DE69228142T2 - Pyrolo[2,3-b]pyridine mit therapeutischer Wirkung und Verfahren zu deren Herstellung - Google Patents

Pyrolo[2,3-b]pyridine mit therapeutischer Wirkung und Verfahren zu deren Herstellung

Info

Publication number
DE69228142T2
DE69228142T2 DE69228142T DE69228142T DE69228142T2 DE 69228142 T2 DE69228142 T2 DE 69228142T2 DE 69228142 T DE69228142 T DE 69228142T DE 69228142 T DE69228142 T DE 69228142T DE 69228142 T2 DE69228142 T2 DE 69228142T2
Authority
DE
Germany
Prior art keywords
compound
formula
pyridine
mmol
6alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69228142T
Other languages
German (de)
English (en)
Other versions
DE69228142D1 (de
Inventor
Carin Briving
Stig Carlsson
Robert Carter
Marie Elebring
Thomas Kuehler
Peter Nordberg
Ingemar Starke
Arne Svensson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Publication of DE69228142D1 publication Critical patent/DE69228142D1/de
Application granted granted Critical
Publication of DE69228142T2 publication Critical patent/DE69228142T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69228142T 1991-03-27 1992-03-25 Pyrolo[2,3-b]pyridine mit therapeutischer Wirkung und Verfahren zu deren Herstellung Expired - Fee Related DE69228142T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100920A SE9100920D0 (sv) 1991-03-27 1991-03-27 New active compounds

Publications (2)

Publication Number Publication Date
DE69228142D1 DE69228142D1 (de) 1999-02-25
DE69228142T2 true DE69228142T2 (de) 1999-07-22

Family

ID=20382295

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69228142T Expired - Fee Related DE69228142T2 (de) 1991-03-27 1992-03-25 Pyrolo[2,3-b]pyridine mit therapeutischer Wirkung und Verfahren zu deren Herstellung

Country Status (30)

Country Link
US (1) US5439917A (show.php)
EP (2) EP0509974B1 (show.php)
JP (1) JP3122792B2 (show.php)
CN (1) CN1067892A (show.php)
AP (1) AP309A (show.php)
AT (1) ATE175672T1 (show.php)
AU (1) AU655634B2 (show.php)
BG (1) BG98124A (show.php)
CA (1) CA2106880A1 (show.php)
DE (1) DE69228142T2 (show.php)
DK (1) DK0509974T3 (show.php)
ES (1) ES2129039T3 (show.php)
FI (1) FI934203A0 (show.php)
GR (1) GR3029834T3 (show.php)
HU (1) HUT65948A (show.php)
IE (1) IE920915A1 (show.php)
IL (1) IL101347A0 (show.php)
IS (1) IS3827A (show.php)
JO (1) JO1704B1 (show.php)
MA (1) MA22477A1 (show.php)
MX (1) MX9201324A (show.php)
NO (1) NO933425L (show.php)
NZ (1) NZ241943A (show.php)
SE (1) SE9100920D0 (show.php)
SK (1) SK103093A3 (show.php)
TN (1) TNSN92026A1 (show.php)
TW (1) TW198032B (show.php)
WO (1) WO1992017477A1 (show.php)
YU (1) YU30292A (show.php)
ZA (1) ZA921823B (show.php)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100920D0 (sv) * 1991-03-27 1991-03-27 Astra Ab New active compounds
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
DZ3377A1 (fr) * 1999-12-24 2001-07-05 Aventis Pharma Ltd Azaindoles
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
EP1490364B1 (en) * 2002-03-28 2007-09-26 Eisai R&D Management Co., Ltd. 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
JP4634144B2 (ja) * 2002-08-01 2011-02-16 ニコックス エスエー ニトロソ化プロトンポンプ阻害剤、組成物および使用方法
GB0305142D0 (en) * 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
PL1606261T3 (pl) 2003-03-10 2010-04-30 Astrazeneca Ab Nowy sposób przygotowania roflumilastu
US6981980B2 (en) 2003-03-19 2006-01-03 Phagia Technology Self-inflating intragastric volume-occupying device
US7612086B2 (en) * 2003-05-16 2009-11-03 Eisai R & D Management Co. Ltd. JNK inhibitors
GB0405055D0 (en) * 2004-03-05 2004-04-07 Eisai London Res Lab Ltd JNK inhibitors
EP1861074B1 (en) * 2005-03-16 2013-04-24 Takeda GmbH Taste masked dosage form containing roflumilast
GB0516156D0 (en) * 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
CL2007002617A1 (es) 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
US20080103169A1 (en) 2006-10-27 2008-05-01 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
AU2009215514B9 (en) 2008-02-20 2014-01-30 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100920D0 (sv) * 1991-03-27 1991-03-27 Astra Ab New active compounds

Also Published As

Publication number Publication date
MA22477A1 (fr) 1992-10-01
IE920915A1 (en) 1992-10-07
NZ241943A (en) 1993-12-23
SK103093A3 (en) 1994-08-10
NO933425L (no) 1993-10-25
WO1992017477A1 (en) 1992-10-15
ES2129039T3 (es) 1999-06-01
CA2106880A1 (en) 1992-09-28
ZA921823B (en) 1992-11-25
TW198032B (show.php) 1993-01-11
AU1426092A (en) 1992-11-02
FI934203A7 (fi) 1993-09-24
ATE175672T1 (de) 1999-01-15
AP309A (en) 1994-01-13
EP0509974B1 (en) 1999-01-13
HU9302741D0 (en) 1993-12-28
DE69228142D1 (de) 1999-02-25
HUT65948A (en) 1994-08-29
AU655634B2 (en) 1995-01-05
FI934203L (fi) 1993-09-24
SE9100920D0 (sv) 1991-03-27
IS3827A (is) 1992-09-28
JPH06506448A (ja) 1994-07-21
YU30292A (sh) 1995-01-31
DK0509974T3 (da) 1999-08-30
IL101347A0 (en) 1992-11-15
US5439917A (en) 1995-08-08
TNSN92026A1 (fr) 1993-06-08
BG98124A (bg) 1994-11-15
CN1067892A (zh) 1993-01-13
EP0509974A1 (en) 1992-10-21
JP3122792B2 (ja) 2001-01-09
FI934203A0 (fi) 1993-09-24
EP0580616A1 (en) 1994-02-02
AP9200369A0 (en) 1992-04-30
MX9201324A (es) 1992-10-01
NO933425D0 (no) 1993-09-24
GR3029834T3 (en) 1999-06-30
JO1704B1 (en) 1992-12-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee