DE69409722D1 - Verfahren zur Herstellung von Diacerein - Google Patents

Verfahren zur Herstellung von Diacerein

Info

Publication number
DE69409722D1
DE69409722D1 DE69409722T DE69409722T DE69409722D1 DE 69409722 D1 DE69409722 D1 DE 69409722D1 DE 69409722 T DE69409722 T DE 69409722T DE 69409722 T DE69409722 T DE 69409722T DE 69409722 D1 DE69409722 D1 DE 69409722D1
Authority
DE
Germany
Prior art keywords
diacerein
production
carboxyanthraquinone
aloin
diacetoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69409722T
Other languages
English (en)
Other versions
DE69409722T2 (de
Inventor
Napoli Guido Di
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MEDIOM LAB
Original Assignee
MEDIOM LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27543486&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69409722(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by MEDIOM LAB filed Critical MEDIOM LAB
Publication of DE69409722D1 publication Critical patent/DE69409722D1/de
Application granted granted Critical
Publication of DE69409722T2 publication Critical patent/DE69409722T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/293—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes
DE69409722T 1993-07-30 1994-07-07 Verfahren zur Herstellung von Diacerein Expired - Lifetime DE69409722T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IT93MI001741A IT1264545B1 (it) 1993-07-30 1993-07-30 Procedimento per la preparazione della diacereina
SK44-95A SK281699B6 (sk) 1993-07-30 1995-01-12 Spôsob prípravy diacereínu
CZ199590A CZ286702B6 (en) 1993-07-30 1995-01-12 Process for preparing diacerein
US08/376,722 US5670695A (en) 1993-07-30 1995-01-23 Process for the preparation of diacerein
HU9500188A HU221980B1 (hu) 1993-07-30 1995-01-23 Eljárás diacerein előállítására és új acilezett aloin intermedier
CA002141247A CA2141247C (en) 1993-07-30 1995-01-27 Process for the preparation of diacerein

Publications (2)

Publication Number Publication Date
DE69409722D1 true DE69409722D1 (de) 1998-05-28
DE69409722T2 DE69409722T2 (de) 1998-08-13

Family

ID=27543486

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69409722T Expired - Lifetime DE69409722T2 (de) 1993-07-30 1994-07-07 Verfahren zur Herstellung von Diacerein

Country Status (12)

Country Link
US (1) US5670695A (de)
EP (1) EP0636602B1 (de)
JP (1) JP3850458B2 (de)
AT (1) ATE165335T1 (de)
CA (1) CA2141247C (de)
CZ (1) CZ286702B6 (de)
DE (1) DE69409722T2 (de)
DK (1) DK0636602T3 (de)
ES (1) ES2115814T3 (de)
HU (1) HU221980B1 (de)
IT (1) IT1264545B1 (de)
SK (1) SK281699B6 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH689279A5 (fr) * 1995-02-07 1999-01-29 Steba Beheer Bv Procédé de purification de la diacétylrhéine.
IT1283771B1 (it) * 1996-07-31 1998-04-30 Medidom Lab Procedimento per la preparazione di derivati della reina
IT1283772B1 (it) * 1996-07-31 1998-04-30 Medidom Lab Procedimento per la preparazione di reina e diacereina
IT1292132B1 (it) * 1997-06-11 1999-01-25 Synteco S R L Procedimento per la preparazione di diacereina
IT1297038B1 (it) * 1997-12-30 1999-08-03 Medidom Lab Procedimento per la preparazione di reina e suoi diacilderivati
US20070141181A1 (en) * 1998-02-13 2007-06-21 Nutramax Laboratories, Inc. Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals
US6797289B2 (en) * 1998-02-13 2004-09-28 Nutramax Laboratories, Inc. Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals
US6451771B1 (en) 1999-02-12 2002-09-17 Nutramax Laboratories, Inc. Use of anabolic agents anti-catabolic agents and antioxidant agents for protection treatment and repair of connective tissues in humans and animals
IT1312309B1 (it) * 1999-05-07 2002-04-15 Synteco Spa Procedimento per la purificazione di diacereina
AR026801A1 (es) 2000-01-12 2003-02-26 Medidom Lab Sustancias para uso en el tratamiento de la psoriasis
IT1318574B1 (it) * 2000-06-13 2003-08-27 Synteco Spa Procedimento per la purificazione di diacereina.
ITMI20022535A1 (it) * 2002-11-29 2004-05-30 Synteco Spa Procedimento per la purificazione della diacereina.
EP2060562A1 (de) 2007-11-16 2009-05-20 Laboratoire Medidom S.A. Dioxoanthracen-Sulfonat-Derivate
WO2009106909A1 (en) * 2008-02-29 2009-09-03 Laboratoire Medidom S.A. Process for the purification of diacerein
WO2009106908A1 (en) 2008-02-29 2009-09-03 Laboratoire Medidom S.A. Process for preparing rhein
WO2011030350A1 (en) 2009-09-08 2011-03-17 Lupin Limited Eco-friendly method for catalytic aerial oxidation of aloe-emodin to rheinal
CN101696164A (zh) * 2009-10-19 2010-04-21 黄再新 一步法用芦荟甙合成双醋瑞因粗品的方法
ITTO20110120A1 (it) 2011-02-11 2012-08-12 Icrom Spa Un nuovo processo di purificazione per derivati antrachinonici
CN104774150B (zh) * 2014-01-14 2017-04-12 北京万生药业有限责任公司 一种双醋瑞因晶体及其制备方法
CN112279767B (zh) * 2020-10-29 2023-02-03 陕西嘉禾生物科技股份有限公司 一种双醋瑞因的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA761627B (en) * 1976-03-16 1978-01-25 C Friedmann Improvements in or relating to the treatment of arthritis
IT1189097B (it) * 1986-05-02 1988-01-28 Proter Spa Sali di diacetilreina e loro impiego terapeutico nel trattamento dell'artrosi
DE4120989C2 (de) * 1991-06-25 1995-07-27 Madaus Ag Verfahren zur Herstellung von Diacetylrhein
US5393898A (en) * 1991-06-25 1995-02-28 Madaus Ag Method of preparing diacetyl rhein

Also Published As

Publication number Publication date
IT1264545B1 (it) 1996-10-02
EP0636602B1 (de) 1998-04-22
JPH0753462A (ja) 1995-02-28
US5670695A (en) 1997-09-23
CA2141247A1 (en) 1996-07-28
EP0636602A1 (de) 1995-02-01
HU9500188D0 (en) 1995-03-28
ES2115814T3 (es) 1998-07-01
ITMI931741A1 (it) 1995-01-30
CZ9095A3 (en) 1996-07-17
CA2141247C (en) 2004-08-31
SK4495A3 (en) 1996-08-07
ITMI931741A0 (it) 1993-07-30
DK0636602T3 (da) 1999-01-11
HUT73498A (en) 1996-08-28
DE69409722T2 (de) 1998-08-13
ATE165335T1 (de) 1998-05-15
CZ286702B6 (en) 2000-06-14
HU221980B1 (hu) 2003-03-28
SK281699B6 (sk) 2001-07-10
JP3850458B2 (ja) 2006-11-29

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