ES2127764T3 - Agente tensioactivo pulmonar sintetico que tiene propiedades antioxidantes. - Google Patents

Agente tensioactivo pulmonar sintetico que tiene propiedades antioxidantes.

Info

Publication number
ES2127764T3
ES2127764T3 ES92921892T ES92921892T ES2127764T3 ES 2127764 T3 ES2127764 T3 ES 2127764T3 ES 92921892 T ES92921892 T ES 92921892T ES 92921892 T ES92921892 T ES 92921892T ES 2127764 T3 ES2127764 T3 ES 2127764T3
Authority
ES
Spain
Prior art keywords
antioxidant properties
synthetic pulmonary
surface agent
pulmonary surface
surfactants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921892T
Other languages
English (en)
Inventor
Larry R Mclean
Marguerite H Payne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2127764T3 publication Critical patent/ES2127764T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE HAN PREPARADO SURFACTANTES PULMONARES SINTETICOS QUE POSEEN ACTIVIDADES ANTIOXIDANTES Y CONSISTEN EN UN COMPLEJO DE UN POLIPEPTIDO, CON UNA UNIDAD ANTIOXIDANTE, QUE TIENE UNA ESTRUCTURA ALFA-HELICOIDAL Y UN LIPIDO QUE CONSISTE EN UNO O MAS DE LOS LIPIDOS ASOCIADOS AL SURFACTANTE PULMONAR NATURAL. ESTOS SURFACTANTES SON UTILES PARA EL TRATAMIENTO DEL SINDROME DE AGOTAMIENTO RESPIRATORIO.
ES92921892T 1991-11-04 1992-10-13 Agente tensioactivo pulmonar sintetico que tiene propiedades antioxidantes. Expired - Lifetime ES2127764T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/789,918 US5272252A (en) 1991-11-04 1991-11-04 Synthetic lung surfactant having antioxidant properties

Publications (1)

Publication Number Publication Date
ES2127764T3 true ES2127764T3 (es) 1999-05-01

Family

ID=25149105

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921892T Expired - Lifetime ES2127764T3 (es) 1991-11-04 1992-10-13 Agente tensioactivo pulmonar sintetico que tiene propiedades antioxidantes.

Country Status (15)

Country Link
US (2) US5272252A (es)
EP (1) EP0666754B1 (es)
JP (1) JPH07502500A (es)
KR (1) KR100250847B1 (es)
AT (1) ATE175116T1 (es)
AU (1) AU667200B2 (es)
CA (1) CA2121147C (es)
DE (1) DE69228077T2 (es)
DK (1) DK0666754T3 (es)
ES (1) ES2127764T3 (es)
FI (1) FI942032A0 (es)
GR (1) GR3029279T3 (es)
HU (1) HUT66424A (es)
NO (1) NO941616D0 (es)
WO (1) WO1993008824A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE36460E (en) * 1990-10-10 1999-12-21 Life Science Holdings, Inc. Method of providing circulation via lung expansion and deflation
US5653685A (en) * 1990-10-10 1997-08-05 Lrt, Inc. Method of providing circulation via lung expansion and deflation
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
AU664112B2 (en) * 1992-07-31 1995-11-02 Merrell Dow Pharmaceuticals Inc. Synthetic peptide lung surfactants having covalently bonded antioxidants
PT886652E (pt) * 1995-11-20 2002-09-30 Ortho Mcneil Pharm Inc Processo de solubilizacao de peptidos tensioactivos pulmonares
US5927273A (en) * 1996-03-08 1999-07-27 Life Resuscitation Technologies, Inc. Combined liquid ventilation and cardiopulmonary resuscitation method
AU2001278864A1 (en) * 2000-06-30 2002-01-30 University Of Cincinnati Peptides with antioxidant and antimicrobial properties
GB2368339B (en) * 2000-10-26 2002-09-18 Yissum Res Dev Co Complex incorporating a plurality of antioxidants
US6998384B2 (en) * 2001-12-12 2006-02-14 The Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
KR101036058B1 (ko) * 2002-04-25 2011-05-19 더 스크립스 리서치 인스티튜트 폐질환 증상의 치료 및 예방
US7290197B2 (en) * 2003-06-03 2007-10-30 Quantum Corporation Correcting data using redundancy blocks
EP1809272A4 (en) * 2004-10-18 2008-01-02 Maroon Biotech Corp METHOD AND COMPOSITIONS FOR TREATING DAMAGES THROUGH FREE RADICALS
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
AU2006203978B2 (en) 2005-01-06 2011-11-03 Discovery Laboratories, Inc. Surfactant treatment regimen for treating or preventing bronchopulmonary dysplasia
WO2007001094A1 (ja) * 2005-06-29 2007-01-04 Sannamu Lee 人工肺サーファクタント組成物
JP2010503731A (ja) * 2006-09-19 2010-02-04 ディスカバリー ラボラトリーズ，インコーポレイテッド 肺サーファクタント製剤および粘液クリアランスの促進方法
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
CN111568853B (zh) * 2020-04-30 2023-07-28 杭州濡湜生物科技有限公司 一种新型肺部智能释药系统

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643988A (en) * 1984-05-15 1987-02-17 Research Corporation Amphipathic peptides
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
US5104853A (en) * 1984-12-11 1992-04-14 California Biotechnology Inc. Alveolar surfactant proteins having cys to ser mutations
US4705684A (en) * 1985-05-31 1987-11-10 The University Of Tennessee Research Corporation Synthetic M proteins - streptococci type 6
FR2586587B1 (fr) * 1985-08-30 1987-10-23 Adir Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent.
US4918161A (en) * 1985-09-26 1990-04-17 Genetics Institute, Inc. Low molecular weight pulmonary surfactant proteins
US4882422A (en) * 1985-10-24 1989-11-21 Genetics Institute, Inc. Pulmonary surfactant proteins
US5055553A (en) * 1985-09-26 1991-10-08 Genetics Institute Inc. Low molecular weight pulmonary surfactant proteins
WO1987006943A1 (en) * 1986-05-06 1987-11-19 Children's Hospital Medical Center Pulmonary hydrophobic surfactant-associated protein of 6,000 daltons molecular weight and multimers thereof
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
WO1989000167A1 (en) * 1987-07-01 1989-01-12 Kabigen Ab Proteins and protein compositions and their use
WO1989004326A1 (en) * 1987-11-04 1989-05-18 California Biotechnology Inc. Alveolar surfactant proteins
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
NZ229737A (en) * 1988-07-01 1991-05-28 Merrell Dow Pharma Polypeptides and derivatives of them with lung surfactant properties and their preparation
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
US5134129A (en) * 1989-03-15 1992-07-28 Board Of Regents, The University Of Texas System Methods employing unique mixtures of polar and neutral lipids for surfactant replacement therapy
CA2049301A1 (en) * 1989-03-31 1990-10-01 Steven Shak Method for treating respiratory distress syndrome
EP0458167B1 (en) * 1990-05-21 1997-04-23 Abbott Laboratories Fatty acid-pulmonary surfactant conjugates
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties

Also Published As

Publication number Publication date
DE69228077T2 (de) 1999-07-08
DK0666754T3 (da) 1999-08-30
EP0666754A1 (en) 1995-08-16
GR3029279T3 (en) 1999-05-28
CA2121147A1 (en) 1993-05-13
FI942032A (fi) 1994-05-03
JPH07502500A (ja) 1995-03-16
HUT66424A (en) 1994-11-28
HU9401293D0 (en) 1994-08-29
EP0666754B1 (en) 1998-12-30
DE69228077D1 (de) 1999-02-11
NO941616D0 (no) 1994-05-03
ATE175116T1 (de) 1999-01-15
AU667200B2 (en) 1996-03-14
CA2121147C (en) 2002-12-10
AU2778392A (en) 1993-06-07
KR100250847B1 (ko) 2000-09-01
NO941616L (es) 1994-06-24
FI942032A0 (fi) 1994-05-03
EP0666754A4 (en) 1996-06-26
US5272252A (en) 1993-12-21
WO1993008824A1 (en) 1993-05-13
US5683982A (en) 1997-11-04

Similar Documents

Publication Publication Date Title
ES2127764T3 (es) Agente tensioactivo pulmonar sintetico que tiene propiedades antioxidantes.
DE3883634D1 (de) Dreidimensionales Hochgeschwindigkeits-Solenoid mit zweifachem Luftspalt.
DK183386A (da) Sucralfatsuspension
ES2025198B3 (es) Butaca plegable con respaldo y reposapies regulable.
ES2107048T3 (es) Tensioactivos pulmonares peptidicos sinteticos con antioxidantes covalentemente unidos.
ES2057881T3 (es) Composicion alimenticia nutritiva de elevada viscosidad, alta en proteinas.
DE58901443D1 (de) Ausscheidungshaertbare nickelbasis-superlegierung mit verbesserten mechanischen eigenschaften im temperaturbereich von 600 bis 750oc.
IT8019370A0 (it) Struttura di sedia o poltrona.
IT8721127A0 (it) Procedimento perfezionato per la realizzazione di una imbottitura con caratteristiche di isolamento termico migliorate, particolarmente studiata per abbigliamento, arredamento e simili.
ES296637Y (es) Disposicion de tapizado para butacas y similares.
DK179384A (da) Interferon og interferoninducere kombineret med tobaksprodukter
IT8422398A0 (it) Procedimento per la conservazione e la calibratura di budella da utilizzarsi in salumifici.
AR215534A1 (es) Herraje para sillones,reposeras y similares
IT7923036V0 (it) Struttura di dispositivo di azionamento del poggiagambe in poltrone e simili.
IT1207077B (it) Poltroncina pieghevole con giunto di articolazione tra le gambe ed i braccioli.
MX9308097A (es) Copletor para maquetas de estructuras tridimensionales.
IT7924564A0 (it) Dispositivo di collegamento, in particolare per collegare tra loro parti di mobili, come per esempio poltrone, tavoli e simili.
AU103662S (en) Trousers
TH10455EX (th) สะพานไฟ
IT8821313V0 (it) Dispositivo di bloccaggio per rotelle di poltrone scrivanie e simili.
IT7925400A0 (it) Metodo per il supporto e bloccaggio di oggetti da fotoesporre nei bromografi e simili.
IT8319379A0 (it) Imbottitura per mobili a sedersi ed a sdraiarsi e procedimento per laproduzione di tale imbottitura.
FI872970A0 (fi) Anordning foer foerhindrande av glidning och formaendringar av delar i limningsfas.
TH514S (th) ขวด
IT8320691A0 (it) Poltroncina pieghevole ed inclinabile con continuita'.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 666754

Country of ref document: ES