DE69119994D1 - Verfahren zur Herstellung von Desoxynukleosiden - Google Patents

Verfahren zur Herstellung von Desoxynukleosiden

Info

Publication number
DE69119994D1
DE69119994D1 DE69119994T DE69119994T DE69119994D1 DE 69119994 D1 DE69119994 D1 DE 69119994D1 DE 69119994 T DE69119994 T DE 69119994T DE 69119994 T DE69119994 T DE 69119994T DE 69119994 D1 DE69119994 D1 DE 69119994D1
Authority
DE
Germany
Prior art keywords
deoxynucleosides
production
substituted
compound
anhydrothymidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69119994T
Other languages
English (en)
Other versions
DE69119994T2 (de
Inventor
Kenneth E Green
John L Considine
Antuono Joseph D Iii
Thurairajah Padmanathan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DE69119994D1 publication Critical patent/DE69119994D1/de
Publication of DE69119994T2 publication Critical patent/DE69119994T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
DE69119994T 1990-08-06 1991-06-26 Verfahren zur Herstellung von Desoxynukleosiden Expired - Lifetime DE69119994T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56359690A 1990-08-06 1990-08-06

Publications (2)

Publication Number Publication Date
DE69119994D1 true DE69119994D1 (de) 1996-07-11
DE69119994T2 DE69119994T2 (de) 1997-01-23

Family

ID=24251148

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69119994T Expired - Lifetime DE69119994T2 (de) 1990-08-06 1991-06-26 Verfahren zur Herstellung von Desoxynukleosiden

Country Status (21)

Country Link
EP (1) EP0470355B1 (de)
JP (1) JP3026861B2 (de)
KR (1) KR0173319B1 (de)
CN (1) CN1031343C (de)
AT (1) ATE138927T1 (de)
AU (1) AU649698B2 (de)
CA (1) CA2048347C (de)
CZ (1) CZ283988B6 (de)
DE (1) DE69119994T2 (de)
DK (1) DK0470355T3 (de)
ES (1) ES2088443T3 (de)
FI (1) FI102375B1 (de)
GR (1) GR3020946T3 (de)
HU (1) HU209310B (de)
IE (1) IE912762A1 (de)
IL (1) IL98685A (de)
NZ (1) NZ239213A (de)
PL (1) PL166101B1 (de)
PT (1) PT98554B (de)
SK (1) SK278598B6 (de)
ZA (1) ZA916156B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100480A0 (en) * 1991-01-15 1992-09-06 American Cyanamid Co Process for the preparation of 3'-fluoropyrimidine nucleosides
GB9309787D0 (en) * 1993-05-12 1993-06-23 Rhone Poulenc Chemicals Purification of fluoronucleosides
DE69412090T2 (de) * 1993-05-12 1999-01-07 Rhodia Ltd Herstellung von fluoro-nukleosiden und dafür geeignete zwischenprodukte
GB9309795D0 (en) * 1993-05-12 1993-06-23 Rhone Poulenc Chemicals Preparation of flouro-compounds
JP3677790B2 (ja) * 1993-08-04 2005-08-03 味の素株式会社 ヌクレオシド誘導体とその製造方法
GB0608876D0 (en) 2006-05-05 2006-06-14 Medivir Ab Combination therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3775397A (en) * 1969-11-12 1973-11-27 Akad Wissenschaften Ddr Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)

Also Published As

Publication number Publication date
KR0173319B1 (ko) 1999-02-18
CA2048347C (en) 2002-01-29
GR3020946T3 (en) 1996-12-31
ES2088443T3 (es) 1996-08-16
HU912601D0 (en) 1992-01-28
EP0470355B1 (de) 1996-06-05
JP3026861B2 (ja) 2000-03-27
EP0470355A1 (de) 1992-02-12
FI913722A0 (fi) 1991-08-05
FI102375B (fi) 1998-11-30
KR920004405A (ko) 1992-03-27
FI913722A (fi) 1992-02-07
ZA916156B (en) 1992-04-29
PL291335A1 (en) 1992-08-24
AU8163591A (en) 1992-02-13
PT98554A (pt) 1992-06-30
PT98554B (pt) 1999-01-29
FI102375B1 (fi) 1998-11-30
DE69119994T2 (de) 1997-01-23
NZ239213A (en) 1993-08-26
CA2048347A1 (en) 1992-02-07
CS242991A3 (en) 1992-02-19
ATE138927T1 (de) 1996-06-15
SK278598B6 (en) 1997-11-05
HU209310B (en) 1994-04-28
PL166101B1 (pl) 1995-03-31
HUT58756A (en) 1992-03-30
CN1058969A (zh) 1992-02-26
IL98685A0 (en) 1992-07-15
CZ283988B6 (cs) 1998-07-15
AU649698B2 (en) 1994-06-02
CN1031343C (zh) 1996-03-20
IL98685A (en) 1996-08-04
DK0470355T3 (da) 1996-07-15
IE912762A1 (en) 1992-02-12
JPH04253993A (ja) 1992-09-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WYETH HOLDINGS CORP., MADISON, N.J., US