DE69224501T2 - Tocopherol-Analoge mit cardioprotectiver Wirkung - Google Patents

Tocopherol-Analoge mit cardioprotectiver Wirkung

Info

Publication number
DE69224501T2
DE69224501T2 DE69224501T DE69224501T DE69224501T2 DE 69224501 T2 DE69224501 T2 DE 69224501T2 DE 69224501 T DE69224501 T DE 69224501T DE 69224501 T DE69224501 T DE 69224501T DE 69224501 T2 DE69224501 T2 DE 69224501T2
Authority
DE
Germany
Prior art keywords
alkyl
compound according
compound
formula
benzopyran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69224501T
Other languages
German (de)
English (en)
Other versions
DE69224501D1 (de
Inventor
Frank Bolkenius
J Martin Grisar
Margaret A Petty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69224501D1 publication Critical patent/DE69224501D1/de
Publication of DE69224501T2 publication Critical patent/DE69224501T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
  • Noodles (AREA)
  • Credit Cards Or The Like (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Cosmetics (AREA)
  • Fire-Detection Mechanisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69224501T 1991-10-02 1992-09-29 Tocopherol-Analoge mit cardioprotectiver Wirkung Expired - Fee Related DE69224501T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91402630A EP0535283A1 (en) 1991-10-02 1991-10-02 Cardioprotective tocopherol analogs

Publications (2)

Publication Number Publication Date
DE69224501D1 DE69224501D1 (de) 1998-04-02
DE69224501T2 true DE69224501T2 (de) 1998-06-25

Family

ID=8208620

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69224501T Expired - Fee Related DE69224501T2 (de) 1991-10-02 1992-09-29 Tocopherol-Analoge mit cardioprotectiver Wirkung

Country Status (17)

Country Link
EP (2) EP0535283A1 (enExample)
JP (1) JP3230699B2 (enExample)
KR (1) KR100253108B1 (enExample)
AT (1) ATE163421T1 (enExample)
AU (1) AU652077B2 (enExample)
CA (1) CA2079289C (enExample)
DE (1) DE69224501T2 (enExample)
DK (1) DK0536036T3 (enExample)
ES (1) ES2115656T3 (enExample)
FI (1) FI105552B (enExample)
GR (1) GR3026242T3 (enExample)
HU (1) HU215123B (enExample)
IL (1) IL103305A0 (enExample)
NO (1) NO923840L (enExample)
NZ (1) NZ244549A (enExample)
TW (1) TW224970B (enExample)
ZA (1) ZA927429B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
CN1318434C (zh) * 1997-11-25 2007-05-30 安迪珀蒂恩生物工艺学有限公司 线粒体靶向的抗氧剂
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
MXPA04000654A (es) 2001-07-27 2004-03-19 Vital Health Sciences Pty Ltd Terapia dermica usando derivados de fosfato de agente de transferencia de electrones.
EP1374882B1 (de) * 2002-06-19 2008-10-01 Cognis IP Management GmbH Verwendung von Wirkstoffgemischen zur Herstellung eines Medikamentes gegen rheumatische Arthritis
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
KR101003960B1 (ko) 2003-08-22 2010-12-30 안티포딘 파마슈티칼스, 인코포레이티드 미토콘드리아 표적화 산화방지제로서 사용되는 미토퀴논 유도체를 포함하는 약제학적 조성물
US7888334B2 (en) 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
WO2005033092A1 (en) 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. Chroman derivatives
RU2477136C2 (ru) 2004-03-03 2013-03-10 Вайтал Хэлф Сайнсис Пти Лтд Алкалоидные составы
US9168216B2 (en) 2005-06-17 2015-10-27 Vital Health Sciences Pty. Ltd. Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
US7813042B2 (en) 2005-09-12 2010-10-12 Sharp Kabushiki Kaisha Multiple-view directional display
WO2008029891A1 (en) 2006-09-07 2008-03-13 Sharp Kabushiki Kaisha Image display device, electronic device, and parallax barrier element
WO2011094814A1 (en) 2010-02-05 2011-08-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
CA2794734C (en) 2010-03-30 2017-12-12 Phosphagenics Limited Transdermal delivery patch
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
US10973761B2 (en) 2015-12-09 2021-04-13 Phosphagenics Limited Pharmaceutical formulation
JP7198754B2 (ja) 2016-12-21 2023-01-04 アベーチョ バイオテクノロジー リミテッド 方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62205091A (ja) * 1986-03-04 1987-09-09 Senjiyu Seiyaku Kk 新規なリン酸ジエステルならびにその塩、その製造法およびそれを含有する製剤
CA2002649C (en) * 1988-11-14 2000-06-06 Margaret Petty Cardioprotective tocopherol analogs
US5500444A (en) 1989-11-14 1996-03-19 Hoechst Marion Roussel, Inc. Cardioprotective tocopherol analogs
US5135945A (en) 1991-06-05 1992-08-04 Merrell Dow Pharmaceuticals Inc. Cholesterol-lowering tocopherol analogs

Also Published As

Publication number Publication date
NO923840L (no) 1993-04-05
CA2079289C (en) 2003-02-18
FI924424A0 (fi) 1992-10-01
JPH05310763A (ja) 1993-11-22
FI105552B (fi) 2000-09-15
HU9203134D0 (en) 1992-12-28
TW224970B (enExample) 1994-06-11
HUT62592A (en) 1993-05-28
EP0536036B1 (en) 1998-02-25
EP0536036A1 (en) 1993-04-07
EP0535283A1 (en) 1993-04-07
IL103305A0 (en) 1993-02-21
ES2115656T3 (es) 1998-07-01
JP3230699B2 (ja) 2001-11-19
DK0536036T3 (da) 1998-03-16
ATE163421T1 (de) 1998-03-15
CA2079289A1 (en) 1993-04-03
AU2538392A (en) 1993-04-08
NZ244549A (en) 1994-07-26
KR100253108B1 (ko) 2000-05-01
FI924424L (fi) 1993-04-03
NO923840D0 (no) 1992-10-01
GR3026242T3 (en) 1998-05-29
ZA927429B (en) 1993-04-07
AU652077B2 (en) 1994-08-11
HU215123B (hu) 1998-09-28
DE69224501D1 (de) 1998-04-02

Similar Documents

Publication Publication Date Title
DE60027648T2 (de) Sulfonamide enthaltende indolderivate
DE68921298T2 (de) Herzschützende tocopherolähnliche Verbindungen.
JP3230699B2 (ja) 心臓保護トコフェロ−ル類似体
DE69008791T2 (de) Benzopyranverbindungen, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen.
EP0157267B1 (de) Substituierte Benzopyrane, Verfahren zu ihrer Herstellung sowie ihre Verwendung in Arzneimitteln
EP0025192A2 (de) Substituierte Oxirancarbonsäuren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Arzneimittel
EP0046961B1 (de) Epoxi-cycloalkylalkancarbonsäuren, Verfahren zu ihrer Herstellung, ihre Verwendung sowie sie enthaltende Arzneimittel
DE69218196T2 (de) Cholesterinsenkende tocopherolanaloga
DE69217473T2 (de) Tocopherol-Analoge zum Gewebeschutz
JPH02180A (ja) ２，２‐ジメチルクロメン誘導体、その製造方法及びこれを含む薬剤組成物
CA2186654A1 (en) Phosphoric diester
DE69314022T2 (de) Derivate von 2,3-dihydro-2,2,4,6,7-pentaalkyl-5-benzofuranen
JPH02184686A (ja) 新規ベンゾピラニルピロリノン誘導体
DE69529807T2 (de) Neue Parabansäure-Derivate als Aldose-Reduktase Inhibitoren
DE69118955T2 (de) Ascorbinsäure Derivate
EP0560399A1 (de) Verwendung substituierter 3,4-Dihydro-2H-benzopyrane als Heilmittel gegen Störungen der ableitenden Harnwege
EP0337885B1 (fr) Nouveaux dérivés triéniques de structure chroménique, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
CA1089867A (fr) Derives du benzofuranne
EP0966455B1 (de) Oxirancarbonsäuren für die behandlung von diabetes
EP0369083A1 (en) Cardioprotective tocopherol analogs
EP0007347B1 (de) Lipidsenkende Alkylenglykolderivate und Verfahren zu ihrer Herstellung
MC1394A1 (fr) Nouveaux derives de l'imidazole
EP0369082A1 (en) Cardioprotective tocopherol analogs
NZ251174A (en) Hydraziniumcarbonyl derivatives of benzopyrans; medicaments
JP3857428B2 (ja) 抗真菌剤

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee