DE69213537T2 - HLE-inhibierende heterozyklische Amide - Google Patents
HLE-inhibierende heterozyklische AmideInfo
- Publication number
- DE69213537T2 DE69213537T2 DE69213537T DE69213537T DE69213537T2 DE 69213537 T2 DE69213537 T2 DE 69213537T2 DE 69213537 T DE69213537 T DE 69213537T DE 69213537 T DE69213537 T DE 69213537T DE 69213537 T2 DE69213537 T2 DE 69213537T2
- Authority
- DE
- Germany
- Prior art keywords
- hle
- heterocyclic amides
- inhibiting
- inhibiting heterocyclic
- amides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919108357A GB9108357D0 (en) | 1991-04-18 | 1991-04-18 | Heterocyclic amides |
GB919108358A GB9108358D0 (en) | 1991-04-18 | 1991-04-18 | Heterocyclic compounds |
GB929205392A GB9205392D0 (en) | 1992-03-12 | 1992-03-12 | Heterocyclic amides |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69213537D1 DE69213537D1 (de) | 1996-10-17 |
DE69213537T2 true DE69213537T2 (de) | 1997-02-20 |
Family
ID=27265602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69213537T Expired - Fee Related DE69213537T2 (de) | 1991-04-18 | 1992-04-15 | HLE-inhibierende heterozyklische Amide |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0509769B1 (de) |
JP (1) | JPH0656785A (de) |
KR (1) | KR920019750A (de) |
AU (1) | AU660664B2 (de) |
CA (1) | CA2065794A1 (de) |
CS (1) | CS117692A3 (de) |
DE (1) | DE69213537T2 (de) |
FI (1) | FI921598A (de) |
GB (1) | GB9207145D0 (de) |
HU (1) | HUT66541A (de) |
IE (1) | IE921159A1 (de) |
IL (1) | IL101555A0 (de) |
NO (1) | NO921451L (de) |
NZ (1) | NZ242322A (de) |
TW (1) | TW262475B (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5521179A (en) * | 1991-04-18 | 1996-05-28 | Zeneca Limited | Heterocyclic amides |
US5486529A (en) * | 1992-04-16 | 1996-01-23 | Zeneca Limited | Certain pyridyl ketones for treating diseases involving leukocyte elastase |
WO1993021214A1 (en) * | 1992-04-16 | 1993-10-28 | Zeneca Limited | Alpha-aminoboronic acid peptides and their use as elastase inhibitors |
CA2133658A1 (en) * | 1992-04-16 | 1993-10-28 | Peter R. Bernstein | Heterocyclic derivatives |
GB9307555D0 (en) * | 1992-04-16 | 1993-06-02 | Zeneca Ltd | Heterocyclic compounds |
US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
GB9211783D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Amide derivatives |
GB9214053D0 (en) * | 1992-07-02 | 1992-08-12 | Ici Plc | Heterocyclic amides |
US5658930A (en) * | 1994-12-13 | 1997-08-19 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
US6608204B1 (en) * | 1994-12-13 | 2003-08-19 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
US5656645A (en) * | 1994-12-13 | 1997-08-12 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
EP0826671B1 (de) * | 1995-04-27 | 2004-12-29 | Mitsubishi Pharma Corporation | Heterocyclische amidverbindungen und deren medizinische verwendung |
EP0835109A4 (de) * | 1995-06-27 | 1999-02-03 | Merck & Co Inc | Pyridinone als thrombininhibitoren |
US5668289A (en) * | 1996-06-24 | 1997-09-16 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
US5872138A (en) * | 1996-09-13 | 1999-02-16 | Merck & Co., Inc. | Thrombin inhibitors |
US5869487A (en) * | 1996-10-24 | 1999-02-09 | Merck & Co., Inc. | Pyrido 3,4-B!pyrazines for use as thrombin inhibitors |
WO1998018794A1 (fr) * | 1996-10-25 | 1998-05-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Nouveaux composes d'amide heterocycliques et leur utilisation a des fins medicinales |
US6017934A (en) * | 1997-01-22 | 2000-01-25 | Merck & Co., Inc. | Thrombin inhibitors |
US5792779A (en) * | 1997-02-19 | 1998-08-11 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
US6011038A (en) * | 1997-09-05 | 2000-01-04 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
US6087373A (en) * | 1997-09-23 | 2000-07-11 | Merck & Co., Inc. | Thrombin inhibitors |
US6133297A (en) * | 1997-09-30 | 2000-10-17 | Merck & Co., Inc. | Thrombin inhibitors |
US6528514B1 (en) | 1998-03-11 | 2003-03-04 | Welfide Corporation | IgE antibody production inhibitors and autoimmune diseases inhibitors |
US6147078A (en) * | 1998-05-19 | 2000-11-14 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
EP1117660A4 (de) * | 1998-09-28 | 2002-01-09 | Merck & Co Inc | Thrombin-inhibitoren |
CA2348530A1 (en) | 1998-10-30 | 2000-05-11 | Merck & Co., Inc. | Thrombin inhibitors |
US6610692B1 (en) | 1998-10-30 | 2003-08-26 | Merck & Co., Inc. | Thrombin inhibitors |
US6239132B1 (en) | 1999-04-23 | 2001-05-29 | Merck & Co., Inc. | Thrombin inhibitors |
UA58636C2 (uk) | 1999-06-04 | 2003-08-15 | Мерк Енд Ко., Інк. | Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням |
CA2374654A1 (en) | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Thrombin inhibitors |
JP2003514905A (ja) | 1999-11-23 | 2003-04-22 | メルク エンド カムパニー インコーポレーテッド | ピラジノン系トロンビン阻害薬 |
CA2403558A1 (en) | 2000-03-23 | 2001-09-27 | Merck & Co., Inc. | Thrombin inhibitors |
TW200500341A (en) * | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
RU2412936C2 (ru) | 2004-11-24 | 2011-02-27 | Вертекс Фармасьютикалз Инкорпорейтед | Производные 3-[2-(3-ациламино-2-оксо-2н-пиридин-1-ил)-ацетиламино]-4-оксо-пентановой кислоты и их применение в качестве ингибиторов каспазы |
AU2006255009B2 (en) * | 2005-06-07 | 2011-10-27 | Pharmacopeia L.L.C. | Azinone and diazinone V3 inhibitors for depression and stress disorders |
RU2007147959A (ru) * | 2005-06-08 | 2009-07-20 | Новартис АГ (CH) | Органические соединения |
CN110950807B (zh) * | 2018-09-26 | 2023-03-03 | 中国科学院上海药物研究所 | 联芳基类化合物、其制备方法、药物组合物及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4474778A (en) * | 1983-11-09 | 1984-10-02 | E. R. Squibb & Sons, Inc. | Lactam containing compounds, their pharmaceutical compositions and method of use |
GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
-
1992
- 1992-04-01 GB GB929207145A patent/GB9207145D0/en active Pending
- 1992-04-10 AU AU14827/92A patent/AU660664B2/en not_active Ceased
- 1992-04-10 FI FI921598A patent/FI921598A/fi not_active Application Discontinuation
- 1992-04-10 HU HU9201225A patent/HUT66541A/hu unknown
- 1992-04-10 KR KR1019920006072A patent/KR920019750A/ko not_active Application Discontinuation
- 1992-04-10 IE IE115992A patent/IE921159A1/en unknown
- 1992-04-10 CA CA002065794A patent/CA2065794A1/en not_active Abandoned
- 1992-04-10 IL IL101555A patent/IL101555A0/xx unknown
- 1992-04-10 NZ NZ242322A patent/NZ242322A/en unknown
- 1992-04-10 NO NO92921451A patent/NO921451L/no unknown
- 1992-04-15 DE DE69213537T patent/DE69213537T2/de not_active Expired - Fee Related
- 1992-04-15 EP EP92303358A patent/EP0509769B1/de not_active Expired - Lifetime
- 1992-04-16 CS CS921176A patent/CS117692A3/cs unknown
- 1992-04-18 JP JP4143140A patent/JPH0656785A/ja active Pending
- 1992-04-29 TW TW081103383A patent/TW262475B/zh active
Also Published As
Publication number | Publication date |
---|---|
JPH0656785A (ja) | 1994-03-01 |
FI921598A0 (fi) | 1992-04-10 |
EP0509769A2 (de) | 1992-10-21 |
EP0509769A3 (en) | 1993-09-01 |
IL101555A0 (en) | 1992-12-30 |
AU1482792A (en) | 1992-10-22 |
DE69213537D1 (de) | 1996-10-17 |
HUT66541A (en) | 1994-12-28 |
IE921159A1 (en) | 1992-10-21 |
KR920019750A (ko) | 1992-11-19 |
TW262475B (en) | 1995-11-11 |
FI921598A (fi) | 1992-10-19 |
CS117692A3 (en) | 1992-11-18 |
NZ242322A (en) | 1994-12-22 |
CA2065794A1 (en) | 1992-10-19 |
NO921451D0 (no) | 1992-04-10 |
EP0509769B1 (de) | 1996-09-11 |
GB9207145D0 (en) | 1992-05-13 |
AU660664B2 (en) | 1995-07-06 |
HU9201225D0 (en) | 1992-07-28 |
NO921451L (no) | 1992-10-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: ASTRAZENECA UK LTD., LONDON, GB |
|
8339 | Ceased/non-payment of the annual fee |