DE69512229T2 - Verbindungen, die ein michael-akzeptor-system enthalten, bevorzugt maleimid- oder maleinsäure-derivate, das direkt oder indirekt mit einer chromophoren gruppe verknüpft ist und deren verwendung in sonnenschutzmitteln mit lang anhaltendem schutz - Google Patents

Verbindungen, die ein michael-akzeptor-system enthalten, bevorzugt maleimid- oder maleinsäure-derivate, das direkt oder indirekt mit einer chromophoren gruppe verknüpft ist und deren verwendung in sonnenschutzmitteln mit lang anhaltendem schutz

Info

Publication number
DE69512229T2
DE69512229T2 DE69512229T DE69512229T DE69512229T2 DE 69512229 T2 DE69512229 T2 DE 69512229T2 DE 69512229 T DE69512229 T DE 69512229T DE 69512229 T DE69512229 T DE 69512229T DE 69512229 T2 DE69512229 T2 DE 69512229T2
Authority
DE
Germany
Prior art keywords
michael acceptor
maleimid
long
maleic acid
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69512229T
Other languages
German (de)
English (en)
Other versions
DE69512229D1 (de
Inventor
Bruce Davison
Bryan Jones
Charon Ganellin
Paul Bishop
David Vanguard Medica Lim Jack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis Development Ltd
Original Assignee
Vanguard Medica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanguard Medica Ltd filed Critical Vanguard Medica Ltd
Application granted granted Critical
Publication of DE69512229D1 publication Critical patent/DE69512229D1/de
Publication of DE69512229T2 publication Critical patent/DE69512229T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/94—Involves covalent bonding to the substrate

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Coloring (AREA)
DE69512229T 1994-05-06 1995-05-09 Verbindungen, die ein michael-akzeptor-system enthalten, bevorzugt maleimid- oder maleinsäure-derivate, das direkt oder indirekt mit einer chromophoren gruppe verknüpft ist und deren verwendung in sonnenschutzmitteln mit lang anhaltendem schutz Expired - Fee Related DE69512229T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9408994A GB9408994D0 (en) 1994-05-06 1994-05-06 Compounds
PCT/GB1995/001035 WO1995030646A1 (en) 1994-05-06 1995-05-09 Compounds containing a michael-acceptor, especially maleimide or maleic acid derivatives, directly or indirectly linked to a chromophore and their use in long lasting sunscreen compositions

Publications (2)

Publication Number Publication Date
DE69512229D1 DE69512229D1 (de) 1999-10-21
DE69512229T2 true DE69512229T2 (de) 2000-04-20

Family

ID=10754654

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69512229T Expired - Fee Related DE69512229T2 (de) 1994-05-06 1995-05-09 Verbindungen, die ein michael-akzeptor-system enthalten, bevorzugt maleimid- oder maleinsäure-derivate, das direkt oder indirekt mit einer chromophoren gruppe verknüpft ist und deren verwendung in sonnenschutzmitteln mit lang anhaltendem schutz

Country Status (20)

Country Link
US (1) US5877204A (ru)
EP (1) EP0758314B1 (ru)
JP (1) JPH10502338A (ru)
CN (1) CN1149866A (ru)
AT (1) ATE184592T1 (ru)
AU (1) AU698618B2 (ru)
BR (1) BR9507624A (ru)
CA (1) CA2189337A1 (ru)
DE (1) DE69512229T2 (ru)
DK (1) DK0758314T3 (ru)
ES (1) ES2137511T3 (ru)
FI (1) FI964444A (ru)
GB (1) GB9408994D0 (ru)
GR (1) GR3032104T3 (ru)
IL (1) IL113639A0 (ru)
NO (1) NO310718B1 (ru)
NZ (1) NZ285132A (ru)
RU (1) RU2162838C2 (ru)
WO (1) WO1995030646A1 (ru)
ZA (1) ZA953655B (ru)

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US6284258B1 (en) 1997-12-08 2001-09-04 Arizona Board Of Regents Long-acting, chemical-resistant skin emollients, moisturizers, and strengtheners
US7601691B2 (en) * 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
CN1496252A (zh) 2001-03-07 2004-05-12 包括1,2-杂原子组成的双烯化妆品键合剂的局部组合物
WO2002072061A2 (en) 2001-03-07 2002-09-19 The Procter & Gamble Company Topical composition comprising an aldehyde or ketone-based cosmetic bonding agent
CN1538834A (zh) 2001-03-07 2004-10-20 包括功能性烷基化化妆品键合剂的局部组合物
MXPA03008106A (es) 2001-03-07 2003-12-12 Procter & Gamble Composicion topica que comprende un agente cosmetico enlazante a base de imidocarbonato ciclico.
JP2004520428A (ja) 2001-03-07 2004-07-08 ザ プロクター アンド ギャンブル カンパニー ジアゾニウム塩に基づく化粧品結合剤を含む局所用組成物
MXPA03008108A (es) 2001-03-07 2003-12-12 Procter & Gamble Composicion topica que comprende un agente cosmetico enlazante de derivado aromatico funcional.
MXPA03008104A (es) 2001-03-07 2003-12-12 Procter & Gamble Composicion topica que contiene un agente cosmetico enlazante con funcion acilante.
MXPA03008100A (es) 2001-03-07 2003-12-12 Procter & Gamble Composicion topica que comprende un agente cosmetico enlazante con base de compuesto ciclico de tres miembros.
CA2448229A1 (en) 2001-03-07 2002-09-19 The Procter & Gamble Company Topical composition comprising a functionalized acid anhydride-based cosmetic bonding agent
CA2448065A1 (en) 2001-05-30 2002-12-05 The Procter & Gamble Company Topical cosmetic composition comprising an alpha-beta-unsaturated ester as bonding agent
EP1392235A2 (en) * 2001-05-30 2004-03-03 The Procter & Gamble Company Topical composition comprising an activated, trans-structured cosmetic bonding agent
MXPA05001961A (es) * 2002-08-30 2005-04-28 Isp Investments Inc Polimeros de sensacion natural.
DE10358432B4 (de) * 2003-12-13 2005-12-01 Ziegler Mechanische Werkstatt, Metallgewebe Und Arbeitsschutz Gmbh Federspanner
US8591885B2 (en) * 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US7022861B1 (en) 2004-06-10 2006-04-04 Sandia National Laboratories Thermally cleavable surfactants
DE102004039281A1 (de) 2004-08-13 2006-02-23 Merck Patent Gmbh UV Filter
DE102005047647A1 (de) 2005-10-05 2007-04-12 Merck Patent Gmbh a,a'-Dihydroxyketonderivate und deren Verwendung als UV-Filter
DE102005058542A1 (de) * 2005-12-08 2007-06-14 Merck Patent Gmbh Erythruloseester als UV Filter
US20090099074A1 (en) * 2007-01-10 2009-04-16 Conjuchem Biotechnologies Inc. Modulating food intake
JP5119767B2 (ja) * 2007-07-05 2013-01-16 コニカミノルタアドバンストレイヤー株式会社 光学フィルム、偏光板、その製造方法及び液晶表示装置
US20100158829A1 (en) * 2008-12-24 2010-06-24 Conopco, Inc., D/B/A Unilever Method and Composition for Color Modulation
US10912761B2 (en) 2012-11-30 2021-02-09 The University Of Chicago Methods and compositions involving RAD51 inhibitors
US11229590B2 (en) * 2018-10-25 2022-01-25 Yimin Sun Sunscreen formulation
TWI692467B (zh) * 2018-12-28 2020-05-01 健裕生技股份有限公司 促進心肌再生之化合物、其製法、醫藥品及其用途
JP6768868B2 (ja) * 2019-03-29 2020-10-14 健裕生技股▲分▼有限公司 心筋再生を促進させるための化合物、その調製方法及びこれらの使用
US11124472B2 (en) 2019-04-08 2021-09-21 Genhealth Pharma Co., Ltd. Myocardial regeneration promoting compounds, preparation method thereof, and pharmaceutical composition
JP2023507516A (ja) * 2019-12-19 2023-02-22 スキノシヴ 接着性光防護化合物及びその使用
JP2020164528A (ja) * 2020-04-28 2020-10-08 健裕生技股▲分▼有限公司 心筋再生を促進させるための化合物、その調製方法、医薬組成物及びこれらの使用
WO2023247598A1 (en) * 2022-06-22 2023-12-28 Skinosive Multi-photoprotective compounds and uses thereof

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Publication number Priority date Publication date Assignee Title
US3322817A (en) * 1963-03-15 1967-05-30 Nat Starch Chem Corp Aromatic and aliphatic esters of hydroxy benzophenone derivatives
US3489739A (en) * 1966-09-08 1970-01-13 Rohm & Haas Novel carboalkoxyphenyl acrylates and polymers thereof
FR1568382A (ru) * 1968-04-09 1969-05-23
US3751449A (en) * 1969-06-26 1973-08-07 Minnesota Mining & Mfg Cycloaliphatic and phenylalkyl acrylates and vinyl esters
FR2278331A1 (fr) * 1974-01-24 1976-02-13 Roussel Uclaf Nouveaux acides carboxyliques et leurs derives, leur application comme medicaments et leur procede de preparation
US4999186A (en) * 1986-06-27 1991-03-12 The Procter & Gamble Company Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn
JP2883107B2 (ja) * 1989-07-10 1999-04-19 塩野義製薬株式会社 紫外線吸収皮膚保護剤組成物

Also Published As

Publication number Publication date
NO964675L (no) 1997-01-06
BR9507624A (pt) 1997-10-07
AU2413695A (en) 1995-11-29
ATE184592T1 (de) 1999-10-15
EP0758314A1 (en) 1997-02-19
ZA953655B (en) 1996-11-05
EP0758314B1 (en) 1999-09-15
US5877204A (en) 1999-03-02
NO310718B1 (no) 2001-08-20
NZ285132A (en) 1999-06-29
WO1995030646A1 (en) 1995-11-16
DK0758314T3 (da) 2000-03-27
FI964444A0 (fi) 1996-11-05
ES2137511T3 (es) 1999-12-16
CN1149866A (zh) 1997-05-14
CA2189337A1 (en) 1995-11-16
GB9408994D0 (en) 1994-06-22
RU2162838C2 (ru) 2001-02-10
DE69512229D1 (de) 1999-10-21
IL113639A0 (en) 1995-08-31
AU698618B2 (en) 1998-11-05
FI964444A (fi) 1997-01-03
GR3032104T3 (en) 2000-03-31
JPH10502338A (ja) 1998-03-03
NO964675D0 (no) 1996-11-05

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