DE69306595D1 - Regioselektive synthese von 4-chlor-2-thiophencarbonsäure - Google Patents

Regioselektive synthese von 4-chlor-2-thiophencarbonsäure

Info

Publication number
DE69306595D1
DE69306595D1 DE69306595T DE69306595T DE69306595D1 DE 69306595 D1 DE69306595 D1 DE 69306595D1 DE 69306595 T DE69306595 T DE 69306595T DE 69306595 T DE69306595 T DE 69306595T DE 69306595 D1 DE69306595 D1 DE 69306595D1
Authority
DE
Germany
Prior art keywords
pct
thiophencarbonsäure
regioselektive
chlor
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69306595T
Other languages
English (en)
Other versions
DE69306595T2 (de
Inventor
Laurence Burgess
Gary Schulte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE69306595D1 publication Critical patent/DE69306595D1/de
Application granted granted Critical
Publication of DE69306595T2 publication Critical patent/DE69306595T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
DE69306595T 1992-11-23 1993-09-17 Regioselektive synthese von 4-chlor-2-thiophencarbonsäure Expired - Fee Related DE69306595T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97998392A 1992-11-23 1992-11-23
PCT/US1993/008613 WO1994012505A1 (en) 1992-11-23 1993-09-17 Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid

Publications (2)

Publication Number Publication Date
DE69306595D1 true DE69306595D1 (en) 1997-01-23
DE69306595T2 DE69306595T2 (de) 1997-04-03

Family

ID=25527268

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69306595T Expired - Fee Related DE69306595T2 (de) 1992-11-23 1993-09-17 Regioselektive synthese von 4-chlor-2-thiophencarbonsäure

Country Status (26)

Country Link
US (1) US5648502A (de)
EP (1) EP0669924B1 (de)
JP (2) JP2706573B2 (de)
KR (1) KR950704727A (de)
CN (4) CN1036001C (de)
AT (1) ATE146181T1 (de)
AU (1) AU670454B2 (de)
BR (1) BR9307503A (de)
CA (1) CA2148616C (de)
CZ (1) CZ131695A3 (de)
DE (1) DE69306595T2 (de)
DK (1) DK0669924T3 (de)
EG (1) EG20200A (de)
ES (1) ES2095080T3 (de)
FI (1) FI935168A (de)
GR (1) GR3022396T3 (de)
HU (1) HUT68757A (de)
IL (2) IL107612A0 (de)
MX (1) MX9307292A (de)
MY (1) MY109037A (de)
NO (1) NO952021L (de)
NZ (1) NZ256279A (de)
PL (1) PL174312B1 (de)
RU (1) RU2114854C1 (de)
WO (1) WO1994012505A1 (de)
ZA (1) ZA938705B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045282A1 (en) * 1997-04-04 1998-10-15 Pfizer Inc. Processes and intermediates for preparing 2-fluorothiophene derivatives
PT1569929E (pt) * 2002-12-10 2010-06-18 Virochem Pharma Inc Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus
US7560551B2 (en) 2006-01-23 2009-07-14 Amgen Inc. Aurora kinase modulators and method of use
CA2699157A1 (en) 2007-09-10 2009-03-19 Calcimedica, Inc. Compounds that modulate intracellular calcium
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
WO2009076454A2 (en) 2007-12-12 2009-06-18 Calcimedica, Inc. Compounds that modulate intracellular calcium
MX2011002149A (es) 2008-08-27 2011-04-05 Calcimedica Inc Compuestos que modulan el calcio intracelular.
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
CN101987842A (zh) * 2009-07-31 2011-03-23 上海开拓者医药发展有限公司 一种2-甲基噻吩衍生物的制备方法
US8618307B2 (en) 2009-09-16 2013-12-31 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9079891B2 (en) 2010-08-27 2015-07-14 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN109096245A (zh) * 2018-09-27 2018-12-28 上海雅本化学有限公司 一种5-氯噻吩-2-甲酸的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4432974A (en) * 1982-03-04 1984-02-21 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes
DE3534286A1 (de) * 1985-09-26 1987-04-02 Hoechst Ag Verfahren zur herstellung von halogenthiophen-2-carbonsaeuren
US5118703A (en) * 1988-10-18 1992-06-02 Pfizer Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
FR2655655A1 (fr) * 1989-12-07 1991-06-14 Rhone Poulenc Chimie Procede de preparation de polysilthiophenediyle et polymeres obtenus a l'issue de ce procede.
HU219131B (hu) * 1991-10-18 2001-02-28 Monsanto Co. Módszer és fungicid készítmény növények torsgombabetegségének gátlására és a hatóanyagok

Also Published As

Publication number Publication date
GR3022396T3 (en) 1997-04-30
PL174312B1 (pl) 1998-07-31
CZ131695A3 (en) 1996-05-15
AU670454B2 (en) 1996-07-18
PL309048A1 (en) 1995-09-18
CN1036001C (zh) 1997-10-01
JPH07508761A (ja) 1995-09-28
DE69306595T2 (de) 1997-04-03
EP0669924A1 (de) 1995-09-06
NZ256279A (en) 1996-11-26
DK0669924T3 (da) 1997-06-16
CN1156725A (zh) 1997-08-13
WO1994012505A1 (en) 1994-06-09
ZA938705B (en) 1995-05-22
NO952021D0 (no) 1995-05-22
ES2095080T3 (es) 1997-02-01
RU2114854C1 (ru) 1998-07-10
FI935168A0 (fi) 1993-11-22
JPH1081683A (ja) 1998-03-31
ATE146181T1 (de) 1996-12-15
BR9307503A (pt) 1999-06-29
CN1158851A (zh) 1997-09-10
CA2148616C (en) 1998-02-03
US5648502A (en) 1997-07-15
CN1158853A (zh) 1997-09-10
FI935168A (fi) 1994-05-24
IL120461A0 (en) 1997-07-13
KR950704727A (ko) 1995-11-20
MY109037A (en) 1996-11-30
HUT68757A (en) 1995-07-28
MX9307292A (es) 1994-05-31
IL107612A0 (en) 1994-02-27
CA2148616A1 (en) 1994-06-09
EG20200A (en) 1997-10-30
CN1093704A (zh) 1994-10-19
AU4858793A (en) 1994-06-22
NO952021L (no) 1995-05-22
JP2795642B2 (ja) 1998-09-10
JP2706573B2 (ja) 1998-01-28
EP0669924B1 (de) 1996-12-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee