DE69133136D1 - Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstums - Google Patents
Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstumsInfo
- Publication number
- DE69133136D1 DE69133136D1 DE69133136T DE69133136T DE69133136D1 DE 69133136 D1 DE69133136 D1 DE 69133136D1 DE 69133136 T DE69133136 T DE 69133136T DE 69133136 T DE69133136 T DE 69133136T DE 69133136 D1 DE69133136 D1 DE 69133136D1
- Authority
- DE
- Germany
- Prior art keywords
- microcapsules
- controlled release
- fiber growth
- stimulating nervous
- nervous fiber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52538390A | 1990-05-16 | 1990-05-16 | |
PCT/US1991/003356 WO1991017772A1 (en) | 1990-05-16 | 1991-05-14 | Controlled release dopamine and its use to stimulate nerve fiber growth |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69133136D1 true DE69133136D1 (de) | 2002-11-21 |
DE69133136T2 DE69133136T2 (de) | 2003-06-18 |
Family
ID=24093026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69133136T Expired - Fee Related DE69133136T2 (de) | 1990-05-16 | 1991-05-14 | Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstums |
Country Status (8)
Country | Link |
---|---|
US (1) | US5360610A (de) |
EP (1) | EP0528978B1 (de) |
JP (2) | JP3359919B2 (de) |
AT (1) | ATE226091T1 (de) |
DE (1) | DE69133136T2 (de) |
DK (1) | DK0528978T3 (de) |
ES (1) | ES2185615T3 (de) |
WO (1) | WO1991017772A1 (de) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6217911B1 (en) | 1995-05-22 | 2001-04-17 | The United States Of America As Represented By The Secretary Of The Army | sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres |
US6410056B1 (en) | 1984-03-16 | 2002-06-25 | The United States Of America As Represented By The Secretary Of The Army | Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix |
US5693343A (en) | 1984-03-16 | 1997-12-02 | The United States Of America As Represented By The Secretary Of The Army | Microparticle carriers of maximal uptake capacity by both M cells and non-M cells |
USRE40786E1 (en) | 1984-03-16 | 2009-06-23 | The United States Of America As Represented By The Secretary Of The Army | Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres |
US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
US5871472A (en) * | 1987-11-17 | 1999-02-16 | Brown University Research Foundation | Planting devices for the focal release of neuroinhibitory compounds |
US6517859B1 (en) | 1990-05-16 | 2003-02-11 | Southern Research Institute | Microcapsules for administration of neuroactive agents |
US5618531A (en) | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
AU8303691A (en) | 1991-04-24 | 1992-12-21 | United States Of America, As Represented By The Secretary Of The Army, The | Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
PT659073E (pt) * | 1992-09-10 | 2002-06-28 | Childrens Medical Center | Matrizes polimericas biodegradaveis para entrega sustentada de agentes anestesicos locais |
US5700485A (en) * | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
US5383873A (en) * | 1992-12-09 | 1995-01-24 | Regents Of The University Of Minnesota | Smooth muscle chemical pacemaker |
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US6939546B2 (en) | 1993-05-21 | 2005-09-06 | The United States Of America As Represented By The Secretary Of The Army | Model for testing immunogenicity of peptides |
HU219487B (hu) * | 1993-11-19 | 2001-04-28 | Janssen Pharmaceutica Nv. | Riszperidont tartalmazó mikrorészecskék, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyászati készítmények és előállításuk |
US5962427A (en) | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
US6074840A (en) | 1994-02-18 | 2000-06-13 | The Regents Of The University Of Michigan | Recombinant production of latent TGF-beta binding protein-3 (LTBP-3) |
US5763416A (en) | 1994-02-18 | 1998-06-09 | The Regent Of The University Of Michigan | Gene transfer into bone cells and tissues |
US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
US5604198A (en) * | 1994-05-12 | 1997-02-18 | Poduslo; Joseph F. | Method to enhance permeability of the blood/brain blood/nerve barriers to therapeutic agents |
US6855331B2 (en) | 1994-05-16 | 2005-02-15 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
US6447796B1 (en) | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
US6902743B1 (en) | 1995-05-22 | 2005-06-07 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix |
US7033608B1 (en) | 1995-05-22 | 2006-04-25 | The United States Of America As Represented By The Secretary Of The Army | “Burst-free” sustained release poly-(lactide/glycolide) microspheres |
WO1998008464A1 (en) * | 1996-08-29 | 1998-03-05 | Advanced Research & Technology Institute | Novel pharmacotherapeutic process and composition for central nervous system disorders |
EP0925067B1 (de) | 1996-09-16 | 2004-02-04 | Purdue Research Foundation | Gewebetransplantat aus der magensubmukosa zur reparatur neurologischen gewebes |
CA2296056A1 (en) * | 1997-07-10 | 1999-01-21 | Keith Baker | Methods for universally distributing therapeutic agents to the brain |
US7923250B2 (en) | 1997-07-30 | 2011-04-12 | Warsaw Orthopedic, Inc. | Methods of expressing LIM mineralization protein in non-osseous cells |
DE69840361D1 (de) | 1997-07-30 | 2009-01-29 | Univ Emory | Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme |
EP1079967A4 (de) | 1998-04-13 | 2003-07-23 | Luminex Corp | Flüssige markierung mit fluorezierenden mikropartikeln |
AP1769A (en) * | 1998-12-16 | 2007-08-22 | Aventisub Ii Inc | Biodegradable polymer encapsulated serotonin receptor antagonist and method for preparing the same. |
US6455526B1 (en) | 1998-12-16 | 2002-09-24 | Aventis Pharmaceuticals, Inc. | Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same |
US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
US7229635B2 (en) * | 2000-04-21 | 2007-06-12 | Indiana University Research And Technology Corporation | Pharmacotherapeutic process and composition for central nervous system disorders |
US7374782B2 (en) | 2000-10-27 | 2008-05-20 | Baxter International Inc. | Production of microspheres |
ES2307779T3 (es) * | 2001-08-16 | 2008-12-01 | Baxter International Inc. | Formulaciones de microparticulas a base de propelentes. |
US6488952B1 (en) * | 2001-08-28 | 2002-12-03 | John P. Kennedy | Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system |
CA2518667C (en) | 2003-03-14 | 2011-07-19 | The Trustees Of Columbia University In The City Of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
US20060076295A1 (en) | 2004-03-15 | 2006-04-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
US20050142205A1 (en) * | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for encapsulating small spherical particles prepared by controlled phase separation |
US20070092452A1 (en) * | 2003-07-18 | 2007-04-26 | Julia Rashba-Step | Methods for fabrication, uses, compositions of inhalable spherical particles |
MXPA06000720A (es) * | 2003-07-18 | 2006-08-23 | Baxter Int | Metodos para fabricacion, usos y composiciones de particulas esfericas pequenas preparadas por separacion de fase controlada. |
EP1646354A4 (de) * | 2003-07-22 | 2010-03-17 | Baxter Int | Kleine kugelförmige teilchen von niedermolekularen organischen molekülen und herstellungs- und anwendungsverfahren dafür |
US7309232B2 (en) * | 2003-10-10 | 2007-12-18 | Dentigenix Inc. | Methods for treating dental conditions using tissue scaffolds |
US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
CA2566075A1 (en) | 2004-05-12 | 2005-12-01 | Baxter Healthcare S.A. | Microspheres comprising protein and showing injectability at high concentrations of said agent |
AU2005244851B2 (en) | 2004-05-12 | 2010-08-26 | Baxter Healthcare S.A. | Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1 |
ES2313350T3 (es) | 2004-05-12 | 2009-03-01 | Baxter International Inc. | Microesferas de acido nucleico, produccion y suministro de las mismas. |
WO2006047299A2 (en) * | 2004-10-22 | 2006-05-04 | University Of Florida Research Foundation, Inc. | Organotypic slice cultures and uses thereof |
WO2006097725A2 (en) * | 2005-03-15 | 2006-09-21 | Queen Mary & Westfield College | Pharmaceutical compositions comprising microparticles for delivery into neurons |
JP2010506599A (ja) | 2006-05-22 | 2010-03-04 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 第1流体と第2流体との間で成分を交換する方法、第1流体から第1成分を清浄する方法、血液の処理方法、流体処理装置、第1流体と第1及び第2成分を含む第2流体との間で成分を交換する装置、第1流体と第2流体との間で成分を交換する装置、血漿から血球を分離する方法 |
US8529928B2 (en) * | 2006-07-07 | 2013-09-10 | Georgia Tech Research Corporation | Biomimetic polymers and uses thereof |
AU2007281737B2 (en) | 2006-08-04 | 2013-09-19 | Baxter Healthcare S.A. | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
EP2077821B1 (de) | 2006-10-12 | 2019-08-14 | The University Of Queensland | Zusammensetzungen und verfahren zur modulierung von immunreaktionen |
CN100462105C (zh) * | 2006-10-19 | 2009-02-18 | 中国人民解放军第四军医大学 | 一种重组合神经替代物的制备方法 |
EP2146691A2 (de) | 2007-04-17 | 2010-01-27 | Baxter International Inc. | Nukleinsäure-mikroteilchen zur abgabe in den lungen |
WO2009100154A1 (en) | 2008-02-04 | 2009-08-13 | Trustees Of Columbia University In The City Of New York | Fluid separation devices, systems and methods |
EP2982753B1 (de) | 2008-04-18 | 2018-06-06 | Baxter International Inc. | Zusammensetzung auf mikrokügelchenbasis zur vorbeugung und/oder abwendung einer neuerkrankung an autoimmunem diabetes |
ES2770273T3 (es) * | 2008-06-27 | 2020-07-01 | Tepha Inc | Administración inyectable de micropartículas y composiciones para ello |
BRPI0916557A2 (pt) | 2008-07-30 | 2020-08-04 | Mesynthes Limited | arcabouços de tecido derivado da matriz extracelular do pré-estômago |
US8367427B2 (en) | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323615B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
EP2308478A1 (de) * | 2009-10-06 | 2011-04-13 | Abbott GmbH & Co. KG | Abgabesystem zur verzögerten Freisetzung von Calciumkanalblocker Arzneistoffen |
JP2013545453A (ja) | 2010-11-01 | 2013-12-26 | ユニバーシティ・オブ・テクノロジー、シドニー | 免疫変調剤およびそれらの使用 |
AU2015268101B2 (en) | 2014-05-27 | 2021-01-28 | The University Of Queensland | Modulation of cellular stress |
KR102418503B1 (ko) * | 2020-11-27 | 2022-07-07 | 주식회사 헤리노브 | 탄소섬유를 사용한 파이프 제조방법 및 이를 통해 제조된 파이프 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
JPS6048923A (ja) * | 1983-08-25 | 1985-03-16 | Mitsui Toatsu Chem Inc | 微小粒子の製造方法 |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
US4832686A (en) * | 1986-06-24 | 1989-05-23 | Anderson Mark E | Method for administering interleukin-2 |
JPS63122620A (ja) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
WO1990015637A2 (en) * | 1989-06-21 | 1990-12-27 | Brown University Research Foundation | Neurological therapy system |
CH679207A5 (de) * | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
JP3187410B2 (ja) * | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | 脳内投与用徐放性製剤 |
-
1991
- 1991-05-14 DK DK91910707T patent/DK0528978T3/da active
- 1991-05-14 DE DE69133136T patent/DE69133136T2/de not_active Expired - Fee Related
- 1991-05-14 AT AT91910707T patent/ATE226091T1/de not_active IP Right Cessation
- 1991-05-14 EP EP91910707A patent/EP0528978B1/de not_active Expired - Lifetime
- 1991-05-14 JP JP51042891A patent/JP3359919B2/ja not_active Expired - Fee Related
- 1991-05-14 WO PCT/US1991/003356 patent/WO1991017772A1/en active IP Right Grant
- 1991-05-14 ES ES91910707T patent/ES2185615T3/es not_active Expired - Lifetime
-
1993
- 1993-03-15 US US08/033,309 patent/US5360610A/en not_active Expired - Lifetime
-
2002
- 2002-05-15 JP JP2002140490A patent/JP4044366B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0528978B1 (de) | 2002-10-16 |
ATE226091T1 (de) | 2002-11-15 |
DE69133136T2 (de) | 2003-06-18 |
ES2185615T3 (es) | 2003-05-01 |
JP4044366B2 (ja) | 2008-02-06 |
DK0528978T3 (da) | 2003-02-17 |
JP2003012506A (ja) | 2003-01-15 |
JP3359919B2 (ja) | 2002-12-24 |
EP0528978A1 (de) | 1993-03-03 |
WO1991017772A1 (en) | 1991-11-28 |
JPH05507486A (ja) | 1993-10-28 |
EP0528978A4 (en) | 1993-06-23 |
US5360610A (en) | 1994-11-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69133136T2 (de) | Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstums | |
DK0767634T3 (da) | Mikrokapsler til administration af neuroaktive midler | |
DE69203596D1 (de) | Biologisch abbaubare und biologisch absorbierbare führungskanäle zur verwendung in der behandlung und regenerierung von nerven. | |
DE69128621D1 (de) | Biokeramisches system zur abgabe von bioaktiven stoffen | |
DE69529054D1 (de) | System zur gezielten wirkstoffzufuhr, verfahren zu seiner herstellung und verwendung | |
EP0702563A4 (de) | Zubereitungen und verfahren für die behandlung von krebs und hyperproliferierenden krankheiten | |
DE3854656D1 (de) | Depotimplantat mit gesteuerter Wirkstoffabgabe zur Behandlung von Krankheiten des Nervensystems. | |
ES2051882T3 (es) | Composicion que comprende implantes oculares biodegradables. | |
ATE241394T1 (de) | Beigeordnetes polymersystem zur verwendung mit einer medizinischen vorrichtung | |
ES2133413T3 (es) | Gel de lecitina inyectable. | |
DE69230112D1 (de) | Fortschrittliches arzneistoffabgabesystem und verfahren zur behandlung von psychiatrischen, neurologischen und anderen erkrankungen mit carbamazepin | |
PT97446A (pt) | Processo para a preparacao de um derivado de tienobenzodiazepina, util como produto farmaceutico | |
DE3777511D1 (de) | Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung. | |
PT777483E (pt) | Metodos e meio para administrar farmacos | |
ATE94069T1 (de) | Verwendung von physiologisch wirksamen substanzen zur herstellung von medikamenten fuer gehirn- und nervenerkrankungen. | |
ATE89485T1 (de) | Neurologisches therapiesystem. | |
BR8603315A (pt) | Processo para produzir um implante de liberacao controlada;implante usado no processo;processo para purificar e concentrar hormonio de crescimento biologicamente ativo em uma forma adequada para incorporacao em um implante para administracao subcutanea | |
GB9313484D0 (en) | Drug system ii | |
DE69013797T2 (de) | Gehirnspezifische Zubereitung mit gesteuerter Abgabe. | |
ATE149361T1 (de) | Nerveneinpflanzungssystem | |
ATE142889T1 (de) | Medikamente zur tumortherapie mit kontrolliertem und reguliertem immunsystem sowie verwendung der einzelsubstanzen zur kombinierten therapie | |
Gonzalez-Lima | Activation of substantia gelatinosa by midbrain reticular stimulation demonstrated with 2-deoxyglucose in the rat spinal cord | |
DK0426098T3 (da) | Fremstilling af et lægemiddel til behandling af hyperphosphatæmisk status | |
UA27060C2 (uk) | Спосіб стимулюваhhя зовhішhьої секреції підшлуhкової залози | |
RU94039254A (ru) | Способ управления физиологическим состоянием организма в геронтологическом периоде онтогенеза |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |