DE69009964D1 - Verfahren zur Herstellung von 1-Phenylimidazolin-2,5-dion-Derivate. - Google Patents

Verfahren zur Herstellung von 1-Phenylimidazolin-2,5-dion-Derivate.

Info

Publication number
DE69009964D1
DE69009964D1 DE69009964T DE69009964T DE69009964D1 DE 69009964 D1 DE69009964 D1 DE 69009964D1 DE 69009964 T DE69009964 T DE 69009964T DE 69009964 T DE69009964 T DE 69009964T DE 69009964 D1 DE69009964 D1 DE 69009964D1
Authority
DE
Germany
Prior art keywords
preparation
formula
image
phenylimidazoline
denote
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69009964T
Other languages
English (en)
Other versions
DE69009964T2 (de
Inventor
Patrick Seuron
Daniel Varraillon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE69009964D1 publication Critical patent/DE69009964D1/de
Publication of DE69009964T2 publication Critical patent/DE69009964T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Reinforced Plastic Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE69009964T 1989-12-22 1990-12-21 Verfahren zur Herstellung von 1-Phenylimidazolin-2,5-dion-Derivate. Expired - Lifetime DE69009964T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8917046A FR2656302B1 (fr) 1989-12-22 1989-12-22 Nouveau procede de preparation de l'anandron et derives de l'anandron.

Publications (2)

Publication Number Publication Date
DE69009964D1 true DE69009964D1 (de) 1994-07-21
DE69009964T2 DE69009964T2 (de) 1994-10-13

Family

ID=9388859

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69009964T Expired - Lifetime DE69009964T2 (de) 1989-12-22 1990-12-21 Verfahren zur Herstellung von 1-Phenylimidazolin-2,5-dion-Derivate.

Country Status (24)

Country Link
US (1) US5166358A (de)
EP (1) EP0436426B1 (de)
JP (1) JP2836041B2 (de)
KR (1) KR0173307B1 (de)
CN (1) CN1048011C (de)
AT (1) ATE107289T1 (de)
AU (1) AU628699B2 (de)
CA (1) CA2032988C (de)
CZ (1) CZ281655B6 (de)
DE (1) DE69009964T2 (de)
DK (1) DK0436426T3 (de)
ES (1) ES2055382T3 (de)
FI (1) FI103203B1 (de)
FR (1) FR2656302B1 (de)
HU (1) HU207301B (de)
IE (1) IE65510B1 (de)
IL (1) IL96696A (de)
NZ (1) NZ236621A (de)
PL (1) PL164694B1 (de)
PT (1) PT96313B (de)
RU (1) RU1836356C (de)
SK (1) SK656790A3 (de)
UA (1) UA27220C2 (de)
ZA (1) ZA909648B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
US5656651A (en) * 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
FR2741346B1 (fr) * 1995-11-16 1997-12-19 Roussel Uclaf Nouveau procede de preparation de derives phenylimidazolidine
FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
JPH1072446A (ja) * 1996-06-24 1998-03-17 Sumitomo Chem Co Ltd １−置換−ヒダントイン類の製造法
CZ20024214A3 (cs) * 2000-06-28 2003-04-16 Bristol-Myers Squibb Company Selektivní androgen receptorový modulátor, způsob jeho identifikace, jeho konstrukce a použití
EP1854798A3 (de) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Kondensierte heterozyklische Succinimid-Verbindungen und Analoga daraus, Modulatoren der nuklearen Hormonrezeptorfunktion
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US8034548B2 (en) * 2003-12-19 2011-10-11 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies
AU2005232526B2 (en) * 2004-02-24 2011-06-23 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
HUE032085T2 (en) 2006-03-27 2017-09-28 Univ California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor related diseases
JP5350217B2 (ja) * 2006-03-29 2013-11-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ジアリールチオヒダントイン化合物
TW201716385A (zh) 2007-10-26 2017-05-16 加州大學董事會 二芳基乙內醯脲類化合物
EP3124481B1 (de) 2010-02-16 2018-03-28 Aragon Pharmaceuticals, Inc. Androgenrezeptormodulatoren und verwendungen davon
SI3305285T1 (sl) 2012-09-26 2021-03-31 Aragon Pharmaceuticals, Inc. Anti-androgeni za zdravljenje proti kastraciji odpornega ne-metastatskega raka
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
JOP20200076A1 (ar) 2017-10-16 2020-04-30 Aragon Pharmaceuticals Inc مضادات أندروجين لعلاج سرطان البروستاتا غير النقيلي المقاوم للاستئصال

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH166004A (de) * 1934-06-06 1933-12-15 Chem Fab Vormals Sandoz Verfahren zur Darstellung eines Derivates des 5,5-Phenyläthylhydantoins.
US2490813A (en) * 1944-11-29 1949-12-13 Standard Oil Co Continuous process for making aryl amines
US2759002A (en) * 1954-03-24 1956-08-14 Abbott Lab 3-benzyl hydantoin and process
US3134663A (en) * 1957-07-23 1964-05-26 Geigy Chem Corp Herbicidal composition and method employing hydantoins
US3914311A (en) * 1973-06-15 1975-10-21 Du Pont Preparation of aromatic secondary and tertiary amines using a nickel complex catalyst
DE2414613A1 (de) * 1974-03-26 1975-10-16 Bayer Ag 1-aryl-5-alkyliden-2,4-dioxo-imidazolidine
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
CA1138334A (en) * 1977-10-28 1982-12-28 Karl Bernauer Pharmaceutical preparations containing certain urea derivatives
GB1598166A (en) * 1978-05-23 1981-09-16 Lilly Industries Ltd 3,5-disubstituted hydantoin derivatives
US4764625A (en) * 1980-12-12 1988-08-16 Xerox Corporation Process for preparing arylamines
DE3382406D1 (de) * 1982-04-08 1991-10-17 Shell Int Research Neue hydantoine, ihre herstellung und verwendung.

Also Published As

Publication number Publication date
PL164694B1 (pl) 1994-09-30
EP0436426A1 (de) 1991-07-10
DK0436426T3 (da) 1994-07-04
IL96696A (en) 1995-08-31
EP0436426B1 (de) 1994-06-15
KR0173307B1 (ko) 1999-02-01
JPH04103573A (ja) 1992-04-06
FI906366A0 (fi) 1990-12-21
CZ281655B6 (cs) 1996-12-11
ZA909648B (en) 1992-02-26
CN1052666A (zh) 1991-07-03
RU1836356C (ru) 1993-08-23
CA2032988A1 (fr) 1991-06-23
ES2055382T3 (es) 1994-08-16
KR910011799A (ko) 1991-08-07
AU628699B2 (en) 1992-09-17
PL288365A1 (en) 1991-09-09
CA2032988C (fr) 2003-04-29
FI103203B (fi) 1999-05-14
JP2836041B2 (ja) 1998-12-14
IL96696A0 (en) 1991-09-16
PT96313B (pt) 1998-06-30
NZ236621A (en) 1992-04-28
FR2656302B1 (fr) 1992-05-07
DE69009964T2 (de) 1994-10-13
ATE107289T1 (de) 1994-07-15
SK278447B6 (en) 1997-06-04
FI906366A (fi) 1991-06-23
FI103203B1 (fi) 1999-05-14
HU908416D0 (en) 1991-07-29
US5166358A (en) 1992-11-24
CZ656790A3 (en) 1996-08-14
CN1048011C (zh) 2000-01-05
PT96313A (pt) 1991-09-30
FR2656302A1 (fr) 1991-06-28
UA27220C2 (uk) 2000-08-15
IE65510B1 (en) 1995-11-01
SK656790A3 (en) 1997-06-04
HU207301B (en) 1993-03-29
IE904142A1 (en) 1991-07-03
AU6826590A (en) 1991-06-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HOECHST MARION ROUSSEL, PUTEAUX, FR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY CEDEX, FR

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC