DE69332542D1 - Synthesen von d-chiro-3-inosose und (+)-d-chiro-inositol - Google Patents

Synthesen von d-chiro-3-inosose und (+)-d-chiro-inositol

Info

Publication number
DE69332542D1
DE69332542D1 DE69332542T DE69332542T DE69332542D1 DE 69332542 D1 DE69332542 D1 DE 69332542D1 DE 69332542 T DE69332542 T DE 69332542T DE 69332542 T DE69332542 T DE 69332542T DE 69332542 D1 DE69332542 D1 DE 69332542D1
Authority
DE
Germany
Prior art keywords
chiro
synthesis
compounds
synthon
inosose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332542T
Other languages
English (en)
Other versions
DE69332542T2 (de
Inventor
Tomas Hudlicky
Martin C O Virginia Tec Mandel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Tech Intellectual Properties Inc
Original Assignee
Virginia Tech Intellectual Properties Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intellectual Properties Inc filed Critical Virginia Tech Intellectual Properties Inc
Publication of DE69332542D1 publication Critical patent/DE69332542D1/de
Application granted granted Critical
Publication of DE69332542T2 publication Critical patent/DE69332542T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C07C29/145—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
    • C07C35/08—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings
    • C07C35/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings with more than one hydroxy group bound to the ring
    • C07C35/16—Inositols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69332542T 1992-10-05 1993-09-23 Synthesen von d-chiro-3-inosose und (+)-d-chiro-inositol Expired - Lifetime DE69332542T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95652292A 1992-10-05 1992-10-05
US97405792A 1992-11-10 1992-11-10
PCT/US1993/009103 WO1994007897A1 (en) 1992-10-05 1993-09-23 Syntheses of d-chiro-3-inosose and (+)-d-chiro-inositol

Publications (2)

Publication Number Publication Date
DE69332542D1 true DE69332542D1 (de) 2003-01-16
DE69332542T2 DE69332542T2 (de) 2003-08-14

Family

ID=27130376

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69333788T Expired - Lifetime DE69333788T2 (de) 1992-10-05 1993-09-23 Zwischenprodukt zur Herstellung von D-chiro-inosose und (+)-D-chiro-inositol
DE69332542T Expired - Lifetime DE69332542T2 (de) 1992-10-05 1993-09-23 Synthesen von d-chiro-3-inosose und (+)-d-chiro-inositol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69333788T Expired - Lifetime DE69333788T2 (de) 1992-10-05 1993-09-23 Zwischenprodukt zur Herstellung von D-chiro-inosose und (+)-D-chiro-inositol

Country Status (11)

Country Link
US (6) US5563281A (de)
EP (2) EP1225175B1 (de)
JP (1) JP4242925B2 (de)
AT (1) ATE292131T1 (de)
AU (1) AU693075B2 (de)
CA (1) CA2146353C (de)
DE (2) DE69333788T2 (de)
DK (1) DK1225175T3 (de)
MX (1) MX9306095A (de)
NZ (3) NZ314111A (de)
WO (1) WO1994007897A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5442079A (en) * 1993-05-10 1995-08-15 Virginia Polytechnic Institute And State University Method for preparing erythruronolactone
JP2001163810A (ja) * 1999-09-30 2001-06-19 Microbial Chem Res Found １ｄ−キロ−イノシトールの新規合成方法および中間体
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
CN101102779A (zh) * 2004-11-17 2008-01-09 乔安妮·麦克劳林 用于治疗蛋白聚集疾病的含鲨肌醇衍生物的组合物和方法
JP2009511568A (ja) * 2005-10-13 2009-03-19 ワラタ ファーマシューティカルズ， インコーポレイテッド イノシトール誘導体、ならびに異常なタンパク質の折りたたみまたは凝集、あるいはアミロイドの形成、沈着、蓄積または残存を特徴とする疾患の処置におけるその使用
US20070197452A1 (en) * 2006-02-17 2007-08-23 Mclaurin Joanne Treatment of amyloid-related diseases
NZ571181A (en) * 2006-03-09 2011-12-22 Waratah Pharmaceuticals Inc A cyclohexane polyalcohol formulation for treatment of disorders of protein aggregation
WO2007134449A1 (en) * 2006-05-19 2007-11-29 Waratah Pharmaceuticals Inc. Screening methods for amyloid beta modulators
US20100173960A1 (en) * 2006-09-21 2010-07-08 Antonio Cruz The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
US20090214474A1 (en) * 2006-11-01 2009-08-27 Barbara Brooke Jennings Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
KR100748210B1 (ko) * 2006-11-21 2007-08-09 주식회사 카이로켐 디-카이로-이노시톨의 제조방법
WO2008061373A1 (en) * 2006-11-24 2008-05-29 Waratah Pharmaceuticals Inc. Combination treatments for alzheimer's disease and similar diseases
CA2683548A1 (en) * 2007-04-12 2008-10-23 Joanne Mclaurin Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases
DK2148667T3 (da) * 2007-04-12 2013-08-26 Waratah Pharmaceuticals Inc Anvendelse af cyclohexanhexolderivater til behandling af øjensygdomme
US20100144891A1 (en) * 2007-04-12 2010-06-10 Mclaurin Joanne Use of cyclohexanehexol derivatives in the treatment of amyotrophic lateral sclerosis
WO2008124929A1 (en) * 2007-04-12 2008-10-23 Joanne Mclaurin USE OF CYCLOHEXANEHEXOL DERIVATIVES IN THE TREATMENT OF α-SYNUCLEINOPATHIES
AU2009301603A1 (en) * 2008-10-09 2010-04-15 Waratah Pharmaceuticals Inc. Use of scyllo-inositols for the treatment of macular degeneration-related disorders
DE102014006563B4 (de) * 2014-05-07 2017-05-11 Nb Technologies Gmbh Imprintstempel sowie Verfahren zur Herstellung und Anwendung eines Imprintstempels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3065636B2 (ja) * 1989-06-29 2000-07-17 塩野義製薬株式会社 ［ジ―ｔｅｒｔ―ブチル（ヒドロキシ）フェニルチオ］置換ヒドロキサム酸誘導体
US5200516A (en) * 1990-02-16 1993-04-06 Virginia Tech Intellectual Properties Synthesis of sugars from substituted and unsubstituted arene diols
EP0477359B1 (de) * 1990-04-16 1995-07-05 Virginia Tech Intellectual Properties, Inc. Synthese ion cyclitolen aus substituierten arendiolen
US5091596A (en) * 1990-12-20 1992-02-25 Univ. Of Va. Alumni Patents Foundation Method for producing chiro-inositol

Also Published As

Publication number Publication date
US5602287A (en) 1997-02-11
EP1225175A1 (de) 2002-07-24
EP0663915B1 (de) 2002-12-04
CA2146353A1 (en) 1994-04-14
WO1994007897A1 (en) 1994-04-14
DE69333788T2 (de) 2006-02-16
US5602263A (en) 1997-02-11
US5633412A (en) 1997-05-27
NZ256610A (en) 1997-03-24
NZ314111A (en) 1997-08-22
JP4242925B2 (ja) 2009-03-25
CA2146353C (en) 2007-04-17
US5600014A (en) 1997-02-04
MX9306095A (es) 1994-06-30
EP0663915A1 (de) 1995-07-26
NZ314112A (en) 1997-08-22
AU5139393A (en) 1994-04-26
US5563281A (en) 1996-10-08
DE69333788D1 (de) 2005-05-04
EP1225175B1 (de) 2005-03-30
DK1225175T3 (da) 2005-06-20
US5578738A (en) 1996-11-26
AU693075B2 (en) 1998-06-25
JPH08502255A (ja) 1996-03-12
ATE292131T1 (de) 2005-04-15
DE69332542T2 (de) 2003-08-14

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