KR920700201A - 신규 1α-히드록시비타민D 2 에피머 및 유도체 - Google Patents

신규 1α-히드록시비타민D 2 에피머 및 유도체

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Publication number
KR920700201A
KR920700201A KR1019900702409A KR900702409A KR920700201A KR 920700201 A KR920700201 A KR 920700201A KR 1019900702409 A KR1019900702409 A KR 1019900702409A KR 900702409 A KR900702409 A KR 900702409A KR 920700201 A KR920700201 A KR 920700201A
Authority
KR
South Korea
Prior art keywords
new
compound
derivatives
vitamin
hydroxyvitamin
Prior art date
Application number
KR1019900702409A
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English (en)
Other versions
KR950005776B1 (ko
Inventor
헥터 에프. 델루카
하인리히 케이. 쉬노에스
카토 엘. 펄만
Original Assignee
원본미기재
위스콘신 알럼나이 리써취 파운데이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 원본미기재, 위스콘신 알럼나이 리써취 파운데이션 filed Critical 원본미기재
Publication of KR920700201A publication Critical patent/KR920700201A/ko
Application granted granted Critical
Publication of KR950005776B1 publication Critical patent/KR950005776B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

신규 1α－히드록시비타민D2에피머 및 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 구조식으로 표시되는 화합물.
    식중, X1및 X2는 수소원자, 아실 및 알킬실릴로 구성된 군 중에서 선택될 수 있다.
  2. 제1항에 있어서, X1및 X2가 수소 원자인 것이 특징인 화합물.
  3. 제약학상 허용되는 부형제와 제1항의 화합물을 함유하는 것이 특징인 제약학적 제제.
  4. 제약학상 허용되는 부형제와 제2항의 화합물을 함유하는 것이 특징인 제약학적 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900702409A 1989-03-09 1990-02-16 신규 1α-히드록시비타민D_2에피머 및 유도체 KR950005776B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US321,254 1989-03-09
US07/321,254 US4973584A (en) 1989-03-09 1989-03-09 Novel 1α-hydroxyvitamin D2 epimer and derivatives
US321254 1989-03-09
PCT/US1990/000952 WO1990010619A1 (en) 1989-03-09 1990-02-16 NOVEL 1α-HYDROXYVITAMIN D2 EPIMER AND DERIVATIVES

Publications (2)

Publication Number Publication Date
KR920700201A true KR920700201A (ko) 1992-02-19
KR950005776B1 KR950005776B1 (ko) 1995-05-30

Family

ID=23249837

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900702409A KR950005776B1 (ko) 1989-03-09 1990-02-16 신규 1α-히드록시비타민D_2에피머 및 유도체

Country Status (15)

Country Link
US (1) US4973584A (ko)
EP (1) EP0386793B1 (ko)
JP (1) JPH0737443B2 (ko)
KR (1) KR950005776B1 (ko)
AT (1) ATE90342T1 (ko)
AU (1) AU631618B2 (ko)
CA (1) CA1335105C (ko)
DE (1) DE69001839T2 (ko)
DK (1) DK0386793T3 (ko)
ES (1) ES2055193T3 (ko)
HU (1) HU207040B (ko)
IL (1) IL93456A (ko)
NZ (1) NZ232735A (ko)
RU (1) RU2065851C1 (ko)
WO (1) WO1990010619A1 (ko)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5756783A (en) * 1990-09-21 1998-05-26 Bone Care International, Inc. 1α-Hydroxy-24-EPI-vitamin D4
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
US5789397A (en) * 1991-01-08 1998-08-04 Bone Care International, Inc. Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
US6251883B1 (en) 1991-01-08 2001-06-26 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US5182396A (en) * 1991-03-29 1993-01-26 Nisshin Flour Milling Co., Ltd. 1-hydroxyvitamin d derivatives
ATE144250T1 (de) * 1991-12-26 1996-11-15 Wisconsin Alumni Res Found 26,27-dimethylen-1-alpha, 25-dihydroxyvitamin-d2 und 26,27-dihydroxyvitamin-d2 und verfahren zu ihrer herstellung
JP2927368B2 (ja) * 1992-01-29 1999-07-28 ボーン ケア インターナショナル インコーポレイテッド １α−ヒドロキシ−２４−ＥＰＩ−ビタミンＤ▲下４▼
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives
ATE181062T1 (de) * 1992-08-28 1999-06-15 Bone Care Int Inc 1alpha,24(s)-dihydroxy vitamin d2, seine synthese und verwendung
TW267161B (ko) * 1992-11-20 1996-01-01 Hoffmann La Roche
JPH0753384A (ja) * 1993-07-13 1995-02-28 Wisconsin Alumni Res Found ２４−エピ−１α−ヒドロキシビタミンＤ２ を含んでなる骨粗鬆症治療剤
US5565589A (en) * 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5373004A (en) * 1993-11-24 1994-12-13 Wisconsin Alumni Research Foundation 26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
US5661140A (en) * 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
WO2000028982A2 (en) 1998-11-19 2000-05-25 The Board Of Trustees For The University Of Arkansas Increasing bone strength with selected bisphosphonates
US6380408B1 (en) * 1999-04-01 2002-04-30 The Johns Hopkins University Non-calcemic, antiproliferative, transcriptionally active sulfur-containing analogs of 1α, 25-dihydroxy vitamin D3
US6479474B2 (en) 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
EP1419143B1 (en) * 2001-08-22 2009-04-15 Johns Hopkins University 24-sulfur-substituted analogs of 1alpha,25-dihydroxy vitamin d3
ES2380748T3 (es) 2002-06-13 2012-05-18 Johns Hopkins University Compuestos de 24-sulfoximina vitamina D3
US8106035B2 (en) 2002-12-18 2012-01-31 Cytochroma Inc. 25-SO2-substituted analogs of 1μ,25-dihydroxyvitamin D3
JP5009617B2 (ja) * 2003-08-20 2012-08-22 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１９−ノル−ビタミンｄ２化合物
CA2750659C (en) 2009-01-27 2017-11-21 Berg Biosystems, Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
EP3603646B1 (en) 2009-08-14 2024-04-03 BPGbio, Inc. Vitamin d3 and analogs thereof for treating alopecia
SG11201509715UA (en) 2013-05-29 2015-12-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907843A (en) * 1974-06-14 1975-09-23 Wisconsin Alumni Res Found 1{60 -Hydroxyergocalciferol and processes for preparing same
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
DE3490215T (de) * 1983-05-09 1985-05-15 Wisconsin Alumni Research Foundation, Madison, Wis. Verfahren zur Herstellung von 1α,25-dihydroxyliertem Vitamin D↓2↓ und verwandten Verbindungen
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4717721A (en) * 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity

Also Published As

Publication number Publication date
NZ232735A (en) 1992-07-28
DK0386793T3 (da) 1993-08-02
IL93456A (en) 1994-02-27
JPH03504508A (ja) 1991-10-03
EP0386793B1 (en) 1993-06-09
AU5192590A (en) 1990-10-09
CA1335105C (en) 1995-04-04
JPH0737443B2 (ja) 1995-04-26
RU2065851C1 (ru) 1996-08-27
HU207040B (en) 1993-03-01
DE69001839T2 (de) 1993-09-16
US4973584A (en) 1990-11-27
DE69001839D1 (de) 1993-07-15
ATE90342T1 (de) 1993-06-15
WO1990010619A1 (en) 1990-09-20
ES2055193T3 (es) 1994-08-16
KR950005776B1 (ko) 1995-05-30
HU902288D0 (en) 1991-07-29
AU631618B2 (en) 1992-12-03
EP0386793A1 (en) 1990-09-12
IL93456A0 (en) 1990-11-29

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