ES2115656T3 - Analogos de tocoferol cardioprotectores. - Google Patents

Analogos de tocoferol cardioprotectores.

Info

Publication number
ES2115656T3
ES2115656T3 ES92402656T ES92402656T ES2115656T3 ES 2115656 T3 ES2115656 T3 ES 2115656T3 ES 92402656 T ES92402656 T ES 92402656T ES 92402656 T ES92402656 T ES 92402656T ES 2115656 T3 ES2115656 T3 ES 2115656T3
Authority
ES
Spain
Prior art keywords
cardioprotectors
tocoferol
analogs
cardioprotectoral
phosphony
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92402656T
Other languages
English (en)
Spanish (es)
Inventor
J Martin Grisar
Margaret A Petty
Frank Bolkenius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2115656T3 publication Critical patent/ES2115656T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Credit Cards Or The Like (AREA)
  • Noodles (AREA)
  • Cosmetics (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Fire-Detection Mechanisms (AREA)
  • Medicines Containing Plant Substances (AREA)
ES92402656T 1991-10-02 1992-09-29 Analogos de tocoferol cardioprotectores. Expired - Lifetime ES2115656T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91402630A EP0535283A1 (en) 1991-10-02 1991-10-02 Cardioprotective tocopherol analogs

Publications (1)

Publication Number Publication Date
ES2115656T3 true ES2115656T3 (es) 1998-07-01

Family

ID=8208620

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92402656T Expired - Lifetime ES2115656T3 (es) 1991-10-02 1992-09-29 Analogos de tocoferol cardioprotectores.

Country Status (17)

Country Link
EP (2) EP0535283A1 (enExample)
JP (1) JP3230699B2 (enExample)
KR (1) KR100253108B1 (enExample)
AT (1) ATE163421T1 (enExample)
AU (1) AU652077B2 (enExample)
CA (1) CA2079289C (enExample)
DE (1) DE69224501T2 (enExample)
DK (1) DK0536036T3 (enExample)
ES (1) ES2115656T3 (enExample)
FI (1) FI105552B (enExample)
GR (1) GR3026242T3 (enExample)
HU (1) HU215123B (enExample)
IL (1) IL103305A0 (enExample)
NO (1) NO923840L (enExample)
NZ (1) NZ244549A (enExample)
TW (1) TW224970B (enExample)
ZA (1) ZA927429B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
ATE296305T1 (de) * 1997-11-25 2005-06-15 Antipodean Biotechnology Ltd Antioxidantien mit spezifischer wirkung auf mitochondrien
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
BR0211673A (pt) 2001-07-27 2004-07-13 Vital Health Sciences Pty Ltd Terapia dermal utilizando derivados de fosfato de agentes de transferência de elétrons
ATE409489T1 (de) * 2002-06-19 2008-10-15 Cognis Ip Man Gmbh Verwendung von wirkstoffgemischen zur herstellung eines medikamentes gegen rheumatische arthritis
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
JP4648319B2 (ja) 2003-08-22 2011-03-09 アンティポディーン ファーマシューティカルズ インコーポレイティド ミトコンドリアを標的とする抗酸化剤として使用されるミトキノン誘導体
US7888334B2 (en) 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
WO2005033093A1 (en) 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. 7,8-bicycloalkyl-chroman derivatives
JP4847437B2 (ja) 2004-03-03 2011-12-28 バイタル ヘルス サイエンシズ プロプライアタリー リミティド アルカロイド製剤
US9168216B2 (en) 2005-06-17 2015-10-27 Vital Health Sciences Pty. Ltd. Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
US7813042B2 (en) 2005-09-12 2010-10-12 Sharp Kabushiki Kaisha Multiple-view directional display
US8687273B2 (en) 2006-09-07 2014-04-01 Sharp Kabushiki Kaisha Image display device, electronic device, and parallax barrier element
EP2531047B1 (en) 2010-02-05 2024-11-13 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
ES2829386T3 (es) 2010-03-30 2021-05-31 Phosphagenics Ltd Parche de administración transdérmica
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
MX383940B (es) 2015-12-09 2025-03-14 Phosphagenics Ltd Formulación farmacéutica que contiene tocol fosfato.
IL267006B2 (en) 2016-12-21 2024-11-01 Phosphagenics Ltd Process for phosphorylation of a complex alcohol with p4o10 at high temperatures, and products thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62205091A (ja) * 1986-03-04 1987-09-09 Senjiyu Seiyaku Kk 新規なリン酸ジエステルならびにその塩、その製造法およびそれを含有する製剤
CA2002649C (en) * 1988-11-14 2000-06-06 Margaret Petty Cardioprotective tocopherol analogs
US5500444A (en) 1989-11-14 1996-03-19 Hoechst Marion Roussel, Inc. Cardioprotective tocopherol analogs
US5135945A (en) 1991-06-05 1992-08-04 Merrell Dow Pharmaceuticals Inc. Cholesterol-lowering tocopherol analogs

Also Published As

Publication number Publication date
DK0536036T3 (da) 1998-03-16
CA2079289C (en) 2003-02-18
FI105552B (fi) 2000-09-15
ZA927429B (en) 1993-04-07
EP0535283A1 (en) 1993-04-07
FI924424L (fi) 1993-04-03
FI924424A0 (fi) 1992-10-01
CA2079289A1 (en) 1993-04-03
TW224970B (enExample) 1994-06-11
DE69224501T2 (de) 1998-06-25
AU652077B2 (en) 1994-08-11
HU215123B (hu) 1998-09-28
KR100253108B1 (ko) 2000-05-01
EP0536036B1 (en) 1998-02-25
GR3026242T3 (en) 1998-05-29
NO923840D0 (no) 1992-10-01
HU9203134D0 (en) 1992-12-28
JP3230699B2 (ja) 2001-11-19
JPH05310763A (ja) 1993-11-22
AU2538392A (en) 1993-04-08
NZ244549A (en) 1994-07-26
DE69224501D1 (de) 1998-04-02
NO923840L (no) 1993-04-05
EP0536036A1 (en) 1993-04-07
IL103305A0 (en) 1993-02-21
HUT62592A (en) 1993-05-28
ATE163421T1 (de) 1998-03-15

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