DE69229476T2 - Ospa proteine von borrelia burgdorferi untergruppen, dafür kodierende gene sowie impfstoffe - Google Patents
Ospa proteine von borrelia burgdorferi untergruppen, dafür kodierende gene sowie impfstoffeInfo
- Publication number
- DE69229476T2 DE69229476T2 DE69229476T DE69229476T DE69229476T2 DE 69229476 T2 DE69229476 T2 DE 69229476T2 DE 69229476 T DE69229476 T DE 69229476T DE 69229476 T DE69229476 T DE 69229476T DE 69229476 T2 DE69229476 T2 DE 69229476T2
- Authority
- DE
- Germany
- Prior art keywords
- groups
- sub
- ospa
- borrelia burgdorferi
- coding genes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 101001086191 Borrelia burgdorferi Outer surface protein A Proteins 0.000 title 1
- 241000589969 Borreliella burgdorferi Species 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 108700006640 OspA Proteins 0.000 abstract 3
- 241000589968 Borrelia Species 0.000 abstract 2
- 208000016604 Lyme disease Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1207—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919117602A GB9117602D0 (en) | 1991-08-15 | 1991-08-15 | Novel antigens |
GB919122301A GB9122301D0 (en) | 1991-10-21 | 1991-10-21 | Novel antigens |
GB929211318A GB9211318D0 (en) | 1992-05-28 | 1992-05-28 | Vaccines |
GB929211317A GB9211317D0 (en) | 1992-05-28 | 1992-05-28 | Novel antigens |
PCT/EP1992/001827 WO1993004175A1 (en) | 1991-08-15 | 1992-08-11 | Osp a proteins of borrelia burgdorferi subgroups, encoding genes and vaccines |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69229476D1 DE69229476D1 (de) | 1999-07-29 |
DE69229476T2 true DE69229476T2 (de) | 2000-03-16 |
Family
ID=27450728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69229476T Expired - Lifetime DE69229476T2 (de) | 1991-08-15 | 1992-08-11 | Ospa proteine von borrelia burgdorferi untergruppen, dafür kodierende gene sowie impfstoffe |
Country Status (15)
Country | Link |
---|---|
US (2) | US6113914A (pt) |
EP (4) | EP0877085A1 (pt) |
JP (1) | JPH07501687A (pt) |
AT (1) | ATE181572T1 (pt) |
AU (1) | AU666326B2 (pt) |
CA (1) | CA2115554A1 (pt) |
DE (1) | DE69229476T2 (pt) |
DK (1) | DK0598816T3 (pt) |
ES (1) | ES2135411T3 (pt) |
GR (1) | GR3031237T3 (pt) |
HK (1) | HK1012420A1 (pt) |
MX (1) | MX9204685A (pt) |
NZ (1) | NZ243952A (pt) |
PT (1) | PT100781B (pt) |
WO (1) | WO1993004175A1 (pt) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6054296A (en) * | 1988-10-24 | 2000-04-25 | Symbicom Ab | 66 kDa antigen from Borrelia |
US6143872A (en) * | 1988-10-24 | 2000-11-07 | Symbicom Aktiebolag | Borrelia burdorferi Osp A and B proteins and immunogenic peptides |
US5777095A (en) * | 1988-10-24 | 1998-07-07 | Symbicom Aktiebolag | Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90 |
DE4015911A1 (de) * | 1989-09-19 | 1991-03-28 | Max Planck Gesellschaft | Impfstoff gegen die lyme-krankheit |
US6676942B1 (en) * | 1991-08-15 | 2004-01-13 | Smithkline Beecham Biologicals (S.A.) | Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines |
JPH06511154A (ja) * | 1991-10-18 | 1994-12-15 | コノート ラボラトリーズ インコーポレイテッド | 組換えBorreliaタンパクの製造法 |
BE1006728A3 (fr) * | 1993-02-19 | 1994-11-29 | Wallone Region | Sondes d'acides nucleiques specifiques au spirochete borrelia burgdorferi. |
US7008625B2 (en) * | 1993-11-01 | 2006-03-07 | Research Foundation Of The State University Of New York | Recombinant constructs of Borrelia burgdorferi |
US6248562B1 (en) | 1993-11-01 | 2001-06-19 | Research Foundation State University Of New York | Chimeric proteins comprising borrelia polypeptides and uses therefor |
CA2187535C (en) * | 1994-04-11 | 2011-09-13 | Jon B. Korshus | Borrelia burgdorferi bacterin |
US6251405B1 (en) * | 1995-06-07 | 2001-06-26 | Connaught Laboratories, Inc. | Immunological combination compositions and methods |
US5846946A (en) * | 1996-06-14 | 1998-12-08 | Pasteur Merieux Serums Et Vaccins | Compositions and methods for administering Borrelia DNA |
WO1998000166A1 (en) | 1996-07-03 | 1998-01-08 | Merial, Inc. | Recombinant canine adenovirus (cav) containing exogenous dna |
DE19629543C2 (de) * | 1996-07-22 | 1999-02-11 | Immuno Ag | Immunassay zum Nachweis von anti-B. burgdorferi Antikörpern und Verfahren zur Serodiagnose bei Lyme Borreliose, diagnostische Mittel und Testkits zur Durchführung der Verfahren |
DE19632862B4 (de) | 1996-08-14 | 2006-08-03 | Mikrogen Molekularbiologische Entwicklungs-Gmbh | Immunologisch aktive Proteine von Borrelia burgdorferi, dafür kodierende Nukleinsäuren sowie deren Verwendung in Testkits und als Impfstoffe |
US6224882B1 (en) | 1997-11-07 | 2001-05-01 | Protein Science Corp. | Insect cells or fractions as adjuvant for antigens |
NO329958B1 (no) * | 1999-09-17 | 2011-01-31 | Pfizer Canada Inc | Anvendelse av en immunogen mengde av OspA-lipoprotein fra Piscirickettsia salmonis, OspA-antigen, og immunogene promiskuose TCE i et OspA-kimaert fusjonsprotein, for fremstilling av medikamenter, og immunologisk in vitro-fremgangsmate for deteksjon av humoralt antistoff mot OspA eller P. salmonis. |
US20040086524A1 (en) * | 1999-09-17 | 2004-05-06 | Kuzyk Michael A. | Vaccines and agents for inducing immunity in fish against rickettsial diseases, and associated preventative therapy |
US6299968B1 (en) * | 1999-11-20 | 2001-10-09 | Intertape Inc. | General purpose multilayer film products |
ATE526994T1 (de) | 2000-06-20 | 2011-10-15 | Corixa Corp | Mtb32a antigen aus mycobakterium tuberculosis mit inaktivierter protease aktivität und fusionsproteine die das antigen enthalten |
DE60131982T2 (de) | 2000-08-18 | 2008-12-11 | Brookhaven Science Associates Llc | Veränderte borrelia burgdorferi ospa |
US20050058661A1 (en) * | 2002-10-18 | 2005-03-17 | Sykes Kathryn F. | Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of the genus Borrelia |
MX2007012108A (es) | 2005-03-31 | 2007-12-05 | Glaxosmithkline Biolog Sa | Vacunas contra infeccion por chlamydia. |
PL2426141T3 (pl) | 2005-04-29 | 2015-02-27 | Glaxosmithkline Biologicals Sa | Sposób profilaktyki lub leczenia zakażenia m. tuberculosis |
TWI367109B (en) | 2006-01-19 | 2012-07-01 | Mary Kay Inc | Compositions comprising kakadu plum extract or acai berry extract |
KR101192127B1 (ko) | 2006-11-03 | 2012-10-17 | 쉐링-프라우 리미티드 | 개 라임병 백신 |
WO2008116468A2 (en) | 2007-03-26 | 2008-10-02 | Dako Denmark A/S | Mhc peptide complexes and uses thereof in infectious diseases |
EP3023436A1 (en) | 2007-07-03 | 2016-05-25 | Dako Denmark A/S | Improved methods for generation, labeling and use of mhc multimers |
EP2197908A2 (en) | 2007-09-27 | 2010-06-23 | Dako Denmark A/S | Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics |
US8466259B2 (en) * | 2007-12-07 | 2013-06-18 | National Health Research Institutes | Adjuvants |
US7833776B2 (en) | 2007-12-12 | 2010-11-16 | National Health Research Institutes | Lipidating sequences and use thereof for producing lipidated proteins in E. coli |
TWI376385B (en) * | 2007-12-07 | 2012-11-11 | Nat Health Research Institutes | Production of lipidated proteins in e. coli |
US10968269B1 (en) | 2008-02-28 | 2021-04-06 | Agilent Technologies, Inc. | MHC multimers in borrelia diagnostics and disease |
EP2288381A2 (en) | 2008-05-02 | 2011-03-02 | Cancer Research Technology Limited | Products and methods for stimulating an immune response |
WO2010009735A2 (en) | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Combinatorial analysis and repair |
GB0817244D0 (en) | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
US8287880B2 (en) | 2009-06-02 | 2012-10-16 | National Health Research Institutes | Lipidated vaccine against dengue virus infection |
EP2445927B1 (en) * | 2009-06-22 | 2014-04-23 | National Health Research Institutes | Lipidated tumor- associated antigens and immunotherapeutic compositions |
EP2470159A1 (en) | 2009-08-28 | 2012-07-04 | Mary Kay, Inc. | Skin care formulations |
SI2528621T1 (sl) | 2010-01-27 | 2017-01-31 | Glaxosmithkline Biologicals S.A., | Modificirani tuberkolozni antigeni |
EA025280B1 (ru) | 2010-03-09 | 2016-12-30 | Амир Максютов | Полиэпитопные конструкции и способы их получения и применения |
US8623375B2 (en) | 2010-05-14 | 2014-01-07 | Baxter International Inc. | Chimeric OspA genes, proteins, and methods of use thereof |
WO2012023033A2 (en) | 2010-08-18 | 2012-02-23 | Purdue Pharma L.P. | Improved peptide immunogens |
TWI507413B (zh) | 2010-11-15 | 2015-11-11 | Nat Health Research Institutes | 脂質化多抗原表位疫苗 |
TW201221642A (en) | 2010-11-15 | 2012-06-01 | Nat Health Research Institutes | Method of producing lipidated polypeptides |
US10100092B2 (en) | 2011-11-03 | 2018-10-16 | Vca, Inc. | Compositions and methods to detect various infectious organisms |
US9562079B2 (en) | 2012-04-18 | 2017-02-07 | Zoetis Services Llc | Vaccines and methods to treat lyme disease in dogs |
UY34745A (es) * | 2012-04-18 | 2013-11-29 | Zoetis Llc | Vacunas y procedimientos para tratar la enfermedad de lyme en perros |
CN104640563A (zh) | 2012-07-27 | 2015-05-20 | 巴克斯特国际公司 | 包含嵌合的ospa分子的组合物及其使用方法 |
WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
WO2023240109A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Multispecific molecules for modulating t-cell activity, and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK590288D0 (da) * | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
SE8405493D0 (sv) * | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
DK425789A (da) * | 1988-08-31 | 1990-03-01 | Smithkline Beecham Corp | Vaccinale polypeptider |
US5777095A (en) * | 1988-10-24 | 1998-07-07 | Symbicom Aktiebolag | Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90 |
DE4015911A1 (de) * | 1989-09-19 | 1991-03-28 | Max Planck Gesellschaft | Impfstoff gegen die lyme-krankheit |
WO1992000055A1 (en) * | 1990-06-15 | 1992-01-09 | Yale University | Compositions and methods for the prevention and diagnosis of lyme disease |
ATE196425T1 (de) * | 1990-07-06 | 2000-10-15 | American Home Prod | Impfstoff gegen die lyme-krankheit |
CA2057536C (en) * | 1990-12-21 | 1999-10-26 | John J. Dunn | Cloning and expression of borrelia lipoproteins |
JPH06511154A (ja) * | 1991-10-18 | 1994-12-15 | コノート ラボラトリーズ インコーポレイテッド | 組換えBorreliaタンパクの製造法 |
AU681572B2 (en) * | 1991-10-21 | 1997-09-04 | Med Immune, Inc. | Bacterial expression vectors containing DNA encoding secretion signals of lipoproteins |
EP0650527B1 (en) * | 1991-10-22 | 2003-03-12 | Symbicom Ab | Improvement in borrelia burgdorferi diagnosis and prophylaxis |
-
1992
- 1992-08-11 DE DE69229476T patent/DE69229476T2/de not_active Expired - Lifetime
- 1992-08-11 EP EP98201599A patent/EP0877085A1/en not_active Withdrawn
- 1992-08-11 US US08/193,159 patent/US6113914A/en not_active Expired - Fee Related
- 1992-08-11 EP EP98201598A patent/EP0874051A3/en not_active Withdrawn
- 1992-08-11 EP EP98201601A patent/EP0878545A3/en not_active Withdrawn
- 1992-08-11 JP JP5504077A patent/JPH07501687A/ja not_active Withdrawn
- 1992-08-11 ES ES92917879T patent/ES2135411T3/es not_active Expired - Lifetime
- 1992-08-11 WO PCT/EP1992/001827 patent/WO1993004175A1/en active IP Right Grant
- 1992-08-11 AT AT92917879T patent/ATE181572T1/de active
- 1992-08-11 CA CA002115554A patent/CA2115554A1/en not_active Abandoned
- 1992-08-11 AU AU24327/92A patent/AU666326B2/en not_active Ceased
- 1992-08-11 DK DK92917879T patent/DK0598816T3/da active
- 1992-08-11 EP EP92917879A patent/EP0598816B1/en not_active Expired - Lifetime
- 1992-08-13 MX MX9204685A patent/MX9204685A/es not_active IP Right Cessation
- 1992-08-14 NZ NZ243952A patent/NZ243952A/en unknown
- 1992-08-14 PT PT100781A patent/PT100781B/pt active IP Right Grant
-
1995
- 1995-05-16 US US08/441,857 patent/US5942236A/en not_active Expired - Fee Related
-
1998
- 1998-12-16 HK HK98113642A patent/HK1012420A1/xx not_active IP Right Cessation
-
1999
- 1999-09-16 GR GR990402328T patent/GR3031237T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2115554A1 (en) | 1993-03-04 |
EP0874051A2 (en) | 1998-10-28 |
EP0878545A3 (en) | 1998-12-16 |
AU666326B2 (en) | 1996-02-08 |
PT100781B (pt) | 1999-07-30 |
EP0598816A1 (en) | 1994-06-01 |
MX9204685A (es) | 1994-06-30 |
DK0598816T3 (da) | 1999-11-22 |
NZ243952A (en) | 1995-06-27 |
WO1993004175A1 (en) | 1993-03-04 |
US5942236A (en) | 1999-08-24 |
US6113914A (en) | 2000-09-05 |
DE69229476D1 (de) | 1999-07-29 |
PT100781A (pt) | 1993-09-30 |
HK1012420A1 (en) | 1999-07-30 |
EP0598816B1 (en) | 1999-06-23 |
GR3031237T3 (en) | 1999-12-31 |
JPH07501687A (ja) | 1995-02-23 |
EP0874051A3 (en) | 1998-11-04 |
EP0877085A1 (en) | 1998-11-11 |
ATE181572T1 (de) | 1999-07-15 |
AU2432792A (en) | 1993-03-16 |
ES2135411T3 (es) | 1999-11-01 |
EP0878545A2 (en) | 1998-11-18 |
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