DE69230420T2 - Referenzsystem mit Mehrfachsignalausgabe für einen Sensor für evaneszente Wellen - Google Patents

Referenzsystem mit Mehrfachsignalausgabe für einen Sensor für evaneszente Wellen

Info

Publication number
DE69230420T2
DE69230420T2 DE69230420T DE69230420T DE69230420T2 DE 69230420 T2 DE69230420 T2 DE 69230420T2 DE 69230420 T DE69230420 T DE 69230420T DE 69230420 T DE69230420 T DE 69230420T DE 69230420 T2 DE69230420 T2 DE 69230420T2
Authority
DE
Germany
Prior art keywords
sensor
signal output
reference system
multiple signal
evanescent waves
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69230420T
Other languages
English (en)
Other versions
DE69230420D1 (de
Inventor
Rudolf E Slovacek
Walter F Love
Thomas A Cook
Richard L Schulkind
Irene M Walczak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE69230420D1 publication Critical patent/DE69230420D1/de
Publication of DE69230420T2 publication Critical patent/DE69230420T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7709—Distributed reagent, e.g. over length of guide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7793—Sensor comprising plural indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE69230420T 1991-06-07 1992-06-04 Referenzsystem mit Mehrfachsignalausgabe für einen Sensor für evaneszente Wellen Expired - Lifetime DE69230420T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71230491A 1991-06-07 1991-06-07

Publications (2)

Publication Number Publication Date
DE69230420D1 DE69230420D1 (de) 2000-01-20
DE69230420T2 true DE69230420T2 (de) 2000-08-03

Family

ID=24861567

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230420T Expired - Lifetime DE69230420T2 (de) 1991-06-07 1992-06-04 Referenzsystem mit Mehrfachsignalausgabe für einen Sensor für evaneszente Wellen

Country Status (5)

Country Link
US (2) US5525466A (de)
EP (1) EP0517516B1 (de)
JP (1) JP3398164B2 (de)
CA (1) CA2069537A1 (de)
DE (1) DE69230420T2 (de)

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DE10043113C2 (de) * 2000-08-31 2002-12-19 Pe Diagnostik Gmbh Verfahren zur Verbesserung der Messgenauigkeit bei Sensoren, insbesondere Bio-Sensoren, die Fluoreszenzstrahlung auswerten
DE102004009543A1 (de) * 2004-02-23 2005-09-08 Siemens Ag Leuchtplatte zur Evaneszenzfeldanregung und Verfahren zu deren Verwendung
DE102008034008A1 (de) * 2008-07-21 2010-01-28 Carl Zeiss Surgical Gmbh Filtersatz zur Beobachtung von Fluoreszenzstrahlung in biologischem Gewebe
WO2016193066A1 (de) 2015-06-02 2016-12-08 Fachhochschule Lübeck Fluidprobenvorrichtung und deren herstellung, fluidanalysevorrichtung und optisches messverfahren
DE102015011441A1 (de) * 2015-09-01 2017-03-02 Carl Zeiss Meditec Ag Fluoreszenzlichtdetektionssystem und Mikroskopiesystem
DE102017203452A1 (de) 2017-03-02 2018-09-06 Carl Zeiss Meditec Ag Fluoreszenzbeobachtungssystem
DE102018202591A1 (de) * 2018-02-21 2019-08-22 Robert Bosch Gmbh Optisches System sowie ein Verfahren zur Herstellung eines optischen Systems
DE102018114969A1 (de) 2018-06-21 2019-12-24 Stiftung für Lasertechnologien in der Medizin und Meßtechnik an der Universität Ulm (ILM) Verfahren und Vorrichtung zur Einkopplung von Licht in einen Lichtleiter
DE102021133357A1 (de) 2021-12-15 2023-06-15 Endress+Hauser Conducta Gmbh+Co. Kg Sensorelement, Sensorsystem und Verfahren zum Herstellen des Sensorelements

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Cited By (15)

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DE10043113C2 (de) * 2000-08-31 2002-12-19 Pe Diagnostik Gmbh Verfahren zur Verbesserung der Messgenauigkeit bei Sensoren, insbesondere Bio-Sensoren, die Fluoreszenzstrahlung auswerten
DE102004009543A1 (de) * 2004-02-23 2005-09-08 Siemens Ag Leuchtplatte zur Evaneszenzfeldanregung und Verfahren zu deren Verwendung
DE102004009543B4 (de) * 2004-02-23 2006-09-28 Siemens Ag Leuchtplatte zur Evaneszenzfeldanregung und Verfahren zu deren Verwendung
DE102008034008A1 (de) * 2008-07-21 2010-01-28 Carl Zeiss Surgical Gmbh Filtersatz zur Beobachtung von Fluoreszenzstrahlung in biologischem Gewebe
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EP0517516B1 (de) 1999-12-15
JPH07198594A (ja) 1995-08-01
JP3398164B2 (ja) 2003-04-21
EP0517516A1 (de) 1992-12-09
US5525466A (en) 1996-06-11
US5738992A (en) 1998-04-14
DE69230420D1 (de) 2000-01-20
CA2069537A1 (en) 1992-12-08

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