ES2129039T3 - Pirrolo(2,3-b)piridinas que tienen actividad terapeutica y un proceso para su fabricacion. - Google Patents
Pirrolo(2,3-b)piridinas que tienen actividad terapeutica y un proceso para su fabricacion.Info
- Publication number
- ES2129039T3 ES2129039T3 ES92850067T ES92850067T ES2129039T3 ES 2129039 T3 ES2129039 T3 ES 2129039T3 ES 92850067 T ES92850067 T ES 92850067T ES 92850067 T ES92850067 T ES 92850067T ES 2129039 T3 ES2129039 T3 ES 2129039T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- halogen
- piridinas
- pirrolo
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Abstract
Un compuesto de la fórmula I I o una de sus sales farmacéuticamente aceptables, en la cual X representa O k -C, O-R 6 j -CH, N-O-R 6 k -C, o -CH2-; R 1 representa H, alquilo (1-6 C), CH2-O-R 7 , halógeno, fenilo o fenilo sustituido con alquilo (1-6 C), alcoxi (1-6 C), acilo (1-6 C), halógeno, o alcoxi (1-6 C)carbonilo; R 2 representa H, alquilo (1-6 C), CH2CN, O k CH2C-NH2 , halógeno, O-R 8 , N== / j CH2-N j n j === , S-CN, CH2OH, CH2CH, CF3, CH2NC o NH2; R 3 representa H, alquilo (1-6 C) , CF3, O-R 9 , NH2, halógeno, CN, O k S-R 10 , S-R 10 o NHCOR 10 ; R 4 y R 5 , que son iguales o diferentes, representan H, alquilo (1-6 C), CN, halógeno, O-R 11 , NO2, NH2, S-R 12 , NHCOR 13 , NHCOR 14 , k O CF3 o O k C-R 15 ; R 6 , R 7 , R 8 , R 9 , R 11 y R 13 , que son iguales o diferentes, representan H o alquilo (1-6 C); R 10 representa alquilo (1-6 C) o fenil-alquilo (1-6 C); R 12 y R 14 , que son iguales o diferentes, representan alquilo (1-6 C); R 15 representa H, alquilo (1-6 C), OH o alcoxi (1-6C); con la condición de que R 1 y R 2 no son simultáneamente H.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9100920A SE9100920D0 (sv) | 1991-03-27 | 1991-03-27 | New active compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2129039T3 true ES2129039T3 (es) | 1999-06-01 |
Family
ID=20382295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92850067T Expired - Lifetime ES2129039T3 (es) | 1991-03-27 | 1992-03-25 | Pirrolo(2,3-b)piridinas que tienen actividad terapeutica y un proceso para su fabricacion. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5439917A (es) |
| EP (2) | EP0509974B1 (es) |
| JP (1) | JP3122792B2 (es) |
| CN (1) | CN1067892A (es) |
| AP (1) | AP309A (es) |
| AT (1) | ATE175672T1 (es) |
| AU (1) | AU655634B2 (es) |
| BG (1) | BG98124A (es) |
| CA (1) | CA2106880A1 (es) |
| DE (1) | DE69228142T2 (es) |
| DK (1) | DK0509974T3 (es) |
| ES (1) | ES2129039T3 (es) |
| FI (1) | FI934203A0 (es) |
| GR (1) | GR3029834T3 (es) |
| HU (1) | HUT65948A (es) |
| IE (1) | IE920915A1 (es) |
| IL (1) | IL101347A0 (es) |
| IS (1) | IS3827A (es) |
| JO (1) | JO1704B1 (es) |
| MA (1) | MA22477A1 (es) |
| MX (1) | MX9201324A (es) |
| NO (1) | NO933425L (es) |
| NZ (1) | NZ241943A (es) |
| SE (1) | SE9100920D0 (es) |
| SK (1) | SK103093A3 (es) |
| TN (1) | TNSN92026A1 (es) |
| TW (1) | TW198032B (es) |
| WO (1) | WO1992017477A1 (es) |
| YU (1) | YU30292A (es) |
| ZA (1) | ZA921823B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9100920D0 (sv) * | 1991-03-27 | 1991-03-27 | Astra Ab | New active compounds |
| US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| CN1615873A (zh) | 1999-12-24 | 2005-05-18 | 阿文蒂斯药物有限公司 | 氮杂吲哚类化合物 |
| UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| WO2003082868A1 (en) | 2002-03-28 | 2003-10-09 | Eisai Co., Ltd. | 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders |
| CA2493618A1 (en) * | 2002-08-01 | 2004-02-12 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
| GB0305142D0 (en) | 2003-03-06 | 2003-04-09 | Eisai London Res Lab Ltd | Synthesis |
| DE602004023921D1 (de) | 2003-03-10 | 2009-12-17 | Nycomed Gmbh | Neues verfahren zur herstellung vonroflumilast |
| US6981980B2 (en) | 2003-03-19 | 2006-01-03 | Phagia Technology | Self-inflating intragastric volume-occupying device |
| EP1628975A2 (en) | 2003-05-16 | 2006-03-01 | Eisai Co., Ltd. | Jnk inhibitors |
| GB0405055D0 (en) * | 2004-03-05 | 2004-04-07 | Eisai London Res Lab Ltd | JNK inhibitors |
| US8663694B2 (en) * | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
| GB0516156D0 (en) | 2005-08-05 | 2005-09-14 | Eisai London Res Lab Ltd | JNK inhibitors |
| CL2007002617A1 (es) | 2006-09-11 | 2008-05-16 | Sanofi Aventis | Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto. |
| WO2008057802A2 (en) | 2006-10-27 | 2008-05-15 | The Curators Of The University Of Missouri | Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same |
| CA2716367C (en) | 2008-02-20 | 2015-05-26 | The Curators Of The University Of Missouri | Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same |
| KR102348222B1 (ko) * | 2020-05-15 | 2022-01-10 | 대한민국 | 아동지킴이 과속방지시설 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9100920D0 (sv) * | 1991-03-27 | 1991-03-27 | Astra Ab | New active compounds |
-
1991
- 1991-03-27 SE SE9100920A patent/SE9100920D0/xx unknown
-
1992
- 1992-03-11 ZA ZA921823A patent/ZA921823B/xx unknown
- 1992-03-12 NZ NZ241943A patent/NZ241943A/xx unknown
- 1992-03-13 TW TW081101912A patent/TW198032B/zh active
- 1992-03-23 AP APAP/P/1992/000369A patent/AP309A/en active
- 1992-03-23 IE IE091592A patent/IE920915A1/en not_active Application Discontinuation
- 1992-03-23 IL IL101347A patent/IL101347A0/xx unknown
- 1992-03-25 ES ES92850067T patent/ES2129039T3/es not_active Expired - Lifetime
- 1992-03-25 EP EP92850067A patent/EP0509974B1/en not_active Expired - Lifetime
- 1992-03-25 US US08/122,442 patent/US5439917A/en not_active Expired - Lifetime
- 1992-03-25 DE DE69228142T patent/DE69228142T2/de not_active Expired - Fee Related
- 1992-03-25 DK DK92850067T patent/DK0509974T3/da active
- 1992-03-25 WO PCT/SE1992/000190 patent/WO1992017477A1/en not_active Application Discontinuation
- 1992-03-25 CA CA002106880A patent/CA2106880A1/en not_active Abandoned
- 1992-03-25 HU HU9302741A patent/HUT65948A/hu unknown
- 1992-03-25 JO JO19921704A patent/JO1704B1/en active
- 1992-03-25 AT AT92850067T patent/ATE175672T1/de not_active IP Right Cessation
- 1992-03-25 SK SK1030-93A patent/SK103093A3/sk unknown
- 1992-03-25 AU AU14260/92A patent/AU655634B2/en not_active Ceased
- 1992-03-25 JP JP04506588A patent/JP3122792B2/ja not_active Expired - Fee Related
- 1992-03-25 EP EP92906977A patent/EP0580616A1/en active Pending
- 1992-03-25 MX MX9201324A patent/MX9201324A/es unknown
- 1992-03-26 MA MA22766A patent/MA22477A1/fr unknown
- 1992-03-26 YU YU30292A patent/YU30292A/sh unknown
- 1992-03-26 IS IS3827A patent/IS3827A/is unknown
- 1992-03-27 CN CN92102170A patent/CN1067892A/zh active Pending
- 1992-03-27 TN TNTNSN92026A patent/TNSN92026A1/fr unknown
-
1993
- 1993-09-23 BG BG98124A patent/BG98124A/xx unknown
- 1993-09-24 FI FI934203A patent/FI934203A0/fi not_active Application Discontinuation
- 1993-09-24 NO NO93933425A patent/NO933425L/no unknown
-
1999
- 1999-03-31 GR GR990400928T patent/GR3029834T3/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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