DE69228077T2 - Synthetische, oberflächen aktive zusammensetzung für die lunge mit antioxidativen eigenschaften - Google Patents

Synthetische, oberflächen aktive zusammensetzung für die lunge mit antioxidativen eigenschaften

Info

Publication number
DE69228077T2
DE69228077T2 DE69228077T DE69228077T DE69228077T2 DE 69228077 T2 DE69228077 T2 DE 69228077T2 DE 69228077 T DE69228077 T DE 69228077T DE 69228077 T DE69228077 T DE 69228077T DE 69228077 T2 DE69228077 T2 DE 69228077T2
Authority
DE
Germany
Prior art keywords
leu
amino acid
lys
group
glu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69228077T
Other languages
German (de)
English (en)
Other versions
DE69228077D1 (de
Inventor
Larry R. Cincinnati Oh 45215 Mclean
Marguerite H. Madison Wi 53715 Payne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69228077D1 publication Critical patent/DE69228077D1/de
Application granted granted Critical
Publication of DE69228077T2 publication Critical patent/DE69228077T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
DE69228077T 1991-11-04 1992-10-13 Synthetische, oberflächen aktive zusammensetzung für die lunge mit antioxidativen eigenschaften Expired - Fee Related DE69228077T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/789,918 US5272252A (en) 1991-11-04 1991-11-04 Synthetic lung surfactant having antioxidant properties
PCT/US1992/008728 WO1993008824A1 (en) 1991-11-04 1992-10-13 Synthetic lung surfactant having antioxidant properties

Publications (2)

Publication Number Publication Date
DE69228077D1 DE69228077D1 (de) 1999-02-11
DE69228077T2 true DE69228077T2 (de) 1999-07-08

Family

ID=25149105

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69228077T Expired - Fee Related DE69228077T2 (de) 1991-11-04 1992-10-13 Synthetische, oberflächen aktive zusammensetzung für die lunge mit antioxidativen eigenschaften

Country Status (15)

Country Link
US (2) US5272252A (enExample)
EP (1) EP0666754B1 (enExample)
JP (1) JPH07502500A (enExample)
KR (1) KR100250847B1 (enExample)
AT (1) ATE175116T1 (enExample)
AU (1) AU667200B2 (enExample)
CA (1) CA2121147C (enExample)
DE (1) DE69228077T2 (enExample)
DK (1) DK0666754T3 (enExample)
ES (1) ES2127764T3 (enExample)
FI (1) FI942032A7 (enExample)
GR (1) GR3029279T3 (enExample)
HU (1) HUT66424A (enExample)
NO (1) NO941616D0 (enExample)
WO (1) WO1993008824A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE36460E (en) * 1990-10-10 1999-12-21 Life Science Holdings, Inc. Method of providing circulation via lung expansion and deflation
US5653685A (en) * 1990-10-10 1997-08-05 Lrt, Inc. Method of providing circulation via lung expansion and deflation
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
ES2107048T3 (es) * 1992-07-31 1997-11-16 Merrell Pharma Inc Tensioactivos pulmonares peptidicos sinteticos con antioxidantes covalentemente unidos.
EP0886652B1 (en) * 1995-11-20 2002-04-17 Ortho-McNeil Pharmaceutical, Inc. Pulmonary surfactant peptide solubilization process
WO1997032621A1 (en) * 1996-03-08 1997-09-12 Life Resuscitation Technologies, Inc. Liquid ventilation method and apparatus
AU2001278864A1 (en) * 2000-06-30 2002-01-30 University Of Cincinnati Peptides with antioxidant and antimicrobial properties
GB2368339B (en) * 2000-10-26 2002-09-18 Yissum Res Dev Co Complex incorporating a plurality of antioxidants
WO2003053455A1 (en) * 2001-12-12 2003-07-03 Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
AU2003223718B2 (en) * 2002-04-25 2007-08-16 The Scripps Research Institute Treatment and prevention of pulmonary conditions
US7290197B2 (en) * 2003-06-03 2007-10-30 Quantum Corporation Correcting data using redundancy blocks
US20060121016A1 (en) * 2004-10-18 2006-06-08 Lee Raphael C Methods and compositions for treatment of free radical injury
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
ES2380046T3 (es) 2005-01-06 2012-05-08 Discovery Laboratories, Inc. Régimen para el tratamiento con tensioactivos para tratar o prevenir la displasia broncopulmonar
WO2007001094A1 (ja) * 2005-06-29 2007-01-04 Sannamu Lee 人工肺サーファクタント組成物
MX2009003002A (es) * 2006-09-19 2009-06-01 Discovery Lab Inc Formulaciones de tensioactivos pulmonares y metodos para promover la aclaracion del moco.
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
KR102221365B1 (ko) * 2019-05-07 2021-03-02 (주)케어젠 트롤록스-펩타이드 결합체 및 그의 용도
CN111568853B (zh) * 2020-04-30 2023-07-28 杭州濡湜生物科技有限公司 一种新型肺部智能释药系统

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643988A (en) * 1984-05-15 1987-02-17 Research Corporation Amphipathic peptides
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
US5104853A (en) * 1984-12-11 1992-04-14 California Biotechnology Inc. Alveolar surfactant proteins having cys to ser mutations
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US4705684A (en) * 1985-05-31 1987-11-10 The University Of Tennessee Research Corporation Synthetic M proteins - streptococci type 6
FR2586587B1 (fr) * 1985-08-30 1987-10-23 Adir Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent.
US4918161A (en) * 1985-09-26 1990-04-17 Genetics Institute, Inc. Low molecular weight pulmonary surfactant proteins
US5055553A (en) * 1985-09-26 1991-10-08 Genetics Institute Inc. Low molecular weight pulmonary surfactant proteins
US4882422A (en) * 1985-10-24 1989-11-21 Genetics Institute, Inc. Pulmonary surfactant proteins
JPS63503222A (ja) * 1986-05-06 1988-11-24 サイオス　ノバ　インコーポレイテッド 肺の疎水性界面活性物質に結合した分子量６，０００ダルトンのタンパク質及びその多量体
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
WO1989000167A1 (en) * 1987-07-01 1989-01-12 Kabigen Ab Proteins and protein compositions and their use
WO1989004326A1 (en) * 1987-11-04 1989-05-18 California Biotechnology Inc. Alveolar surfactant proteins
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
US5134129A (en) * 1989-03-15 1992-07-28 Board Of Regents, The University Of Texas System Methods employing unique mixtures of polar and neutral lipids for surfactant replacement therapy
WO1990011768A2 (en) * 1989-03-31 1990-10-18 Genentech, Inc. Method for treating respiratory distress syndrome
EP0458167B1 (en) * 1990-05-21 1997-04-23 Abbott Laboratories Fatty acid-pulmonary surfactant conjugates
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties

Also Published As

Publication number Publication date
ES2127764T3 (es) 1999-05-01
EP0666754B1 (en) 1998-12-30
EP0666754A1 (en) 1995-08-16
FI942032L (fi) 1994-05-03
FI942032A0 (fi) 1994-05-03
JPH07502500A (ja) 1995-03-16
AU667200B2 (en) 1996-03-14
DE69228077D1 (de) 1999-02-11
DK0666754T3 (da) 1999-08-30
GR3029279T3 (en) 1999-05-28
EP0666754A4 (en) 1996-06-26
FI942032A7 (fi) 1994-05-03
HU9401293D0 (en) 1994-08-29
CA2121147C (en) 2002-12-10
US5683982A (en) 1997-11-04
CA2121147A1 (en) 1993-05-13
NO941616D0 (no) 1994-05-03
WO1993008824A1 (en) 1993-05-13
ATE175116T1 (de) 1999-01-15
KR100250847B1 (ko) 2000-09-01
AU2778392A (en) 1993-06-07
NO941616L (enExample) 1994-06-24
HUT66424A (en) 1994-11-28
US5272252A (en) 1993-12-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee