAS, University of, University of Kansas Medical Center filed Critical KANSAS MEDICAL CT KANSAS, University of
Application granted granted Critical
Publication of DE69621645D1 publication Critical patent/DE69621645D1/de
Publication of DE69621645T2 publication Critical patent/DE69621645T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
DE69621645T 1995-09-12 1996-09-11 Zwischenverbindungen von fortgeschrittenen glykosylierung-endprodukten und post-amadorische inhibitor Expired - Lifetime DE69621645T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US362895P 1995-09-12 1995-09-12
PCT/US1996/014544 WO1997009981A1 (en) 1995-09-12 1996-09-11 Advanced glycation end-product intermediaries and post-amadori inhibition

Publications (2)

Publication Number Publication Date
DE69621645D1 true DE69621645D1 (de) 2002-07-11
DE69621645T2 DE69621645T2 (de) 2002-09-19

Family

ID=21706786

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69628214T Expired - Lifetime DE69628214T2 (de) 1995-09-12 1996-09-11 Intermediaires des produits definitifs de glycosylation avancee et inhibition des produits age post-amadori
DE69621645T Expired - Lifetime DE69621645T2 (de) 1995-09-12 1996-09-11 Zwischenverbindungen von fortgeschrittenen glykosylierung-endprodukten und post-amadorische inhibitor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69628214T Expired - Lifetime DE69628214T2 (de) 1995-09-12 1996-09-11 Intermediaires des produits definitifs de glycosylation avancee et inhibition des produits age post-amadori

Country Status (11)

Country Link
US (4) US5744451A (de)
EP (1) EP0871443B1 (de)
JP (2) JPH11512432A (de)
AT (2) ATE240103T1 (de)
AU (1) AU717485B2 (de)
CA (1) CA2231772C (de)
DE (2) DE69628214T2 (de)
DK (1) DK0871443T3 (de)
ES (2) ES2199913T3 (de)
PT (2) PT1190713E (de)
WO (1) WO1997009981A1 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716858B1 (en) 1995-08-28 2004-04-06 Kansas University Medical Center Methods for inhibiting diabetic complications
US6740668B1 (en) 1995-08-28 2004-05-25 Kansas University Medical Center Methods for inhibiting diabetic complications
US6228858B1 (en) * 1995-09-12 2001-05-08 University Of Kansas Medical Center Advanced glycation end-product intermediaries and post-amadori inhibition
US6750209B1 (en) * 1995-09-12 2004-06-15 Kansas University Medical Center Advanced glycation end-product intermediaries and post-amadori inhibition
US6730686B1 (en) 1995-09-12 2004-05-04 Kansas University Medical Center Methods for inhibiting oxidative modification of proteins
US6436969B1 (en) * 1995-09-12 2002-08-20 Kansas University Medical Center Research Institute Inc. Dialysis solutions and methods
US5744451A (en) * 1995-09-12 1998-04-28 Warner-Lambert Company N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
US7030146B2 (en) 1996-09-10 2006-04-18 University Of South Carolina Methods for treating diabetic neuropathy
US20030013746A1 (en) * 1996-09-10 2003-01-16 University Of Kansas Medical Center. Advanced glycation end-product intermediaries and post-amadori inhibition
US7071298B2 (en) 1997-02-05 2006-07-04 Fox Chase Cancer Center Compounds and methods for treating glycogen storage disease and other pathological conditions resulting from formation of age-proteins
WO1998043649A2 (en) * 1997-03-28 1998-10-08 Otsuka Pharmaceutical Co., Ltd. Age production inhibitory composition comprising a maillard reaction inhibitor and vitamin b¿6?
US7393663B2 (en) * 1997-08-01 2008-07-01 Serono Genetics Institute S.A. Expressed sequence tags and encoded human proteins
EP1009452A4 (de) * 1997-08-07 2004-03-31 Ajay Gupta Wasserlösliche vitamine und nährstoffe enthaltende dialyselösung
US7220717B2 (en) * 1997-08-14 2007-05-22 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use
US7704944B2 (en) * 1997-08-14 2010-04-27 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
US6184210B1 (en) 1997-10-10 2001-02-06 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
JP2002506829A (ja) * 1998-03-16 2002-03-05 サイトビア インコーポレイテッド ジペプチドのアポトーシスインヒビターおよびそれらの使用
DE69939689D1 (de) 1998-03-19 2008-11-20 Vertex Pharma Caspase inhibitoren
EP1108434B1 (de) 1998-08-24 2014-05-14 Kurokawa, Kiyoshi Medikamente zur verringerung der carbonylbelastung und peritonealdialysate
US6753150B2 (en) * 1998-10-05 2004-06-22 The Trustees Of Columbia University In The City Of New York Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage
WO2000021516A2 (en) * 1998-10-14 2000-04-20 Kansas University Medical Center Research Institute, Inc. Methods for inhibiting diabetic complications
DE69908630T2 (de) * 1998-10-22 2004-04-29 University Of South Carolina Verfahren zur hemmung von diabetischen komplikationen
WO2000024405A1 (en) * 1998-10-28 2000-05-04 Fox Chase Cancer Center Compounds and their therapeutic use with diabetic complications
US6121300A (en) * 1998-11-10 2000-09-19 Wagle; Dilip R. Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts
CA2360740A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
WO2000051987A2 (en) 1999-03-05 2000-09-08 Kansas University Medical Center Inhibitors of advanced, post-amadori glycosylation reactions
DE60030097T2 (de) 1999-03-16 2007-03-08 Cytovia, Inc., San Diego Substituierte 2-aminobenzamin caspase inhibitoren und ihre verwendung
CA2360311C (en) * 1999-04-06 2003-03-18 Raja Khalifah Improved dialysis solutions and methods
MXPA01010127A (es) 1999-04-09 2002-08-20 Cytovia Inc Inhibidores de la caspasa y el uso de los mismos.
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US6489345B1 (en) * 1999-07-13 2002-12-03 Medicure, Inc. Treatment of diabetes and related pathologies
BR0013666A (pt) 1999-08-27 2002-05-14 Cytovia Inc "alfa"-hidróxi-ácidos substituìdos inibidores de caspases e o seu uso
US6420364B1 (en) * 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
US6566338B1 (en) 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
KR20020086540A (ko) * 2000-02-21 2002-11-18 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. Ｉｌ-18 저해물질의 용도
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
WO2002022622A2 (en) 2000-09-13 2002-03-21 Georgetown University Synthesis of 2-hydroxymethylglutamic acid and congeners thereof
ES2367891T3 (es) * 2000-09-29 2011-11-10 Schering Corporation Interleucina-10 pegilada.
WO2002039994A2 (en) 2000-11-20 2002-05-23 University Of Kansas Medical Center Methods for the treatment and prevention of urinary stone disease
DE60130030T2 (de) * 2000-12-29 2008-04-30 Alteon Inc. Verfahren zur behandlung von glaukom
DE10134568C2 (de) * 2001-07-16 2003-07-24 Inst Chemo Biosensorik Verfahren zur quantitativen Bestimmung von alpha-Oxoaldehyd
JP2006501247A (ja) * 2002-08-30 2006-01-12 バイオストラタム，インコーポレイティド ポストａｍａｄｒｉの後生的糖化最終産物の阻害物質
US20090082407A1 (en) * 2004-06-18 2009-03-26 Biostratum, Inc. Pyridoxamine for the Treatment of Diabetic Kidney Disease
ES2374399T3 (es) * 2003-06-20 2012-02-16 Nephrogenex, Inc. Piridoxamina para uso en el tratamiento de nefropatía diabética en diabetes tipo ii.
JPWO2005018649A1 (ja) * 2003-08-25 2007-11-01 財団法人名古屋産業科学研究所 最終糖化産物生成抑制剤
CN1886126A (zh) * 2003-09-25 2006-12-27 Dmi生物科学公司 利用n－酰基－l－天冬氨酸的方法和产品
WO2005077902A2 (en) * 2004-02-09 2005-08-25 Biostratum, Inc. Methods for the synthesis of pyridoxamine
JP4848367B2 (ja) 2004-05-15 2011-12-28 バーテックス ファーマシューティカルズ インコーポレイテッド Ｉｃｅインヒビターを使用した発作の処置
EP2295054A1 (de) 2004-05-27 2011-03-16 Vertex Pharmaceuticals Incorporated Ice-hemmer zur Behandlung von autoinflammatorischen Erkrankungen
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
US20060035890A1 (en) * 2004-08-10 2006-02-16 Amit Banerjee Compounds and methods for the treatment of ubiquitin conjugating disorders
KR20070053239A (ko) * 2004-09-06 2007-05-23 코와 가부시키가이샤 사구체 질환 치료제
DE102005020976A1 (de) * 2005-04-29 2006-11-02 WÖRWAG PHARMA GmbH & Co. KG Prophylaxe und Behandlung von Erkrankungen
CN101227904A (zh) * 2005-05-24 2008-07-23 学校法人东海大学 腹膜保护剂
WO2007044309A2 (en) * 2005-10-05 2007-04-19 Vasix Corporation Device and method for inhibiting age complex formation
US20080032990A1 (en) * 2006-07-07 2008-02-07 Khalifah Raja G Inhibitors of advanced glycation end products
US20130196937A1 (en) 2010-02-10 2013-08-01 Oryza Oil & Fat Chemical Co., Ltd. Age production inhibitor
US20140309172A1 (en) 2010-11-05 2014-10-16 Dagmar Ringe Ice inhibiting compounds and uses thereof
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
CN103924249A (zh) * 2013-01-11 2014-07-16 南京工业大学 一种席夫碱吡啶类碳钢酸洗缓蚀剂及其应用
RU2679889C2 (ru) 2013-04-18 2019-02-14 Армо Байосайенсиз, Инк. Способы применения интерлейкина-10 для лечения заболеваний и расстройств
CA2914837A1 (en) 2013-06-17 2014-12-24 Armo Biosciences, Inc. Method for assessing protein identity and stability
US10010588B2 (en) 2013-08-30 2018-07-03 Armo Biosciences, Inc. Methods of using pegylated interleukin-10 for treating hyperlipidemia
JP6148127B2 (ja) * 2013-09-09 2017-06-14 株式会社パーマケム・アジア ピリドキサール・アミノグアニジン誘導体またはそれらの塩、及び、その製造方法
WO2015070060A1 (en) 2013-11-11 2015-05-14 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
CN106573072A (zh) 2014-06-02 2017-04-19 阿尔莫生物科技股份有限公司 降低血清胆固醇的方法
WO2016031839A1 (ja) * 2014-08-29 2016-03-03 株式会社プロジェクトＰｍ ピリドキサミン化合物及びチアミン化合物を組み合わせてなる医薬組成物
EP3206713A4 (de) 2014-10-14 2018-06-27 Armo Biosciences, Inc. Interleukin-15-zusammensetzungen und verwendungen davon
CN107106655A (zh) 2014-10-22 2017-08-29 阿尔莫生物科技股份有限公司 使用白细胞介素‑10治疗疾病和病症的方法
WO2016126615A1 (en) 2015-02-03 2016-08-11 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
EP3302547A1 (de) 2015-05-28 2018-04-11 Armo Biosciences, Inc. Pegyliertes interleukin-10 zur behandlung von krebs
AU2016312510A1 (en) 2015-08-25 2018-03-08 Armo Biosciences, Inc. Methods of using Interleukin-10 for treating diseases and disorders
JP6105111B1 (ja) 2016-03-02 2017-03-29 国立大学法人東北大学 自閉スペクトラム症改善用組成物
CN114502546A (zh) 2019-08-01 2022-05-13 普拉特戈公司 晚期糖基化终产物的抑制剂

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR4673M (de) 1965-05-19 1966-12-19
FR7238M (de) 1968-03-27 1969-09-01
CH607773A5 (en) 1974-12-24 1978-10-31 Steigerwald Arzneimittelwerk Process for the preparation of novel pyridoxine derivatives
DE2461742C2 (de) 1974-12-28 1983-01-27 Steigerwald Arzneimittelwerk Gmbh, 6100 Darmstadt Pyridoxin-5'-phosphorsäureester-Derivate sowie deren Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2349330A1 (fr) 1976-04-29 1977-11-25 Savini Emile Composition destinee au traitement des hyperlipidemies
US5318982A (en) * 1984-03-19 1994-06-07 The Rockefeller University Inhibition of the advanced glycosylation of proteins using substituted-1,2,4-triazoles
US5358960A (en) * 1984-03-19 1994-10-25 The Rockefeller University Method for inhibiting advanced glycosylation of proteins using aminosubstituted imidazoles
US4908446A (en) * 1985-11-14 1990-03-13 The Rockefeller University Inhibitors of nonenzymatic cross-linking
US5272176A (en) * 1984-03-19 1993-12-21 The Rockefeller University Advanced glycation inhibitors containing amino-benzoic acids and derivatives, and methods of use
US4665192A (en) * 1984-03-19 1987-05-12 The Rockefeller University 2-(2-furoyl)-4(5)-2(furanyl)-1H-imidazole
US4758583A (en) * 1984-03-19 1988-07-19 The Rockefeller University Method and agents for inhibiting protein aging
US5218001A (en) * 1984-03-19 1993-06-08 The Rockefeller University Inhibitors of the advanced glycosylation of proteins and methods of use therefor
US5262152A (en) * 1984-03-19 1993-11-16 The Rockefeller University Amidrazones and derivatives thereof
US5137916A (en) * 1985-11-14 1992-08-11 The Rockefeller University Advanced glycation inhibitors containing amino-benzoic acids and derivatives, and methods of use
US5130324A (en) * 1984-03-19 1992-07-14 The Rockefeller University 2-alkylidene-aminoguanidines and methods of use therefor
US5334617A (en) * 1984-03-19 1994-08-02 The Rockefeller University Amino acids useful as inhibitors of the advanced glycosylation of proteins
US5100919A (en) * 1984-03-19 1992-03-31 The Rockefeller University Biguanides and derivatives thereof as inhibitors of advanced glycosylation of a target protein
US5140048A (en) * 1984-03-19 1992-08-18 The Rockefeller University Inhibitors of nonenzymatic cross-linking
US5258381A (en) * 1984-03-19 1993-11-02 The Rockefeller University 2-substituted-2-imidazolines
US5221683A (en) * 1984-03-19 1993-06-22 The Rockefeller University Diaminopyridine compounds and methods of use
US5272165A (en) * 1984-03-19 1993-12-21 The Rockefeller University 2-alkylidene-aminoguanidines and methods of use therefor
US5175192A (en) * 1984-03-19 1992-12-29 The Rockefeller University Inhibitors of the advanced glycosylation of proteins and methods of use therefor
US4983604A (en) * 1987-11-13 1991-01-08 The Rockefeller University Inhibitors of nonenzymatic cross-linking
US5254572A (en) * 1987-11-27 1993-10-19 Vesta Medicines (Pty) Ltd. Method and composition for supplementing vitamin B6 where the PN-PLP pathway is disturbed
DE3705549A1 (de) 1987-02-18 1988-09-01 Ulrich Speck Verwendung von pyridoxin-derivaten bei der prophylaxe und therapie von hyperlipidaemien und atherosklerose
US5288716A (en) * 1987-02-18 1994-02-22 Ulrich Speck Use of pyridoxine derivatives in the prevention and treatment of hyperlipidaemia and atherosclerosis
US5017696A (en) * 1987-09-17 1991-05-21 The Rockefeller University Advanced glycosylation end products and associated methods
US5010175A (en) * 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5242593A (en) * 1988-12-09 1993-09-07 Oberkofler Joerg Method for reducing the build-up of slime and/or film in water circulation systems
KR920700632A (ko) 1990-02-19 1992-08-10 요시다 쇼오지 메일라드 반응저해제
AU8449591A (en) * 1990-08-01 1992-03-02 Rockefeller University, The Advanced glycation inhibitors containing amino-benzoic acids and derivatives, and methods of use
CA2055990A1 (en) 1990-11-22 1992-05-23 David G. Schena Phospholipid-vitamin derivatives and methods for preparation thereof
JPH06510986A (ja) * 1991-06-14 1994-12-08 カイロン　コーポレイション ピコルナウイルスプロテアーゼのインヒビター
US5552400A (en) * 1994-06-08 1996-09-03 Sterling Winthrop Inc. Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
WO1996030395A2 (en) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
US6228858B1 (en) 1995-09-12 2001-05-08 University Of Kansas Medical Center Advanced glycation end-product intermediaries and post-amadori inhibition
US5744451A (en) * 1995-09-12 1998-04-28 Warner-Lambert Company N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity

Also Published As

Publication number Publication date
JP3769003B2 (ja) 2006-04-19
ATE240103T1 (de) 2003-05-15
AU7156696A (en) 1997-04-01
US5985857A (en) 1999-11-16
JPH11512432A (ja) 1999-10-26
JP2005170935A (ja) 2005-06-30
DE69628214D1 (de) 2003-06-18
DE69621645T2 (de) 2002-09-19
ES2199913T3 (es) 2004-03-01
CA2231772C (en) 2011-05-31
DE69628214T2 (de) 2003-11-27
EP0871443A1 (de) 1998-10-21
PT1190713E (pt) 2003-09-30
ATE218341T1 (de) 2002-06-15
CA2231772A1 (en) 1997-03-20
EP0871443B1 (de) 2002-06-05
WO1997009981A1 (en) 1997-03-20
ES2177804T3 (es) 2002-12-16
US6472400B1 (en) 2002-10-29
US5744451A (en) 1998-04-28
AU717485B2 (en) 2000-03-30
PT871443E (pt) 2002-10-31
DK0871443T3 (da) 2002-07-01
US5932549A (en) 1999-08-03

Similar Documents

Publication Publication Date Title
DE69621645D1 (de) Zwischenverbindungen von fortgeschrittenen glykosylierung-endprodukten und post-amadorische inhibitor
NO971889L (no) Forbindelser og sammensetninger for levering av aktive midler
FI964473A (fi) Uudet aminohappojohdannaiset, menetelmä niiden valmistamiseksi ja näitä yhdisteitä sisältävät farmaseuttiset koostumukset (II)
HUP0001539A2 (hu) 2-(1-Imino-etil-amino)-etil-homocisztein, eljárás előállítására és az ezt tartalmazó gyógyszerkészítmények
AU7474187A (en) Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation
ATE216590T1 (de) Arzneimittelformulierungen für il-12
CA2293706A1 (en) N-substituted urea inhibitors of farnesyl-protein transferase
ATE230749T1 (de) Glucocorticoid selektive entzündungshemmende mittel
TR199801861T2 (xx) Farmas�tik olarak yararl� bile�imler.
ES2173887T3 (es) Nuevos usos farmaceuticos de las enzimas de krill.
HUP0000288A3 (en) Azetidinone derivatives as inhibitors of the enzymatic activity of psa, intermediates, process for their preparation and pharmaceutical compositions thereof
NZ212436A (en) D,l-glutamic and d,l-aspartic acid derivatives and pharmaceutical compositions
CA2320388A1 (en) Novel dihydroxyhexanoic acid derivatives
FI962464A (fi) Kiteisiä N-asetyyliamiinihappojohdannaisia ja menetelmiä niiden valmistamiseksi
IT1276162B1 (it) Geranilgeranil-derivati,procedimento per la loro preparazione e relative composizioni farmaceutiche
IT1196377B (it) Derivati di acidi biliari,procedimento per la loro preparazione e relative composizioni farmaceutiche
CA2263846A1 (en) Novel pyranoside derivatives
IS3947A (is) Amínósýru afleiður, aðferð til framleiðslu þeirraog notkunar sem lyfja
IT1214729B (it) Derivati di acido tiofenacetico,procedimento per la loro preparazione, composizioni farmaceutiche che licontengono e loro impiego come medicamenti
RU94015603A (ru) Производные 3-гидроксиантраниловой кислоты, способ их получения, фармацевтическая композиция, способ лечения и промежуточные соединения
NZ232153A (en) Carboxylic acid derivatives, preparation, and pharmaceutical compositions
RU93057886A (ru) Производные 2-тиенилимидазо (2,1-b) бензтиазол-3-уксусной кислоты, способ их получения и фармацевтическая композиция на их основе
ITMI931657A1 (it) Amidi di acidi biliari, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
ES2196566T3 (es) Nuevos compuestos triciclicos de aminooxiamida inhibidores de la farnesil-proteina-transferasa.
IT8819510A0 (it) Derivato di amminoacido della serie d, sua preparazione e composizioni farmaceutiche che lo contengono per il trattamento del rallentato metabolismo cerebrale.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition