DE69232259T2 - Verfahren zur Herstellung von Interleukin-6 Zusammensetzungen - Google Patents
Verfahren zur Herstellung von Interleukin-6 ZusammensetzungenInfo
- Publication number
- DE69232259T2 DE69232259T2 DE69232259T DE69232259T DE69232259T2 DE 69232259 T2 DE69232259 T2 DE 69232259T2 DE 69232259 T DE69232259 T DE 69232259T DE 69232259 T DE69232259 T DE 69232259T DE 69232259 T2 DE69232259 T2 DE 69232259T2
- Authority
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- Germany
- Prior art keywords
- cells
- carrier
- human
- medium
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000011152 sodium sulphate Nutrition 0.000 description 1
- YFGAFXCSLUUJRG-WCCKRBBISA-M sodium;(2s)-2-amino-5-(diaminomethylideneamino)pentanoate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCCN=C(N)N YFGAFXCSLUUJRG-WCCKRBBISA-M 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0656—Adult fibroblasts
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8660291 | 1991-04-18 | ||
| JP8828491 | 1991-04-19 | ||
| PCT/JP1992/000487 WO1992018537A1 (en) | 1991-04-18 | 1992-04-17 | Interleukin 6 composition and production thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69232259D1 DE69232259D1 (de) | 2002-01-17 |
| DE69232259T2 true DE69232259T2 (de) | 2002-06-13 |
Family
ID=26427716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69232259T Expired - Fee Related DE69232259T2 (de) | 1991-04-18 | 1992-04-17 | Verfahren zur Herstellung von Interleukin-6 Zusammensetzungen |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0550756B1 (cg-RX-API-DMAC10.html) |
| KR (1) | KR930700550A (cg-RX-API-DMAC10.html) |
| AT (1) | ATE210150T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU1554592A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2085744A1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE69232259T2 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2164050T3 (cg-RX-API-DMAC10.html) |
| FI (1) | FI925745A7 (cg-RX-API-DMAC10.html) |
| TW (1) | TW221379B (cg-RX-API-DMAC10.html) |
| WO (1) | WO1992018537A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338834A (en) * | 1993-01-26 | 1994-08-16 | Allelix Biopharmaceuticals Inc. | Ultrapure human interleukin-6 |
| WO1999028455A1 (de) | 1997-12-03 | 1999-06-10 | Roche Diagnostics Gmbh | Verfahren zur herstellung von polypeptiden mit geeigneter glykosilierung |
| PT1137789E (pt) | 1998-12-09 | 2010-10-21 | Phyton Holdings Llc | Um método para produzir glicoproteínas possuindo glicosilação de tipo humano |
| ATE365219T1 (de) | 1999-10-26 | 2007-07-15 | Plant Res Int Bv | Glykolisierung des säugetiertyps in pflanzen |
| CN100385006C (zh) | 2001-01-19 | 2008-04-30 | 陶氏化学公司 | 利用植物细胞分泌性生产具有人型糖链的糖蛋白的方法 |
| CA2478294C (en) | 2002-03-19 | 2013-09-03 | Plant Research International B.V. | Gntiii (udp-n-acetylglucosamine:beta-d mannoside beta (1,4)-n-acetylglucosaminyltransferase iii) expression in plants |
| CA2923247A1 (en) | 2002-03-19 | 2003-09-25 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
| AR042145A1 (es) | 2002-11-27 | 2005-06-08 | Dow Agrociences Llc | Produccion de inmunoglobulinas en plantas con una fucocilacion reducida |
| KR101426667B1 (ko) | 2007-04-17 | 2014-08-06 | 스티칭 디엔스트 랜드보위쿤디그 온데조에크 | 비-포유동물 글리코실트랜스퍼라제의 발현에 의한 식물에서의 포유동물형 글리코실화 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6062997A (ja) * | 1983-09-17 | 1985-04-11 | Mochida Pharmaceut Co Ltd | インタ−フエロンの生産方法 |
| DE3519011A1 (de) * | 1985-05-25 | 1986-11-27 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung eines materials zur affinitaetschromatographie |
| JPS62153755A (ja) * | 1985-12-27 | 1987-07-08 | Showa Denko Kk | クロマトグラフイ−用吸着担体 |
| JP2648860B2 (ja) * | 1986-05-08 | 1997-09-03 | イエダ リサーチ アンド デベロップメント コンパニー リミテッド | ヒトインターフエロン−β２Ａ及びヒトインターフエロン−β２Ｂ、該インターフエロンをコードする遺伝子を含むベクター、該インターフエロンを産生するセルライン及び該インターフエロンの医薬品としての用途 |
| IE67035B1 (en) * | 1986-07-08 | 1996-02-21 | Genetics Inst | Production and use of non-glycosylated IL-6 |
| JP2676336B2 (ja) * | 1986-08-06 | 1997-11-12 | 忠三 岸本 | ヒトｂ細胞分化因子の遺伝子 |
| JPS63150297A (ja) * | 1986-12-12 | 1988-06-22 | Ajinomoto Co Inc | 新規ｂ細胞分化因子蛋白標品 |
| ES2064336T3 (es) * | 1987-10-13 | 1995-02-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de proteinas. |
| JPH03133935A (ja) * | 1989-10-19 | 1991-06-07 | Toray Ind Inc | ヒト天然型インターロイキン６組成物 |
-
1992
- 1992-04-17 FI FI925745A patent/FI925745A7/fi not_active Application Discontinuation
- 1992-04-17 ES ES92908258T patent/ES2164050T3/es not_active Expired - Lifetime
- 1992-04-17 AT AT92908258T patent/ATE210150T1/de not_active IP Right Cessation
- 1992-04-17 EP EP92908258A patent/EP0550756B1/en not_active Expired - Lifetime
- 1992-04-17 CA CA002085744A patent/CA2085744A1/en not_active Abandoned
- 1992-04-17 AU AU15545/92A patent/AU1554592A/en not_active Abandoned
- 1992-04-17 DE DE69232259T patent/DE69232259T2/de not_active Expired - Fee Related
- 1992-04-17 WO PCT/JP1992/000487 patent/WO1992018537A1/ja not_active Ceased
- 1992-04-30 TW TW081103408A patent/TW221379B/zh active
- 1992-12-16 KR KR1019920703255A patent/KR930700550A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0550756A4 (cg-RX-API-DMAC10.html) | 1994-04-27 |
| FI925745L (fi) | 1992-12-17 |
| CA2085744A1 (en) | 1992-10-19 |
| TW221379B (cg-RX-API-DMAC10.html) | 1994-03-01 |
| FI925745A0 (fi) | 1992-12-17 |
| EP0550756A1 (en) | 1993-07-14 |
| FI925745A7 (fi) | 1992-12-17 |
| ATE210150T1 (de) | 2001-12-15 |
| DE69232259D1 (de) | 2002-01-17 |
| WO1992018537A1 (en) | 1992-10-29 |
| ES2164050T3 (es) | 2002-02-16 |
| KR930700550A (ko) | 1993-03-15 |
| EP0550756B1 (en) | 2001-12-05 |
| AU1554592A (en) | 1992-11-17 |
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