DE69332830T2 - Antiallergische triazolobenzazepinderivate - Google Patents
Antiallergische triazolobenzazepinderivate Download PDFInfo
- Publication number
- DE69332830T2 DE69332830T2 DE69332830T DE69332830T DE69332830T2 DE 69332830 T2 DE69332830 T2 DE 69332830T2 DE 69332830 T DE69332830 T DE 69332830T DE 69332830 T DE69332830 T DE 69332830T DE 69332830 T2 DE69332830 T2 DE 69332830T2
- Authority
- DE
- Germany
- Prior art keywords
- 4alkyl
- pct
- substituted
- hydroxycarbonyl
- alk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000003266 anti-allergic effect Effects 0.000 title 1
- QDEVEJYEXBFIJD-UHFFFAOYSA-N triazolo[4,5-i][1]benzazepine Chemical class C1=CC2=CC=CC=NC2=C2C1=NN=N2 QDEVEJYEXBFIJD-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92203776 | 1992-12-04 | ||
| PCT/EP1993/003320 WO1994013671A1 (en) | 1992-12-04 | 1993-11-25 | Antiallergic triazolobenzazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69332830D1 DE69332830D1 (de) | 2003-05-08 |
| DE69332830T2 true DE69332830T2 (de) | 2004-01-29 |
Family
ID=8211104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69332830T Expired - Fee Related DE69332830T2 (de) | 1992-12-04 | 1993-11-25 | Antiallergische triazolobenzazepinderivate |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5932569A (de) |
| EP (1) | EP0675887B1 (de) |
| JP (1) | JP3572074B2 (de) |
| KR (1) | KR100251893B1 (de) |
| AT (1) | ATE236164T1 (de) |
| AU (1) | AU676701B2 (de) |
| CA (1) | CA2150806C (de) |
| DE (1) | DE69332830T2 (de) |
| ES (1) | ES2196020T3 (de) |
| FI (1) | FI952722A (de) |
| HU (1) | HU223464B1 (de) |
| NO (1) | NO305250B1 (de) |
| NZ (1) | NZ258551A (de) |
| PL (1) | PL176593B1 (de) |
| RU (1) | RU2126802C1 (de) |
| WO (1) | WO1994013671A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE194350T1 (de) * | 1992-12-04 | 2000-07-15 | Janssen Pharmaceutica Nv | Antiallergisch triazolo (pyrrolo, thieno oder furano) azepinderivate |
| CN100491378C (zh) | 2001-06-12 | 2009-05-27 | 詹森药业有限公司 | 新的取代四环咪唑衍生物,其制备方法,包含它们的药物组合物及它们作为药物的用途 |
| EP1785424A3 (de) * | 2003-04-11 | 2009-12-23 | High Point Pharmaceuticals, LLC | Kondensierte 1,2,4-Triazole und deren pharmazeutische Verwendungen |
| JP2006522747A (ja) * | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 縮合１，２，４−トリアゾールの薬学的使用 |
| EP1802623A1 (de) * | 2004-10-12 | 2007-07-04 | Novo Nordisk A/S | 11beta-hydroxysteroid-dehydrogenase-typ-1-aktive spiroverbindungen |
| KR20080076916A (ko) * | 2005-11-01 | 2008-08-20 | 트랜스테크 파르마, 인크. | 치환된 아미드의 약학적 사용 |
| CN101355938A (zh) * | 2005-11-01 | 2009-01-28 | 高点制药有限责任公司 | 取代的酰胺的药学应用 |
| US20100168083A1 (en) * | 2006-03-21 | 2010-07-01 | Soren Ebdrup | Adamantane derivatives for the treatment of the metabolic syndrome |
| BRPI0710669A2 (pt) | 2006-04-07 | 2011-08-16 | High Point Pharmaceuticals Llc | compostos ativos de dehidrogenase de 11b-hidroxiesteróide tipo 1 |
| US8048908B2 (en) * | 2006-07-13 | 2011-11-01 | High Point Pharmaceuticals, Llc | 11β-hydroxysteroid dehydrogenase type 1 active compounds |
| EP1878721A1 (de) * | 2006-07-13 | 2008-01-16 | Novo Nordisk A/S | 4-Piperidylbenzamide als Inhibitoren der 11-beta-hydroxysteroiddehydrogenase Typ 1 |
| US8334305B2 (en) * | 2007-02-23 | 2012-12-18 | High Point Pharmaceuticals, Llc | N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase |
| US20110003852A1 (en) * | 2007-02-23 | 2011-01-06 | Soren Ebdrup | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| ZA200904916B (en) | 2007-02-23 | 2010-09-29 | High Point Pharmaceuticals Llc | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| US20110003856A1 (en) * | 2007-02-23 | 2011-01-06 | Soren Ebdrup | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| BRPI0721430A2 (pt) * | 2007-03-09 | 2013-01-08 | High Point Pharmaceuticals Llc | amidas indol e benzimidazol como inibidoras de hidroxiesteràide deidrogenase |
| WO2008119017A1 (en) * | 2007-03-28 | 2008-10-02 | High Point Pharmaceuticals, Llc | 11beta-hsd1 active compounds |
| US20100137377A1 (en) * | 2007-04-11 | 2010-06-03 | Soren Ebdrup Et Al | Novel compounds |
| CA2685036A1 (en) * | 2007-04-24 | 2008-11-06 | High Point Pharmaceuticals, Llc | Pharmaceutical use of substituted amides |
| ES2901114T3 (es) | 2014-08-29 | 2022-03-21 | Tes Pharma S R L | Inhibidores de ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8902591A (en) * | 1990-10-10 | 1992-05-20 | Schering Corporation | Substituted imidazobenzazepines and imidazopyridoazepines |
| IL101850A (en) * | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them |
| HU223466B1 (hu) * | 1992-12-04 | 2004-07-28 | Janssen Pharmaceutica N.V. | Allergia elleni imidazo[1,2a]tieno[2,3-d]azepin-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények |
| ATE194350T1 (de) * | 1992-12-04 | 2000-07-15 | Janssen Pharmaceutica Nv | Antiallergisch triazolo (pyrrolo, thieno oder furano) azepinderivate |
-
1993
- 1993-11-25 CA CA002150806A patent/CA2150806C/en not_active Expired - Fee Related
- 1993-11-25 HU HU9501621A patent/HU223464B1/hu not_active IP Right Cessation
- 1993-11-25 AU AU56278/94A patent/AU676701B2/en not_active Ceased
- 1993-11-25 ES ES94901886T patent/ES2196020T3/es not_active Expired - Lifetime
- 1993-11-25 US US08/433,388 patent/US5932569A/en not_active Expired - Fee Related
- 1993-11-25 AT AT94901886T patent/ATE236164T1/de not_active IP Right Cessation
- 1993-11-25 EP EP94901886A patent/EP0675887B1/de not_active Expired - Lifetime
- 1993-11-25 JP JP51372094A patent/JP3572074B2/ja not_active Expired - Fee Related
- 1993-11-25 NZ NZ258551A patent/NZ258551A/en unknown
- 1993-11-25 PL PL93309253A patent/PL176593B1/pl not_active IP Right Cessation
- 1993-11-25 DE DE69332830T patent/DE69332830T2/de not_active Expired - Fee Related
- 1993-11-25 KR KR1019950702169A patent/KR100251893B1/ko not_active IP Right Cessation
- 1993-11-25 RU RU95114439A patent/RU2126802C1/ru not_active IP Right Cessation
- 1993-11-25 WO PCT/EP1993/003320 patent/WO1994013671A1/en active IP Right Grant
-
1995
- 1995-06-02 NO NO952198A patent/NO305250B1/no unknown
- 1995-06-02 FI FI952722A patent/FI952722A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI952722A0 (fi) | 1995-06-02 |
| ES2196020T3 (es) | 2003-12-16 |
| HUT71811A (en) | 1996-02-28 |
| AU5627894A (en) | 1994-07-04 |
| JP3572074B2 (ja) | 2004-09-29 |
| JPH08503952A (ja) | 1996-04-30 |
| DE69332830D1 (de) | 2003-05-08 |
| HU9501621D0 (en) | 1995-08-28 |
| FI952722A (fi) | 1995-06-02 |
| CA2150806C (en) | 2006-01-31 |
| NZ258551A (en) | 1996-06-25 |
| HU223464B1 (hu) | 2004-07-28 |
| RU95114439A (ru) | 1997-06-10 |
| KR100251893B1 (ko) | 2000-04-15 |
| PL309253A1 (en) | 1995-10-02 |
| EP0675887B1 (de) | 2003-04-02 |
| AU676701B2 (en) | 1997-03-20 |
| NO952198D0 (no) | 1995-06-02 |
| EP0675887A1 (de) | 1995-10-11 |
| ATE236164T1 (de) | 2003-04-15 |
| NO305250B1 (no) | 1999-04-26 |
| WO1994013671A1 (en) | 1994-06-23 |
| NO952198L (no) | 1995-08-03 |
| RU2126802C1 (ru) | 1999-02-27 |
| PL176593B1 (pl) | 1999-06-30 |
| CA2150806A1 (en) | 1994-06-23 |
| US5932569A (en) | 1999-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |