ES2127764T3 - Agente tensioactivo pulmonar sintetico que tiene propiedades antioxidantes. - Google Patents

Agente tensioactivo pulmonar sintetico que tiene propiedades antioxidantes.

Info

Publication number
ES2127764T3
ES2127764T3 ES92921892T ES92921892T ES2127764T3 ES 2127764 T3 ES2127764 T3 ES 2127764T3 ES 92921892 T ES92921892 T ES 92921892T ES 92921892 T ES92921892 T ES 92921892T ES 2127764 T3 ES2127764 T3 ES 2127764T3
Authority
ES
Spain
Prior art keywords
antioxidant properties
synthetic pulmonary
surface agent
pulmonary surface
surfactants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921892T
Other languages
English (en)
Inventor
Larry R Mclean
Marguerite H Payne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2127764T3 publication Critical patent/ES2127764T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE HAN PREPARADO SURFACTANTES PULMONARES SINTETICOS QUE POSEEN ACTIVIDADES ANTIOXIDANTES Y CONSISTEN EN UN COMPLEJO DE UN POLIPEPTIDO, CON UNA UNIDAD ANTIOXIDANTE, QUE TIENE UNA ESTRUCTURA ALFA-HELICOIDAL Y UN LIPIDO QUE CONSISTE EN UNO O MAS DE LOS LIPIDOS ASOCIADOS AL SURFACTANTE PULMONAR NATURAL. ESTOS SURFACTANTES SON UTILES PARA EL TRATAMIENTO DEL SINDROME DE AGOTAMIENTO RESPIRATORIO.
ES92921892T 1991-11-04 1992-10-13 Agente tensioactivo pulmonar sintetico que tiene propiedades antioxidantes. Expired - Lifetime ES2127764T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/789,918 US5272252A (en) 1991-11-04 1991-11-04 Synthetic lung surfactant having antioxidant properties

Publications (1)

Publication Number Publication Date
ES2127764T3 true ES2127764T3 (es) 1999-05-01

Family

ID=25149105

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921892T Expired - Lifetime ES2127764T3 (es) 1991-11-04 1992-10-13 Agente tensioactivo pulmonar sintetico que tiene propiedades antioxidantes.

Country Status (15)

Country Link
US (2) US5272252A (es)
EP (1) EP0666754B1 (es)
JP (1) JPH07502500A (es)
KR (1) KR100250847B1 (es)
AT (1) ATE175116T1 (es)
AU (1) AU667200B2 (es)
CA (1) CA2121147C (es)
DE (1) DE69228077T2 (es)
DK (1) DK0666754T3 (es)
ES (1) ES2127764T3 (es)
FI (1) FI942032A (es)
GR (1) GR3029279T3 (es)
HU (1) HUT66424A (es)
NO (1) NO941616D0 (es)
WO (1) WO1993008824A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5653685A (en) * 1990-10-10 1997-08-05 Lrt, Inc. Method of providing circulation via lung expansion and deflation
USRE36460E (en) * 1990-10-10 1999-12-21 Life Science Holdings, Inc. Method of providing circulation via lung expansion and deflation
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
NZ254496A (en) * 1992-07-31 1996-08-27 Merrell Dow Pharma Polypeptides (3-4 amino acids) with antioxidant moieties covalently attached and their use as pulmonary surfactants
EP0886652B1 (en) * 1995-11-20 2002-04-17 Ortho-McNeil Pharmaceutical, Inc. Pulmonary surfactant peptide solubilization process
CA2247876A1 (en) * 1996-03-08 1997-09-12 Ronald M. Klatz Liquid ventilation method and apparatus
AU2001278864A1 (en) * 2000-06-30 2002-01-30 University Of Cincinnati Peptides with antioxidant and antimicrobial properties
GB2368339B (en) * 2000-10-26 2002-09-18 Yissum Res Dev Co Complex incorporating a plurality of antioxidants
AU2002357168A1 (en) * 2001-12-12 2003-07-09 Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
MXPA04010560A (es) * 2002-04-25 2005-08-15 Scripps Research Inst Tratamiento y prevencion de condiciones pulmonares.
US7290197B2 (en) * 2003-06-03 2007-10-30 Quantum Corporation Correcting data using redundancy blocks
EP1809272A4 (en) * 2004-10-18 2008-01-02 Maroon Biotech Corp METHOD AND COMPOSITIONS FOR TREATING DAMAGES THROUGH FREE RADICALS
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
SI1841458T1 (sl) 2005-01-06 2012-04-30 Discovery Lab Inc Zdravljenje s predpisanim odmerjanjem surfaktanta za zdravljenje ali preprečevanje bronhopulmonalne displazije
WO2007001094A1 (ja) * 2005-06-29 2007-01-04 Sannamu Lee 人工肺サーファクタント組成物
KR20090060348A (ko) * 2006-09-19 2009-06-11 디스커버리 래보래토리스, 인크. 폐 계면활성제 제제 및 점액 클리어런스 촉진 방법
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
CN111568853B (zh) * 2020-04-30 2023-07-28 杭州濡湜生物科技有限公司 一种新型肺部智能释药系统

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643988A (en) * 1984-05-15 1987-02-17 Research Corporation Amphipathic peptides
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US5104853A (en) * 1984-12-11 1992-04-14 California Biotechnology Inc. Alveolar surfactant proteins having cys to ser mutations
US4705684A (en) * 1985-05-31 1987-11-10 The University Of Tennessee Research Corporation Synthetic M proteins - streptococci type 6
FR2586587B1 (fr) * 1985-08-30 1987-10-23 Adir Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5055553A (en) * 1985-09-26 1991-10-08 Genetics Institute Inc. Low molecular weight pulmonary surfactant proteins
US4882422A (en) * 1985-10-24 1989-11-21 Genetics Institute, Inc. Pulmonary surfactant proteins
US4918161A (en) * 1985-09-26 1990-04-17 Genetics Institute, Inc. Low molecular weight pulmonary surfactant proteins
EP0273916A4 (en) * 1986-05-06 1989-11-30 Childrens Hosp Medical Center LUNG HYDROPHOBES, PROTEIN ASSOCIATED TO A SURFACE ACTIVE MEDIUM OF 6000 DALTON MOLECULAR WEIGHT AND MULTIMEREOUS ITEMS.
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
WO1989000167A1 (en) * 1987-07-01 1989-01-12 Kabigen Ab Proteins and protein compositions and their use
JP2602968B2 (ja) * 1987-11-04 1997-04-23 カリフォルニア バイオテクノロジー インコーポレイテッド 肺胞の界面活性タンパク類
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
NZ229737A (en) * 1988-07-01 1991-05-28 Merrell Dow Pharma Polypeptides and derivatives of them with lung surfactant properties and their preparation
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
US5134129A (en) * 1989-03-15 1992-07-28 Board Of Regents, The University Of Texas System Methods employing unique mixtures of polar and neutral lipids for surfactant replacement therapy
CA2049301A1 (en) * 1989-03-31 1990-10-01 Steven Shak Method for treating respiratory distress syndrome
EP0458167B1 (en) * 1990-05-21 1997-04-23 Abbott Laboratories Fatty acid-pulmonary surfactant conjugates
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties

Also Published As

Publication number Publication date
DE69228077D1 (de) 1999-02-11
EP0666754B1 (en) 1998-12-30
HUT66424A (en) 1994-11-28
DE69228077T2 (de) 1999-07-08
GR3029279T3 (en) 1999-05-28
CA2121147A1 (en) 1993-05-13
US5272252A (en) 1993-12-21
ATE175116T1 (de) 1999-01-15
KR100250847B1 (ko) 2000-09-01
JPH07502500A (ja) 1995-03-16
WO1993008824A1 (en) 1993-05-13
AU2778392A (en) 1993-06-07
EP0666754A4 (en) 1996-06-26
FI942032A0 (fi) 1994-05-03
HU9401293D0 (en) 1994-08-29
CA2121147C (en) 2002-12-10
AU667200B2 (en) 1996-03-14
US5683982A (en) 1997-11-04
NO941616L (es) 1994-06-24
NO941616D0 (no) 1994-05-03
FI942032A (fi) 1994-05-03
DK0666754T3 (da) 1999-08-30
EP0666754A1 (en) 1995-08-16

Similar Documents

Publication Publication Date Title
ES2127764T3 (es) Agente tensioactivo pulmonar sintetico que tiene propiedades antioxidantes.
DK183386A (da) Sucralfatsuspension
ES2098029T3 (es) Vacunas de hepatitis que contienen monofosforil lipido a 3-o-desacilado.
FI881676A0 (fi) Anordning foer upphaengning och behandling av skivorgan.
NO873510L (no) Ligge- og/eller sittemoebel.
ES2025198B3 (es) Butaca plegable con respaldo y reposapies regulable.
ES2107048T3 (es) Tensioactivos pulmonares peptidicos sinteticos con antioxidantes covalentemente unidos.
ES2057881T3 (es) Composicion alimenticia nutritiva de elevada viscosidad, alta en proteinas.
DE58901443D1 (de) Ausscheidungshaertbare nickelbasis-superlegierung mit verbesserten mechanischen eigenschaften im temperaturbereich von 600 bis 750oc.
IT1046041B (it) Perfezionamenti nelle poltrone e,o nei divani
IT8721127A0 (it) Procedimento perfezionato per la realizzazione di una imbottitura con caratteristiche di isolamento termico migliorate, particolarmente studiata per abbigliamento, arredamento e simili.
ES296637Y (es) Disposicion de tapizado para butacas y similares.
DK179384A (da) Interferon og interferoninducere kombineret med tobaksprodukter
IT8340120A1 (it) Poltrona in particolare per sale cinematografiche, teatri e simili
IT7923036V0 (it) Struttura di dispositivo di azionamento del poggiagambe in poltrone e simili.
Bishko Qualities of motion: expression in animation and the influence of dance
ITMI920396V0 (it) Tessuto con effetto di plissettatura in particolare per la realizzazione di coperture di divani, poltrone, sedili o simili
NO930712L (no) Ensilasje-additiv
AU103662S (en) Trousers
ES254341Y (es) Reposabrazos tecnico para butacas y similares
IT8459810V0 (it) Combinazione di confezione (di vendita) con parti di pollo, preparate e pronte per l'uso, sistemate, in determinato modo, nella confezione stessa.
IT8409507A0 (it) Procedimento e macchina per confezionare coppie di sedie ed altro per la spedizione, con l'impiego di pellicola elasticamente estensibile
IT7925400A0 (it) Metodo per il supporto e bloccaggio di oggetti da fotoesporre nei bromografi e simili.
ATE3609T1 (de) Sitz- und liegemoebel.
IT8411851V0 (it) Procedimento e macchina per confezionare coppie di sedie ed altro per la spedizione, con l' impiego di pellicola elasticamente estensibile

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 666754

Country of ref document: ES