DE69017983T2 - Anti-sens Nukleotidsequenz, anti-RNS des alpha-TNFS, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel und pharmazeutische Präparate davon. - Google Patents

Anti-sens Nukleotidsequenz, anti-RNS des alpha-TNFS, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel und pharmazeutische Präparate davon.

Info

Publication number
DE69017983T2
DE69017983T2 DE69017983T DE69017983T DE69017983T2 DE 69017983 T2 DE69017983 T2 DE 69017983T2 DE 69017983 T DE69017983 T DE 69017983T DE 69017983 T DE69017983 T DE 69017983T DE 69017983 T2 DE69017983 T2 DE 69017983T2
Authority
DE
Germany
Prior art keywords
rna
preparation
pharmaceutical preparations
tnfs
sens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69017983T
Other languages
English (en)
Other versions
DE69017983D1 (de
Inventor
Abdel Karim Braham
Pierre Smets
Rene Zalisz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE69017983D1 publication Critical patent/DE69017983D1/de
Publication of DE69017983T2 publication Critical patent/DE69017983T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02K—DYNAMO-ELECTRIC MACHINES
    • H02K2203/00—Specific aspects not provided for in the other groups of this subclass relating to the windings
    • H02K2203/03—Machines characterised by the wiring boards, i.e. printed circuit boards or similar structures for connecting the winding terminations
DE69017983T 1989-08-23 1990-08-22 Anti-sens Nukleotidsequenz, anti-RNS des alpha-TNFS, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel und pharmazeutische Präparate davon. Expired - Lifetime DE69017983T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8911171A FR2651130B1 (fr) 1989-08-23 1989-08-23 Sequence d'oligonucleotides anti-sens, anti-arn message du tnf alpha, procede de preparation, application a titre de medicaments et compositions pharmaceutiques.

Publications (2)

Publication Number Publication Date
DE69017983D1 DE69017983D1 (de) 1995-04-27
DE69017983T2 true DE69017983T2 (de) 1995-09-28

Family

ID=9384878

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69017983T Expired - Lifetime DE69017983T2 (de) 1989-08-23 1990-08-22 Anti-sens Nukleotidsequenz, anti-RNS des alpha-TNFS, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel und pharmazeutische Präparate davon.

Country Status (19)

Country Link
US (1) US5705389A (de)
EP (1) EP0414607B1 (de)
JP (1) JPH0391485A (de)
KR (1) KR0151153B1 (de)
CN (1) CN1028760C (de)
AT (1) ATE120201T1 (de)
AU (1) AU642423B2 (de)
CA (1) CA2023899C (de)
DE (1) DE69017983T2 (de)
DK (1) DK0414607T3 (de)
ES (1) ES2069715T3 (de)
FR (1) FR2651130B1 (de)
GR (1) GR3015527T3 (de)
HU (1) HU215242B (de)
IE (1) IE68592B1 (de)
IL (1) IL95342A (de)
PT (1) PT95067B (de)
RU (1) RU2066325C1 (de)
ZA (1) ZA906675B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1250722B (it) * 1991-07-30 1995-04-21 Univ Degli Studi Milano Oligonucleotidi antisenso
TW323284B (de) * 1992-03-23 1997-12-21 Novartis Ag
WO1994018325A1 (en) * 1993-02-03 1994-08-18 N.V. Innogenetics S.A. Tnf-alpha muteins and a process for preparing them
US6090382A (en) * 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
AU1249299A (en) * 1997-11-25 1999-06-15 Brax Genomics Limited Chimeric antisense oligonucleotides against tnf-alpha and their uses
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US20040006036A1 (en) * 2000-04-12 2004-01-08 Gmr, A Delaware Corporation Silencing transcription by methylation
CA2868614A1 (en) 2001-06-08 2002-12-08 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US20040009172A1 (en) * 2002-04-26 2004-01-15 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
NZ555692A (en) * 2002-07-19 2009-02-28 Abbott Biotech Ltd Treatment of TNF alpha related disorders
EP1807111A4 (de) * 2004-10-08 2009-05-27 Abbott Biotech Ltd Infektion mit dem respiratorischen synzytial-virus
CN101500607B (zh) 2005-05-16 2013-11-27 阿布维生物技术有限公司 TNFα抑制剂治疗腐蚀性多关节炎的用途
US20070041905A1 (en) * 2005-08-19 2007-02-22 Hoffman Rebecca S Method of treating depression using a TNF-alpha antibody
US9399061B2 (en) 2006-04-10 2016-07-26 Abbvie Biotechnology Ltd Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
US9624295B2 (en) 2006-04-10 2017-04-18 Abbvie Biotechnology Ltd. Uses and compositions for treatment of psoriatic arthritis
US20080118496A1 (en) * 2006-04-10 2008-05-22 Medich John R Uses and compositions for treatment of juvenile rheumatoid arthritis
US20080131374A1 (en) * 2006-04-19 2008-06-05 Medich John R Uses and compositions for treatment of rheumatoid arthritis
EP2171451A4 (de) 2007-06-11 2011-12-07 Abbott Biotech Ltd Verfahren zur behandlung juveniler idiopathischer arthritis
CN101235064B (zh) * 2008-02-27 2011-08-10 东南大学 可脱保护的硫代核苷酸单体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0090789A1 (de) * 1982-03-26 1983-10-05 Monsanto Company Chemische DNA-Synthese
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
FR2584090B1 (fr) 1985-06-27 1987-08-28 Roussel Uclaf Nouveaux supports, leur preparation et les intermediaires obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus
WO1988006625A2 (en) * 1987-02-26 1988-09-07 Cetus Corporation Arginine-depleted human tumor necrosis factor
ATE137806T1 (de) * 1988-07-05 1996-05-15 Baylor College Medicine Verfahren zur identifizierung von bakterien

Also Published As

Publication number Publication date
CA2023899A1 (fr) 1991-02-24
CA2023899C (fr) 2002-05-14
CN1028760C (zh) 1995-06-07
ES2069715T3 (es) 1995-05-16
KR0151153B1 (ko) 1998-08-17
IE68592B1 (en) 1996-06-26
GR3015527T3 (en) 1995-06-30
IE903036A1 (en) 1991-02-27
HUT56113A (en) 1991-07-29
CN1049668A (zh) 1991-03-06
HU215242B (hu) 1998-11-30
DE69017983D1 (de) 1995-04-27
JPH0391485A (ja) 1991-04-17
IL95342A0 (en) 1991-06-30
FR2651130A1 (fr) 1991-03-01
DK0414607T3 (da) 1995-06-06
FR2651130B1 (fr) 1991-12-13
EP0414607A2 (de) 1991-02-27
PT95067B (pt) 1997-05-28
AU6119090A (en) 1991-02-28
ATE120201T1 (de) 1995-04-15
EP0414607B1 (de) 1995-03-22
IL95342A (en) 1995-01-24
KR910004198A (ko) 1991-03-28
AU642423B2 (en) 1993-10-21
ZA906675B (en) 1991-10-30
EP0414607A3 (en) 1991-04-03
HU905302D0 (en) 1991-02-28
RU2066325C1 (ru) 1996-09-10
US5705389A (en) 1998-01-06
PT95067A (pt) 1991-04-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HOECHST MARION ROUSSEL, PUTEAUX, FR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY CEDEX, FR

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC