NO305250B1 - Triazolbenzazepinderivater med antiallergisk virkning - Google Patents
Triazolbenzazepinderivater med antiallergisk virkningInfo
- Publication number
- NO305250B1 NO305250B1 NO952198A NO952198A NO305250B1 NO 305250 B1 NO305250 B1 NO 305250B1 NO 952198 A NO952198 A NO 952198A NO 952198 A NO952198 A NO 952198A NO 305250 B1 NO305250 B1 NO 305250B1
- Authority
- NO
- Norway
- Prior art keywords
- 4alkyl
- pct
- substituted
- hydroxycarbonyl
- alk
- Prior art date
Links
- -1 Triazole benzazepine derivatives Chemical class 0.000 title 1
- 230000003266 anti-allergic effect Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92203776 | 1992-12-04 | ||
| PCT/EP1993/003320 WO1994013671A1 (en) | 1992-12-04 | 1993-11-25 | Antiallergic triazolobenzazepine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO952198D0 NO952198D0 (no) | 1995-06-02 |
| NO952198L NO952198L (no) | 1995-08-03 |
| NO305250B1 true NO305250B1 (no) | 1999-04-26 |
Family
ID=8211104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO952198A NO305250B1 (no) | 1992-12-04 | 1995-06-02 | Triazolbenzazepinderivater med antiallergisk virkning |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5932569A (de) |
| EP (1) | EP0675887B1 (de) |
| JP (1) | JP3572074B2 (de) |
| KR (1) | KR100251893B1 (de) |
| AT (1) | ATE236164T1 (de) |
| AU (1) | AU676701B2 (de) |
| CA (1) | CA2150806C (de) |
| DE (1) | DE69332830T2 (de) |
| ES (1) | ES2196020T3 (de) |
| FI (1) | FI952722A (de) |
| HU (1) | HU223464B1 (de) |
| NO (1) | NO305250B1 (de) |
| NZ (1) | NZ258551A (de) |
| PL (1) | PL176593B1 (de) |
| RU (1) | RU2126802C1 (de) |
| WO (1) | WO1994013671A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ258553A (en) * | 1992-12-04 | 1996-06-25 | Janssen Pharmaceutica Nv | Azepine derivatives; compounds, process for preparation and pharmaceutical compositions containing such compounds |
| WO2002100862A2 (en) | 2001-06-12 | 2002-12-19 | Janssen Pharmaceutica N.V. | Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine |
| JP2006522747A (ja) * | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 縮合１，２，４−トリアゾールの薬学的使用 |
| EP1785424A3 (de) * | 2003-04-11 | 2009-12-23 | High Point Pharmaceuticals, LLC | Kondensierte 1,2,4-Triazole und deren pharmazeutische Verwendungen |
| JP2008515956A (ja) * | 2004-10-12 | 2008-05-15 | ノボ ノルディスク アクティーゼルスカブ | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型活性スピロ化合物 |
| US20090124598A1 (en) * | 2005-11-01 | 2009-05-14 | Henrik Sune Andersen | Pharmaceutical use of substituted amides |
| WO2007051811A2 (en) * | 2005-11-01 | 2007-05-10 | Transtech Pharma | Pharmaceutical use of substituted amides |
| WO2007107550A1 (en) * | 2006-03-21 | 2007-09-27 | High Point Pharmaceuticals, Llc | Adamantane derivatives for the treatment of the metabolic syndrome |
| JP2009532418A (ja) | 2006-04-07 | 2009-09-10 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型活性化合物 |
| EP1878721A1 (de) * | 2006-07-13 | 2008-01-16 | Novo Nordisk A/S | 4-Piperidylbenzamide als Inhibitoren der 11-beta-hydroxysteroiddehydrogenase Typ 1 |
| CA2657078A1 (en) * | 2006-07-13 | 2008-01-17 | High Point Pharmaceuticals, Llc | 11beta-hydroxysteroid dehydrogenase type 1 active compounds |
| US8334305B2 (en) * | 2007-02-23 | 2012-12-18 | High Point Pharmaceuticals, Llc | N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase |
| JP2010519240A (ja) * | 2007-02-23 | 2010-06-03 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | １１−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害剤としての、ｎ−アダマンチルベンズアミド |
| AU2008219326B2 (en) * | 2007-02-23 | 2012-12-13 | Vtv Therapeutics Llc | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| US20110003852A1 (en) * | 2007-02-23 | 2011-01-06 | Soren Ebdrup | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| US8153798B2 (en) * | 2007-03-09 | 2012-04-10 | High Point Pharmaceuticals, Llc | Indole- and benzimidazole amides as hydroxysteroid dehydrogenase inhibitors |
| WO2008119017A1 (en) * | 2007-03-28 | 2008-10-02 | High Point Pharmaceuticals, Llc | 11beta-hsd1 active compounds |
| CA2683852A1 (en) * | 2007-04-11 | 2008-10-23 | High Point Pharmaceuticals, Llc | Novel compounds |
| JP2010526777A (ja) * | 2007-04-24 | 2010-08-05 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | 置換アミドの医薬用途 |
| CA2959208C (en) | 2014-08-29 | 2023-09-19 | Tes Pharma S.R.L. | Pyrimidine derivatives and their use as inhibitors of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH089616B2 (ja) * | 1990-10-10 | 1996-01-31 | シェリング・コーポレーション | 置換されたイミダゾベンズアゼピン類およびイミダゾピリドアゼピン類 |
| IL101850A (en) * | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them |
| RU2134269C1 (ru) * | 1992-12-04 | 1999-08-10 | Жансен Фармасетика Н.В. | Производные имидазо/1,2а/тиено/2,3-d/азепинов, способ их получения, промежуточные для их получения, фармацевтическая композиция и способ их получения |
| NZ258553A (en) * | 1992-12-04 | 1996-06-25 | Janssen Pharmaceutica Nv | Azepine derivatives; compounds, process for preparation and pharmaceutical compositions containing such compounds |
-
1993
- 1993-11-25 ES ES94901886T patent/ES2196020T3/es not_active Expired - Lifetime
- 1993-11-25 DE DE69332830T patent/DE69332830T2/de not_active Expired - Fee Related
- 1993-11-25 HU HU9501621A patent/HU223464B1/hu not_active IP Right Cessation
- 1993-11-25 KR KR1019950702169A patent/KR100251893B1/ko not_active IP Right Cessation
- 1993-11-25 WO PCT/EP1993/003320 patent/WO1994013671A1/en active IP Right Grant
- 1993-11-25 AU AU56278/94A patent/AU676701B2/en not_active Ceased
- 1993-11-25 EP EP94901886A patent/EP0675887B1/de not_active Expired - Lifetime
- 1993-11-25 CA CA002150806A patent/CA2150806C/en not_active Expired - Fee Related
- 1993-11-25 PL PL93309253A patent/PL176593B1/pl not_active IP Right Cessation
- 1993-11-25 US US08/433,388 patent/US5932569A/en not_active Expired - Fee Related
- 1993-11-25 NZ NZ258551A patent/NZ258551A/en unknown
- 1993-11-25 RU RU95114439A patent/RU2126802C1/ru not_active IP Right Cessation
- 1993-11-25 AT AT94901886T patent/ATE236164T1/de not_active IP Right Cessation
- 1993-11-25 JP JP51372094A patent/JP3572074B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-02 NO NO952198A patent/NO305250B1/no unknown
- 1995-06-02 FI FI952722A patent/FI952722A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2150806C (en) | 2006-01-31 |
| WO1994013671A1 (en) | 1994-06-23 |
| NZ258551A (en) | 1996-06-25 |
| NO952198D0 (no) | 1995-06-02 |
| FI952722A0 (fi) | 1995-06-02 |
| ATE236164T1 (de) | 2003-04-15 |
| PL176593B1 (pl) | 1999-06-30 |
| RU2126802C1 (ru) | 1999-02-27 |
| JP3572074B2 (ja) | 2004-09-29 |
| RU95114439A (ru) | 1997-06-10 |
| DE69332830D1 (de) | 2003-05-08 |
| US5932569A (en) | 1999-08-03 |
| ES2196020T3 (es) | 2003-12-16 |
| KR100251893B1 (ko) | 2000-04-15 |
| AU676701B2 (en) | 1997-03-20 |
| AU5627894A (en) | 1994-07-04 |
| HU223464B1 (hu) | 2004-07-28 |
| NO952198L (no) | 1995-08-03 |
| CA2150806A1 (en) | 1994-06-23 |
| EP0675887B1 (de) | 2003-04-02 |
| PL309253A1 (en) | 1995-10-02 |
| EP0675887A1 (de) | 1995-10-11 |
| DE69332830T2 (de) | 2004-01-29 |
| FI952722A (fi) | 1995-06-02 |
| HUT71811A (en) | 1996-02-28 |
| JPH08503952A (ja) | 1996-04-30 |
| HU9501621D0 (en) | 1995-08-28 |
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