DE69220084T2 - Diagnostische Anwendungen der Bildung von doppelten D-Loops. - Google Patents

Diagnostische Anwendungen der Bildung von doppelten D-Loops.

Info

Publication number
DE69220084T2
DE69220084T2 DE69220084T DE69220084T DE69220084T2 DE 69220084 T2 DE69220084 T2 DE 69220084T2 DE 69220084 T DE69220084 T DE 69220084T DE 69220084 T DE69220084 T DE 69220084T DE 69220084 T2 DE69220084 T2 DE 69220084T2
Authority
DE
Germany
Prior art keywords
dna
probe
target
probes
reca
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69220084T
Other languages
German (de)
English (en)
Other versions
DE69220084D1 (de
Inventor
Cornelia Calhoun
Elissa Sena
David Zarling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tapestry Pharmaceuticals Inc
Original Assignee
Daikin Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/520,321 external-priority patent/US5223414A/en
Priority claimed from US07/755,462 external-priority patent/US5273881A/en
Application filed by Daikin Industries Ltd filed Critical Daikin Industries Ltd
Publication of DE69220084D1 publication Critical patent/DE69220084D1/de
Application granted granted Critical
Publication of DE69220084T2 publication Critical patent/DE69220084T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Stabilization Of Oscillater, Synchronisation, Frequency Synthesizers (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69220084T 1990-05-07 1992-09-04 Diagnostische Anwendungen der Bildung von doppelten D-Loops. Expired - Fee Related DE69220084T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/520,321 US5223414A (en) 1990-05-07 1990-05-07 Process for nucleic acid hybridization and amplification
US07/755,462 US5273881A (en) 1990-05-07 1991-09-04 Diagnostic applications of double D-loop formation
US91079192A 1992-07-09 1992-07-09
PCT/JP1992/001135 WO1993005178A1 (en) 1990-05-07 1992-09-04 Diagnostic applications of double d-loop formation

Publications (2)

Publication Number Publication Date
DE69220084D1 DE69220084D1 (de) 1997-07-03
DE69220084T2 true DE69220084T2 (de) 1997-09-11

Family

ID=27414753

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69220084T Expired - Fee Related DE69220084T2 (de) 1990-05-07 1992-09-04 Diagnostische Anwendungen der Bildung von doppelten D-Loops.

Country Status (13)

Country Link
US (1) US5670316A (Direct)
EP (1) EP0612352B1 (Direct)
JP (1) JP2745816B2 (Direct)
KR (1) KR100245284B1 (Direct)
AT (1) ATE153707T1 (Direct)
AU (1) AU661505B2 (Direct)
CA (1) CA2116215C (Direct)
DE (1) DE69220084T2 (Direct)
DK (1) DK0612352T3 (Direct)
ES (1) ES2101867T3 (Direct)
FI (1) FI941016L (Direct)
NO (1) NO313557B1 (Direct)
WO (1) WO1993005178A1 (Direct)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017114537A1 (de) * 2017-06-29 2019-01-03 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und optischer Sensor

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506098A (en) * 1991-09-04 1996-04-09 Daikin Industries, Ltd. In situ hybridization method
DE69333955D1 (de) * 1992-04-24 2006-02-02 Stanford Res Inst Int Targeting homologer sequenzen in eukaryotenzellen
US5929043A (en) 1995-01-31 1999-07-27 Pangene Corporation Recombinase mediated DNA therapies
FR2737502B1 (fr) * 1995-07-31 1997-10-24 Genset Sa Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
US6335164B1 (en) 1996-08-29 2002-01-01 Daikin Industries, Ltd. Methods for targeting, enriching, detecting and/or isolating target nucleic acid sequence using RecA-like recombinase
JP3891620B2 (ja) * 1996-11-14 2007-03-14 株式会社アイシン・コスモス研究所 ヘアピン型構造の核酸プローブ分子、及び該核酸プローブ分子を利用した核酸検出方法
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
US6342350B1 (en) * 1997-09-05 2002-01-29 The General Hospital Corporation Alpha-2-macroglobulin diagnostic test
EP1038017A2 (en) * 1997-12-11 2000-09-27 Pangene Corporation The use of consensus sequences for targeted homologous gene isolation and recombination in gene families
DE19980548D2 (de) * 1998-04-01 2001-07-12 Juergen Wolfrum Verfahren und Vorrichtung zur Quantifizierung von DNA und RNA
US6287772B1 (en) * 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
US6541227B1 (en) * 1998-10-12 2003-04-01 Aisin Seiki Kabushiki Kaisha Preparation of labeled DNA
JP4265028B2 (ja) * 1999-04-14 2009-05-20 アイシン精機株式会社 二本鎖ｄｎａの特異的切断方法およびそのためのキット
WO2000063365A1 (en) * 1999-04-21 2000-10-26 Pangene Corporation Locked nucleic acid hybrids and methods of use
JP2003517842A (ja) * 1999-12-21 2003-06-03 オーソ−クリニカル・ダイアグノスティックス・インコーポレイテッド 核酸の検出方法
AU2610301A (en) * 1999-12-28 2001-07-09 Napro Biotherapeutics, Inc. Recombinase mediated gene chip detection
AU2002311761B2 (en) * 2001-02-21 2007-07-19 Gene Check, Inc. Mutation detection using MutS and RecA
AU2002303176A1 (en) 2001-03-27 2002-10-15 University Of Delaware Genomics applications for modified oligonucleotides
WO2002086167A1 (en) * 2001-04-20 2002-10-31 The Penn State Research Foundation Methods for nucleic acid manipulation
US7468244B2 (en) 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
AU2002341898A2 (en) * 2001-09-28 2003-04-07 University Of Delaware Polymorphism detection and separation
US7244562B2 (en) * 2001-11-01 2007-07-17 Gene Check, Inc. RecA assisted detection of mutations, single nucleotide polymorphisms and specific sequences
US7399590B2 (en) * 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
US8030000B2 (en) * 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
EP1992706B1 (en) * 2002-02-21 2014-11-19 Alere San Diego, Inc. Recombinase polymerase amplification
WO2005118853A2 (en) * 2004-06-01 2005-12-15 Asm Scientific, Inc. Recombinase polymerase amplification
CN1330775C (zh) * 2002-05-08 2007-08-08 爱科来株式会社 靶核酸的检测方法
AU2003251986A1 (en) * 2002-07-17 2004-02-02 U.S.Genomics, Inc. Methods and compositions for analyzing polymers using chimeric tags
EP1613768A4 (en) * 2003-03-11 2006-05-31 Gene Check Inc RECA-SUPPORTED ALLELSPECIFIC OLIGONUCLEOTIDE EXTENSION PROCESS
WO2005012575A1 (en) * 2003-08-01 2005-02-10 U.S. Genomics, Inc. Methods and compositions related to the use of sequence-specific endonucleases for analyzing nucleic acids under non-cleaving conditions
WO2005017205A2 (en) * 2003-08-04 2005-02-24 U. S. Genomics, Inc. Nucleic acid mapping using linear analysis
JP2006055065A (ja) * 2004-08-19 2006-03-02 Toyo Kohan Co Ltd 非対称ｐｃｒを用いた核酸の検出方法、ポリヌクレオチドプローブ、それを固定するプローブ固定化担体およびキット
WO2006051988A1 (ja) * 2004-11-15 2006-05-18 Riken 核酸の増幅方法
EP2829615B1 (en) 2005-07-25 2018-05-09 Alere San Diego, Inc. Kit for multiplexing recombinase polymerase amplification
US20090064377A1 (en) * 2005-09-29 2009-03-05 Daphne Yvette Rainey-Wittich Method and means for targeted nucleotide exchange
US20070202522A1 (en) * 2006-02-27 2007-08-30 Salinas Frank G Isothermal screening of tumor cell related nucleic acids
US20090061413A1 (en) * 2006-02-27 2009-03-05 Salinas Frank G Isothermal screening of hiv-1 related nucleic acids
US20080003600A1 (en) * 2006-02-27 2008-01-03 Salinas Frank G Isothermal screening of breast cancer related nucleic acid
US20080220421A1 (en) * 2006-02-27 2008-09-11 Salinas Frank G Isothermal screening for nucleic acids associated with diseases and conditions of the gi tract
WO2008035205A2 (en) 2006-05-04 2008-03-27 Asm Scientific, Inc. Recombinase polymerase amplification
WO2010135310A1 (en) 2009-05-20 2010-11-25 Biosite Incorporated Dna glycosylase/lyase and ap endonuclease substrates
EP2438196B1 (en) 2009-06-05 2016-12-21 Alere San Diego, Inc. Recombinase polymerase amplification reagents and kits
US8623603B2 (en) 2010-03-08 2014-01-07 Dana-Farber Cancer Institute, Inc. Full cold-PCR enrichment with reference blocking sequence
EP3333269B1 (en) 2011-03-31 2021-05-05 Dana-Farber Cancer Institute, Inc. Methods to enable multiplex cold-pcr
EP3978620A1 (en) 2011-04-07 2022-04-06 Abbott Diagnostics Scarborough, Inc. Monitoring recombinase polymerase amplification mixtures
EP2839026B1 (en) 2012-04-19 2016-08-10 Life Technologies Corporation Nucleic acid amplification
WO2013158313A1 (en) 2012-04-19 2013-10-24 Life Technologies Corporation Nucleic acid amplification
WO2014020137A1 (en) * 2012-08-02 2014-02-06 Qiagen Gmbh Recombinase mediated targeted dna enrichment for next generation sequencing
EP3257952B1 (en) 2012-09-11 2020-02-12 Life Technologies Corporation Nucleic acid amplification
WO2014043143A1 (en) 2012-09-11 2014-03-20 Life Technologies Corporation Nucleic acid amplification
EP3102691B1 (en) 2014-02-03 2019-09-11 Thermo Fisher Scientific Baltics UAB Method for controlled dna fragmentation
EP3155127B1 (en) 2014-06-13 2020-07-22 Life Technologies Corporation Multiplex nucleic acid amplification
US10344336B2 (en) 2015-06-09 2019-07-09 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
WO2016210224A1 (en) * 2015-06-24 2016-12-29 Dana-Farber Cancer Institute, Inc. Selective degradation of wild-type dna and enrichment of mutant alleles using nuclease
US20180363037A1 (en) 2015-12-09 2018-12-20 Life Technologies Corporation Detection and quantification of nucleic acid molecules associated with a surface
WO2017121836A1 (en) 2016-01-15 2017-07-20 Thermo Fisher Scientific Baltics Uab Thermophilic dna polymerase mutants
US11268117B2 (en) 2016-06-10 2022-03-08 Life Technologies Corporation Methods and compositions for nucleic acid amplification
WO2018071522A1 (en) 2016-10-11 2018-04-19 Life Technologies Corporation Rapid amplification of nucleic acids
EP3551756A4 (en) 2016-12-12 2020-07-15 Dana Farber Cancer Institute, Inc. COMPOSITIONS AND METHODS FOR MOLECULAR BARCODE CODING OF DNA MOLECULES BEFORE ENRICHMENT OF MUTATIONS AND / OR DETECTION OF MUTATIONS
US11542540B2 (en) 2017-06-16 2023-01-03 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
WO2019002178A1 (en) 2017-06-26 2019-01-03 Thermo Fisher Scientific Baltics Uab DNA MUTANTS THERMOPHILIC POLYMERASES
US11293056B2 (en) 2017-11-07 2022-04-05 Life Technologies Corporation Methods and compositions for manipulating nucleic acids
US12226745B2 (en) 2017-11-07 2025-02-18 Life Technologies Corporation Methods and compositions for manipulating nucleic acids
EP3963103B1 (en) 2019-05-03 2024-02-28 Life Technologies Corporation Methods and compositions for manipulating nucleic acids
WO2021034711A1 (en) 2019-08-21 2021-02-25 Life Technologies Corporation System and method for sequencing
US20220170093A1 (en) 2020-11-16 2022-06-02 Life Technologies Corporation System and method for sequencing
NL2033124B1 (en) * 2022-09-23 2024-03-29 Rapidemic B V Methods and device for multiple-label nucleic acid amplification and detection
US20250215421A1 (en) 2023-12-29 2025-07-03 Life Technologies Corporation Enrichment of clonal substrates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
CA1254114A (en) * 1984-05-07 1989-05-16 Allied Corporation Displacement polynucleotide assay employing recombination protein and diagnostic kit
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
EP0183822A4 (en) * 1984-06-01 1988-08-29 Nat Biomedical Res Foundation HYBRIDIZATION OF CATALYZED NUCLEIC ACIDS USING AN ENZYMATIC REAGENT.
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4888274A (en) * 1985-09-18 1989-12-19 Yale University RecA nucleoprotein filament and methods
WO1987001730A1 (en) * 1985-09-18 1987-03-26 Yale University RecA NUCLEOPROTEIN FILAMENT AND METHODS
AU2735988A (en) * 1987-12-21 1989-07-13 Amoco Corporation Target and background capture methods with amplification for affinity assays
EP0322311B1 (en) * 1987-12-21 1994-03-23 Applied Biosystems, Inc. Method and kit for detecting a nucleic acid sequence
US5273881A (en) * 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
US5223414A (en) * 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
US5506098A (en) * 1991-09-04 1996-04-09 Daikin Industries, Ltd. In situ hybridization method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017114537A1 (de) * 2017-06-29 2019-01-03 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und optischer Sensor

Also Published As

Publication number Publication date
AU661505B2 (en) 1995-07-27
JPH06510201A (ja) 1994-11-17
DE69220084D1 (de) 1997-07-03
ATE153707T1 (de) 1997-06-15
EP0612352A1 (en) 1994-08-31
DK0612352T3 (da) 1997-06-30
NO940744D0 (no) 1994-03-03
FI941016A0 (fi) 1994-03-03
FI941016A7 (fi) 1994-05-03
CA2116215A1 (en) 1993-03-05
NO313557B1 (no) 2002-10-21
EP0612352B1 (en) 1997-05-28
CA2116215C (en) 1998-12-22
ES2101867T3 (es) 1997-07-16
JP2745816B2 (ja) 1998-04-28
US5670316A (en) 1997-09-23
AU2540192A (en) 1993-04-05
NO940744L (Direct) 1994-05-02
WO1993005178A1 (en) 1993-03-18
KR100245284B1 (ko) 2000-03-02
FI941016L (fi) 1994-05-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NAPRO BIO THERAPEUTICS.INC., NEWARK, DEL., US

8328 Change in the person/name/address of the agent

Representative=s name: VOSSIUS & PARTNER, 81675 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: TAPESTRY PHARMACEUTICALS, INC. (N.D.GES.D. STAATES

8339 Ceased/non-payment of the annual fee