DE69112716T2 - Verfahren zur biologischen Herstellung einer Hydroxyvitamin-D-Verbindung. - Google Patents

Verfahren zur biologischen Herstellung einer Hydroxyvitamin-D-Verbindung.

Info

Publication number
DE69112716T2
DE69112716T2 DE69112716T DE69112716T DE69112716T2 DE 69112716 T2 DE69112716 T2 DE 69112716T2 DE 69112716 T DE69112716 T DE 69112716T DE 69112716 T DE69112716 T DE 69112716T DE 69112716 T2 DE69112716 T2 DE 69112716T2
Authority
DE
Germany
Prior art keywords
compound
vitamin
hydroxyvitamin
cyclodextrin
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69112716T
Other languages
German (de)
English (en)
Other versions
DE69112716D1 (de
Inventor
Takashi Adachi
Kiyoshi Kimura
Rokuro Okamoto
Kazuhiko Okamura
Sadafumi Omura
Joji Sasaki
Koji Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mercian Corp
Original Assignee
Mercian Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mercian Corp filed Critical Mercian Corp
Application granted granted Critical
Publication of DE69112716D1 publication Critical patent/DE69112716D1/de
Publication of DE69112716T2 publication Critical patent/DE69112716T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69112716T 1990-06-15 1991-06-14 Verfahren zur biologischen Herstellung einer Hydroxyvitamin-D-Verbindung. Expired - Fee Related DE69112716T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15705490 1990-06-15
JP33428390A JP3201411B2 (ja) 1990-06-15 1990-11-30 ビタミンｄ類の生物学的製造方法

Publications (2)

Publication Number Publication Date
DE69112716D1 DE69112716D1 (de) 1995-10-12
DE69112716T2 true DE69112716T2 (de) 1996-02-01

Family

ID=26484632

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69112716T Expired - Fee Related DE69112716T2 (de) 1990-06-15 1991-06-14 Verfahren zur biologischen Herstellung einer Hydroxyvitamin-D-Verbindung.

Country Status (9)

Country Link
US (1) US5474923A (enExample)
EP (1) EP0461921B1 (enExample)
JP (1) JP3201411B2 (enExample)
KR (1) KR100190412B1 (enExample)
AT (1) ATE127523T1 (enExample)
CA (1) CA2044550C (enExample)
DE (1) DE69112716T2 (enExample)
ES (1) ES2079573T3 (enExample)
TW (1) TW234147B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3201411B2 (ja) * 1990-06-15 2001-08-20 メルシャン株式会社 ビタミンｄ類の生物学的製造方法
EP0653490A4 (en) * 1992-06-25 1997-01-08 Taisho Pharmaceutical Co Ltd VITAMIN D HYDROXYLASE GENE
WO1997008336A1 (fr) 1995-08-28 1997-03-06 Mercian Corporation Procede de production de cholesterols hydroxyles par conversion biologique et dihydroxycholesterols obtenus selon ce procede
EP1172442A4 (en) * 1999-04-14 2004-10-13 Mercian Corp VITAMIN D DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
MXPA04005260A (es) * 2001-12-03 2005-03-23 Novacea Inc Composiciones farmaceuticas que comprenden compuestos activos de vitamina d.
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
JPWO2005073223A1 (ja) * 2004-01-29 2007-09-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 マクロライド系化合物の安定化方法
EP2011781B1 (en) 2006-03-15 2014-03-05 MicroBiopharm Japan Co., Ltd. Process for production of indene derivative, and intermediate for production of the derivative
JP5624555B2 (ja) * 2008-12-19 2014-11-12 イルドン ファーマ カンパニー リミテッド カルシトリオール又はカルシフェジオールの生産促進用バッファ組成物及びこれを利用したカルシトリオール又はカルシフェジオール製産方法
CN117625566A (zh) * 2023-12-01 2024-03-01 四川润格生物科技有限公司 一种提高酶催化效率的制剂及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307025A (en) * 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3
JPH0717686B2 (ja) * 1986-08-08 1995-03-01 メルシャン株式会社 部分メチル化シクロデキストリン及びその製造方法
US4892821A (en) * 1987-07-08 1990-01-09 Taisho Pharmaceutical Co., Ltd. Method for preparing vitamin D compounds
JP2663294B2 (ja) * 1989-03-04 1997-10-15 メルシャン株式会社 ビタミンｄ類の製造方法
JP3201411B2 (ja) * 1990-06-15 2001-08-20 メルシャン株式会社 ビタミンｄ類の生物学的製造方法

Also Published As

Publication number Publication date
EP0461921A3 (en) 1992-05-20
JPH04166090A (ja) 1992-06-11
JP3201411B2 (ja) 2001-08-20
ATE127523T1 (de) 1995-09-15
TW234147B (enExample) 1994-11-11
KR920000934A (ko) 1992-01-29
EP0461921A2 (en) 1991-12-18
ES2079573T3 (es) 1996-01-16
CA2044550C (en) 2000-09-26
EP0461921B1 (en) 1995-09-06
DE69112716D1 (de) 1995-10-12
KR100190412B1 (ko) 1999-06-01
US5474923A (en) 1995-12-12
CA2044550A1 (en) 1991-12-16

Similar Documents

Publication Publication Date Title
DE69112716T2 (de) Verfahren zur biologischen Herstellung einer Hydroxyvitamin-D-Verbindung.
DE3884870T2 (de) Verfahren zur Herstellung von Vitamin-D-Derivaten.
HU185264B (en) Improved microbiological process for producing androstane steroides
CH657871A5 (de) Verfahren zur umwandlung von 1,2-gesaettigten 3-ketosteroiden in 1,2-dehydrosteroide.
AT396480B (de) Verfahren zur herstellung von 9alpha-hydroxy-4-androsten-3,17-dion
DE69024910T2 (de) Natürliche Delta-Lactone und Verfahren zu deren Herstellung
DD249041A5 (de) Verfahren zur herstellung von 4-androsten-3,17-dion und 1,4-androstadien-3,17-dion
EP0355679B1 (de) Neuer Mikroorganismus zum Abbau von Moenomycinen, Verfahren zum Abbau sowie die Verwendung der Abbauprodukte
DD204267A5 (de) Verfahren zur intensivierung der mikrobiologischen umwandlung von steroidverbindungen
DE2349816A1 (de) Verfahren zur mikrobiologischen reduktion von 10(11)-ungesaettigten prostaglandinen
DE1543462C3 (de) Verfahren zur mikrobiologischen 11-Hydroxylierung von Steroiden der Pregnanreihe in Gegenwart von Dimethylsulfoxyd
EP0046769B1 (en) Fermentation of bile
US6410759B1 (en) Dihydroxycholesterol hydroxylated at 17- and 25-positions
EP1172442A1 (en) Vitamin d derivatives and process for producing the same
DE3706838C2 (de) Neue, physiologisch aktive Substanz, die einen Aldose-Reduktaseinhibitor darstellt, und Verfahren zu ihrer Herstellung
DE69734657T2 (de) Biologisches verfahren zur herstellung von 25-hydroxylierten steroiden
DD140478A5 (de) Verfahren zur herstellung von steroidalkoholen
DE2921052C2 (enExample)
JP2000295999A (ja) １α，２４−ジヒドロキシビタミンＤ３の生物学的製造方法
JP3434860B2 (ja) Ｆｏ−２５４６物質およびその製造法
EP0518661A1 (en) Microbial conversion of bile acids
DE1036254B (de) Verfahren zur Racematspaltung
JPH04320692A (ja) Ｍａの製造方法
EP0135297A2 (en) Synthesis of indanedionepropionic acids and products therefrom, microorganisms for use therein and their production
DD248143B1 (de) Verfahren zur herstellung von produktionsgemischen mit 1,4-androstadien-3,17-dion sowie 4-androsten-3,17-dion

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee