DE69333788D1 - Zwischenprodukt zur Herstellung von D-chiro-inosose und (+)-D-chiro-inositol - Google Patents

Zwischenprodukt zur Herstellung von D-chiro-inosose und (+)-D-chiro-inositol

Info

Publication number
DE69333788D1
DE69333788D1 DE69333788T DE69333788T DE69333788D1 DE 69333788 D1 DE69333788 D1 DE 69333788D1 DE 69333788 T DE69333788 T DE 69333788T DE 69333788 T DE69333788 T DE 69333788T DE 69333788 D1 DE69333788 D1 DE 69333788D1
Authority
DE
Germany
Prior art keywords
chiro
compounds
synthesis
synthon
inosose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69333788T
Other languages
English (en)
Other versions
DE69333788T2 (de
Inventor
Tomas Hudlicky
Martin Mandel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Tech Intellectual Properties Inc
Original Assignee
Virginia Tech Intellectual Properties Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intellectual Properties Inc filed Critical Virginia Tech Intellectual Properties Inc
Publication of DE69333788D1 publication Critical patent/DE69333788D1/de
Application granted granted Critical
Publication of DE69333788T2 publication Critical patent/DE69333788T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C07C29/145—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
    • C07C35/08—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings
    • C07C35/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings with more than one hydroxy group bound to the ring
    • C07C35/16—Inositols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69333788T 1992-10-05 1993-09-23 Zwischenprodukt zur Herstellung von D-chiro-inosose und (+)-D-chiro-inositol Expired - Lifetime DE69333788T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95652292A 1992-10-05 1992-10-05
US956522 1992-10-05
US97405792A 1992-11-10 1992-11-10
US974057 1992-11-10

Publications (2)

Publication Number Publication Date
DE69333788D1 true DE69333788D1 (de) 2005-05-04
DE69333788T2 DE69333788T2 (de) 2006-02-16

Family

ID=27130376

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69332542T Expired - Lifetime DE69332542T2 (de) 1992-10-05 1993-09-23 Synthesen von d-chiro-3-inosose und (+)-d-chiro-inositol
DE69333788T Expired - Lifetime DE69333788T2 (de) 1992-10-05 1993-09-23 Zwischenprodukt zur Herstellung von D-chiro-inosose und (+)-D-chiro-inositol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69332542T Expired - Lifetime DE69332542T2 (de) 1992-10-05 1993-09-23 Synthesen von d-chiro-3-inosose und (+)-d-chiro-inositol

Country Status (11)

Country Link
US (6) US5563281A (de)
EP (2) EP1225175B1 (de)
JP (1) JP4242925B2 (de)
AT (1) ATE292131T1 (de)
AU (1) AU693075B2 (de)
CA (1) CA2146353C (de)
DE (2) DE69332542T2 (de)
DK (1) DK1225175T3 (de)
MX (1) MX9306095A (de)
NZ (3) NZ314112A (de)
WO (1) WO1994007897A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5442079A (en) * 1993-05-10 1995-08-15 Virginia Polytechnic Institute And State University Method for preparing erythruronolactone
JP2001163810A (ja) * 1999-09-30 2001-06-19 Microbial Chem Res Found １ｄ−キロ−イノシトールの新規合成方法および中間体
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
CN103301094A (zh) * 2004-11-17 2013-09-18 乔安妮·麦克劳林 用于治疗蛋白聚集疾病的含鲨肌醇衍生物的组合物和方法
WO2007119108A2 (en) * 2005-10-13 2007-10-25 Waratah Pharmaceuticals Inc. Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence
US20070197452A1 (en) * 2006-02-17 2007-08-23 Mclaurin Joanne Treatment of amyloid-related diseases
BRPI0708725A2 (pt) * 2006-03-09 2011-06-07 Waratah Pharmaceuticals Inc formulação de poliálcool de ciclohexano para o tratamento de doenças de agregação de proteìna
CA2652449A1 (en) * 2006-05-19 2007-11-29 Waratah Pharmaceuticals Inc. Screening methods for amyloid beta modulators
US20100173960A1 (en) * 2006-09-21 2010-07-08 Antonio Cruz The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases
US20090214474A1 (en) * 2006-11-01 2009-08-27 Barbara Brooke Jennings Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
KR100748210B1 (ko) * 2006-11-21 2007-08-09 주식회사 카이로켐 디-카이로-이노시톨의 제조방법
JP2010510254A (ja) * 2006-11-24 2010-04-02 ワラタ ファーマシューティカルズ， インコーポレイテッド アルツハイマー病および関連の神経変性疾患のための併用処置
EP2148667B1 (de) * 2007-04-12 2013-05-22 Waratah Pharmaceuticals, Inc. Verwendung von cyclohexanhexol-derivaten bei der behandlung von augenerkrankungen
US20100331267A1 (en) * 2007-04-12 2010-12-30 Mclaurin Joanne Use of cyclohexanehexol derivatives in the treatment of alpha-synucleinopathies
WO2008124931A1 (en) * 2007-04-12 2008-10-23 Joanne Mclaurin Use of cyclohexanehexol derivatives in the treatment of amyotrophic lateral sclerosis
CA2683548A1 (en) * 2007-04-12 2008-10-23 Joanne Mclaurin Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases
US20100093648A1 (en) * 2008-10-09 2010-04-15 Antonio Cruz Treatment of macular degeneration-related disorders
DE102014006563B4 (de) * 2014-05-07 2017-05-11 Nb Technologies Gmbh Imprintstempel sowie Verfahren zur Herstellung und Anwendung eines Imprintstempels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3065636B2 (ja) * 1989-06-29 2000-07-17 塩野義製薬株式会社 ［ジ―ｔｅｒｔ―ブチル（ヒドロキシ）フェニルチオ］置換ヒドロキサム酸誘導体
US5200516A (en) * 1990-02-16 1993-04-06 Virginia Tech Intellectual Properties Synthesis of sugars from substituted and unsubstituted arene diols
JPH082817B2 (ja) * 1990-04-16 1996-01-17 ヴァージニア テック インテレクチュアル プロパティーズ インコーポレイテッド 置換アレーンジオールからのシクリトールの合成
US5091596A (en) * 1990-12-20 1992-02-25 Univ. Of Va. Alumni Patents Foundation Method for producing chiro-inositol

Also Published As

Publication number Publication date
EP1225175A1 (de) 2002-07-24
WO1994007897A1 (en) 1994-04-14
DK1225175T3 (da) 2005-06-20
JP4242925B2 (ja) 2009-03-25
US5633412A (en) 1997-05-27
DE69332542T2 (de) 2003-08-14
DE69332542D1 (de) 2003-01-16
EP1225175B1 (de) 2005-03-30
NZ256610A (en) 1997-03-24
AU5139393A (en) 1994-04-26
AU693075B2 (en) 1998-06-25
CA2146353A1 (en) 1994-04-14
DE69333788T2 (de) 2006-02-16
EP0663915B1 (de) 2002-12-04
US5602263A (en) 1997-02-11
NZ314111A (en) 1997-08-22
US5600014A (en) 1997-02-04
NZ314112A (en) 1997-08-22
US5563281A (en) 1996-10-08
ATE292131T1 (de) 2005-04-15
US5602287A (en) 1997-02-11
US5578738A (en) 1996-11-26
JPH08502255A (ja) 1996-03-12
EP0663915A1 (de) 1995-07-26
CA2146353C (en) 2007-04-17
MX9306095A (es) 1994-06-30

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