DE69316068T2 - 1-[2-(Arylsulfonylamino)-1-oxoethyl]piperidin-Derivate, ihre Herstellung und therapeutische Verwendung - Google Patents

1-[2-(Arylsulfonylamino)-1-oxoethyl]piperidin-Derivate, ihre Herstellung und therapeutische Verwendung

Info

Publication number
DE69316068T2
DE69316068T2 DE69316068T DE69316068T DE69316068T2 DE 69316068 T2 DE69316068 T2 DE 69316068T2 DE 69316068 T DE69316068 T DE 69316068T DE 69316068 T DE69316068 T DE 69316068T DE 69316068 T2 DE69316068 T2 DE 69316068T2
Authority
DE
Germany
Prior art keywords
group
hydrogen atom
alkyl group
alkyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69316068T
Other languages
English (en)
Other versions
DE69316068D1 (de
Inventor
Gilbert Lassalle
Thomas Purcell
Daniel Galtier
Paul Howard Williams
Frederic Galli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of DE69316068D1 publication Critical patent/DE69316068D1/de
Application granted granted Critical
Publication of DE69316068T2 publication Critical patent/DE69316068T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69316068T 1992-03-30 1993-03-25 1-[2-(Arylsulfonylamino)-1-oxoethyl]piperidin-Derivate, ihre Herstellung und therapeutische Verwendung Expired - Fee Related DE69316068T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9203828A FR2689130B1 (fr) 1992-03-30 1992-03-30 Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.

Publications (2)

Publication Number Publication Date
DE69316068D1 DE69316068D1 (de) 1998-02-12
DE69316068T2 true DE69316068T2 (de) 1998-08-13

Family

ID=9428242

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69316068T Expired - Fee Related DE69316068T2 (de) 1992-03-30 1993-03-25 1-[2-(Arylsulfonylamino)-1-oxoethyl]piperidin-Derivate, ihre Herstellung und therapeutische Verwendung

Country Status (21)

Country Link
US (1) US5453430A (de)
EP (2) EP0565396B1 (de)
JP (2) JP2550276B2 (de)
KR (1) KR930019664A (de)
CN (1) CN1076928A (de)
AT (1) ATE161839T1 (de)
AU (1) AU655876B2 (de)
CA (1) CA2092867A1 (de)
CZ (1) CZ52893A3 (de)
DE (1) DE69316068T2 (de)
FI (1) FI931413A (de)
FR (1) FR2689130B1 (de)
HU (1) HUT64758A (de)
IL (1) IL105028A0 (de)
MX (1) MX9301783A (de)
NO (2) NO302572B1 (de)
NZ (1) NZ247277A (de)
PL (1) PL298299A1 (de)
SK (1) SK26393A3 (de)
TW (1) TW234717B (de)
ZA (1) ZA932228B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689130B1 (fr) 1992-03-30 1994-05-27 Synthelabo Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.
CA2122397A1 (en) * 1993-05-03 1994-11-04 Spencer D. Kimball Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors
FR2710066B1 (fr) * 1993-09-14 1995-10-20 Synthelabo Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2710061B1 (fr) * 1993-09-14 1995-12-29 Synthelabo Acides et chlorures d'acides 1,2,3, 4-tétrahydroquinoléine-8-sulfoniques, et leur utilisation comme intermédiaires de synthèse.
FR2718439B3 (fr) * 1994-04-12 1996-02-09 Synthelabo Dérivés de l'acide pipécolique, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2718443B1 (fr) * 1994-04-12 1996-05-10 Synthelabo Dérivés de 1-[2-[[(3-méthyl-1, 2, 3, 4-tétrahydroquinoléin-8-yl)sulfonyl] amino]-1-oxo-5-(1H-imidazol-4-yl)pentyl]pipéridine, leur préparation et leur application en thérapeutique.
FR2718442B1 (fr) * 1994-04-12 1996-05-10 Synthelabo Dérivés de 5-(1H-imidazol-4-yl)-1-oxopentylpipéridine, leur préparation et leur application en thérapeutique.
FR2718444B1 (fr) * 1994-04-12 1996-05-10 Synthelabo Dérivés de (3-méthyl-1, 2, 3, 4-tétrahydroquinoléin-8-yl)sulfonyle, leur préparation et leur application en thérapeutique.
DE4424828A1 (de) * 1994-07-14 1996-01-18 Thomae Gmbh Dr K Neue substituierte Arylsulfonamide, ihre Herstellung und ihre Verwendung als Arzneimittel
FR2727413B1 (fr) * 1994-11-25 1996-12-20 Synthelabo Derives de 5-(1h-imidazol-4-yl)-1-oxo-2-(phenylsulfonamino)- pentylpiperidine, leur preparation et leur application en therapeutique
FR2728570B1 (fr) * 1994-12-23 1997-04-11 Synthelabo Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique
GB9505538D0 (en) * 1995-03-18 1995-05-03 Ciba Geigy Ag New compounds
US5811402A (en) * 1996-03-22 1998-09-22 Eli Lilly And Company Antithrombotic diamides
IL125918A0 (en) * 1996-04-22 1999-04-11 Synthelabo Propargylgycine derivatives preparation and utilisation thereof as synthesis intermediates
FR2747676B1 (fr) * 1996-04-22 1998-06-05 Synthelabo Derives de [1-oxo-2-(sulfonylamino)ethyl] piperidine, leur preparation et leur application en therapeutique
FR2747677B1 (fr) * 1996-04-22 1998-06-05 Synthelabo Derives de propargylglycine, leur preparation et leur utilisation comme intermediaires de synthese
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
FR2756285B1 (fr) * 1996-11-22 1998-12-18 Synthelabo Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique
US5773089A (en) * 1996-12-18 1998-06-30 E. I. Du Pont De Nemours And Company Process for treating aramid surfaces to be plated
FR2765220B1 (fr) * 1997-06-25 1999-07-30 Synthelabo Derives de 1-oxo-2-(phenylsulfonyl)aminopentyle, leur preparation et leur application en therapeutique
FR2771094B1 (fr) * 1997-11-19 2000-02-04 Synthelabo Derives de piperidine-2-carboxylate, leur preparation et leur application en therapeutique
US20100048549A1 (en) * 2005-05-18 2010-02-25 Siegfried Wurster Peptidomimetics selective for the somatostatin receptor subtypes 1 and/or 4
EP3009123A1 (de) * 2008-12-22 2016-04-20 Pola Chemical Industries Inc. Melaninproduktionshemmer
CN101794567B (zh) * 2010-02-10 2014-01-01 中兴通讯股份有限公司 图片加载的方法及终端
CN104098647B (zh) * 2014-06-24 2017-12-08 安徽省逸欣铭医药科技有限公司 阿加曲班类似物及其制备方法和医药用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE48623B1 (en) * 1978-08-31 1985-03-20 Mitsubishi Chem Ind Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
EP0008596A1 (de) * 1978-09-04 1980-03-19 DEVINTER Europe S.A. Société anonyme dite: Verfahren zur Herstellung von 4-Hydroxymethyl-imidazolderivaten aus übereinstimmenden 4-Imidazolkarbonsäureestern
SE8203887D0 (sv) * 1982-06-23 1982-06-23 Kabivitrum Ab Nya trombininhiberande foreningar
EP0242973B1 (de) 1986-03-17 1991-07-17 Glaxo Group Limited Indol-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
CA2043741C (en) * 1990-06-07 2003-04-01 Kiyofumi Ishikawa Endothelin antagonistic peptide derivatives
FR2689130B1 (fr) 1992-03-30 1994-05-27 Synthelabo Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
FR2689130A1 (fr) 1993-10-01
NO975664L (no) 1993-10-01
CA2092867A1 (fr) 1993-10-01
IL105028A0 (en) 1993-07-08
MX9301783A (es) 1994-02-28
DE69316068D1 (de) 1998-02-12
JPH0798807B2 (ja) 1995-10-25
TW234717B (en) 1994-11-21
JPH06199807A (ja) 1994-07-19
FI931413A (fi) 1993-10-01
SK26393A3 (en) 1993-12-08
US5453430A (en) 1995-09-26
CZ52893A3 (en) 1994-02-16
NO302572B1 (no) 1998-03-23
HU9300915D0 (en) 1993-06-28
EP0565396B1 (de) 1998-01-07
JP2550276B2 (ja) 1996-11-06
HUT64758A (en) 1994-02-28
KR930019664A (ko) 1993-10-18
PL298299A1 (en) 1993-10-18
NO975664D0 (no) 1997-12-05
AU3556093A (en) 1993-10-07
AU655876B2 (en) 1995-01-12
CN1076928A (zh) 1993-10-06
ATE161839T1 (de) 1998-01-15
NZ247277A (en) 1995-07-26
EP0579277A1 (de) 1994-01-19
EP0565396A1 (de) 1993-10-13
ZA932228B (en) 1993-10-28
NO931166L (no) 1993-10-01
JPH06157514A (ja) 1994-06-03
NO931166D0 (no) 1993-03-29
FI931413A0 (fi) 1993-03-29
FR2689130B1 (fr) 1994-05-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee