DE69326772D1 - Verfahren zur steigerung der arzneistoffabgabe mit modifizierten saponinen - Google Patents
Verfahren zur steigerung der arzneistoffabgabe mit modifizierten saponinenInfo
- Publication number
- DE69326772D1 DE69326772D1 DE69326772T DE69326772T DE69326772D1 DE 69326772 D1 DE69326772 D1 DE 69326772D1 DE 69326772 T DE69326772 T DE 69326772T DE 69326772 T DE69326772 T DE 69326772T DE 69326772 D1 DE69326772 D1 DE 69326772D1
- Authority
- DE
- Germany
- Prior art keywords
- saponines
- modified
- drug delivery
- increasing drug
- increasing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/906,870 US5273965A (en) | 1992-07-02 | 1992-07-02 | Methods for enhancing drug delivery with modified saponins |
PCT/US1993/006348 WO1994001118A1 (en) | 1992-07-02 | 1993-07-01 | Methods for enhancing drug delivery with modified saponins |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69326772D1 true DE69326772D1 (de) | 1999-11-18 |
DE69326772T2 DE69326772T2 (de) | 2000-06-29 |
Family
ID=25423119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69326772T Expired - Fee Related DE69326772T2 (de) | 1992-07-02 | 1993-07-01 | Verfahren zur steigerung der arzneistoffabgabe mit modifizierten saponinen |
Country Status (11)
Country | Link |
---|---|
US (2) | US5273965A (de) |
EP (1) | EP0658111B1 (de) |
JP (1) | JP3684370B2 (de) |
AU (1) | AU687005B2 (de) |
BR (1) | BR9306594A (de) |
CA (1) | CA2139437A1 (de) |
DE (1) | DE69326772T2 (de) |
FI (1) | FI946173A (de) |
HU (1) | HUT73814A (de) |
MX (1) | MX9303977A (de) |
WO (1) | WO1994001118A1 (de) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583112A (en) * | 1987-05-29 | 1996-12-10 | Cambridge Biotech Corporation | Saponin-antigen conjugates and the use thereof |
NL9002314A (nl) * | 1990-10-23 | 1992-05-18 | Nederlanden Staat | Immunogene complexen, in het bijzonder iscoms. |
US5780444A (en) * | 1991-12-13 | 1998-07-14 | Trustees Of Princeton University | Compositions and methods for cell transformation |
US5795870A (en) * | 1991-12-13 | 1998-08-18 | Trustees Of Princeton University | Compositions and methods for cell transformation |
US5693769A (en) * | 1991-12-13 | 1997-12-02 | Transcell Technologies, Inc. | Glycosylated steroid derivatives for transport across biological membranes and process for making and using same |
US5650398A (en) * | 1992-07-02 | 1997-07-22 | Cambridge Biotech Corporation | Drug delivery enhancement via modified saponins |
DK1159974T3 (da) | 1993-07-19 | 2007-11-26 | Angiotech Pharm Inc | Antiangiogene sammensætninger indeholdende taxol og en ikke-bionedbrydelig bærer og deres anvendelse |
US5397778A (en) * | 1994-02-25 | 1995-03-14 | New England Deaconess Hospital Corporation | Enteral formulations for treatment of inflammation and infection |
AU1928295A (en) * | 1994-02-25 | 1995-09-11 | New England Deaconess Hospital Corporation | Anti-inflammatory and infection protective effects of sesamin-based lignans |
US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
AUPM873294A0 (en) * | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
AU686891B2 (en) * | 1994-10-12 | 1998-02-12 | Iscotec A.B. | Saponin preparations and use thereof in iscoms |
US5962428A (en) * | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
AU773686B2 (en) * | 1996-02-21 | 2004-06-03 | Intarcia Therapeutics, Inc. | Use of cell membrane permeants in the treatment of cellular proliferative diseases |
CA2247481A1 (en) * | 1996-02-21 | 1997-08-28 | Matrix Pharmaceutical, Inc. | Use of cell membrane permeants in the treatment of cellular proliferative diseases |
DK0952771T3 (da) * | 1996-12-02 | 2008-05-19 | Antigenics Inc | Hidtil ukendte saponinpræparater og anvendelser deraf |
CA2628857C (en) | 1996-12-30 | 2011-09-13 | Batelle Memorial Institute | Formulation and method for treating neoplasms by inhalation |
US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
NZ500779A (en) * | 1997-05-20 | 2001-06-29 | Galenica Pharmaceuticals Inc | Triterpene saponin analogs having adjuvant and immunostimulatory activity |
US7153845B2 (en) | 1998-08-25 | 2006-12-26 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US8765177B2 (en) | 1997-09-12 | 2014-07-01 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US20040265377A1 (en) * | 1997-10-27 | 2004-12-30 | Harry Seager | Solid dispersing vaccine composition for oral delivery |
US20070059327A2 (en) * | 1998-01-15 | 2007-03-15 | Wyeth | Streptococcus equi compositions and methods of use |
US7070799B1 (en) * | 1998-02-10 | 2006-07-04 | Generex Pharmaceuticals, Inc. | Method for administering insulin to the buccal region |
AU3589899A (en) | 1998-04-17 | 1999-11-08 | Her Majesty The Queen In Right Of Canada As Represented By The Department Of Agriculture And Agri-Food Canada | Process for recovery and purification of saponins and sapogenins from quinoa ((chenopodium quinoa)) |
US20010034330A1 (en) * | 1998-08-10 | 2001-10-25 | Charlotte Kensil | Innate immunity-stimulating compositions of CpG and saponin and methods thereof |
AU773204C (en) | 1998-08-10 | 2005-05-19 | Antigenics Llc | Compositions of CPG and saponin adjuvants and methods thereof |
US6262029B1 (en) | 1998-08-14 | 2001-07-17 | Galenica Pharmaceuticals, Inc. | Chemically modified saponins and the use thereof as adjuvants |
US7776343B1 (en) | 1999-02-17 | 2010-08-17 | Csl Limited | Immunogenic complexes and methods relating thereto |
EP1239876B1 (de) * | 1999-11-19 | 2008-07-30 | Csl Limited | Hcv-impfstoff zusammensetzungen |
AU5697001A (en) * | 2000-03-31 | 2001-10-15 | Purdue Research Foundation | Method of treatment using ligand-immunogen conjugates |
US7449557B2 (en) | 2000-06-02 | 2008-11-11 | University Of Connecticut Health Center | Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy |
AU2001277961A1 (en) * | 2000-08-07 | 2002-02-18 | Antigenics, Llc | Compositions comprising heat shock proteins or alpha(2)macroglobulin, antigenic molecules and saponins, and methods of use thereof |
EP1377320B1 (de) | 2001-04-04 | 2008-10-01 | Nordic Vaccine Technology A/S | Polynukleotide-bindende komplexe die sterolen und saponine enthalten |
PL367102A1 (en) * | 2001-05-02 | 2005-02-21 | Purdue Research Foundation | Treatment and diagnosis of macrophage mediated disease |
US20030138434A1 (en) * | 2001-08-13 | 2003-07-24 | Campbell Robert L. | Agents for enhancing the immune response |
ATE451935T1 (de) * | 2001-09-28 | 2010-01-15 | Purdue Research Foundation | Behandlungsverfahren mit liganden- immunogenkonjugaten |
WO2003055514A1 (en) * | 2001-12-21 | 2003-07-10 | Antigenics Inc. | Compositions comprising immunoreactive reagents and saponins, and methods of use thereof |
JP2005538954A (ja) * | 2002-05-31 | 2005-12-22 | トーマス・ジェファーソン・ユニバーシティ | 分子の経上皮輸送用組成物及び方法 |
US20040037809A1 (en) * | 2002-06-28 | 2004-02-26 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of interferon beta |
WO2004092329A2 (en) * | 2003-04-08 | 2004-10-28 | Galenica Pharmaceuticals, Inc. | Semi-synthetic saponin analogs with carrier and immune stimulatory activities for dna and rna vaccines |
EP1670507A4 (de) | 2003-09-12 | 2007-10-17 | Antigenics Inc | Vakzine zur behandlung und prävention von herpes simplex-virusinfektion |
US20050175623A1 (en) * | 2004-02-10 | 2005-08-11 | Zheng-Pin Wang | Saponins as anticancer agent |
BRPI0507680A (pt) * | 2004-02-13 | 2007-07-17 | Nod Pharmaceuticals Inc | partìculas de fosfato de cálcio terapêuticas e métodos de fabricação e uso das mesmas |
US7666914B2 (en) * | 2004-06-03 | 2010-02-23 | Richlin David M | Topical preparation and method for transdermal delivery and localization of therapeutic agents |
US20080287662A1 (en) * | 2005-06-22 | 2008-11-20 | Zeev Wiesman | Balanites Aegyptiaca Saponins and Uses Thereof |
WO2007092299A2 (en) * | 2006-02-03 | 2007-08-16 | Purdue Research Foundation | Targeted conjugates and radiation |
WO2009000277A1 (en) * | 2007-06-27 | 2008-12-31 | Coloplast A/S | Treatment of urinary tract infections with a mixture of saponin and an antibiotic |
JP5554713B2 (ja) * | 2007-11-15 | 2014-07-23 | エンドサイト,インク. | 接合体を投与する方法 |
CN102946900A (zh) | 2010-03-11 | 2013-02-27 | 免疫设计公司 | 用于大流行流感的疫苗 |
US8939388B1 (en) | 2010-09-27 | 2015-01-27 | ZoomEssence, Inc. | Methods and apparatus for low heat spray drying |
US9332776B1 (en) | 2010-09-27 | 2016-05-10 | ZoomEssence, Inc. | Methods and apparatus for low heat spray drying |
EP2675473A1 (de) | 2011-02-15 | 2013-12-25 | Immune Design Corp. | Verfahren zur verbesserung von immunogenspezifischen immunreaktionen durch vektorisierte impfstoffe |
SI2680712T1 (sl) | 2011-03-04 | 2019-08-30 | International Flavors & Fragrances Inc. | Postopek izdelave s pršenjem sušenih spojin, zmožnih zadrževanja hlapnih spojin |
US20130022728A1 (en) * | 2011-03-04 | 2013-01-24 | International Flavor & Fragrances Inc. | Spray-Dried Compositions Capable of Retaining Volatile Compounds and Methods of Producing the Same |
EP3632463A1 (de) | 2011-04-08 | 2020-04-08 | Immune Design Corp. | Immunogene zusammensetzungen und verfahren zur verwendung der zusammensetzungen zur induzierung humoraler und zellulärer immunreaktionen |
WO2012149307A2 (en) | 2011-04-27 | 2012-11-01 | Immune Design Corp. | Synthetic long peptide (slp)-based vaccines |
NZ701881A (en) | 2012-05-16 | 2016-10-28 | Immune Design Corp | Vaccines for hsv-2 |
WO2015017280A1 (en) * | 2013-07-28 | 2015-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations that induce a th2 immune response |
CN105960241A (zh) | 2014-01-21 | 2016-09-21 | 免疫设计公司 | 用于治疗过敏性病症的组合物 |
CA2939093A1 (en) | 2014-02-14 | 2015-08-20 | Immune Design Corp. | Immunotherapy of cancer through combination of local and systemic immune stimulation |
AU2015289773A1 (en) | 2014-07-15 | 2017-02-02 | Immune Design Corp. | Prime-boost regimens with a TLR4 agonist adjuvant and a lentiviral vector |
CA2984643A1 (en) | 2015-05-13 | 2016-11-17 | Agenus Inc. | Vaccines for treatment and prevention of cancer |
WO2018231706A1 (en) | 2017-06-11 | 2018-12-20 | Molecular Express, Inc. | Methods and compositions for substance use disorder vaccine formulations and uses thereof |
CA3071115C (en) | 2017-08-04 | 2022-06-21 | ZoomEssence, Inc. | Ultrahigh efficiency spray drying apparatus and process |
US10155234B1 (en) | 2017-08-04 | 2018-12-18 | ZoomEssence, Inc. | Ultrahigh efficiency spray drying apparatus and process |
US10486173B2 (en) | 2017-08-04 | 2019-11-26 | ZoomEssence, Inc. | Ultrahigh efficiency spray drying apparatus and process |
US9993787B1 (en) | 2017-08-04 | 2018-06-12 | ZoomEssence, Inc. | Ultrahigh efficiency spray drying apparatus and process |
US9861945B1 (en) | 2017-08-04 | 2018-01-09 | ZoomEssence, Inc. | Ultrahigh efficiency spray drying apparatus and process |
US10569244B2 (en) | 2018-04-28 | 2020-02-25 | ZoomEssence, Inc. | Low temperature spray drying of carrier-free compositions |
WO2020044267A1 (en) | 2018-08-29 | 2020-03-05 | Centre Hospitalier Universitaire Vaudois | Ebola vaccine compositions and methods of using same |
EP4003425A2 (de) * | 2019-07-25 | 2022-06-01 | Sapreme Technologies B.V. | Mit einer funktionellen einheit verbundenes bioaktives saponin |
JP2023504659A (ja) | 2019-12-03 | 2023-02-06 | ニューボーゲン,インコーポレイティド | 腫瘍細胞ワクチン |
EP4126029A1 (de) | 2020-03-23 | 2023-02-08 | Loyola University of Chicago | Coronavirus-impfstoffzusammensetzungen und verfahren zur verwendung davon |
IL299356A (en) * | 2020-06-24 | 2023-02-01 | Sapreme Tech Bv | hydrazone derivatives of saponin |
WO2021260061A2 (en) * | 2020-06-24 | 2021-12-30 | Sapreme Technologies B.V. | Saponin derivatives with improved therapeutic window |
EP4236995A2 (de) | 2020-11-02 | 2023-09-06 | Neuvogen, Inc. | Impfstoffe gegen tumorzellen |
CN113480985A (zh) * | 2021-07-07 | 2021-10-08 | 东营煜煌能源技术有限公司 | 一种微纳米膨胀胶束弹性颗粒驱油乳液制备方法及应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD160763A3 (de) * | 1978-06-05 | 1984-03-07 | Loeffler Friedrich Inst | Verfahren zur herstellung von konzentratvakzinen |
FR2456116A1 (fr) * | 1979-05-11 | 1980-12-05 | Sarget Lab | Nouvelle saponine triterpenique derivee de la caulophyllogenine et ses applications therapeutiques |
GB2064320B (en) * | 1979-10-13 | 1983-10-12 | Welsh Nat School Med | Intra-ocular irrigation fluid |
US4443432A (en) * | 1981-10-05 | 1984-04-17 | Alcon Laboratories, Inc. | Ophthmalic irrigating solution |
US4550022A (en) * | 1981-10-05 | 1985-10-29 | Alcon Laboratories, Inc. | Tissue irrigating solution |
US4548922A (en) * | 1983-06-06 | 1985-10-22 | Beth Israel Hospital | Drug administration |
NZ217844A (en) * | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
JPS62126135A (ja) * | 1985-11-25 | 1987-06-08 | Sumitomo Pharmaceut Co Ltd | 経鼻投与用grf製剤 |
US4938970A (en) * | 1987-02-06 | 1990-07-03 | Hustead Robert E | Painless electrolyte solutions |
US5166139A (en) * | 1987-02-26 | 1992-11-24 | Indena, S.P.A. | Complexes of saponins and their aglycons with phospholipids and pharmaceutical and cosmetic compositions containing them |
US5583112A (en) * | 1987-05-29 | 1996-12-10 | Cambridge Biotech Corporation | Saponin-antigen conjugates and the use thereof |
US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
CA1331443C (en) * | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
US5118676A (en) * | 1988-04-08 | 1992-06-02 | Whitby Research, Inc. | Penetration enhancers for transdermal delivery of systemic agents |
US5118692A (en) * | 1988-04-08 | 1992-06-02 | Whitby Research, Inc. | Penetration enhances for transdermal delivery of systemic agents |
US5182258A (en) * | 1989-03-20 | 1993-01-26 | Orbon Corporation | Systemic delivery of polypeptides through the eye |
-
1992
- 1992-07-02 US US07/906,870 patent/US5273965A/en not_active Expired - Lifetime
-
1993
- 1993-07-01 MX MX9303977A patent/MX9303977A/es not_active IP Right Cessation
- 1993-07-01 DE DE69326772T patent/DE69326772T2/de not_active Expired - Fee Related
- 1993-07-01 WO PCT/US1993/006348 patent/WO1994001118A1/en active IP Right Grant
- 1993-07-01 AU AU46649/93A patent/AU687005B2/en not_active Ceased
- 1993-07-01 HU HU9500001A patent/HUT73814A/hu unknown
- 1993-07-01 EP EP93916972A patent/EP0658111B1/de not_active Expired - Lifetime
- 1993-07-01 CA CA002139437A patent/CA2139437A1/en not_active Abandoned
- 1993-07-01 BR BR9306594A patent/BR9306594A/pt not_active Application Discontinuation
- 1993-07-01 JP JP50560193A patent/JP3684370B2/ja not_active Expired - Fee Related
- 1993-09-24 US US08/126,190 patent/US5443829A/en not_active Expired - Lifetime
-
1994
- 1994-12-30 FI FI946173A patent/FI946173A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX9303977A (es) | 1994-04-29 |
CA2139437A1 (en) | 1994-01-20 |
JP3684370B2 (ja) | 2005-08-17 |
EP0658111B1 (de) | 1999-10-13 |
AU687005B2 (en) | 1998-02-19 |
EP0658111A1 (de) | 1995-06-21 |
JPH07509440A (ja) | 1995-10-19 |
EP0658111A4 (de) | 1996-02-07 |
BR9306594A (pt) | 1998-12-08 |
HUT73814A (en) | 1996-09-30 |
AU4664993A (en) | 1994-01-31 |
US5443829A (en) | 1995-08-22 |
FI946173A (fi) | 1995-02-15 |
HU9500001D0 (en) | 1995-03-28 |
DE69326772T2 (de) | 2000-06-29 |
US5273965A (en) | 1993-12-28 |
FI946173A0 (fi) | 1994-12-30 |
WO1994001118A1 (en) | 1994-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: AQUILA BIOPHARMACEUTICALS, INC., FRAMINGHAM, MASS. |
|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |