DE69430126D1 - Cyclodextrine zur reduzierung des durch zytotoxische substanzen verursachten gefässaustritts - Google Patents
Cyclodextrine zur reduzierung des durch zytotoxische substanzen verursachten gefässaustrittsInfo
- Publication number
- DE69430126D1 DE69430126D1 DE69430126T DE69430126T DE69430126D1 DE 69430126 D1 DE69430126 D1 DE 69430126D1 DE 69430126 T DE69430126 T DE 69430126T DE 69430126 T DE69430126 T DE 69430126T DE 69430126 D1 DE69430126 D1 DE 69430126D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- cytotoxic
- cyclodextrin
- reducing
- ulceration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nanotechnology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Crystallography & Structural Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11672493A | 1993-09-03 | 1993-09-03 | |
US08/297,249 US5602112A (en) | 1992-06-19 | 1994-08-26 | Pharmaceutical formulation |
PCT/US1994/009879 WO1995006485A1 (en) | 1993-09-03 | 1994-09-02 | Improved pharmaceutical formulation |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69430126D1 true DE69430126D1 (de) | 2002-04-18 |
DE69430126T2 DE69430126T2 (de) | 2002-08-01 |
Family
ID=26814548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69430126T Expired - Fee Related DE69430126T2 (de) | 1993-09-03 | 1994-09-02 | Cyclodextrine zur reduzierung des durch zytotoxische substanzen verursachten gefässaustritts |
Country Status (13)
Country | Link |
---|---|
US (6) | US5602112A (de) |
EP (1) | EP0717638B1 (de) |
JP (1) | JPH09502185A (de) |
AT (1) | ATE214290T1 (de) |
AU (1) | AU7718694A (de) |
CA (1) | CA2172159C (de) |
DE (1) | DE69430126T2 (de) |
DK (1) | DK0717638T3 (de) |
ES (1) | ES2171462T3 (de) |
HU (1) | HUT73778A (de) |
IL (1) | IL110825A0 (de) |
PT (1) | PT717638E (de) |
WO (1) | WO1995006485A1 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602112A (en) * | 1992-06-19 | 1997-02-11 | Supergen, Inc. | Pharmaceutical formulation |
US20040014695A1 (en) * | 1992-06-19 | 2004-01-22 | Supergen, Inc. | Pharmaceutical formulation |
EP0865789B1 (de) * | 1993-03-26 | 2005-03-16 | Franciscus Wilhelmus Henricus Maria Merkus | Pharmazeutische Zusammensetzungen zur intranasalen Verabreichung von Dihydroergotamin |
DK0914102T3 (da) | 1996-05-24 | 2006-01-09 | Angiotech Pharm Inc | Præparater og fremgangsmåder til behandling eller forebyggelse af syddomme i legemskanaler |
AU741439B2 (en) | 1996-12-30 | 2001-11-29 | Battelle Memorial Institute | Formulation and method for treating neoplasms by inhalation |
US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
HUP9701945A3 (en) * | 1997-11-10 | 2000-04-28 | Hexal Ag | Pharmaceutical composition for injection containing cyclodextrin and taxoids |
US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
GB9921958D0 (en) * | 1999-09-16 | 1999-11-17 | Pharmacia & Upjohn Spa | Formulations for parenteral use of estramustine phosphate and sulfoalkylether-cyclodextrins |
GB9921954D0 (en) * | 1999-09-16 | 1999-11-17 | Pharmacia & Upjohn Spa | Formulations for parenteral use of estramustine phosphate with improved pharmacological properties |
SI1278549T1 (sl) * | 2000-05-02 | 2009-04-30 | Theravance Inc | Sestavek, ki vsebuje ciklodekstrin in glikopeptidni antibiotik |
WO2001083520A2 (en) * | 2000-05-02 | 2001-11-08 | Theravance,Inc | Polyacid glycopeptide derivatives |
US6872804B2 (en) * | 2000-06-22 | 2005-03-29 | Theravance, Inc. | Glycopeptide disulfide and thioester derivatives |
AU2001259303A1 (en) * | 2000-06-22 | 2002-01-02 | Advanced Medicine, Inc. | Glycopeptide carboxy-saccharide derivatives |
WO2001098329A1 (en) | 2000-06-22 | 2001-12-27 | Theravance, Inc. | Polyhydroxy glycopeptide derivatives |
UA75083C2 (uk) * | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Похідні глікопептидфосфонатів |
US6468989B1 (en) * | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
PE20020300A1 (es) * | 2000-08-22 | 2002-05-10 | Pharmacia Corp | Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco |
IT1318689B1 (it) * | 2000-09-12 | 2003-08-27 | Pharmacia & Upjohn Spa | Uso dell'arginina nella preparazione di un medicamento per lapreparazione e trattamento degli effetti collaterali associati alla |
US6884885B2 (en) | 2000-12-21 | 2005-04-26 | Cerestar Holding B.V. | Production of cyclodextrin complexes |
US20020197261A1 (en) * | 2001-04-26 | 2002-12-26 | Chun Li | Therapeutic agent/ligand conjugate compositions, their methods of synthesis and use |
US6528076B2 (en) | 2001-07-06 | 2003-03-04 | Magic Herb Corp. | Topical compositions and methods for treating pain |
GB0127677D0 (en) * | 2001-11-19 | 2002-01-09 | Vianex S A | Inclusion complex |
US7261875B2 (en) * | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
US6828311B2 (en) | 2002-05-29 | 2004-12-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Formulation for the parenteral application of a sodium channel blocker |
BR0314068A (pt) * | 2002-09-05 | 2005-07-05 | Bharat Serums & Vaccines Ltd | Processo para a preparação de uma composição estável com baixo nìvel de toxicidade; composição estável que contém oxazafosforina; uso de uma composição estável que contém oxazafosforina; e método de tratamento de uma doença maligna |
US7157446B2 (en) * | 2003-05-02 | 2007-01-02 | Bristol Myers Squibb Company | Complex of ras-farnesyltransferase inhibitor, a cyclodextrin, and ethanol |
LT1713504T (lt) * | 2004-01-30 | 2017-09-11 | Zoetis Services Llc | Antimikrobinis konservantas, skirtas multi-dozinėms kompozicijoms, panaudojant beta-ciklodekstrinus, skirtas skystoms vaisto formoms |
AU2006341131A1 (en) * | 2005-10-14 | 2007-10-04 | Janssen Pharmaceutica, N.V. | Formulations of tipifarnib for intravenous administration |
CN100411688C (zh) * | 2006-09-12 | 2008-08-20 | 南京师范大学 | 含有环糊精/多烯紫杉醇包合物的药物组合物及其制备方法 |
CN100486645C (zh) | 2006-09-12 | 2009-05-13 | 南京师范大学 | 含有环糊精紫杉醇包合物的药物组合物及其制备方法 |
US8455471B2 (en) | 2006-10-20 | 2013-06-04 | Icos Corporation | Compositions of CHK1 inhibitors and cyclodextrin |
US20100021400A1 (en) * | 2008-04-25 | 2010-01-28 | Rhode Island Hospital | Active Sunscreen Composition |
CN102421451B (zh) | 2009-02-25 | 2013-11-06 | 休普拉特克药品有限公司 | 苯达莫司汀环多糖组合物 |
NZ596515A (en) | 2009-05-29 | 2014-03-28 | Cydex Pharmaceuticals Inc | Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same |
US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
US8389558B2 (en) * | 2009-07-20 | 2013-03-05 | Supratek Pharma Inc. | Bendamustine amphiphilic anionic compositions |
US20110015245A1 (en) * | 2009-07-20 | 2011-01-20 | Valery Alakhov | Bendamustine amphiphilic cationic compositions |
TWI438009B (zh) * | 2010-02-19 | 2014-05-21 | Teikoku Pharma Usa Inc | 紫杉烷前-乳劑調配物及其製造與使用之方法 |
CN109745287A (zh) | 2010-05-03 | 2019-05-14 | 帝国制药美国公司 | 非水性紫杉烷前-乳剂制剂以及制备和使用该制剂的方法 |
US8383663B2 (en) | 2010-07-19 | 2013-02-26 | Supratek Pharma Inc. | Bendamustine anionic-catioinic cyclopolysaccharide compositions |
JP2014526512A (ja) * | 2011-09-18 | 2014-10-06 | ユーロ−セルティーク エス.エイ. | 医薬組成物 |
TWI573792B (zh) | 2012-02-01 | 2017-03-11 | 歐陸斯迪公司 | 新穎治療劑 |
JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
WO2015017803A1 (en) * | 2013-08-02 | 2015-02-05 | Children's Hospital Medical Center | Compositions and methods for treating disease states associated with activated t cells and/or b cells |
US9919002B2 (en) | 2013-10-21 | 2018-03-20 | North Carolina State University | Methods and constructs for compound delivery |
RU2587716C2 (ru) * | 2014-01-14 | 2016-06-20 | Борис Игоревич Круглый | Стабильный фармацевтический состав на основе актиномицина д для инъекций |
GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
CA3040155C (en) | 2016-10-11 | 2024-01-16 | Euro-Celtique S.A. | Compound for use in the treatment of hodgkin lymphoma |
GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
GB201709405D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5735189B2 (de) * | 1972-01-06 | 1982-07-27 | ||
US4024223A (en) * | 1972-11-11 | 1977-05-17 | Teijin Limited | Stripe composition and method of reducing smell associated therewith |
JPS53136513A (en) * | 1977-05-06 | 1978-11-29 | Ono Pharmaceut Co Ltd | Stabilization of prostaglandin-x-related compounds |
HU176215B (en) * | 1978-01-27 | 1981-01-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing a cyclodextrin-indomethacin inclusion complex with a ratio of at about 2:1 |
JPS54115368A (en) * | 1978-03-01 | 1979-09-07 | Ono Pharmaceut Co Ltd | Prostaglandin i2 analog, its preparation, and drug composition containing it as active constituent |
GB2017699B (en) * | 1978-03-31 | 1983-01-12 | Ono Pharmaceutical Co | 6,9-methano-pgi2 analogues |
US4352793A (en) * | 1979-04-26 | 1982-10-05 | Sumitomo Chemical Company, Limited | Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin |
JPS6033430B2 (ja) * | 1980-05-12 | 1985-08-02 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
NZ199543A (en) * | 1981-01-23 | 1985-04-30 | Wellcome Found | Inclusion complexes of cyclodextrins and cardiac clycosides;pharmaceutical formulations |
US4407795A (en) * | 1981-07-16 | 1983-10-04 | American Cyanamid Company | Inclusion compound of p-hexadecylamino benzoic acid in cyclodextrin and method of use |
JPS5813541A (ja) * | 1981-07-16 | 1983-01-26 | Kureha Chem Ind Co Ltd | エイコサペンタエン酸又はドコサヘキサエン酸のシクロデキストリン包接化合物 |
JPS5838250A (ja) * | 1981-09-01 | 1983-03-05 | Teikoku Chem Ind Corp Ltd | 複合体 |
JPS58126810A (ja) * | 1981-12-24 | 1983-07-28 | Kaken Pharmaceut Co Ltd | 抗炎症眼科用液剤およびその製法 |
US4383992A (en) * | 1982-02-08 | 1983-05-17 | Lipari John M | Water-soluble steroid compounds |
JPS58177949A (ja) * | 1982-04-12 | 1983-10-18 | Takeda Chem Ind Ltd | ランカシジン群抗生物質包接化合物 |
US4659696A (en) * | 1982-04-30 | 1987-04-21 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition and its nasal or vaginal use |
DE3315356A1 (de) * | 1982-04-30 | 1983-11-17 | Ono Pharmaceutical Co. Ltd., Osaka | Verwendung von prostaglandinanalogen |
US4425336A (en) * | 1982-05-24 | 1984-01-10 | Key Pharmaceuticals, Inc. | 3,4-Dihydroxy-N-[3-(4-dihydroxyphenyl)-1-methyl-n-propyl]-beta-phenethylamine cyclodextrin complexes |
US4424209A (en) * | 1982-06-21 | 1984-01-03 | Key Pharmaceuticals, Inc. | 3,4-Di-isobutyryloxy-N- 3-(4-isobutyryloxyphenyl)-1-methyl-n-propyl!-beta-phenethylamine cyclodextrin complexes |
JPS5910510A (ja) * | 1982-07-08 | 1984-01-20 | Nippon Zenyaku Kogyo Kk | 低刺激性チアムリン注射剤 |
JPS5920230A (ja) * | 1982-07-19 | 1984-02-01 | チバ−ガイギ−・アクチエンゲゼルシヤフト | ピルプロフエン含有薬剤 |
HU190818B (en) * | 1982-11-09 | 1986-11-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Process for producing complexes of piperonyl-butoxide-cyclodextrin |
JPS6025967A (ja) * | 1983-07-21 | 1985-02-08 | Eisai Co Ltd | トリパミド包接化合物 |
US4751095A (en) * | 1983-07-28 | 1988-06-14 | Karl Curtis L | Aspartame stabilization with cyclodextrin |
JPS6081166A (ja) * | 1983-10-11 | 1985-05-09 | Fujisawa Pharmaceut Co Ltd | 2−ニトロオキシメチル−6−クロロピリジンのβ−シクロデキストリン包接化合物およびその製造法 |
IT1196033B (it) * | 1984-02-22 | 1988-11-10 | Chiesi Farma Spa | Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche |
US4675395A (en) * | 1984-03-14 | 1987-06-23 | Seiwa Technological Laboratories Limited | Cyclodextrin inclusion compound and process for its preparation |
US4596795A (en) * | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
JPS61207380A (ja) * | 1985-03-11 | 1986-09-13 | Taiyo Yakuhin Kogyo Kk | モベンゾキサミンの経口製剤 |
JPS61286318A (ja) * | 1985-06-13 | 1986-12-16 | Ichiro Shibauchi | 浴剤の製造方法 |
US4663316A (en) * | 1985-06-28 | 1987-05-05 | Warner-Lambert Company | Antibiotic clathrates and pharmaceutical compositions thereof |
US4728509A (en) * | 1985-08-19 | 1988-03-01 | Takeda Chemical Industries, Ltd. | Aqueous liquid preparation |
US4623641A (en) * | 1985-09-09 | 1986-11-18 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | Method of treating ulcers and erosions in the gastrointestinal system using PGI2 -methyl ester-beta cyclodextrin inclusion complexes |
US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
EP1004318A3 (de) * | 1991-06-21 | 2002-08-07 | Takeda Chemical Industries, Ltd. | Zyklodextrin-zusammensetzung |
JP3176716B2 (ja) * | 1991-06-21 | 2001-06-18 | 武田薬品工業株式会社 | 溶解性が向上した難水溶性薬物組成物 |
US5602112A (en) * | 1992-06-19 | 1997-02-11 | Supergen, Inc. | Pharmaceutical formulation |
JPH06157330A (ja) * | 1992-11-27 | 1994-06-03 | Ensuiko Sugar Refining Co Ltd | タキソールのサイクロデキストリン包接物,その製造法と用途 |
-
1994
- 1994-08-26 US US08/297,249 patent/US5602112A/en not_active Expired - Lifetime
- 1994-08-30 IL IL11082594A patent/IL110825A0/xx unknown
- 1994-09-02 JP JP7508268A patent/JPH09502185A/ja active Pending
- 1994-09-02 ES ES94927983T patent/ES2171462T3/es not_active Expired - Lifetime
- 1994-09-02 CA CA002172159A patent/CA2172159C/en not_active Expired - Fee Related
- 1994-09-02 DE DE69430126T patent/DE69430126T2/de not_active Expired - Fee Related
- 1994-09-02 WO PCT/US1994/009879 patent/WO1995006485A1/en active IP Right Grant
- 1994-09-02 HU HU9600612A patent/HUT73778A/hu unknown
- 1994-09-02 AT AT94927983T patent/ATE214290T1/de active
- 1994-09-02 PT PT94927983T patent/PT717638E/pt unknown
- 1994-09-02 DK DK94927983T patent/DK0717638T3/da active
- 1994-09-02 AU AU77186/94A patent/AU7718694A/en not_active Abandoned
- 1994-09-02 EP EP94927983A patent/EP0717638B1/de not_active Expired - Lifetime
-
1997
- 1997-02-03 US US08/790,223 patent/US5804568A/en not_active Expired - Lifetime
-
1998
- 1998-08-28 US US09/143,412 patent/US6048845A/en not_active Expired - Lifetime
-
1999
- 1999-07-02 US US09/347,096 patent/US6218374B1/en not_active Expired - Fee Related
-
2000
- 2000-10-05 US US09/684,375 patent/US6284747B1/en not_active Expired - Fee Related
-
2001
- 2001-08-23 US US09/938,473 patent/US6583125B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20020058634A1 (en) | 2002-05-16 |
US6048845A (en) | 2000-04-11 |
CA2172159C (en) | 2003-07-29 |
HUT73778A (en) | 1996-09-30 |
JPH09502185A (ja) | 1997-03-04 |
ATE214290T1 (de) | 2002-03-15 |
US6583125B2 (en) | 2003-06-24 |
DE69430126T2 (de) | 2002-08-01 |
US6218374B1 (en) | 2001-04-17 |
ES2171462T3 (es) | 2002-09-16 |
EP0717638A1 (de) | 1996-06-26 |
AU7718694A (en) | 1995-03-22 |
DK0717638T3 (da) | 2002-07-01 |
WO1995006485A1 (en) | 1995-03-09 |
US5602112A (en) | 1997-02-11 |
US5804568A (en) | 1998-09-08 |
CA2172159A1 (en) | 1995-03-09 |
IL110825A0 (en) | 1995-05-26 |
US6284747B1 (en) | 2001-09-04 |
HU9600612D0 (en) | 1996-05-28 |
EP0717638B1 (de) | 2002-03-13 |
PT717638E (pt) | 2002-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69430126D1 (de) | Cyclodextrine zur reduzierung des durch zytotoxische substanzen verursachten gefässaustritts | |
KR950702994A (ko) | 탁솔과 복합된, 단백질 키나제 억제제 및 관련 화합물(protein kinase inhibitors and related compounds combined with taxol) | |
ATE87319T1 (de) | Inklusionskomplexe von 7-isopropoxy-isoflavon mit cyclodextrinen, verfahren zu deren herstellung und diese inklusionskomplexe enthaltende pharmazeutische praeparate. | |
CA2159450A1 (en) | 1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors | |
TR199901127T2 (xx) | Antibakteriyel etkili 6-O-ikameli ketolitler. | |
WO2001072721A3 (en) | Synergistic methods and compositions for treating cancer | |
WO2000044761A3 (en) | Ketolide antibiotics | |
DE69413237D1 (en) | Plättchenaggregationsinhibitoren | |
AU678344B2 (en) | Lipophilic oligosaccharide antibiotic salt compositions | |
KR960013370A (ko) | 트리글리세리드 과다 방지 조성물 | |
KR987000322A (ko) | 신규 안트라시클린 화합물 유도체 및 이를 함유하는 의약 제제(novel anthracycline compound derivative and pharmaceutical preparation containing the same) | |
BR0212036A (pt) | Composições farmacêuticas compreendendo conjugados de polissacarìdeos para a inibição da metástase ou prevenção da recorrência de tumor maligno | |
CA2140927A1 (en) | Platelet aggregation inhibitors | |
WO1996023771A3 (en) | Platelet aggregation inhibitors | |
ATE140458T1 (de) | Imidazole derivate und diese enthaltende arzneimittel | |
NZ242155A (en) | 4-aminobutoxyphosphonic acid derivatives, their preparation using streptomyces platensis, and pharmaceutical compositions | |
GEP20032970B (en) | Pharmaceutical Compositions of Tizoxanide and Nitazoxanide | |
TNSN00211A1 (fr) | Derives d'hygromycine a nouveaux, compositions les contenant et leur utilisation | |
DE69902925D1 (de) | Ramoplaninhaltige neue injizierbare arzneizubereitungen | |
WO2002024711A1 (fr) | Nouveaux composes bicycliques thiazole | |
PT777471E (pt) | Metodo de inibicao da biosintese de leucotrieno | |
AR004223A1 (es) | Composiciones para inhibir la agregacion de plaquetas y el uso de las mismas en la manufactura de un medicamento. | |
RU92016472A (ru) | Противовирусные средства, содержащие гетерополимолибдаты, способ лечения или профилактики инфекций, связанных с ретровирусом, применение гетерополимолибдатов для получения лекарственных средств, гетерополимолибдаты |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: SUPERGEN, INC., DUBLIN, CALIF., US |
|
8339 | Ceased/non-payment of the annual fee |