DE69127384D1 - Verfahren zur Reinigung von Immunserumglobulinen - Google Patents

Verfahren zur Reinigung von Immunserumglobulinen

Info

Publication number
DE69127384D1
DE69127384D1 DE69127384T DE69127384T DE69127384D1 DE 69127384 D1 DE69127384 D1 DE 69127384D1 DE 69127384 T DE69127384 T DE 69127384T DE 69127384 T DE69127384 T DE 69127384T DE 69127384 D1 DE69127384 D1 DE 69127384D1
Authority
DE
Germany
Prior art keywords
serum globulin
immune
immune serum
serum
globulins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69127384T
Other languages
English (en)
Other versions
DE69127384T3 (de
DE69127384T2 (de
Inventor
Maria Erlinda C Sarno
Gerald Neslund
Clifford Gaf
Sau-Gee Yung
James Burnham
Jean Kim
Rodolfo Anthony Vazquez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23880046&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69127384(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter International Inc filed Critical Baxter International Inc
Publication of DE69127384D1 publication Critical patent/DE69127384D1/de
Application granted granted Critical
Publication of DE69127384T2 publication Critical patent/DE69127384T2/de
Publication of DE69127384T3 publication Critical patent/DE69127384T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69127384T 1990-02-01 1991-01-31 Verfahren zur Reinigung von Immunserumglobulinen Expired - Lifetime DE69127384T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US473559 1990-02-01
US07/473,559 US5177194A (en) 1990-02-01 1990-02-01 Process for purifying immune serum globulins

Publications (3)

Publication Number Publication Date
DE69127384D1 true DE69127384D1 (de) 1997-10-02
DE69127384T2 DE69127384T2 (de) 1998-03-26
DE69127384T3 DE69127384T3 (de) 2004-05-19

Family

ID=23880046

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69127384T Expired - Lifetime DE69127384T3 (de) 1990-02-01 1991-01-31 Verfahren zur Reinigung von Immunserumglobulinen

Country Status (6)

Country Link
US (1) US5177194A (de)
EP (1) EP0440483B2 (de)
JP (1) JP3094167B2 (de)
AT (1) ATE157373T1 (de)
DE (1) DE69127384T3 (de)
ES (1) ES2108704T3 (de)

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US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
US5525519A (en) * 1992-01-07 1996-06-11 Middlesex Sciences, Inc. Method for isolating biomolecules from a biological sample with linear polymers
FR2706466B1 (fr) * 1993-06-14 1995-08-25 Aetsrn Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.
DE59309332D1 (de) * 1993-12-27 1999-03-04 Rotkreuzstiftung Zentratrallab Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält
TW541179B (en) * 1997-03-19 2003-07-11 Green Cross Corp Process for preparing immunoglobulin preparation
US5886154A (en) * 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
US6955917B2 (en) * 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
IL121900A (en) * 1997-10-07 2001-12-23 Omrix Biopharmaceuticals Ltd A method for the purification of immunoglobulins
US6159471A (en) * 1997-10-23 2000-12-12 Yoshitomi Pharmaceutical Industries, Ltd. Room temperature storable immunoglobulin preparation for intravenous injection
UA64742C2 (uk) * 1997-12-24 2004-03-15 Альфа Терапевтик Корпорейшн СПОСІБ ОДЕРЖАННЯ РОЗЧИНУ <font face="Symbol">g</font>-ГЛОБУЛІНУ, ПРИЗНАЧЕНОГО ДЛЯ ВНУТРІШНЬОВЕННОГО ВВЕДЕННЯ, І ПРОДУКТ, ЩО ОДЕРЖУЄТЬСЯ У ЦЕЙ СПОСІБ (ВАРІАНТИ)
BRPI9910332B8 (pt) * 1998-05-06 2021-05-25 Genentech Inc método para purificação de um polipeptídio a partir de uma composição
ES2421736T3 (es) * 1998-06-09 2013-09-05 Csl Behring Ag Procedimiento para la preparación de inmunoglobulinas para administración intravenosa y otros productos inmunoglobulínicos
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
ATE342112T1 (de) 1999-02-22 2006-11-15 Ncsrt Inc Reinigung von biologischen substanzen
DE19916352A1 (de) * 1999-04-12 2000-10-19 Braun Melsungen Ag Entfernung von hüllehaltigen Viren aus Blut, Plasma oder Serum
US6441144B1 (en) * 1999-05-20 2002-08-27 Alpha Therapeutic Corporation Method for repairing dual virally inactivated immune globulin for intravenous administration
KR100416483B1 (ko) * 2000-08-08 2004-01-31 주식회사 웰진 동물세포 배양용 혈청의 단계적 여과 시스템
US6962700B1 (en) 2000-09-13 2005-11-08 Atopix Pharmaceuticals Corporation Method of manufacturing immune globulin
ES2184594B1 (es) * 2001-01-17 2004-01-01 Probitas Pharma Sa Procedimiento para la produccion de gammaglobulina g humana inactivada de virus.
WO2002096977A1 (fr) * 2001-05-30 2002-12-05 Nanocarrier Co., Ltd. Procede de liaison d'une substance a incorporer a une terminaison polymere
AU2003262087B2 (en) 2002-09-11 2010-11-11 Chugai Seiyaku Kabushiki Kaisha Protein purification method
EP1532983A1 (de) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulinpräparationen mit erhöhter Stabilität
US20060051347A1 (en) 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
TWI320788B (en) 2005-05-25 2010-02-21 Hoffmann La Roche Method for the purification of antibodies
EP3673919A1 (de) 2005-06-14 2020-07-01 Amgen Inc. Selbstpuffernde proteinformulierungen
US8293242B2 (en) * 2005-09-01 2012-10-23 Plasma Technologies, Llc Ultra-high yield of alpha-1-anti-trypsin
US20070049732A1 (en) * 2005-09-01 2007-03-01 Zurlo Eugene J Ultra-high yield intravenous immune globulin preparation
US7879332B2 (en) * 2005-09-01 2011-02-01 Plasma Technologies, Llc Ultra-high yield intravenous immune globulin preparation
US20070128693A1 (en) * 2005-12-06 2007-06-07 Advantek Serum Laboratories Limited3/F Method for the inactivation and removal of dengue virus from biological samples
JP5555626B2 (ja) 2007-08-13 2014-07-23 バクスター・インターナショナル・インコーポレイテッド 多発性硬化症、アルツハイマー病およびパーキンソン病を処置するためのケモカインのｉｖｉｇ調節
TWI489994B (zh) 2008-03-17 2015-07-01 Baxter Healthcare Sa 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
PL2271382T3 (pl) 2008-04-15 2013-08-30 Grifols Therapeutics Inc Dwuetapowa ultrafiltracja/diafiltracja
EP3708581A3 (de) 2009-05-27 2021-10-20 Takeda Pharmaceutical Company Limited Verfahren zur herstellung eines hochkonzentrierten immunglobulinpräparats zur subkutanen verwendung
WO2010148117A1 (en) 2009-06-17 2010-12-23 Scantibodies Laboratory, Inc. Therapeutic and diagnostic affinity purified specific polyclonal antibodies
AT516600B1 (de) 2009-07-23 2016-07-15 Baxter Int Herstellung von faktor h (fh) und fh-derivaten aus plasma
JP5734985B2 (ja) 2009-09-17 2015-06-17 バクスター・ヘルスケヤー・ソシエテ・アノニムＢａｘｔｅｒ Ｈｅａｌｔｈｃａｒｅ ＳＡ ヒアルロニダーゼおよび免疫グロブリンの安定な共製剤およびそれらの使用方法
IT1397061B1 (it) * 2009-12-28 2012-12-28 Kedrion Spa Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale.
WO2011095543A1 (en) 2010-02-04 2011-08-11 Csl Behring Ag Immunoglobulin preparation
EP2361636A1 (de) 2010-02-26 2011-08-31 CSL Behring AG Immunglobulinpräparat und Aufbewahrungssystem für ein Immunglobulinpräparat
WO2011150284A2 (en) 2010-05-26 2011-12-01 Baxter International Inc. Removal of serine proteases by treatment with finely divided silicon dioxide
US8796430B2 (en) 2010-05-26 2014-08-05 Baxter International Inc. Method to produce an immunoglobulin preparation with improved yield
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
WO2012012773A1 (en) 2010-07-23 2012-01-26 Baxter International Inc. Manufacture of inter -alpha - inhibitor proteins (iaip) from plasma
AR083035A1 (es) 2010-09-17 2013-01-30 Baxter Int ESTABILIZACION DE INMUNOGLOBULINAS MEDIANTE UNA FORMULACION ACUOSA CON HISTIDINA A pH ACIDO DEBIL A NEUTRO, COMPOSICION ACUOSA DE INMUNOGLOBULINA
DK2651962T3 (en) 2010-12-16 2016-09-26 Baxalta GmbH Real-time monitoring and control methods of protein production using impedance spectroscopy
CA2842180C (en) 2011-07-18 2020-06-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for inhibiting polyomavirus-associated pathology
BR112014004445B1 (pt) 2011-08-26 2022-11-22 Takeda Pharmaceutical Company Limited Método para reduzir conteúdo de fator xi e/ou fator xia em uma composição de imunoglobulina
TWI629283B (zh) 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
CN110343171A (zh) 2012-02-29 2019-10-18 百深公司 周围神经的IgG刺激髓鞘再生
WO2015071177A1 (en) * 2013-11-15 2015-05-21 Novartis Ag Removal of residual cell culture impurities
EP3411383A4 (de) 2016-02-03 2019-08-14 Plasma Technologies, LLC Verfahren zur extraktion von proteinen aus blutbasiertem material
JP6884858B2 (ja) 2016-10-21 2021-06-09 アムジエン・インコーポレーテツド 医薬製剤及びその製造方法
US10815270B1 (en) 2019-09-20 2020-10-27 Plasma Technologies, Llc Compositions and methods for high efficiency protein precipitation

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US3869436A (en) * 1971-06-01 1975-03-04 Statens Bakteriologiska Lab Method for fractionating plasma proteins using peg and ion-exchangers
US3962421A (en) * 1973-06-18 1976-06-08 American Home Products Corporation Method for the disruption of lipid-containing viruses
US4315919A (en) * 1980-10-06 1982-02-16 Edward Shanbrom Depyrogenation process
US4314997A (en) * 1980-10-06 1982-02-09 Edward Shanbrom Purification of plasma protein products
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4719290A (en) * 1983-09-02 1988-01-12 Armour Pharmaceutical Corporation Composition of intravenous immune globulin
US4683294A (en) * 1985-04-03 1987-07-28 Smith Kline Rit, S.A. Process for the extraction and purification of proteins from culture media producing them
US4606825A (en) * 1985-04-22 1986-08-19 J. T. Baker Chemical Company Purification of immunoglobulin G
DE3640513A1 (de) * 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
DE3730533A1 (de) * 1987-09-11 1989-03-30 Biotest Pharma Gmbh Verfahren zur sterilisation von plasma oder plasmafraktionen

Also Published As

Publication number Publication date
ES2108704T3 (es) 1998-01-01
EP0440483A3 (en) 1992-09-23
US5177194A (en) 1993-01-05
JP3094167B2 (ja) 2000-10-03
EP0440483A2 (de) 1991-08-07
EP0440483B2 (de) 2003-06-18
ATE157373T1 (de) 1997-09-15
EP0440483B1 (de) 1997-08-27
JPH06136000A (ja) 1994-05-17
DE69127384T3 (de) 2004-05-19
DE69127384T2 (de) 1998-03-26

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings