ES2069715T3 - Secuencia de oligonucleotidos antisentido, anti-arn mensajero del tnf alfa, procedimiento de preparacion, aplicacion como medicamentos y composiciones farmaceuticas. - Google Patents

Secuencia de oligonucleotidos antisentido, anti-arn mensajero del tnf alfa, procedimiento de preparacion, aplicacion como medicamentos y composiciones farmaceuticas.

Info

Publication number
ES2069715T3
ES2069715T3 ES90402329T ES90402329T ES2069715T3 ES 2069715 T3 ES2069715 T3 ES 2069715T3 ES 90402329 T ES90402329 T ES 90402329T ES 90402329 T ES90402329 T ES 90402329T ES 2069715 T3 ES2069715 T3 ES 2069715T3
Authority
ES
Spain
Prior art keywords
sequence
application
pharmaceutical compositions
messenger rna
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90402329T
Other languages
English (en)
Inventor
Abdel Karim Braham
Pierre Smets
Rene Zalisz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of ES2069715T3 publication Critical patent/ES2069715T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02K—DYNAMO-ELECTRIC MACHINES
    • H02K2203/00—Specific aspects not provided for in the other groups of this subclass relating to the windings
    • H02K2203/03—Machines characterised by the wiring boards, i.e. printed circuit boards or similar structures for connecting the winding terminations

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thin Magnetic Films (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)

Abstract

LA SOLICITUD SE REFIERE A UNA SECUENCIA DE OLIGONUCLEOTIDOS ANTISENTIDO, ANTI-ARN MENSAJERO DEL TNF ALFA, DE FORMULA (I), EN LA QUE F ES HIDROGENO O UNA SECUENCIA DE 1 A 17 OLIGONUCLEOTIDOS EN FORMA LIBRE, ALCOHILADA, SULFURADA O DE DERIVADOS DE LA POLI L-LISINA, PROCEDIMIENTO DE PREPARACION, APLICACION COMO MEDICAMENTO Y COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTA NUEVA SECUENCIA.
ES90402329T 1989-08-23 1990-08-22 Secuencia de oligonucleotidos antisentido, anti-arn mensajero del tnf alfa, procedimiento de preparacion, aplicacion como medicamentos y composiciones farmaceuticas. Expired - Lifetime ES2069715T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8911171A FR2651130B1 (fr) 1989-08-23 1989-08-23 Sequence d'oligonucleotides anti-sens, anti-arn message du tnf alpha, procede de preparation, application a titre de medicaments et compositions pharmaceutiques.

Publications (1)

Publication Number Publication Date
ES2069715T3 true ES2069715T3 (es) 1995-05-16

Family

ID=9384878

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90402329T Expired - Lifetime ES2069715T3 (es) 1989-08-23 1990-08-22 Secuencia de oligonucleotidos antisentido, anti-arn mensajero del tnf alfa, procedimiento de preparacion, aplicacion como medicamentos y composiciones farmaceuticas.

Country Status (19)

Country Link
US (1) US5705389A (es)
EP (1) EP0414607B1 (es)
JP (1) JPH0391485A (es)
KR (1) KR0151153B1 (es)
CN (1) CN1028760C (es)
AT (1) ATE120201T1 (es)
AU (1) AU642423B2 (es)
CA (1) CA2023899C (es)
DE (1) DE69017983T2 (es)
DK (1) DK0414607T3 (es)
ES (1) ES2069715T3 (es)
FR (1) FR2651130B1 (es)
GR (1) GR3015527T3 (es)
HU (1) HU215242B (es)
IE (1) IE68592B1 (es)
IL (1) IL95342A (es)
PT (1) PT95067B (es)
RU (1) RU2066325C1 (es)
ZA (1) ZA906675B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1250722B (it) * 1991-07-30 1995-04-21 Univ Degli Studi Milano Oligonucleotidi antisenso
TW323284B (es) * 1992-03-23 1997-12-21 Novartis Ag
WO1994018325A1 (en) * 1993-02-03 1994-08-18 N.V. Innogenetics S.A. Tnf-alpha muteins and a process for preparing them
US6090382A (en) * 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
WO1999027086A1 (en) * 1997-11-25 1999-06-03 Brax Group Limited Chimeric antisense oligonucleotides against tnf-alpha and their uses
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US20040006036A1 (en) * 2000-04-12 2004-01-08 Gmr, A Delaware Corporation Silencing transcription by methylation
CA2817619A1 (en) 2001-06-08 2002-12-08 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US20040009172A1 (en) * 2002-04-26 2004-01-15 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
EP2371859A3 (en) * 2002-07-19 2011-12-28 Abbott Biotechnology Ltd Treatment of TNF alpha related disorders
US20060083741A1 (en) * 2004-10-08 2006-04-20 Hoffman Rebecca S Treatment of respiratory syncytial virus (RSV) infection
AU2006246721B2 (en) 2005-05-16 2012-12-13 Abbvie Biotechnology Ltd Use of TNF inhibitor for treatment of erosive polyarthritis
US20070041905A1 (en) * 2005-08-19 2007-02-22 Hoffman Rebecca S Method of treating depression using a TNF-alpha antibody
US20080118496A1 (en) * 2006-04-10 2008-05-22 Medich John R Uses and compositions for treatment of juvenile rheumatoid arthritis
US9624295B2 (en) 2006-04-10 2017-04-18 Abbvie Biotechnology Ltd. Uses and compositions for treatment of psoriatic arthritis
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
US9399061B2 (en) 2006-04-10 2016-07-26 Abbvie Biotechnology Ltd Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis
US20080131374A1 (en) * 2006-04-19 2008-06-05 Medich John R Uses and compositions for treatment of rheumatoid arthritis
WO2008154543A2 (en) 2007-06-11 2008-12-18 Abbott Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis
CN101235064B (zh) * 2008-02-27 2011-08-10 东南大学 可脱保护的硫代核苷酸单体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0090789A1 (en) * 1982-03-26 1983-10-05 Monsanto Company Chemical DNA synthesis
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
FR2584090B1 (fr) 1985-06-27 1987-08-28 Roussel Uclaf Nouveaux supports, leur preparation et les intermediaires obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus
WO1988006625A2 (en) * 1987-02-26 1988-09-07 Cetus Corporation Arginine-depleted human tumor necrosis factor
WO1990000624A1 (en) * 1988-07-05 1990-01-25 Baylor College Of Medecine Antisense oligonucleotide antibiotics complementary to the macromolecular synthesis operon, methods of treating bacterial infections and methods for identification of bacteria

Also Published As

Publication number Publication date
CA2023899C (fr) 2002-05-14
JPH0391485A (ja) 1991-04-17
CA2023899A1 (fr) 1991-02-24
KR910004198A (ko) 1991-03-28
RU2066325C1 (ru) 1996-09-10
FR2651130A1 (fr) 1991-03-01
IL95342A0 (en) 1991-06-30
PT95067B (pt) 1997-05-28
ZA906675B (en) 1991-10-30
AU642423B2 (en) 1993-10-21
DK0414607T3 (da) 1995-06-06
EP0414607A3 (en) 1991-04-03
AU6119090A (en) 1991-02-28
ATE120201T1 (de) 1995-04-15
IL95342A (en) 1995-01-24
CN1028760C (zh) 1995-06-07
HU905302D0 (en) 1991-02-28
HU215242B (hu) 1998-11-30
IE68592B1 (en) 1996-06-26
DE69017983D1 (de) 1995-04-27
GR3015527T3 (en) 1995-06-30
IE903036A1 (en) 1991-02-27
FR2651130B1 (fr) 1991-12-13
EP0414607A2 (fr) 1991-02-27
KR0151153B1 (ko) 1998-08-17
DE69017983T2 (de) 1995-09-28
HUT56113A (en) 1991-07-29
CN1049668A (zh) 1991-03-06
PT95067A (pt) 1991-04-18
US5705389A (en) 1998-01-06
EP0414607B1 (fr) 1995-03-22

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